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Optic nerve sheath meningioma

MedGen UID:
138057
Concept ID:
C0346328
Neoplastic Process
Synonyms: Meningioma of optic nerve sheath; Meningioma of Optic Nerve Sheath; meningioma of optic nerve sheath; Meningioma of the Optic Nerve Sheath; meningioma of the optic nerve sheath; Optic Nerve Sheath Meningioma; optic nerve sheath meningioma
SNOMED CT: Optic nerve sheath meningioma (254978007); Meningioma of optic nerve sheath (254978007)
 
HPO: HP:0500089
Monarch Initiative: MONDO:0003557

Definition

A benign tumor of meningothelial cells of the meninges that usually occurs in middle age. It is typically unilateral and there is an association with neurofibromatosis type 2. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOptic nerve sheath meningioma

Conditions with this feature

Neurofibromatosis, type 2
MedGen UID:
18014
Concept ID:
C0027832
Neoplastic Process
Neurofibromatosis 2 (NF2) is characterized by bilateral vestibular schwannomas with associated symptoms of tinnitus, hearing loss, and balance dysfunction. The average age of onset is 18 to 24 years. Almost all affected individuals develop bilateral vestibular schwannomas by age 30 years. Affected individuals may also develop schwannomas of other cranial and peripheral nerves, meningiomas, ependymomas, and, very rarely, astrocytomas. Because NF2 is considered an adult-onset disease, it may be underrecognized in children, in whom skin tumors and ocular findings (retinal hamartoma, thickened optic nerves, cortical wedge cataracts, third cranial nerve palsy) may be the first manifestations. Mononeuropathy that occurs in childhood is an increasingly recognized finding; it frequently presents as a persistent facial palsy or hand/foot drop.

Professional guidelines

PubMed

Shapey J, Sabin HI, Danesh-Meyer HV, Kaye AH
J Clin Neurosci 2013 Aug;20(8):1045-56. Epub 2013 Jun 25 doi: 10.1016/j.jocn.2013.03.008. PMID: 23809100
Berman D, Miller NR
Ann Acad Med Singap 2006 Mar;35(3):168-74. PMID: 16625265
Turbin RE, Pokorny K
Cancer Control 2004 Sep-Oct;11(5):334-41. doi: 10.1177/107327480401100508. PMID: 15377993

Recent clinical studies

Etiology

Donaldson L, Margolin E
J Neurol Sci 2021 May 15;424:117414. Epub 2021 Mar 24 doi: 10.1016/j.jns.2021.117414. PMID: 33799215
Hawy E, Sharma RA, Peragallo JH, Dattilo M, Newman NJ, Biousse V
J Neuroophthalmol 2021 Dec 1;41(4):e523-e534. doi: 10.1097/WNO.0000000000001136. PMID: 33394642
Ovens C, Dean B, Gzell C, Patanjali N, Jonker B, O'Connor M, Estoesta P, DeMartin T, Fraser C
J Clin Neurosci 2020 Oct;80:162-168. Epub 2020 Aug 19 doi: 10.1016/j.jocn.2020.08.017. PMID: 33099341
Halliday D, Parry A, Evans DG
Curr Opin Oncol 2019 Nov;31(6):562-567. doi: 10.1097/CCO.0000000000000579. PMID: 31425178
Berman D, Miller NR
Ann Acad Med Singap 2006 Mar;35(3):168-74. PMID: 16625265

Diagnosis

Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Jacobi DM
Clin Exp Optom 2019 Mar;102(2):188-190. Epub 2018 Jul 28 doi: 10.1111/cxo.12819. PMID: 30054955
Shapey J, Sabin HI, Danesh-Meyer HV, Kaye AH
J Clin Neurosci 2013 Aug;20(8):1045-56. Epub 2013 Jun 25 doi: 10.1016/j.jocn.2013.03.008. PMID: 23809100
Eddleman CS, Liu JK
Neurosurg Focus 2007;23(5):E4. doi: 10.3171/FOC-07/11/E4. PMID: 18004966
Turbin RE, Pokorny K
Cancer Control 2004 Sep-Oct;11(5):334-41. doi: 10.1177/107327480401100508. PMID: 15377993

