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Ciliary body melanoma

MedGen UID:
138062
•Concept ID:
C0346379
•
Neoplastic Process
Synonyms: Ciliary Body Malignant Melanoma; ciliary body malignant melanoma; Ciliary Body Melanoma; ciliary body melanoma; ciliary body melanoma (disease); malignant ciliary body melanoma; Malignant melanoma of ciliary body; Malignant Melanoma of Ciliary Body; malignant melanoma of ciliary body; Malignant Melanoma of the Ciliary Body; malignant melanoma of the ciliary body; melanoma (disease) of ciliary body; Melanoma of Ciliary Body; melanoma of ciliary body; Melanoma of the Ciliary Body; melanoma of the ciliary body
SNOMED CT: Ciliary body melanoma (255015006); Malignant melanoma of ciliary body (255015006)
 
HPO: HP:0012055
Monarch Initiative: MONDO:0003912

Definition

Malignant tumor of melanocytes of the ciliary body. [from HPO]

Professional guidelines

PubMed

Robotic CyberKnife Radiosurgery for the Treatment of Choroidal and Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P
Am J Ophthalmol 2023 Jun;250:177-185. Epub 2023 Jan 13 doi: 10.1016/j.ajo.2022.12.021. PMID: 36642391
Ciliary body melanoma treatment by stereotactic radiosurgery.
Furdová A, Juhas J, Šramka M, Králik G
Cesk Slov Oftalmol 2018 Spring;73(5-6):204-210. PMID: 30541301
Diagnosis and treatment of uveal melanoma.
Shields JA, Shields CL, De Potter P, Singh AD
Semin Oncol 1996 Dec;23(6):763-7. PMID: 8970600

Recent clinical studies

Etiology

Cytogenetic Abnormalities for Predicting the Risk of Metastases in Choroidal and Ciliary Body Melanoma.
Chao AN, Rose K, Racher H, Altomare F, Krema H
Invest Ophthalmol Vis Sci 2023 Jan 3;64(1):15. doi: 10.1167/iovs.64.1.15. PMID: 36656566Free PMC Article
Robotic CyberKnife Radiosurgery for the Treatment of Choroidal and Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P
Am J Ophthalmol 2023 Jun;250:177-185. Epub 2023 Jan 13 doi: 10.1016/j.ajo.2022.12.021. PMID: 36642391
Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma.
Rantala ES, Parrozzani R, Hernberg MM, Chiarion-Sileni V, Kivelä TT, Midena E
Am J Ophthalmol 2023 Feb;246:258-272. Epub 2022 Nov 1 doi: 10.1016/j.ajo.2022.10.017. PMID: 36328199
Ciliary body melanoma treatment by stereotactic radiosurgery.
Furdová A, Juhas J, Šramka M, Králik G
Cesk Slov Oftalmol 2018 Spring;73(5-6):204-210. PMID: 30541301
An Update on Oculodermal Melanocytosis and Rare Associated Conditions.
Plateroti AM, Scavella V, Abdolrahimzadeh B, Plateroti R, Rahimi S
Semin Ophthalmol 2017;32(4):524-528. Epub 2016 Apr 15 doi: 10.3109/08820538.2015.1118133. PMID: 27083007

Diagnosis

Robotic CyberKnife Radiosurgery for Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Foerster MH, Muacevic A, Priglinger SG, Schaller UC, Foerster P
Ophthalmol Retina 2020 Sep;4(9):954-956. Epub 2020 Apr 20 doi: 10.1016/j.oret.2020.03.031. PMID: 32595095
Ciliary body melanoma treatment by stereotactic radiosurgery.
Furdová A, Juhas J, Šramka M, Králik G
Cesk Slov Oftalmol 2018 Spring;73(5-6):204-210. PMID: 30541301
An Update on Oculodermal Melanocytosis and Rare Associated Conditions.
Plateroti AM, Scavella V, Abdolrahimzadeh B, Plateroti R, Rahimi S
Semin Ophthalmol 2017;32(4):524-528. Epub 2016 Apr 15 doi: 10.3109/08820538.2015.1118133. PMID: 27083007
The Pediatric Choroidal and Ciliary Body Melanoma Study: A Survey by the European Ophthalmic Oncology Group.
Al-Jamal RT, Cassoux N, Desjardins L, Damato B, Konstantinidis L, Coupland SE, Heimann H, Petrovic A, Zografos L, Schalenbourg A, Velazquez-Martin JP, Krema H, Bogdali A, Markiewicz A, Romanowska-Dixon B, Metz CH, Biewald E, Bornfeld N, Kiratli H, Bronkhorst IH, Jager MJ, Marinkovic M, Fili M, Seregard S, Frenkel S, Pe'er J, Salvi SM, Rennie IG, Rospond-Kubiak I, Kociecki J, Kiilgaard JF, Heegaard S, Cohen VM, Sagoo MS, Amiryan A, Saakyan S, Eide N, Krohn J, Midena E, Parrozzani R, Grange JD, Kilic E, Blasi MA, Saornil MA, Kivelä TT
Ophthalmology 2016 Apr;123(4):898-907. Epub 2016 Feb 4 doi: 10.1016/j.ophtha.2015.12.024. PMID: 26854035
Ciliary body melanoma: a special challenge.
Simpson ER
Can J Ophthalmol 2004 Jun;39(4):365-71. doi: 10.1016/s0008-4182(04)80007-3. PMID: 15327101

