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Malignant Choroid Plexus Neoplasm

MedGen UID:
138053
•Concept ID:
C0346289
•
Neoplastic Process
Synonyms: Malignant Choroid Plexus Neoplasms; Malignant Choroid Plexus Tumor; Malignant Choroid Plexus Tumors; Malignant neoplasm of choroid plexus; Malignant Neoplasm of Choroid Plexus; Malignant Neoplasm of the Choroid Plexus; Malignant tumor of choroid plexus; Malignant Tumor of Choroid Plexus; Malignant Tumor of the Choroid Plexus
SNOMED CT: Malignant tumor of choroid plexus (188292007); Malignant neoplasm of choroid plexus (188292007)

Definition

A malignant neoplasm that arises from the choroid plexus. The vast majority are carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Choroid Plexus Neoplasm

Professional guidelines

PubMed

Primary intraventricular tumors - Imaging characteristics, post-treatment changes and relapses.
Chong AW, McAdory LE, Low DCY, Lim EJ, Leong NWL, Ho CL
Clin Imaging 2022 Feb;82:38-52. Epub 2021 Oct 29 doi: 10.1016/j.clinimag.2021.10.008. PMID: 34773811
Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.
Thomas C, Metrock K, Kordes U, Hasselblatt M, Dhall G
J Neurooncol 2020 May;148(1):39-45. Epub 2020 Apr 28 doi: 10.1007/s11060-020-03509-5. PMID: 32342334Free PMC Article
Diagnosis and management of brain and spinal cord tumors in the neonate.
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555

Recent clinical studies

Etiology

Management of Intraventricular Meningiomas.
Bamimore MA, Marenco-Hillembrand L, Ravindran K, Agyapong D, Greco E, Middlebrooks EH, Chaichana KL
Neurosurg Clin N Am 2023 Jul;34(3):403-415. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.005. PMID: 37210129
Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.
Thomas C, Metrock K, Kordes U, Hasselblatt M, Dhall G
J Neurooncol 2020 May;148(1):39-45. Epub 2020 Apr 28 doi: 10.1007/s11060-020-03509-5. PMID: 32342334Free PMC Article
Perinatal (fetal and neonatal) choroid plexus tumors: a review.
Crawford JR, Isaacs H Jr
Childs Nerv Syst 2019 Jun;35(6):937-944. Epub 2019 Apr 5 doi: 10.1007/s00381-019-04135-x. PMID: 30953158
Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives.
Zaky W, Finlay JL
Pediatr Blood Cancer 2018 Jul;65(7):e27031. Epub 2018 Mar 12 doi: 10.1002/pbc.27031. PMID: 29528196
WHO 2016 Classification of gliomas.
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663

Diagnosis

Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.
Thomas C, Metrock K, Kordes U, Hasselblatt M, Dhall G
J Neurooncol 2020 May;148(1):39-45. Epub 2020 Apr 28 doi: 10.1007/s11060-020-03509-5. PMID: 32342334Free PMC Article
MRI of intracranial intraventricular lesions.
Muly S, Liu S, Lee R, Nicolaou S, Rojas R, Khosa F
Clin Imaging 2018 Nov-Dec;52:226-239. Epub 2018 Aug 1 doi: 10.1016/j.clinimag.2018.07.021. PMID: 30138862
Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives.
Zaky W, Finlay JL
Pediatr Blood Cancer 2018 Jul;65(7):e27031. Epub 2018 Mar 12 doi: 10.1002/pbc.27031. PMID: 29528196
A diagnostic conundrum.
Keddie S, Jaunmuktane Z, Brandner S, Shah S, Maddison P, Rees JH, Hanna MG, Lunn MPT, Reilly MM, Rossor AM, Carr AS
Pract Neurol 2018 Apr;18(2):137-142. Epub 2018 Jan 23 doi: 10.1136/practneurol-2017-001801. PMID: 29363556Free PMC Article
Choroid plexus carcinoma.
Gopal P, Parker JR, Debski R, Parker JC Jr
Arch Pathol Lab Med 2008 Aug;132(8):1350-4. doi: 10.5858/2008-132-1350-CPC. PMID: 18684041

