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Malignant breast melanoma

MedGen UID:
138069
•Concept ID:
C0346787
•
Neoplastic Process
Synonyms: Breast Melanoma; breast melanoma; breast melanoma (disease); Malignant Breast Melanoma; malignant breast melanoma; Malignant melanoma of breast; Malignant Melanoma of Breast; malignant melanoma of breast; Malignant Melanoma of the Breast; malignant melanoma of the breast; melanoma (disease) of breast
SNOMED CT: Malignant melanoma of breast (188050009)
 
Monarch Initiative: MONDO:0002975

Definition

A melanoma that arises usually from the breast skin and less often from the breast glandular tissue. Primary breast melanomas are rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant breast melanoma

Professional guidelines

PubMed

Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors.
Nieder C, Grosu AL, Astner S, Thamm R, Molls M
Radiat Oncol 2006 Jun 27;1:19. doi: 10.1186/1748-717X-1-19. PMID: 16800900Free PMC Article

Recent clinical studies

Etiology

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial.
Reijers ILM, Menzies AM, van Akkooi ACJ, Versluis JM, van den Heuvel NMJ, Saw RPM, Pennington TE, Kapiteijn E, van der Veldt AAM, Suijkerbuijk KPM, Hospers GAP, Rozeman EA, Klop WMC, van Houdt WJ, Sikorska K, van der Hage JA, Grünhagen DJ, Wouters MW, Witkamp AJ, Zuur CL, Lijnsvelt JM, Torres Acosta A, Grijpink-Ongering LG, Gonzalez M, Jóźwiak K, Bierman C, Shannon KF, Ch'ng S, Colebatch AJ, Spillane AJ, Haanen JBAG, Rawson RV, van de Wiel BA, van de Poll-Franse LV, Scolyer RA, Boekhout AH, Long GV, Blank CU
Nat Med 2022 Jun;28(6):1178-1188. Epub 2022 Jun 5 doi: 10.1038/s41591-022-01851-x. PMID: 35661157
Spindle cell lesions of the breast: a diagnostic approach.
Rakha EA, Brogi E, Castellano I, Quinn C
Virchows Arch 2022 Jan;480(1):127-145. Epub 2021 Jul 29 doi: 10.1007/s00428-021-03162-x. PMID: 34322734Free PMC Article
Combined anti-PD-1 and anti-CTLA-4 checkpoint blockade: Treatment of melanoma and immune mechanisms of action.
Willsmore ZN, Coumbe BGT, Crescioli S, Reci S, Gupta A, Harris RJ, Chenoweth A, Chauhan J, Bax HJ, McCraw A, Cheung A, Osborn G, Hoffmann RM, Nakamura M, Laddach R, Geh JLC, MacKenzie-Ross A, Healy C, Tsoka S, Spicer JF, Josephs DH, Papa S, Lacy KE, Karagiannis SN
Eur J Immunol 2021 Mar;51(3):544-556. Epub 2021 Feb 23 doi: 10.1002/eji.202048747. PMID: 33450785
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599

Diagnosis

Organ-Specificity of Breast Cancer Metastasis.
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Epigenetics in the Diagnosis and Therapy of Malignant Melanoma.
Santourlidis S, Schulz WA, Araúzo-Bravo MJ, Gerovska D, Ott P, Bendhack ML, Hassan M, Erichsen L
Int J Mol Sci 2022 Jan 28;23(3) doi: 10.3390/ijms23031531. PMID: 35163453Free PMC Article
Spindle cell lesions of the breast: a diagnostic approach.
Rakha EA, Brogi E, Castellano I, Quinn C
Virchows Arch 2022 Jan;480(1):127-145. Epub 2021 Jul 29 doi: 10.1007/s00428-021-03162-x. PMID: 34322734Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599

Therapy

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial.
Reijers ILM, Menzies AM, van Akkooi ACJ, Versluis JM, van den Heuvel NMJ, Saw RPM, Pennington TE, Kapiteijn E, van der Veldt AAM, Suijkerbuijk KPM, Hospers GAP, Rozeman EA, Klop WMC, van Houdt WJ, Sikorska K, van der Hage JA, Grünhagen DJ, Wouters MW, Witkamp AJ, Zuur CL, Lijnsvelt JM, Torres Acosta A, Grijpink-Ongering LG, Gonzalez M, Jóźwiak K, Bierman C, Shannon KF, Ch'ng S, Colebatch AJ, Spillane AJ, Haanen JBAG, Rawson RV, van de Wiel BA, van de Poll-Franse LV, Scolyer RA, Boekhout AH, Long GV, Blank CU
Nat Med 2022 Jun;28(6):1178-1188. Epub 2022 Jun 5 doi: 10.1038/s41591-022-01851-x. PMID: 35661157
LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer.
Pérez-Núñez I, Rozalén C, Palomeque JÁ, Sangrador I, Dalmau M, Comerma L, Hernández-Prat A, Casadevall D, Menendez S, Liu DD, Shen M, Berenguer J, Ruiz IR, Peña R, Montañés JC, Albà MM, Bonnin S, Ponomarenko J, Gomis RR, Cejalvo JM, Servitja S, Marzese DM, Morey L, Voorwerk L, Arribas J, Bermejo B, Kok M, Pusztai L, Kang Y, Albanell J, Celià-Terrassa T
Nat Cancer 2022 Mar;3(3):355-370. Epub 2022 Mar 17 doi: 10.1038/s43018-022-00339-4. PMID: 35301507
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy.
Shiao SL, Kershaw KM, Limon JJ, You S, Yoon J, Ko EY, Guarnerio J, Potdar AA, McGovern DPB, Bose S, Dar TB, Noe P, Lee J, Kubota Y, Maymi VI, Davis MJ, Henson RM, Choi RY, Yang W, Tang J, Gargus M, Prince AD, Zumsteg ZS, Underhill DM
Cancer Cell 2021 Sep 13;39(9):1202-1213.e6. Epub 2021 Jul 29 doi: 10.1016/j.ccell.2021.07.002. PMID: 34329585Free PMC Article
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Amaria RN, Reddy SM, Tawbi HA, Davies MA, Ross MI, Glitza IC, Cormier JN, Lewis C, Hwu WJ, Hanna E, Diab A, Wong MK, Royal R, Gross N, Weber R, Lai SY, Ehlers R, Blando J, Milton DR, Woodman S, Kageyama R, Wells DK, Hwu P, Patel SP, Lucci A, Hessel A, Lee JE, Gershenwald J, Simpson L, Burton EM, Posada L, Haydu L, Wang L, Zhang S, Lazar AJ, Hudgens CW, Gopalakrishnan V, Reuben A, Andrews MC, Spencer CN, Prieto V, Sharma P, Allison J, Tetzlaff MT, Wargo JA
Nat Med 2018 Nov;24(11):1649-1654. Epub 2018 Oct 8 doi: 10.1038/s41591-018-0197-1. PMID: 30297909Free PMC Article
Leptomeningeal metastasis.
Taillibert S, Chamberlain MC
Handb Clin Neurol 2018;149:169-204. doi: 10.1016/B978-0-12-811161-1.00013-X. PMID: 29307353