Therapy

Robotic CyberKnife Radiosurgery for the Treatment of Choroidal and Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P
Am J Ophthalmol 2023 Jun;250:177-185. Epub 2023 Jan 13 doi: 10.1016/j.ajo.2022.12.021. PMID: 36642391
Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma.
Rantala ES, Parrozzani R, Hernberg MM, Chiarion-Sileni V, Kivelä TT, Midena E
Am J Ophthalmol 2023 Feb;246:258-272. Epub 2022 Nov 1 doi: 10.1016/j.ajo.2022.10.017. PMID: 36328199
Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Surgical treatment of iris and ciliary body melanoma: follow-up of a 25-year series of patients.
Klauber S, Jensen PK, Prause JU, Kessing SV
Acta Ophthalmol 2012 Mar;90(2):122-6. Epub 2010 Apr 28 doi: 10.1111/j.1755-3768.2010.01889.x. PMID: 20456258
Management of ciliary body melanoma with iodine-125 plaque brachytherapy.
Krema H, Simpson ER, Pavlin CJ, Payne D, Vasquez LM, McGowan H
Can J Ophthalmol 2009 Aug;44(4):395-400. doi: 10.3129/i09-097. PMID: 19606159

Prognosis

Cytogenetic Abnormalities for Predicting the Risk of Metastases in Choroidal and Ciliary Body Melanoma.
Chao AN, Rose K, Racher H, Altomare F, Krema H
Invest Ophthalmol Vis Sci 2023 Jan 3;64(1):15. doi: 10.1167/iovs.64.1.15. PMID: 36656566Free PMC Article
Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma.
Rantala ES, Parrozzani R, Hernberg MM, Chiarion-Sileni V, Kivelä TT, Midena E
Am J Ophthalmol 2023 Feb;246:258-272. Epub 2022 Nov 1 doi: 10.1016/j.ajo.2022.10.017. PMID: 36328199
The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.
Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261
Robotic CyberKnife Radiosurgery for Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Foerster MH, Muacevic A, Priglinger SG, Schaller UC, Foerster P
Ophthalmol Retina 2020 Sep;4(9):954-956. Epub 2020 Apr 20 doi: 10.1016/j.oret.2020.03.031. PMID: 32595095
The Pediatric Choroidal and Ciliary Body Melanoma Study: A Survey by the European Ophthalmic Oncology Group.
Al-Jamal RT, Cassoux N, Desjardins L, Damato B, Konstantinidis L, Coupland SE, Heimann H, Petrovic A, Zografos L, Schalenbourg A, Velazquez-Martin JP, Krema H, Bogdali A, Markiewicz A, Romanowska-Dixon B, Metz CH, Biewald E, Bornfeld N, Kiratli H, Bronkhorst IH, Jager MJ, Marinkovic M, Fili M, Seregard S, Frenkel S, Pe'er J, Salvi SM, Rennie IG, Rospond-Kubiak I, Kociecki J, Kiilgaard JF, Heegaard S, Cohen VM, Sagoo MS, Amiryan A, Saakyan S, Eide N, Krohn J, Midena E, Parrozzani R, Grange JD, Kilic E, Blasi MA, Saornil MA, Kivelä TT
Ophthalmology 2016 Apr;123(4):898-907. Epub 2016 Feb 4 doi: 10.1016/j.ophtha.2015.12.024. PMID: 26854035

Clinical prediction guides

Cytogenetic Abnormalities for Predicting the Risk of Metastases in Choroidal and Ciliary Body Melanoma.
Chao AN, Rose K, Racher H, Altomare F, Krema H
Invest Ophthalmol Vis Sci 2023 Jan 3;64(1):15. doi: 10.1167/iovs.64.1.15. PMID: 36656566Free PMC Article
Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma.
Rantala ES, Parrozzani R, Hernberg MM, Chiarion-Sileni V, Kivelä TT, Midena E
Am J Ophthalmol 2023 Feb;246:258-272. Epub 2022 Nov 1 doi: 10.1016/j.ajo.2022.10.017. PMID: 36328199
Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma.
Xu TT, Pulido JS, Deufel CL, Corbin KS, Petersen IA, Dalvin LA
Eye (Lond) 2021 Oct;35(10):2754-2762. Epub 2020 Nov 24 doi: 10.1038/s41433-020-01295-y. PMID: 33235338Free PMC Article
The Pediatric Choroidal and Ciliary Body Melanoma Study: A Survey by the European Ophthalmic Oncology Group.
Al-Jamal RT, Cassoux N, Desjardins L, Damato B, Konstantinidis L, Coupland SE, Heimann H, Petrovic A, Zografos L, Schalenbourg A, Velazquez-Martin JP, Krema H, Bogdali A, Markiewicz A, Romanowska-Dixon B, Metz CH, Biewald E, Bornfeld N, Kiratli H, Bronkhorst IH, Jager MJ, Marinkovic M, Fili M, Seregard S, Frenkel S, Pe'er J, Salvi SM, Rennie IG, Rospond-Kubiak I, Kociecki J, Kiilgaard JF, Heegaard S, Cohen VM, Sagoo MS, Amiryan A, Saakyan S, Eide N, Krohn J, Midena E, Parrozzani R, Grange JD, Kilic E, Blasi MA, Saornil MA, Kivelä TT
Ophthalmology 2016 Apr;123(4):898-907. Epub 2016 Feb 4 doi: 10.1016/j.ophtha.2015.12.024. PMID: 26854035
Surgical treatment of iris and ciliary body melanoma: follow-up of a 25-year series of patients.
Klauber S, Jensen PK, Prause JU, Kessing SV
Acta Ophthalmol 2012 Mar;90(2):122-6. Epub 2010 Apr 28 doi: 10.1111/j.1755-3768.2010.01889.x. PMID: 20456258

Recent systematic reviews

The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.
Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261
Secondary glaucoma as initial manifestation of ring melanoma: a case report and review of literature.
Zhao M, Mu Y, Dang Y, Zhu Y
Int J Clin Exp Pathol 2014;7(11):8163-9. Epub 2014 Oct 15 PMID: 25550867Free PMC Article

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