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Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative

MedGen UID:
1379017
•Concept ID:
C4329625
•
Neoplastic Process
Synonym: Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative

Definition

An anaplastic large cell lymphoma, ALK-negative, arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative

Recent clinical studies

Etiology

Primary central nervous system ALK-negative anaplastic large cell lymphoma: a case report and literature review.
Yuan C, Duan H, Wang Y, Zhang J, Ou J, Wang W, Zhang M
Ann Palliat Med 2022 Apr;11(4):1554-1560. Epub 2021 Jul 1 doi: 10.21037/apm-21-557. PMID: 34263607
Comparison of tumor mutation burden of 300 various non-Hodgkin lymphomas using panel based massively parallel sequencing.
Cho J, Yoon SE, Kim SJ, Ko YH, Kim WS
BMC Cancer 2021 Aug 30;21(1):972. doi: 10.1186/s12885-021-08695-7. PMID: 34461835Free PMC Article
Isolated Central Nervous System Progression During Systemic Treatment With Brentuximab Vedotin Monotherapy in a Pediatric Patient With Recurrent ALK-negative Anaplastic Large Cell Lymphoma.
Kim Y, Sudo A, Oyama R, Keino D, Tomizawa D, Kato M, Osumi T, Mori T
J Pediatr Hematol Oncol 2021 Aug 1;43(6):e864-e866. doi: 10.1097/MPH.0000000000001914. PMID: 32769561

Diagnosis

ALK-negative CNS anaplastic large cell lymphoma: case report and review of literature.
Lannon M, Lu JQ, Chum M, Wang BH
Br J Neurosurg 2023 Oct;37(5):1245-1250. Epub 2020 Nov 30 doi: 10.1080/02688697.2020.1839630. PMID: 33253051
Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement.
Magaki S, Satyadev R, Chen Z, Yung KS, Vinters HV, Kinney MC, Said JW
Brain Tumor Pathol 2022 Jan;39(1):25-34. Epub 2021 Nov 18 doi: 10.1007/s10014-021-00415-0. PMID: 34791573Free PMC Article
Primary central nervous system ALK-negative anaplastic large cell lymphoma: a case report and literature review.
Yuan C, Duan H, Wang Y, Zhang J, Ou J, Wang W, Zhang M
Ann Palliat Med 2022 Apr;11(4):1554-1560. Epub 2021 Jul 1 doi: 10.21037/apm-21-557. PMID: 34263607
Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.
Menon MP, Nicolae A, Meeker H, Raffeld M, Xi L, Jegalian AG, Miller DC, Pittaluga S, Jaffe ES
Am J Surg Pathol 2015 Dec;39(12):1719-1729. doi: 10.1097/PAS.0000000000000503. PMID: 26379152Free PMC Article

Therapy

Primary central nervous system ALK-negative anaplastic large cell lymphoma: a case report and literature review.
Yuan C, Duan H, Wang Y, Zhang J, Ou J, Wang W, Zhang M
Ann Palliat Med 2022 Apr;11(4):1554-1560. Epub 2021 Jul 1 doi: 10.21037/apm-21-557. PMID: 34263607
Isolated Central Nervous System Progression During Systemic Treatment With Brentuximab Vedotin Monotherapy in a Pediatric Patient With Recurrent ALK-negative Anaplastic Large Cell Lymphoma.
Kim Y, Sudo A, Oyama R, Keino D, Tomizawa D, Kato M, Osumi T, Mori T
J Pediatr Hematol Oncol 2021 Aug 1;43(6):e864-e866. doi: 10.1097/MPH.0000000000001914. PMID: 32769561

Prognosis

Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement.
Magaki S, Satyadev R, Chen Z, Yung KS, Vinters HV, Kinney MC, Said JW
Brain Tumor Pathol 2022 Jan;39(1):25-34. Epub 2021 Nov 18 doi: 10.1007/s10014-021-00415-0. PMID: 34791573Free PMC Article
Comparison of tumor mutation burden of 300 various non-Hodgkin lymphomas using panel based massively parallel sequencing.
Cho J, Yoon SE, Kim SJ, Ko YH, Kim WS
BMC Cancer 2021 Aug 30;21(1):972. doi: 10.1186/s12885-021-08695-7. PMID: 34461835Free PMC Article
Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.
Menon MP, Nicolae A, Meeker H, Raffeld M, Xi L, Jegalian AG, Miller DC, Pittaluga S, Jaffe ES
Am J Surg Pathol 2015 Dec;39(12):1719-1729. doi: 10.1097/PAS.0000000000000503. PMID: 26379152Free PMC Article
Brain metastasis of ALK positive anaplastic large cell lymphoma after a long-term disease free survival in an old adult.
Wang CX, Wang H, Li J, Ma HH, Yu B, Shi SS, Zhou XJ, Shi QL
Int J Clin Exp Pathol 2014;7(3):1182-7. Epub 2014 Feb 15 PMID: 24696735Free PMC Article
Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression.
George DH, Scheithauer BW, Aker FV, Kurtin PJ, Burger PC, Cameselle-Teijeiro J, McLendon RE, Parisi JE, Paulus W, Roggendorf W, Sotelo C
Am J Surg Pathol 2003 Apr;27(4):487-93. doi: 10.1097/00000478-200304000-00008. PMID: 12657933

Clinical prediction guides

Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.
Menon MP, Nicolae A, Meeker H, Raffeld M, Xi L, Jegalian AG, Miller DC, Pittaluga S, Jaffe ES
Am J Surg Pathol 2015 Dec;39(12):1719-1729. doi: 10.1097/PAS.0000000000000503. PMID: 26379152Free PMC Article

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