Prognosis

Cancer statistics, 2024.
Siegel RL, Giaquinto AN, Jemal A
CA Cancer J Clin 2024 Jan-Feb;74(1):12-49. Epub 2024 Jan 17 doi: 10.3322/caac.21820. PMID: 38230766
Cancer statistics, 2023.
Siegel RL, Miller KD, Wagle NS, Jemal A
CA Cancer J Clin 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763. PMID: 36633525
Annual report to the nation on the status of cancer, part 1: National cancer statistics.
Cronin KA, Scott S, Firth AU, Sung H, Henley SJ, Sherman RL, Siegel RL, Anderson RN, Kohler BA, Benard VB, Negoita S, Wiggins C, Cance WG, Jemal A
Cancer 2022 Dec 15;128(24):4251-4284. Epub 2022 Oct 27 doi: 10.1002/cncr.34479. PMID: 36301149Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Epidemiology of brain metastases.
Nayak L, Lee EQ, Wen PY
Curr Oncol Rep 2012 Feb;14(1):48-54. doi: 10.1007/s11912-011-0203-y. PMID: 22012633

Clinical prediction guides

Idiopathic Granulomatous Mastitis.
Dilaveri C, Degnim A, Lee C, DeSimone D, Moldoveanu D, Ghosh K
Breast J 2024;2024:6693720. Epub 2024 Jan 25 doi: 10.1155/2024/6693720. PMID: 38304866Free PMC Article
IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma.
Reijers ILM, Rao D, Versluis JM, Menzies AM, Dimitriadis P, Wouters MW, Spillane AJ, Klop WMC, Broeks A, Bosch LJW, Lopez-Yurda M, van Houdt WJ, Rawson RV, Grijpink-Ongering LG, Gonzalez M, Cornelissen S, Bouwman J, Sanders J, Plasmeijer E, Elshot YS, Scolyer RA, van de Wiel BA, Peeper DS, van Akkooi ACJ, Long GV, Blank CU
J Exp Med 2023 May 1;220(5) Epub 2023 Mar 15 doi: 10.1084/jem.20221952. PMID: 36920329Free PMC Article
The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial.
Reijers ILM, Menzies AM, van Akkooi ACJ, Versluis JM, van den Heuvel NMJ, Saw RPM, Pennington TE, Kapiteijn E, van der Veldt AAM, Suijkerbuijk KPM, Hospers GAP, Rozeman EA, Klop WMC, van Houdt WJ, Sikorska K, van der Hage JA, Grünhagen DJ, Wouters MW, Witkamp AJ, Zuur CL, Lijnsvelt JM, Torres Acosta A, Grijpink-Ongering LG, Gonzalez M, Jóźwiak K, Bierman C, Shannon KF, Ch'ng S, Colebatch AJ, Spillane AJ, Haanen JBAG, Rawson RV, van de Wiel BA, van de Poll-Franse LV, Scolyer RA, Boekhout AH, Long GV, Blank CU
Nat Med 2022 Jun;28(6):1178-1188. Epub 2022 Jun 5 doi: 10.1038/s41591-022-01851-x. PMID: 35661157
Metabolism in the progression and metastasis of brain tumors.
Tyagi A, Wu SY, Watabe K
Cancer Lett 2022 Jul 28;539:215713. Epub 2022 May 2 doi: 10.1016/j.canlet.2022.215713. PMID: 35513201Free PMC Article

Recent systematic reviews

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.
Lee YC, Lee YL, Li CY
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090905. PMID: 34577828Free PMC Article
Endometriosis and cancer: a systematic review and meta-analysis.
Kvaskoff M, Mahamat-Saleh Y, Farland LV, Shigesi N, Terry KL, Harris HR, Roman H, Becker CM, As-Sanie S, Zondervan KT, Horne AW, Missmer SA
Hum Reprod Update 2021 Feb 19;27(2):393-420. doi: 10.1093/humupd/dmaa045. PMID: 33202017
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

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