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Unresectable Osteosarcoma

MedGen UID:
1379232
•Concept ID:
C4331477
•
Neoplastic Process

Definition

An osteosarcoma which is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Osteosarcoma

Professional guidelines

PubMed

Multimodality treatment of osteosarcoma: radiation in a high-risk cohort.
Mahajan A, Woo SY, Kornguth DG, Hughes D, Huh W, Chang EL, Herzog CE, Pelloski CE, Anderson P
Pediatr Blood Cancer 2008 May;50(5):976-82. doi: 10.1002/pbc.21451. PMID: 18213710

Recent clinical studies

Etiology

Gemcitabine plus sirolimus for relapsed and progressing osteosarcoma patients after standard chemotherapy: a multicenter, single-arm phase II trial of Spanish Group for Research on Sarcoma (GEIS).
Martin-Broto J, Redondo A, Valverde C, Vaz MA, Mora J, Garcia Del Muro X, Gutierrez A, Tous C, Carnero A, Marcilla D, Carranza A, Sancho P, Martinez-Trufero J, Diaz-Beveridge R, Cruz J, Encinas V, Taron M, Moura DS, Luna P, Hindi N, Lopez-Pousa A
Ann Oncol 2017 Dec 1;28(12):2994-2999. doi: 10.1093/annonc/mdx536. PMID: 29045512
Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial.
Grignani G, Palmerini E, Ferraresi V, D'Ambrosio L, Bertulli R, Asaftei SD, Tamburini A, Pignochino Y, Sangiolo D, Marchesi E, Capozzi F, Biagini R, Gambarotti M, Fagioli F, Casali PG, Picci P, Ferrari S, Aglietta M; Italian Sarcoma Group
Lancet Oncol 2015 Jan;16(1):98-107. Epub 2014 Dec 11 doi: 10.1016/S1470-2045(14)71136-2. PMID: 25498219
Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk.
Matsunobu A, Imai R, Kamada T, Imaizumi T, Tsuji H, Tsujii H, Shioyama Y, Honda H, Tatezaki S; Working Group for Bone and Soft Tissue Sarcomas
Cancer 2012 Sep 15;118(18):4555-63. Epub 2012 Feb 22 doi: 10.1002/cncr.27451. PMID: 22359113
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study.
Grignani G, Palmerini E, Dileo P, Asaftei SD, D'Ambrosio L, Pignochino Y, Mercuri M, Picci P, Fagioli F, Casali PG, Ferrari S, Aglietta M
Ann Oncol 2012 Feb;23(2):508-16. Epub 2011 Apr 28 doi: 10.1093/annonc/mdr151. PMID: 21527590
Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric Oncology Group Trial.
Ferguson WS, Harris MB, Goorin AM, Gebhardt MC, Link MP, Shochat SJ, Siegal GP, Devidas M, Grier HE
J Pediatr Hematol Oncol 2001 Aug-Sep;23(6):340-8. doi: 10.1097/00043426-200108000-00004. PMID: 11563767

Diagnosis

Apatinib for Advanced Osteosarcoma after Failure of Standard Multimodal Therapy: An Open Label Phase II Clinical Trial.
Xie L, Xu J, Sun X, Tang X, Yan T, Yang R, Guo W
Oncologist 2019 Jul;24(7):e542-e550. Epub 2018 Dec 17 doi: 10.1634/theoncologist.2018-0542. PMID: 30559126Free PMC Article
RANK ligand blockade with denosumab in combination with sorafenib in chemorefractory osteosarcoma: a possible step forward?
Cathomas R, Rothermundt C, Bode B, Fuchs B, von Moos R, Schwitter M
Oncology 2015;88(4):257-60. Epub 2014 Dec 17 doi: 10.1159/000369975. PMID: 25531914
Palliative embolization for osteosarcoma.
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
Palliative therapy for osteosarcoma.
Errani C, Longhi A, Rossi G, Rimondi E, Biazzo A, Toscano A, Alì N, Ruggieri P, Alberghini M, Picci P, Bacci G, Mercuri M
Expert Rev Anticancer Ther 2011 Feb;11(2):217-27. doi: 10.1586/era.10.172. PMID: 21342041
Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric Oncology Group Trial.
Ferguson WS, Harris MB, Goorin AM, Gebhardt MC, Link MP, Shochat SJ, Siegal GP, Devidas M, Grier HE
J Pediatr Hematol Oncol 2001 Aug-Sep;23(6):340-8. doi: 10.1097/00043426-200108000-00004. PMID: 11563767

