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Migraine without aura

MedGen UID:
137899
Concept ID:
C0338480
Disease or Syndrome
Synonyms: Common Migraine; Common Migraines; Migraine without Aura; Migraine, Common; Migraines, Common
SNOMED CT: Migraine without aura (56097005); Common migraine (56097005); Atypical migraine (56097005)
 
HPO: HP:0002083
Monarch Initiative: MONDO:0100431

Definition

Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Migraine without aura

Conditions with this feature

Spinocerebellar ataxia type 6
MedGen UID:
148458
Concept ID:
C0752124
Disease or Syndrome
Spinocerebellar ataxia type 6 (SCA6) is characterized by adult-onset, slowly progressive cerebellar ataxia, dysarthria, and nystagmus. The age of onset ranges from 19 to 73 years; mean age of onset is between 43 and 52 years. Initial symptoms are gait unsteadiness, stumbling, and imbalance (in ~90%) and dysarthria (in ~10%). Eventually all persons have gait ataxia, upper-limb incoordination, intention tremor, and dysarthria. Dysphagia and choking are common. Visual disturbances may result from diplopia, difficulty fixating on moving objects, horizontal gaze-evoked nystagmus, and vertical nystagmus. Hyperreflexia and extensor plantar responses occur in up to 40%-50%. Basal ganglia signs, including dystonia and blepharospasm, occur in up to 25%. Mentation is generally preserved.
Migraine with or without aura, susceptibility to, 6
MedGen UID:
334829
Concept ID:
C1843765
Finding
Migraine with or without aura, susceptibility to, 5
MedGen UID:
334831
Concept ID:
C1843771
Finding
For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300).
Migraine without aura, susceptibility to, 4
MedGen UID:
336040
Concept ID:
C1843773
Finding
An inherited susceptibility or predisposition to developing migraines without aura.
Migraine with or without aura, susceptibility to, 3
MedGen UID:
375283
Concept ID:
C1843782
Finding
Migraine, familial typical, susceptibility to, 2
MedGen UID:
341144
Concept ID:
C1848066
Finding
Migraine with or without aura, susceptibility to, 11
MedGen UID:
387900
Concept ID:
C1857751
Finding
Migraine with or without aura, susceptibility to, 10
MedGen UID:
341839
Concept ID:
C1857752
Finding
Migraine, with or without aura, susceptibility to, 13
MedGen UID:
462258
Concept ID:
C3150908
Finding
Any migraine disorder in which the cause of the disease is a mutation in the KCNK18 gene.
Advanced sleep phase syndrome 2
MedGen UID:
815204
Concept ID:
C3808874
Disease or Syndrome
Advanced sleep phase syndrome is characterized by very early sleep onset and offset (summary by Jones et al., 1999). For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (604348).
Migraine with or without aura, susceptibility to, 1
MedGen UID:
854348
Concept ID:
C3887485
Finding
Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; 607498), 14q21.2-q22.3 (MGR4; 607501), 19p13 (MGR5; 607508), 1q31 (MGR6; 607516), 15q11-q13 (MGR7; 609179), 5q21 (with or without aura, MGR8, 609570; with aura, MGR9, 609670), 17p13 (MGR10; 610208), 18q12 (MGR11; 610209), 10q22-q23 (MGR12; 611706), and the X chromosome (MGR2; 300125). Mutation in the KCNK18 gene (613655) on chromosome 10q25 causes migraine with aura (MGR13; 613656). See also familial hemiplegic migraine-1 (FHM1; 141500), a subtype of autosomal dominant migraine with aura (MA).

