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Internal ophthalmoplegia

MedGen UID:
137925
•Concept ID:
C0339693
•
Finding; Finding
Synonyms: Internal Ophthalmoplegia; Internal Ophthalmoplegias; Ophthalmoplegia, Internal; Ophthalmoplegias, Internal
SNOMED CT: Internal ophthalmoplegia (232146005)
 
HPO: HP:0007942

Definition

Paralysis of the iris and ciliary apparatus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInternal ophthalmoplegia

Conditions with this feature

Ophthalmoplegia, familial total, with iris transillumination
MedGen UID:
371665
•Concept ID:
C1833836
•
Disease or Syndrome
See: Condition Record
Ophthalmoplegia, familial total, with iris transillumination

Professional guidelines

PubMed

Diagnosis and treatment of retrobulbar haematomas following blunt orbital trauma: a description of eight cases.
Gerbino G, Ramieri GA, Nasi A
Int J Oral Maxillofac Surg 2005 Mar;34(2):127-31. doi: 10.1016/j.ijom.2004.05.001. PMID: 15695039

Recent clinical studies

Etiology

Isolated squamous cell carcinoma of the orbital apex.
Peckinpaugh JL, Winn BJ, Barrett RV, Jacobsen DW, Sires BS, Meyer DR, Jian-Amadi A
Ophthalmic Plast Reconstr Surg 2012 May-Jun;28(3):e72-4. doi: 10.1097/IOP.0b013e31822ddd91. PMID: 22082594
Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody.
Lee SH, Lim GH, Kim JS, Oh SY, Kim JK, Cha JK, Yun CH, Kang JK, Lee H, Song HK, Chung KC
Neurology 2008 Aug 5;71(6):426-9. doi: 10.1212/01.wnl.0000324266.95814.74. PMID: 18678825
Diagnosis and treatment of retrobulbar haematomas following blunt orbital trauma: a description of eight cases.
Gerbino G, Ramieri GA, Nasi A
Int J Oral Maxillofac Surg 2005 Mar;34(2):127-31. doi: 10.1016/j.ijom.2004.05.001. PMID: 15695039
Pupil involvement in patients with diabetes-associated oculomotor nerve palsy.
Jacobson DM
Arch Ophthalmol 1998 Jun;116(6):723-7. doi: 10.1001/archopht.116.6.723. PMID: 9639439
Clinical profile of herpes zoster ophthalmicus.
Nigam P, Kumar A, Kapoor KK, Sarkari NB, Gupta AK, Lal BB, Mukhija RD
J Indian Med Assoc 1991 May;89(5):117-9. PMID: 1748774

Diagnosis

Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies.
Murakami K, Kajimoto Y, Ito H
Intern Med 2022 Oct 15;61(20):3121-3124. Epub 2022 Apr 2 doi: 10.2169/internalmedicine.8416-21. PMID: 35370231Free PMC Article
Isolated Bilateral Internal Ophthalmoplegia as an Atypical Initial Presentation of anti-GQ1b Antibody Syndrome.
Jebaraj AP, Swiston CJ, Vegunta S, Warner JEA
J Neuroophthalmol 2022 Mar 1;42(1):e389-e390. Epub 2021 Jul 23 doi: 10.1097/WNO.0000000000001314. PMID: 34310460
One-sided triangle: A case of double vision.
Wang JW, Robbins SL, Moster ML
Surv Ophthalmol 2018 Nov-Dec;63(6):880-883. Epub 2018 Jun 18 doi: 10.1016/j.survophthal.2018.06.004. PMID: 29920248
Neuro-ophthalmic sarcoidosis.
Turner RG, James DG, Friedmann AI, Vijendram M, Davies JP
Br J Ophthalmol 1975 Nov;59(11):657-63. doi: 10.1136/bjo.59.11.657. PMID: 1203222Free PMC Article
Unilateral internal ophthalmoplegia with intracranial aneurysm.
Payne JW, Adamkiewicz J Jr
Am J Ophthalmol 1969 Aug;68(2):349-52. doi: 10.1016/0002-9394(69)94084-7. PMID: 5798817