Therapy

Gadolinium-Bisphosphonate Nanoparticle-Based Low-Dose Radioimmunotherapy for Osteosarcoma.
Zhang S, Wu Y, Yu J, Ma C, Wang Y, Wang Y, Li L, Zhang LW
ACS Biomater Sci Eng 2022 Dec 12;8(12):5329-5337. Epub 2022 Nov 16 doi: 10.1021/acsbiomaterials.2c00880. PMID: 36383732
Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial.
Grignani G, Palmerini E, Ferraresi V, D'Ambrosio L, Bertulli R, Asaftei SD, Tamburini A, Pignochino Y, Sangiolo D, Marchesi E, Capozzi F, Biagini R, Gambarotti M, Fagioli F, Casali PG, Picci P, Ferrari S, Aglietta M; Italian Sarcoma Group
Lancet Oncol 2015 Jan;16(1):98-107. Epub 2014 Dec 11 doi: 10.1016/S1470-2045(14)71136-2. PMID: 25498219
Palliative embolization for osteosarcoma.
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study.
Grignani G, Palmerini E, Dileo P, Asaftei SD, D'Ambrosio L, Pignochino Y, Mercuri M, Picci P, Fagioli F, Casali PG, Ferrari S, Aglietta M
Ann Oncol 2012 Feb;23(2):508-16. Epub 2011 Apr 28 doi: 10.1093/annonc/mdr151. PMID: 21527590
Palliative therapy for osteosarcoma.
Errani C, Longhi A, Rossi G, Rimondi E, Biazzo A, Toscano A, Alì N, Ruggieri P, Alberghini M, Picci P, Bacci G, Mercuri M
Expert Rev Anticancer Ther 2011 Feb;11(2):217-27. doi: 10.1586/era.10.172. PMID: 21342041

Prognosis

Apatinib for Advanced Osteosarcoma after Failure of Standard Multimodal Therapy: An Open Label Phase II Clinical Trial.
Xie L, Xu J, Sun X, Tang X, Yan T, Yang R, Guo W
Oncologist 2019 Jul;24(7):e542-e550. Epub 2018 Dec 17 doi: 10.1634/theoncologist.2018-0542. PMID: 30559126Free PMC Article
Palliative embolization for osteosarcoma.
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study.
Grignani G, Palmerini E, Dileo P, Asaftei SD, D'Ambrosio L, Pignochino Y, Mercuri M, Picci P, Fagioli F, Casali PG, Ferrari S, Aglietta M
Ann Oncol 2012 Feb;23(2):508-16. Epub 2011 Apr 28 doi: 10.1093/annonc/mdr151. PMID: 21527590
Multimodality treatment of osteosarcoma: radiation in a high-risk cohort.
Mahajan A, Woo SY, Kornguth DG, Hughes D, Huh W, Chang EL, Herzog CE, Pelloski CE, Anderson P
Pediatr Blood Cancer 2008 May;50(5):976-82. doi: 10.1002/pbc.21451. PMID: 18213710
Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric Oncology Group Trial.
Ferguson WS, Harris MB, Goorin AM, Gebhardt MC, Link MP, Shochat SJ, Siegal GP, Devidas M, Grier HE
J Pediatr Hematol Oncol 2001 Aug-Sep;23(6):340-8. doi: 10.1097/00043426-200108000-00004. PMID: 11563767

Clinical prediction guides

Palliative embolization for osteosarcoma.
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk.
Matsunobu A, Imai R, Kamada T, Imaizumi T, Tsuji H, Tsujii H, Shioyama Y, Honda H, Tatezaki S; Working Group for Bone and Soft Tissue Sarcomas
Cancer 2012 Sep 15;118(18):4555-63. Epub 2012 Feb 22 doi: 10.1002/cncr.27451. PMID: 22359113
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study.
Grignani G, Palmerini E, Dileo P, Asaftei SD, D'Ambrosio L, Pignochino Y, Mercuri M, Picci P, Fagioli F, Casali PG, Ferrari S, Aglietta M
Ann Oncol 2012 Feb;23(2):508-16. Epub 2011 Apr 28 doi: 10.1093/annonc/mdr151. PMID: 21527590
High-activity samarium-153-EDTMP therapy followed by autologous peripheral blood stem cell support in unresectable osteosarcoma.
Franzius C, Bielack S, Flege S, Eckardt J, Sciuk J, Jürgens H, Schober O
Nuklearmedizin 2001 Dec;40(6):215-20. PMID: 11797510

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