Professional guidelines

PubMed

Chalmer MA, Kogelman LJA, Ullum H, Sørensen E, Didriksen M, Mikkelsen S, Dinh KM, Brodersen T, Nielsen KR, Bruun MT, Banasik K, Brunak S, Erikstrup C, Pedersen OB, Ostrowski SR, Olesen J, Hansen TF
JAMA Netw Open 2023 May 1;6(5):e2313235. doi: 10.1001/jamanetworkopen.2023.13235. PMID: 37184838
Gungor M, Guler MA, Karagoz YS
Pediatr Int 2023 Jan;65(1):e15406. doi: 10.1111/ped.15406. PMID: 36326638
Diener HC, Dodick DW, Goadsby PJ, Lipton RB, Olesen J, Silberstein SD
Nat Rev Neurol 2012 Feb 14;8(3):162-71. doi: 10.1038/nrneurol.2012.13. PMID: 22331030

Recent clinical studies

Etiology

Verhagen IE, van der Arend BW, van Casteren DS, Thiermann NJ, Tange E, MaassenVanDenBrink A, Terwindt GM
Cephalalgia 2023 Jun;43(6):3331024231164322. doi: 10.1177/03331024231164322. PMID: 37259230
Magalhães JE, Sampaio Rocha-Filho PA
Headache 2018 Sep;58(8):1277-1286. Epub 2018 Aug 17 doi: 10.1111/head.13378. PMID: 30117565
Güven B, Güven H, Çomoğlu SS
Headache 2018 Feb;58(2):210-216. Epub 2017 Sep 27 doi: 10.1111/head.13195. PMID: 28960327
Capo A, Affaitati G, Giamberardino MA, Amerio P
J Eur Acad Dermatol Venereol 2018 Jan;32(1):57-61. Epub 2017 Aug 2 doi: 10.1111/jdv.14472. PMID: 28707753
MacGregor EA
Headache 2013 Feb;53(2):247-76. doi: 10.1111/head.12035. PMID: 23432442

Diagnosis

Paemeleire K, Vandenbussche N, Stark R
Handb Clin Neurol 2023;198:151-167. doi: 10.1016/B978-0-12-823356-6.00007-X. PMID: 38043959
He Q, Wang W, Xiong Y, Tao C, Ma L, Ma J, You C; International Headache Genetics Consortium
J Headache Pain 2023 Jul 17;24(1):90. doi: 10.1186/s10194-023-01609-x. PMID: 37460956Free PMC Article
Güven B, Güven H, Çomoğlu SS
Headache 2018 Feb;58(2):210-216. Epub 2017 Sep 27 doi: 10.1111/head.13195. PMID: 28960327
Lewis DW
Neurol Clin 2009 May;27(2):481-501. doi: 10.1016/j.ncl.2008.11.003. PMID: 19289227
Tfelt-Hansen P
Pharmacol Toxicol 1994;75 Suppl 2:72-5. doi: 10.1111/j.1600-0773.1994.tb02003.x. PMID: 7816788

Therapy

He Q, Wang W, Xiong Y, Tao C, Ma L, Ma J, You C; International Headache Genetics Consortium
J Headache Pain 2023 Jul 17;24(1):90. doi: 10.1186/s10194-023-01609-x. PMID: 37460956Free PMC Article
Onofri A, Pensato U, Rosignoli C, Wells-Gatnik W, Stanyer E, Ornello R, Chen HZ, De Santis F, Torrente A, Mikulenka P, Monte G, Marschollek K, Waliszewska-Prosół M, Wiels W, Boucherie DM, Onan D, Farham F, Al-Hassany L, Sacco S; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2023 Feb 14;24(1):8. doi: 10.1186/s10194-023-01541-0. PMID: 36782182Free PMC Article
Xu S, Yu L, Luo X, Wang M, Chen G, Zhang Q, Liu W, Zhou Z, Song J, Jing H, Huang G, Liang F, Wang H, Wang W
BMJ 2020 Mar 25;368:m697. doi: 10.1136/bmj.m697. PMID: 32213509Free PMC Article
Zhao L, Chen J, Li Y, Sun X, Chang X, Zheng H, Gong B, Huang Y, Yang M, Wu X, Li X, Liang F
JAMA Intern Med 2017 Apr 1;177(4):508-515. doi: 10.1001/jamainternmed.2016.9378. PMID: 28241154
Linde K, Allais G, Brinkhaus B, Fei Y, Mehring M, Vertosick EA, Vickers A, White AR
Cochrane Database Syst Rev 2016 Jun 28;2016(6):CD001218. doi: 10.1002/14651858.CD001218.pub3. PMID: 27351677Free PMC Article

