U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Infantile Hemangioma

MedGen UID:
1380698
•Concept ID:
C4317089
•
Neoplastic Process
Synonyms: Cellular Hemangioma; Infantile Hemangioendothelioma; Juvenile Capillary Hemangioma; Juvenile Hemangioma; Strawberry Nevus

Definition

A capillary hemangioma that may regress spontaneously. It occurs in infants and children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfantile Hemangioma

Professional guidelines

PubMed

Laser treatment of infantile hemangioma.
Ziad K, Badi J, Roaa Z, Emily AH
J Cosmet Dermatol 2023 Jun;22 Suppl 2:1-7. Epub 2023 Feb 12 doi: 10.1111/jocd.15671. PMID: 36774645
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article

Recent clinical studies

Etiology

Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial.
Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article

Diagnosis

Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment.
Rodríguez Bandera AI, Sebaratnam DF, Wargon O, Wong LF
J Am Acad Dermatol 2021 Dec;85(6):1379-1392. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.019. PMID: 34419524
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article

Therapy

Laser treatment of infantile hemangioma.
Ziad K, Badi J, Roaa Z, Emily AH
J Cosmet Dermatol 2023 Jun;22 Suppl 2:1-7. Epub 2023 Feb 12 doi: 10.1111/jocd.15671. PMID: 36774645
Infantile Hemangiomas.
Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial.
Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034

Prognosis

Laser treatment of infantile hemangioma.
Ziad K, Badi J, Roaa Z, Emily AH
J Cosmet Dermatol 2023 Jun;22 Suppl 2:1-7. Epub 2023 Feb 12 doi: 10.1111/jocd.15671. PMID: 36774645
Hemangioma Endothelial Cells and Hemangioma Stem Cells in Infantile Hemangioma.
Sun Y, Qiu F, Hu C, Guo Y, Lei S
Ann Plast Surg 2022 Feb 1;88(2):244-249. doi: 10.1097/SAP.0000000000002835. PMID: 35023872
Infantile Hemangioma: A Current Review.
Pahl KS, McLean TW
J Pediatr Hematol Oncol 2022 Mar 1;44(2):31-39. doi: 10.1097/MPH.0000000000002384. PMID: 34966091
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993

Clinical prediction guides

OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis.
Li M, Wang X, Yang E, Li Y, Geng Y, Chen Z, Huang S, Zhang D, Wu H
Arterioscler Thromb Vasc Biol 2023 May;43(5):654-673. Epub 2023 Mar 30 doi: 10.1161/ATVBAHA.123.319177. PMID: 36994729
Incidence and clinical factors associated with ulceration in infantile hemangiomas.
Fernández Faith E, Shah SD, Braun M, Pope E, Lara-Corrales I, Witman PM, Harfmann K, Bradley F, Keesari R, Jackson K, Hallagan A, Frieden IJ
J Am Acad Dermatol 2023 Feb;88(2):414-420. Epub 2022 Oct 28 doi: 10.1016/j.jaad.2022.10.047. PMID: 36404484
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Recent systematic reviews

Skin sequelae in patients with infantile hemangioma: a systematic review.
Li W, Kang J, Bai S, Yuan L, Liu J, Bi Y, Sun J, He Y
Eur J Pediatr 2023 Feb;182(2):479-488. Epub 2022 Nov 24 doi: 10.1007/s00431-022-04688-1. PMID: 36434402
Sirolimus for diffuse intestinal infantile hemangioma with PHACE features: systematic review.
Kleinman EP, Blei F, Adams D, Greenberger S
Pediatr Res 2023 May;93(6):1470-1479. Epub 2022 Sep 30 doi: 10.1038/s41390-022-02325-z. PMID: 36180586
Should Propranolol Remain the Gold Standard for Treatment of Infantile Hemangioma? A Systematic Review and Meta-Analysis of Propranolol Versus Atenolol.
Chen T, Gudipudi R, Nguyen SA, Carroll W, Clemmens C
Ann Otol Rhinol Laryngol 2023 Mar;132(3):332-340. Epub 2022 Apr 25 doi: 10.1177/00034894221089758. PMID: 35466712
Propranolol Therapy in Infantile Hemangioma: It Is Not Just About the Beta.
Lee JC, Modiri O, England RW, Shawber CJ, Wu JK
Plast Reconstr Surg 2021 Apr 1;147(4):875-885. doi: 10.1097/PRS.0000000000007699. PMID: 33776033
Laser treatment of infantile hemangioma: A systematic review.
Chinnadurai S, Sathe NA, Surawicz T
Lasers Surg Med 2016 Mar;48(3):221-33. Epub 2015 Dec 29 doi: 10.1002/lsm.22455. PMID: 26711436

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...