Therapy

Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies.
Murakami K, Kajimoto Y, Ito H
Intern Med 2022 Oct 15;61(20):3121-3124. Epub 2022 Apr 2 doi: 10.2169/internalmedicine.8416-21. PMID: 35370231Free PMC Article
Orbital apex syndrome secondary to herpes zoster virus infection.
Merino-Iglesias A, Montero JA, Calabuig-Goena M, Giraldo-Agudelo LF
BMJ Case Rep 2014 Mar 10;2014 doi: 10.1136/bcr-2013-203200. PMID: 24614776Free PMC Article
Benign episodic bilateral juvenile internal ophthalmoplegia.
Zak TA
J Pediatr Ophthalmol Strabismus 1983 Jan-Feb;20(1):8-10. doi: 10.3928/0191-3913-19830101-01. PMID: 6864414
Cryptococcal meningitis and internal ophthalmoplegia.
Lesser RL, Simon RM, Leon H, Siegel N
Am J Ophthalmol 1979 May;87(5):682-7. doi: 10.1016/0002-9394(79)90304-0. PMID: 443340
Internal 'ophthalmoplegia' in myasthenia gravis.
Herishanu Y, Lavy S
Ophthalmologica 1971;163(5):302-5. doi: 10.1159/000306658. PMID: 5157885

Prognosis

Orbital apex syndrome as a complication of herpes zoster ophthalmicus.
Chandrasekharan A, Gandhi U, Badakere A, Sangwan V
BMJ Case Rep 2017 Feb 24;2017 doi: 10.1136/bcr-2016-217382. PMID: 28237946Free PMC Article
Isolated squamous cell carcinoma of the orbital apex.
Peckinpaugh JL, Winn BJ, Barrett RV, Jacobsen DW, Sires BS, Meyer DR, Jian-Amadi A
Ophthalmic Plast Reconstr Surg 2012 May-Jun;28(3):e72-4. doi: 10.1097/IOP.0b013e31822ddd91. PMID: 22082594
Diagnosis and treatment of retrobulbar haematomas following blunt orbital trauma: a description of eight cases.
Gerbino G, Ramieri GA, Nasi A
Int J Oral Maxillofac Surg 2005 Mar;34(2):127-31. doi: 10.1016/j.ijom.2004.05.001. PMID: 15695039
Clinical profile of herpes zoster ophthalmicus.
Nigam P, Kumar A, Kapoor KK, Sarkari NB, Gupta AK, Lal BB, Mukhija RD
J Indian Med Assoc 1991 May;89(5):117-9. PMID: 1748774
Benign episodic bilateral juvenile internal ophthalmoplegia.
Zak TA
J Pediatr Ophthalmol Strabismus 1983 Jan-Feb;20(1):8-10. doi: 10.3928/0191-3913-19830101-01. PMID: 6864414

Clinical prediction guides

A case of Graves' disease presenting with internal ophthalmoplegia during methylmercaptoimidazole treatment.
Okamura K, Ibayashi H, Sato K, Fujikawa M, Bandai S, Shibasaki H, Kitazono T
Endocr J 2022 Feb 28;69(2):173-177. Epub 2021 Sep 18 doi: 10.1507/endocrj.EJ21-0340. PMID: 34544941
Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody.
Lee SH, Lim GH, Kim JS, Oh SY, Kim JK, Cha JK, Yun CH, Kang JK, Lee H, Song HK, Chung KC
Neurology 2008 Aug 5;71(6):426-9. doi: 10.1212/01.wnl.0000324266.95814.74. PMID: 18678825
Delayed internal ophthalmoplegia and amblyopia following chickenpox.
Orssaud C, Roche O, El Dirani H, Dufier JL
Eur J Pediatr 2006 Oct;165(10):728-9. Epub 2006 May 12 doi: 10.1007/s00431-006-0155-7. PMID: 16691403
Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.
Kremens B, Hero B, Esser J, Weinel P, Filger-Brillinger J, Fleischhack G, Graf N, Grüttner HP, Niemeyer C, Schulz A, Wickmann L, Berthold F
Cancer Immunol Immunother 2002 Apr;51(2):107-10. Epub 2002 Feb 1 doi: 10.1007/s00262-001-0259-x. PMID: 11904735Free PMC Article
Clinical profile of herpes zoster ophthalmicus.
Nigam P, Kumar A, Kapoor KK, Sarkari NB, Gupta AK, Lal BB, Mukhija RD
J Indian Med Assoc 1991 May;89(5):117-9. PMID: 1748774

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