Therapy

Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.
Jang A, Petrova B, Cheong TC, Zawadzki ME, Jones JK, Culhane AJ, Shipley FB, Chiarle R, Wong ET, Kanarek N, Lehtinen MK
Neuron 2022 Oct 19;110(20):3288-3301.e8. Epub 2022 Sep 6 doi: 10.1016/j.neuron.2022.08.009. PMID: 36070751Free PMC Article
Final results of the Choroid Plexus Tumor study CPT-SIOP-2000.
Wolff JE, Van Gool SW, Kutluk T, Diez B, Kebudi R, Timmermann B, Garami M, Sterba J, Fuller GN, Bison B, Kordes UR
J Neurooncol 2022 Feb;156(3):599-613. Epub 2022 Jan 8 doi: 10.1007/s11060-021-03942-0. PMID: 34997889Free PMC Article
Effect of Surgery, Adjuvant Therapy, and Other Prognostic Factors on Choroid Plexus Carcinoma: A Systematic Review and Individual Patient Data Analysis.
Mallick S, Benson R, Melgandi W, Rath GK
Int J Radiat Oncol Biol Phys 2017 Dec 1;99(5):1199-1206. Epub 2017 Aug 18 doi: 10.1016/j.ijrobp.2017.08.012. PMID: 28939225
Intra-axial brain tumors.
Rapalino O, Batchelor T, González RG
Handb Clin Neurol 2016;135:253-274. doi: 10.1016/B978-0-444-53485-9.00014-3. PMID: 27432670
Hydrocephalus.
Paine RS
Pediatr Clin North Am 1967 Nov;14(4):779-96. doi: 10.1016/s0031-3955(16)32055-7. PMID: 4875462

Prognosis

Imaging of fetal brain tumors.
Cornejo P, Feygin T, Vaughn J, Pfeifer CM, Korostyshevska A, Patel M, Bardo DME, Miller J, Goncalves LF
Pediatr Radiol 2020 Dec;50(13):1959-1973. Epub 2020 Nov 30 doi: 10.1007/s00247-020-04777-z. PMID: 33252762
Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.
Thomas C, Metrock K, Kordes U, Hasselblatt M, Dhall G
J Neurooncol 2020 May;148(1):39-45. Epub 2020 Apr 28 doi: 10.1007/s11060-020-03509-5. PMID: 32342334Free PMC Article
Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives.
Zaky W, Finlay JL
Pediatr Blood Cancer 2018 Jul;65(7):e27031. Epub 2018 Mar 12 doi: 10.1002/pbc.27031. PMID: 29528196
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article
Choroid plexus carcinoma.
Gopal P, Parker JR, Debski R, Parker JC Jr
Arch Pathol Lab Med 2008 Aug;132(8):1350-4. doi: 10.5858/2008-132-1350-CPC. PMID: 18684041

Clinical prediction guides

Management of Intraventricular Meningiomas.
Bamimore MA, Marenco-Hillembrand L, Ravindran K, Agyapong D, Greco E, Middlebrooks EH, Chaichana KL
Neurosurg Clin N Am 2023 Jul;34(3):403-415. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.005. PMID: 37210129
Molecular insights into malignant progression of atypical choroid plexus papilloma.
Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R
Cold Spring Harb Mol Case Stud 2021 Feb;7(1) Epub 2021 Feb 19 doi: 10.1101/mcs.a005272. PMID: 33608379Free PMC Article
Pediatric atypical choroid plexus papilloma: Clinical features and diagnosis.
Chen Y, Zhao R, Shi W, Li H
Clin Neurol Neurosurg 2021 Jan;200:106345. Epub 2020 Nov 4 doi: 10.1016/j.clineuro.2020.106345. PMID: 33203591
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article
Third ventricular meningiomas.
Li P, Diao X, Bi Z, Hao S, Ren X, Zhang J, Xing J
J Clin Neurosci 2015 Nov;22(11):1776-84. Epub 2015 Aug 29 doi: 10.1016/j.jocn.2015.05.025. PMID: 26455422

Recent systematic reviews

Metastasis of the choroid plexuses: A systematic review of the literature and case illustration.
Garrido E, Alqahtani K, Lozouet M, Derrey S, Gilard V
Neurochirurgie 2023 Mar;69(2):101412. Epub 2023 Jan 14 doi: 10.1016/j.neuchi.2023.101412. PMID: 36649887
Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case.
Gaddi MJS, Lappay JI, Chan KIP, Pascual JSG, Salonga AEM
Childs Nerv Syst 2021 Mar;37(3):799-807. Epub 2020 Sep 26 doi: 10.1007/s00381-020-04896-w. PMID: 32980905
Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review.
Bunevicius A, Matukevicius A, Deltuva V, Gudinaviciene I, Pranys D, Tamasauskas A
World Neurosurg 2018 May;113:129-134. Epub 2018 Feb 13 doi: 10.1016/j.wneu.2018.02.012. PMID: 29452330
Effect of Surgery, Adjuvant Therapy, and Other Prognostic Factors on Choroid Plexus Carcinoma: A Systematic Review and Individual Patient Data Analysis.
Mallick S, Benson R, Melgandi W, Rath GK
Int J Radiat Oncol Biol Phys 2017 Dec 1;99(5):1199-1206. Epub 2017 Aug 18 doi: 10.1016/j.ijrobp.2017.08.012. PMID: 28939225
How specific is the MRI appearance of supratentorial atypical teratoid rhabdoid tumors?
Au Yong KJ, Jaremko JL, Jans L, Bhargava R, Coleman LT, Mehta V, Ditchfield MR
Pediatr Radiol 2013 Mar;43(3):347-54. Epub 2012 Nov 10 doi: 10.1007/s00247-012-2530-z. PMID: 23143401

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