Therapy

Matoušek P, Cvek J, Čábalová L, Misiorzová E, Krejčí O, Lipina R, Krejčí T
Medicina (Kaunas) 2022 Aug 22;58(8) doi: 10.3390/medicina58081137. PMID: 36013604Free PMC Article
Vaishnav YJ, Singh R, Didwania P, Lehrer EJ, Bakaeva T, Harris TJ, Migliori ME, Sheehan JP, Trifiletti DM
World Neurosurg 2022 Aug;164:e929-e944. Epub 2022 May 21 doi: 10.1016/j.wneu.2022.05.064. PMID: 35609728
Chen H, Zhang Q, Tan S, Fu H, Farris BK, Yang Z
Restor Neurol Neurosci 2017;35(3):275-286. doi: 10.3233/rnn-160693. PMID: 28339414
Seregard S, Pelayes DE, Singh AD
Dev Ophthalmol 2013;52:114-23. Epub 2013 Aug 26 doi: 10.1159/000351088. PMID: 23989132
Lesser RL, Knisely JP, Wang SL, Yu JB, Kupersmith MJ
Br J Ophthalmol 2010 May;94(5):559-63. Epub 2009 Dec 3 doi: 10.1136/bjo.2009.167346. PMID: 19965820

Prognosis

Ganz JC
Prog Brain Res 2022;268(1):315-327. Epub 2021 Dec 14 doi: 10.1016/bs.pbr.2021.10.039. PMID: 35074088
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Sasano H, Shikishima K, Aoki M, Sakai T, Tsutsumi Y, Nakano T
Graefes Arch Clin Exp Ophthalmol 2019 Oct;257(10):2297-2306. Epub 2019 Aug 3 doi: 10.1007/s00417-019-04424-w. PMID: 31377848
Savignac A, Lecler A
World Neurosurg 2018 Feb;110:301-302. Epub 2017 Nov 28 doi: 10.1016/j.wneu.2017.11.107. PMID: 29191527
Turbin RE, Pokorny K
Cancer Control 2004 Sep-Oct;11(5):334-41. doi: 10.1177/107327480401100508. PMID: 15377993

Clinical prediction guides

de Melo LP, Arruda Viani G, de Paula JS
Radiother Oncol 2021 Dec;165:135-141. Epub 2021 Oct 21 doi: 10.1016/j.radonc.2021.10.009. PMID: 34688809
Rassi MS, Al-Mefty O
Oper Neurosurg (Hagerstown) 2021 May 13;20(6):E418-E419. doi: 10.1093/ons/opab052. PMID: 33940610
Halliday D, Parry A, Evans DG
Curr Opin Oncol 2019 Nov;31(6):562-567. doi: 10.1097/CCO.0000000000000579. PMID: 31425178
Berman D, Miller NR
Ann Acad Med Singap 2006 Mar;35(3):168-74. PMID: 16625265
Turbin RE, Pokorny K
Cancer Control 2004 Sep-Oct;11(5):334-41. doi: 10.1177/107327480401100508. PMID: 15377993

Recent systematic reviews

Vaishnav YJ, Singh R, Didwania P, Lehrer EJ, Bakaeva T, Harris TJ, Migliori ME, Sheehan JP, Trifiletti DM
World Neurosurg 2022 Aug;164:e929-e944. Epub 2022 May 21 doi: 10.1016/j.wneu.2022.05.064. PMID: 35609728
de Melo LP, Arruda Viani G, de Paula JS
Radiother Oncol 2021 Dec;165:135-141. Epub 2021 Oct 21 doi: 10.1016/j.radonc.2021.10.009. PMID: 34688809

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