Prognosis

Krause DN, Warfvinge K, Haanes KA, Edvinsson L
Nat Rev Neurol 2021 Oct;17(10):621-633. Epub 2021 Sep 20 doi: 10.1038/s41582-021-00544-2. PMID: 34545218
Hadjikhani N, Vincent M
J Headache Pain 2019 Apr 3;20(1):32. doi: 10.1186/s10194-019-0983-2. PMID: 30943894Free PMC Article
Allais G, Chiarle G, Sinigaglia S, Airola G, Schiapparelli P, Benedetto C
Neurol Sci 2018 Jun;39(Suppl 1):11-20. doi: 10.1007/s10072-018-3333-2. PMID: 29904828
Vincent MB
Headache 2015 Apr;55(4):595-9. Epub 2015 Mar 11 doi: 10.1111/head.12531. PMID: 25758366
Lewis DW
Neurol Clin 2009 May;27(2):481-501. doi: 10.1016/j.ncl.2008.11.003. PMID: 19289227

Clinical prediction guides

Welander NZ, Rukh G, Rask-Andersen M, Harder AVE; International Headache Genetics Consortium, van den Maagdenberg AMJM, Schiöth HB, Mwinyi J
Headache 2023 May;63(5):642-651. Epub 2023 Jan 27 doi: 10.1111/head.14470. PMID: 36705326
Hadjikhani N, Vincent M
J Headache Pain 2019 Apr 3;20(1):32. doi: 10.1186/s10194-019-0983-2. PMID: 30943894Free PMC Article
Capo A, Affaitati G, Giamberardino MA, Amerio P
J Eur Acad Dermatol Venereol 2018 Jan;32(1):57-61. Epub 2017 Aug 2 doi: 10.1111/jdv.14472. PMID: 28707753
Zhao L, Chen J, Li Y, Sun X, Chang X, Zheng H, Gong B, Huang Y, Yang M, Wu X, Li X, Liang F
JAMA Intern Med 2017 Apr 1;177(4):508-515. doi: 10.1001/jamainternmed.2016.9378. PMID: 28241154
Nappi RE, Albani F, Sances G, Terreno E, Brambilla E, Polatti F
Curr Pain Headache Rep 2011 Aug;15(4):289-94. doi: 10.1007/s11916-011-0200-8. PMID: 21465113

Recent systematic reviews

Sun Z, Kleine-Borgmann J, Suh J, McDermott GC, Vishnevetsky A, Rist PM
Eur Stroke J 2023 Dec;8(4):904-914. Epub 2023 Aug 9 doi: 10.1177/23969873231191860. PMID: 37555306Free PMC Article
Onofri A, Pensato U, Rosignoli C, Wells-Gatnik W, Stanyer E, Ornello R, Chen HZ, De Santis F, Torrente A, Mikulenka P, Monte G, Marschollek K, Waliszewska-Prosół M, Wiels W, Boucherie DM, Onan D, Farham F, Al-Hassany L, Sacco S; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2023 Feb 14;24(1):8. doi: 10.1186/s10194-023-01541-0. PMID: 36782182Free PMC Article
Zhang X, Zhou J, Guo M, Cheng S, Chen Y, Jiang N, Li X, Hu S, Tian Z, Li Z, Zeng F
J Neurol 2023 Jan;270(1):152-170. Epub 2022 Sep 13 doi: 10.1007/s00415-022-11363-w. PMID: 36098838
Scutelnic A, Mattle HP, Branca M, Jung S, Reichlin T, Fischer U, Schankin CJ
Eur J Neurol 2022 Mar;29(3):910-920. Epub 2021 Dec 8 doi: 10.1111/ene.15198. PMID: 34826198
Linde K, Allais G, Brinkhaus B, Fei Y, Mehring M, Vertosick EA, Vickers A, White AR
Cochrane Database Syst Rev 2016 Jun 28;2016(6):CD001218. doi: 10.1002/14651858.CD001218.pub3. PMID: 27351677Free PMC Article

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