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Abnormal cardiac biomarker test

MedGen UID:
1379094
•Concept ID:
C4477079
•
Finding
HPO: HP:0500020

Definition

Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes. [from HPO]

Professional guidelines

PubMed

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV, Williams L, Daly A, Richard G, Bale S, Macaya D, Chung WK
Genet Test Mol Biomarkers 2013 Jul;17(7):553-61. Epub 2013 Apr 30 doi: 10.1089/gtmb.2012.0118. PMID: 23631430

Recent clinical studies

Etiology

Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H, Zhang Y, Wang D, Chen X, Li M, Huang X, Jiang Y, Dou Y, Wang Y, Ma X, Sheng W, Jia B, Yan W, Huang G; SPCC (Shanghai Preconception Cohort) Group
Ann Intern Med 2022 Sep;175(9):1212-1220. Epub 2022 Aug 23 doi: 10.7326/M22-0741. PMID: 35994746
Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome.
Guevara-Cruz M, Flores-López AG, Aguilar-López M, Sánchez-Tapia M, Medina-Vera I, Díaz D, Tovar AR, Torres N
J Am Heart Assoc 2019 Sep 3;8(17):e012401. Epub 2019 Aug 27 doi: 10.1161/JAHA.119.012401. PMID: 31451009Free PMC Article
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV, Williams L, Daly A, Richard G, Bale S, Macaya D, Chung WK
Genet Test Mol Biomarkers 2013 Jul;17(7):553-61. Epub 2013 Apr 30 doi: 10.1089/gtmb.2012.0118. PMID: 23631430

Diagnosis

Biomarkers for the Diagnosis of Heart Failure in People with Diabetes: A Consensus Report from Diabetes Technology Society.
Yeung AM, Huang J, Pandey A, Hashim IA, Kerr D, Pop-Busui R, Rhee CM, Shah VN, Bally L, Bayes-Genis A, Bee YM, Bergenstal R, Butler J, Fleming GA, Gilbert G, Greene SJ, Kosiborod MN, Leiter LA, Mankovsky B, Martens TW, Mathieu C, Mohan V, Patel KV, Peters A, Rhee EJ, Rosano GMC, Sacks DB, Sandoval Y, Seley JJ, Schnell O, Umpierrez G, Waki K, Wright EE Jr, Wu AHB, Klonoff DC
Prog Cardiovasc Dis 2023 Jul-Aug;79:65-79. Epub 2023 May 11 doi: 10.1016/j.pcad.2023.05.002. PMID: 37178991
Kawasaki disease: characteristics, diagnosis, and unusual presentations.
Jindal AK, Pilania RK, Prithvi A, Guleria S, Singh S
Expert Rev Clin Immunol 2019 Oct;15(10):1089-1104. Epub 2019 Oct 1 doi: 10.1080/1744666X.2019.1659726. PMID: 31456443
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV, Williams L, Daly A, Richard G, Bale S, Macaya D, Chung WK
Genet Test Mol Biomarkers 2013 Jul;17(7):553-61. Epub 2013 Apr 30 doi: 10.1089/gtmb.2012.0118. PMID: 23631430

