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Abnormal cardiac biomarker test

MedGen UID:
1379094
•Concept ID:
C4477079
•
Finding
HPO: HP:0500020

Definition

Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes. [from HPO]

Professional guidelines

PubMed

Heart failure in congenital heart disease: management options and clinical challenges.
Leusveld EM, Kauling RM, Geenen LW, Roos-Hesselink JW
Expert Rev Cardiovasc Ther 2020 Aug;18(8):503-516. Epub 2020 Aug 24 doi: 10.1080/14779072.2020.1797488. PMID: 32684011
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV, Williams L, Daly A, Richard G, Bale S, Macaya D, Chung WK
Genet Test Mol Biomarkers 2013 Jul;17(7):553-61. Epub 2013 Apr 30 doi: 10.1089/gtmb.2012.0118. PMID: 23631430

Recent clinical studies

Etiology

Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H, Zhang Y, Wang D, Chen X, Li M, Huang X, Jiang Y, Dou Y, Wang Y, Ma X, Sheng W, Jia B, Yan W, Huang G; SPCC (Shanghai Preconception Cohort) Group
Ann Intern Med 2022 Sep;175(9):1212-1220. Epub 2022 Aug 23 doi: 10.7326/M22-0741. PMID: 35994746
Kawasaki disease: characteristics, diagnosis, and unusual presentations.
Jindal AK, Pilania RK, Prithvi A, Guleria S, Singh S
Expert Rev Clin Immunol 2019 Oct;15(10):1089-1104. Epub 2019 Oct 1 doi: 10.1080/1744666X.2019.1659726. PMID: 31456443
Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome.
Guevara-Cruz M, Flores-López AG, Aguilar-López M, Sánchez-Tapia M, Medina-Vera I, Díaz D, Tovar AR, Torres N
J Am Heart Assoc 2019 Sep 3;8(17):e012401. Epub 2019 Aug 27 doi: 10.1161/JAHA.119.012401. PMID: 31451009Free PMC Article
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113

Diagnosis

Association between inflammatory biomarkers and cognitive aging.
Fang Y, Doyle MF, Chen J, Alosco ML, Mez J, Satizabal CL, Qiu WQ, Murabito JM, Lunetta KL
PLoS One 2022;17(9):e0274350. Epub 2022 Sep 9 doi: 10.1371/journal.pone.0274350. PMID: 36083988Free PMC Article
Kawasaki disease: characteristics, diagnosis, and unusual presentations.
Jindal AK, Pilania RK, Prithvi A, Guleria S, Singh S
Expert Rev Clin Immunol 2019 Oct;15(10):1089-1104. Epub 2019 Oct 1 doi: 10.1080/1744666X.2019.1659726. PMID: 31456443
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Accuracy of first-trimester combined test in screening for trisomies 21, 18 and 13.
Santorum M, Wright D, Syngelaki A, Karagioti N, Nicolaides KH
Ultrasound Obstet Gynecol 2017 Jun;49(6):714-720. Epub 2017 Apr 26 doi: 10.1002/uog.17283. PMID: 27549925
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113

Therapy

Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H, Zhang Y, Wang D, Chen X, Li M, Huang X, Jiang Y, Dou Y, Wang Y, Ma X, Sheng W, Jia B, Yan W, Huang G; SPCC (Shanghai Preconception Cohort) Group
Ann Intern Med 2022 Sep;175(9):1212-1220. Epub 2022 Aug 23 doi: 10.7326/M22-0741. PMID: 35994746
A Combined Echocardiography Approach for the Diagnosis of Cancer Therapy-Related Cardiac Dysfunction in Women With Early-Stage Breast Cancer.
Esmaeilzadeh M, Urzua Fresno CM, Somerset E, Shalmon T, Amir E, Fan CS, Brezden-Masley C, Thampinathan B, Thevakumaran Y, Yared K, Koch CA, Abdel-Qadir H, Woo A, Yip P, Marwick TH, Chan R, Wintersperger BJ, Thavendiranathan P
JAMA Cardiol 2022 Mar 1;7(3):330-340. doi: 10.1001/jamacardio.2021.5881. PMID: 35138325Free PMC Article
One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction.
Hieda M, Sarma S, Hearon CM Jr, MacNamara JP, Dias KA, Samels M, Palmer D, Livingston S, Morris M, Levine BD
Circulation 2021 Sep 21;144(12):934-946. Epub 2021 Sep 20 doi: 10.1161/CIRCULATIONAHA.121.054117. PMID: 34543068Free PMC Article
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Committees and Investigators
Eur J Heart Fail 2013 Sep;15(9):1062-73. Epub 2013 Apr 5 doi: 10.1093/eurjhf/hft052. PMID: 23563576Free PMC Article

