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Choroidal melanoma

MedGen UID:
138064
•Concept ID:
C0346388
•
Neoplastic Process
Synonyms: Choroid Malignant Melanoma; choroid malignant melanoma; Choroid Melanoma; choroid melanoma; Choroidal Melanoma; choroidal melanoma; malignant choroid melanoma; Malignant melanoma of choroid; Malignant Melanoma of Choroid; malignant melanoma of choroid; Malignant Melanoma of the Choroid; malignant melanoma of the choroid; melanoma (disease) of optic choroid; Melanoma of Choroid; melanoma of choroid; Melanoma of the Choroid; melanoma of the choroid; optic choroid melanoma; optic choroid melanoma (disease)
SNOMED CT: Malignant melanoma of choroid (255021005)
 
HPO: HP:0012054
Monarch Initiative: MONDO:0003878

Definition

Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented). [from HPO]

Professional guidelines

PubMed

Laser treatment for choroidal melanoma: Current concepts.
Maheshwari A, Finger PT
Surv Ophthalmol 2023 Mar-Apr;68(2):211-224. Epub 2022 May 27 doi: 10.1016/j.survophthal.2022.05.002. PMID: 35644256
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Photodynamic therapy in treatment of cutaneous and choroidal melanoma.
Kawczyk-Krupka A, Bugaj AM, Latos W, Zaremba K, Sieroń A
Photodiagnosis Photodyn Ther 2013 Dec;10(4):503-9. Epub 2013 Jun 17 doi: 10.1016/j.pdpdt.2013.05.006. PMID: 24284103

Recent clinical studies

Etiology

Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas.
Shields CL, Manalac J, Das C, Ferguson K, Shields JA
Curr Opin Ophthalmol 2014 May;25(3):177-85. doi: 10.1097/ICU.0000000000000041. PMID: 24614143
Ocular phototherapy.
Singh AD
Eye (Lond) 2013 Feb;27(2):190-8. Epub 2012 Dec 14 doi: 10.1038/eye.2012.258. PMID: 23238445Free PMC Article
Choroidal melanoma.
Sallam A, Hungerford J
Br J Hosp Med (Lond) 2007 Dec;68(12):669-73. doi: 10.12968/hmed.2007.68.12.669. PMID: 18186408
Melanoma.
Kalkman E, Baxter G
Clin Radiol 2004 Apr;59(4):313-26. doi: 10.1016/j.crad.2003.09.020. PMID: 15041450

Diagnosis

Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Choroidal Melanoma Resection.
Hamza HS, Elhusseiny AM
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):65-70. doi: 10.4103/meajo.MEAJO_73_18. PMID: 30122851Free PMC Article
Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas.
Shields CL, Manalac J, Das C, Ferguson K, Shields JA
Curr Opin Ophthalmol 2014 May;25(3):177-85. doi: 10.1097/ICU.0000000000000041. PMID: 24614143
Choroidal melanoma.
Sallam A, Hungerford J
Br J Hosp Med (Lond) 2007 Dec;68(12):669-73. doi: 10.12968/hmed.2007.68.12.669. PMID: 18186408
Choroidal osteoma.
Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

Therapy

Photodynamic therapy for choroidal melanoma: What is the response rate?
Yordi S, Soto H, Bowen RC, Singh AD
Surv Ophthalmol 2021 Jul-Aug;66(4):552-559. Epub 2021 Jan 2 doi: 10.1016/j.survophthal.2020.09.006. PMID: 33400941
VITREOUS SEEDING OF CHOROIDAL MELANOMA.
Raval V, Bowen RC, Soto H, Biscotti C, Yeaney G, Sears J, Singh A
Retina 2021 Apr 1;41(4):890-894. doi: 10.1097/IAE.0000000000002989. PMID: 33009220
Statins in ophthalmology.
Ooi KG, Khoo P, Vaclavik V, Watson SL
Surv Ophthalmol 2019 May-Jun;64(3):401-432. Epub 2019 Jan 28 doi: 10.1016/j.survophthal.2019.01.013. PMID: 30703407
Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma.
Vasalaki M, Fabian ID, Reddy MA, Cohen VM, Sagoo MS
Br Med Bull 2017 Jan 1;121(1):107-119. doi: 10.1093/bmb/ldw053. PMID: 28069617
Photodynamic therapy in treatment of cutaneous and choroidal melanoma.
Kawczyk-Krupka A, Bugaj AM, Latos W, Zaremba K, Sieroń A
Photodiagnosis Photodyn Ther 2013 Dec;10(4):503-9. Epub 2013 Jun 17 doi: 10.1016/j.pdpdt.2013.05.006. PMID: 24284103