Therapy

Baseline characteristics of the North American prodromal Synucleinopathy cohort.
Elliott JE, Lim MM, Keil AT, Postuma RB, Pelletier A, Gagnon JF, St Louis EK, Forsberg LK, Fields JA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS; North American Prodromal Synucleinopathy (NAPS) Consortium
Ann Clin Transl Neurol 2023 Apr;10(4):520-535. Epub 2023 Feb 8 doi: 10.1002/acn3.51738. PMID: 36751940Free PMC Article
Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H, Zhang Y, Wang D, Chen X, Li M, Huang X, Jiang Y, Dou Y, Wang Y, Ma X, Sheng W, Jia B, Yan W, Huang G; SPCC (Shanghai Preconception Cohort) Group
Ann Intern Med 2022 Sep;175(9):1212-1220. Epub 2022 Aug 23 doi: 10.7326/M22-0741. PMID: 35994746
A Combined Echocardiography Approach for the Diagnosis of Cancer Therapy-Related Cardiac Dysfunction in Women With Early-Stage Breast Cancer.
Esmaeilzadeh M, Urzua Fresno CM, Somerset E, Shalmon T, Amir E, Fan CS, Brezden-Masley C, Thampinathan B, Thevakumaran Y, Yared K, Koch CA, Abdel-Qadir H, Woo A, Yip P, Marwick TH, Chan R, Wintersperger BJ, Thavendiranathan P
JAMA Cardiol 2022 Mar 1;7(3):330-340. doi: 10.1001/jamacardio.2021.5881. PMID: 35138325Free PMC Article
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Committees and Investigators
Eur J Heart Fail 2013 Sep;15(9):1062-73. Epub 2013 Apr 5 doi: 10.1093/eurjhf/hft052. PMID: 23563576Free PMC Article

Prognosis

Should We Test for Diastolic Dysfunction? How and How Often?
Litwin SE, Zile MR
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):297-309. Epub 2019 Jun 12 doi: 10.1016/j.jcmg.2019.02.029. PMID: 31202743
Cardiac Surgery and the Blood-Brain Barrier.
Hendy A, Hall R
Anesthesiol Clin 2019 Dec;37(4):787-800. Epub 2019 Oct 9 doi: 10.1016/j.anclin.2019.08.009. PMID: 31677691
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV, Williams L, Daly A, Richard G, Bale S, Macaya D, Chung WK
Genet Test Mol Biomarkers 2013 Jul;17(7):553-61. Epub 2013 Apr 30 doi: 10.1089/gtmb.2012.0118. PMID: 23631430
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Committees and Investigators
Eur J Heart Fail 2013 Sep;15(9):1062-73. Epub 2013 Apr 5 doi: 10.1093/eurjhf/hft052. PMID: 23563576Free PMC Article

Clinical prediction guides

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.
Kirkham JK, Estepp JH, Weiss MJ, Rashkin SR
JAMA Netw Open 2023 Oct 2;6(10):e2337484. doi: 10.1001/jamanetworkopen.2023.37484. PMID: 37851445Free PMC Article
Should We Test for Diastolic Dysfunction? How and How Often?
Litwin SE, Zile MR
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):297-309. Epub 2019 Jun 12 doi: 10.1016/j.jcmg.2019.02.029. PMID: 31202743
Cardiac Surgery and the Blood-Brain Barrier.
Hendy A, Hall R
Anesthesiol Clin 2019 Dec;37(4):787-800. Epub 2019 Oct 9 doi: 10.1016/j.anclin.2019.08.009. PMID: 31677691
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Lieve KV, Williams L, Daly A, Richard G, Bale S, Macaya D, Chung WK
Genet Test Mol Biomarkers 2013 Jul;17(7):553-61. Epub 2013 Apr 30 doi: 10.1089/gtmb.2012.0118. PMID: 23631430

Recent systematic reviews

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.
Kirkham JK, Estepp JH, Weiss MJ, Rashkin SR
JAMA Netw Open 2023 Oct 2;6(10):e2337484. doi: 10.1001/jamanetworkopen.2023.37484. PMID: 37851445Free PMC Article
What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analyses.
Shields N, Downs J, de Haan JB, Taylor NF, Torr J, Fernhall B, Kingsley M, Mnatzaganian G, Leonard H
J Sci Med Sport 2018 Jun;21(6):596-603. Epub 2017 Oct 19 doi: 10.1016/j.jsams.2017.10.015. PMID: 29103914
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB, Lau R
Cochrane Database Syst Rev 2015 May 1;2015(5):CD006174. doi: 10.1002/14651858.CD006174.pub3. PMID: 25929461Free PMC Article
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB
Cochrane Database Syst Rev 2010 Mar 17;(3):CD006174. doi: 10.1002/14651858.CD006174.pub2. PMID: 20238343

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