Prognosis

A multisystem, cardio-renal investigation of post-COVID-19 illness.
Morrow AJ, Sykes R, McIntosh A, Kamdar A, Bagot C, Bayes HK, Blyth KG, Briscoe M, Bulluck H, Carrick D, Church C, Corcoran D, Findlay I, Gibson VB, Gillespie L, Grieve D, Hall Barrientos P, Ho A, Lang NN, Lennie V, Lowe DJ, Macfarlane PW, Mark PB, Mayne KJ, McConnachie A, McGeoch R, McGinley C, McKee C, Nordin S, Payne A, Rankin AJ, Robertson KE, Roditi G, Ryan N, Sattar N, Allwood-Spiers S, Stobo D, Touyz RM, Veldtman G, Watkins S, Weeden S, Weir RA, Welsh P, Wereski R; CISCO-19 Consortium, Mangion K, Berry C
Nat Med 2022 Jun;28(6):1303-1313. Epub 2022 May 23 doi: 10.1038/s41591-022-01837-9. PMID: 35606551Free PMC Article
Cardiac Surgery and the Blood-Brain Barrier.
Hendy A, Hall R
Anesthesiol Clin 2019 Dec;37(4):787-800. Epub 2019 Oct 9 doi: 10.1016/j.anclin.2019.08.009. PMID: 31677691
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Accuracy of first-trimester combined test in screening for trisomies 21, 18 and 13.
Santorum M, Wright D, Syngelaki A, Karagioti N, Nicolaides KH
Ultrasound Obstet Gynecol 2017 Jun;49(6):714-720. Epub 2017 Apr 26 doi: 10.1002/uog.17283. PMID: 27549925
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Committees and Investigators
Eur J Heart Fail 2013 Sep;15(9):1062-73. Epub 2013 Apr 5 doi: 10.1093/eurjhf/hft052. PMID: 23563576Free PMC Article

Clinical prediction guides

Global Longitudinal Strain Monitoring to Guide Cardioprotective Medications During Anthracycline Treatment.
Marwick TH
Curr Oncol Rep 2022 Jun;24(6):687-694. Epub 2022 Mar 3 doi: 10.1007/s11912-022-01242-y. PMID: 35239105Free PMC Article
Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis.
Zhao Y, Patel J, Huang Y, Yin L, Tang L
Am J Emerg Med 2021 Nov;49:62-70. Epub 2021 May 18 doi: 10.1016/j.ajem.2021.05.044. PMID: 34082189Free PMC Article
Cardiac Surgery and the Blood-Brain Barrier.
Hendy A, Hall R
Anesthesiol Clin 2019 Dec;37(4):787-800. Epub 2019 Oct 9 doi: 10.1016/j.anclin.2019.08.009. PMID: 31677691
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Accuracy of first-trimester combined test in screening for trisomies 21, 18 and 13.
Santorum M, Wright D, Syngelaki A, Karagioti N, Nicolaides KH
Ultrasound Obstet Gynecol 2017 Jun;49(6):714-720. Epub 2017 Apr 26 doi: 10.1002/uog.17283. PMID: 27549925

Recent systematic reviews

Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis.
Zhao Y, Patel J, Huang Y, Yin L, Tang L
Am J Emerg Med 2021 Nov;49:62-70. Epub 2021 May 18 doi: 10.1016/j.ajem.2021.05.044. PMID: 34082189Free PMC Article
What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analyses.
Shields N, Downs J, de Haan JB, Taylor NF, Torr J, Fernhall B, Kingsley M, Mnatzaganian G, Leonard H
J Sci Med Sport 2018 Jun;21(6):596-603. Epub 2017 Oct 19 doi: 10.1016/j.jsams.2017.10.015. PMID: 29103914
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB
Cochrane Database Syst Rev 2010 Mar 17;(3):CD006174. doi: 10.1002/14651858.CD006174.pub2. PMID: 20238343
A systematic review of troponin T and I values as a prognostic tool for patients with chest pain.
Ebell MH, White LL, Weismantel D
J Fam Pract 2000 Aug;49(8):746-53. PMID: 10947143

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