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Unresectable Transitional Cell Carcinoma

MedGen UID:
1379032
•Concept ID:
C4331479
•
Neoplastic Process

Definition

A transitional cell carcinoma which is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Emerging monoclonal antibody therapies in the treatment of metastatic urothelial carcinoma.
Jain RK, Singh AM, Wang X, Guevara-Patiño JA, Sonpavde G
Expert Opin Emerg Drugs 2023 Mar;28(1):17-26. Epub 2023 Mar 7 doi: 10.1080/14728214.2023.2186398. PMID: 36882977
Treatment Approaches for Cisplatin-Ineligible Patients with Invasive Bladder Cancer.
Einstein DJ, Sonpavde G
Curr Treat Options Oncol 2019 Feb 11;20(2):12. doi: 10.1007/s11864-019-0609-6. PMID: 30741358
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430

Recent clinical studies

Etiology

Multicenter Phase 2 Trial of Gemcitabine, Carboplatin, and Sorafenib in Patients With Metastatic or Unresectable Transitional-Cell Carcinoma.
Hurwitz ME, Markowski P, Yao X, Deshpande H, Patel J, Mortazavi A, Donadio A, Stein MN, Kelly WK, Petrylak DP, Mehnert JM
Clin Genitourin Cancer 2018 Dec;16(6):437-444.e6. Epub 2018 Jul 29 doi: 10.1016/j.clgc.2018.07.021. PMID: 30177237
Evaluation of chemotherapy with magnetic resonance imaging in patients with regionally metastatic or unresectable bladder cancer.
Schrier BP, Peters M, Barentsz JO, Witjes JA
Eur Urol 2006 Apr;49(4):698-703. Epub 2006 Jan 31 doi: 10.1016/j.eururo.2006.01.022. PMID: 16464531
Phase II trial of carboplatin and paclitaxel in cisplatin-pretreated advanced transitional cell carcinoma: a Southwest Oncology Group study.
Vaishampayan UN, Faulkner JR, Small EJ, Redman BG, Keiser WL, Petrylak DP, Crawford ED
Cancer 2005 Oct 15;104(8):1627-32. doi: 10.1002/cncr.21370. PMID: 16138364

Diagnosis

Evaluation of chemotherapy with magnetic resonance imaging in patients with regionally metastatic or unresectable bladder cancer.
Schrier BP, Peters M, Barentsz JO, Witjes JA
Eur Urol 2006 Apr;49(4):698-703. Epub 2006 Jan 31 doi: 10.1016/j.eururo.2006.01.022. PMID: 16464531
A phase II trial of sequential chemotherapy with docetaxel and methotrexate followed by gemcitabine and cisplatin for metastatic urothelial cancer.
Artz A, Stadler WM, Vogelzang NJ, Zimmerman T, Ryan C
Am J Clin Oncol 2005 Apr;28(2):109-13. doi: 10.1097/01.coc.0000142591.62299.8f. PMID: 15803001

Therapy

Multicenter Phase 2 Trial of Gemcitabine, Carboplatin, and Sorafenib in Patients With Metastatic or Unresectable Transitional-Cell Carcinoma.
Hurwitz ME, Markowski P, Yao X, Deshpande H, Patel J, Mortazavi A, Donadio A, Stein MN, Kelly WK, Petrylak DP, Mehnert JM
Clin Genitourin Cancer 2018 Dec;16(6):437-444.e6. Epub 2018 Jul 29 doi: 10.1016/j.clgc.2018.07.021. PMID: 30177237
Evaluation of chemotherapy with magnetic resonance imaging in patients with regionally metastatic or unresectable bladder cancer.
Schrier BP, Peters M, Barentsz JO, Witjes JA
Eur Urol 2006 Apr;49(4):698-703. Epub 2006 Jan 31 doi: 10.1016/j.eururo.2006.01.022. PMID: 16464531
Phase II trial of carboplatin and paclitaxel in cisplatin-pretreated advanced transitional cell carcinoma: a Southwest Oncology Group study.
Vaishampayan UN, Faulkner JR, Small EJ, Redman BG, Keiser WL, Petrylak DP, Crawford ED
Cancer 2005 Oct 15;104(8):1627-32. doi: 10.1002/cncr.21370. PMID: 16138364
Paclitaxel, carboplatin, and gemcitabine in the treatment of patients with advanced transitional cell carcinoma of the urothelium.
Hainsworth JD, Meluch AA, Litchy S, Schnell FM, Bearden JD, Yost K, Greco FA
Cancer 2005 Jun 1;103(11):2298-303. doi: 10.1002/cncr.21078. PMID: 15856431
A phase II trial of sequential chemotherapy with docetaxel and methotrexate followed by gemcitabine and cisplatin for metastatic urothelial cancer.
Artz A, Stadler WM, Vogelzang NJ, Zimmerman T, Ryan C
Am J Clin Oncol 2005 Apr;28(2):109-13. doi: 10.1097/01.coc.0000142591.62299.8f. PMID: 15803001

Prognosis

Evaluation of chemotherapy with magnetic resonance imaging in patients with regionally metastatic or unresectable bladder cancer.
Schrier BP, Peters M, Barentsz JO, Witjes JA
Eur Urol 2006 Apr;49(4):698-703. Epub 2006 Jan 31 doi: 10.1016/j.eururo.2006.01.022. PMID: 16464531
Phase II trial of carboplatin and paclitaxel in cisplatin-pretreated advanced transitional cell carcinoma: a Southwest Oncology Group study.
Vaishampayan UN, Faulkner JR, Small EJ, Redman BG, Keiser WL, Petrylak DP, Crawford ED
Cancer 2005 Oct 15;104(8):1627-32. doi: 10.1002/cncr.21370. PMID: 16138364
Paclitaxel, carboplatin, and gemcitabine in the treatment of patients with advanced transitional cell carcinoma of the urothelium.
Hainsworth JD, Meluch AA, Litchy S, Schnell FM, Bearden JD, Yost K, Greco FA
Cancer 2005 Jun 1;103(11):2298-303. doi: 10.1002/cncr.21078. PMID: 15856431

Clinical prediction guides

Evaluation of chemotherapy with magnetic resonance imaging in patients with regionally metastatic or unresectable bladder cancer.
Schrier BP, Peters M, Barentsz JO, Witjes JA
Eur Urol 2006 Apr;49(4):698-703. Epub 2006 Jan 31 doi: 10.1016/j.eururo.2006.01.022. PMID: 16464531
A phase II trial of sequential chemotherapy with docetaxel and methotrexate followed by gemcitabine and cisplatin for metastatic urothelial cancer.
Artz A, Stadler WM, Vogelzang NJ, Zimmerman T, Ryan C
Am J Clin Oncol 2005 Apr;28(2):109-13. doi: 10.1097/01.coc.0000142591.62299.8f. PMID: 15803001

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