Prognosis

Photodynamic therapy for choroidal melanoma: What is the response rate?
Yordi S, Soto H, Bowen RC, Singh AD
Surv Ophthalmol 2021 Jul-Aug;66(4):552-559. Epub 2021 Jan 2 doi: 10.1016/j.survophthal.2020.09.006. PMID: 33400941
Small choroidal melanoma: detection with multimodal imaging and management with plaque radiotherapy or AU-011 nanoparticle therapy.
Shields CL, Lim LS, Dalvin LA, Shields JA
Curr Opin Ophthalmol 2019 May;30(3):206-214. doi: 10.1097/ICU.0000000000000560. PMID: 30844944
Choroidal melanoma and pregnancy.
Lemaître S, Lévy-Gabriel C, Desjardins L, Plancher C, Asselain B, Vincent-Salomon A, Lumbroso-Le Rouic L, Dendale R, Rouzier R, Delacroix S, Cassoux N
Acta Ophthalmol 2016 Nov;94(7):e652-e660. Epub 2016 Mar 24 doi: 10.1111/aos.12984. PMID: 27009598
Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas.
Shields CL, Manalac J, Das C, Ferguson K, Shields JA
Curr Opin Ophthalmol 2014 May;25(3):177-85. doi: 10.1097/ICU.0000000000000041. PMID: 24614143
Choroidal osteoma.
Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

Clinical prediction guides

Photodynamic therapy for choroidal melanoma: What is the response rate?
Yordi S, Soto H, Bowen RC, Singh AD
Surv Ophthalmol 2021 Jul-Aug;66(4):552-559. Epub 2021 Jan 2 doi: 10.1016/j.survophthal.2020.09.006. PMID: 33400941
VITREOUS SEEDING OF CHOROIDAL MELANOMA.
Raval V, Bowen RC, Soto H, Biscotti C, Yeaney G, Sears J, Singh A
Retina 2021 Apr 1;41(4):890-894. doi: 10.1097/IAE.0000000000002989. PMID: 33009220
Small choroidal melanoma: detection with multimodal imaging and management with plaque radiotherapy or AU-011 nanoparticle therapy.
Shields CL, Lim LS, Dalvin LA, Shields JA
Curr Opin Ophthalmol 2019 May;30(3):206-214. doi: 10.1097/ICU.0000000000000560. PMID: 30844944
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Circumscribed choroidal hemangioma.
Mashayekhi A, Shields CL
Curr Opin Ophthalmol 2003 Jun;14(3):142-9. doi: 10.1097/00055735-200306000-00006. PMID: 12777933

Recent systematic reviews

Vitreoretinal Surgery in the Prevention and Treatment of Toxic Tumour Syndrome in Uveal Melanoma: A Systematic Review.
Romano MR, Catania F, Confalonieri F, Zollet P, Allegrini D, Sergenti J, Lanza FB, Ferrara M, Angi M
Int J Mol Sci 2021 Sep 17;22(18) doi: 10.3390/ijms221810066. PMID: 34576231Free PMC Article
Updated Systematic Review and Clinical Spectrum of Peripheral Exudative Hemorrhagic Chorioretinopathy.
Badawi AH, Semidey VA, Magliyah M, Al-Dhibi H
Middle East Afr J Ophthalmol 2020 Jan-Mar;27(1):4-9. Epub 2020 Apr 29 doi: 10.4103/meajo.MEAJO_85_20. PMID: 32549717Free PMC Article
Estimating the risk of malignant transformation of a choroidal nevus.
Singh AD, Kalyani P, Topham A
Ophthalmology 2005 Oct;112(10):1784-9. doi: 10.1016/j.ophtha.2005.06.011. PMID: 16154197

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