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Metastatic Malignant Neoplasm in the Large Intestine

MedGen UID:
138071
•Concept ID:
C0346973
•
Neoplastic Process
Synonyms: Cancer metastatic to large intestine; Metastases to Large Intestine; Metastasis to Large Bowel; Metastasis to large intestine; Metastasis to the Large Bowel; Metastasis to the Large Intestine; Metastatic malignant neoplasm of large intestine; Metastatic malignant neoplasm to large intestine; Metastatic Malignant Neoplasm to the Large Intestine; Metastatic Neoplasm to the Large Intestine; Metastatic Tumor to the Large Intestine; Secondary malignant neoplasm of large intestine
SNOMED CT: Metastasis to large intestine (94365007); Secondary malignant neoplasm of large intestine (94365007); Metastatic malignant neoplasm to large intestine (94365007); Cancer metastatic to large intestine (94365007); Metastatic malignant neoplasm of large intestine (94365007)

Definition

The spread of a malignant neoplasm to the large intestine. This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Large Intestine

Professional guidelines

PubMed

Malignant Melanoma of the Gastrointestinal Tract: Symptoms, Diagnosis, and Current Treatment Options.
Kohoutova D, Worku D, Aziz H, Teare J, Weir J, Larkin J
Cells 2021 Feb 5;10(2) doi: 10.3390/cells10020327. PMID: 33562484Free PMC Article
Controversies in the treatment of RAS wild-type metastatic colorectal cancer.
Vera R, Salgado M, Safont MJ, Gallego J, González E, Élez E, Aranda E
Clin Transl Oncol 2021 Apr;23(4):827-839. Epub 2020 Aug 13 doi: 10.1007/s12094-020-02475-8. PMID: 32789773Free PMC Article
The Neuropeptide System and Colorectal Cancer Liver Metastases: Mechanisms and Management.
Kasprzak A, Adamek A
Int J Mol Sci 2020 May 15;21(10) doi: 10.3390/ijms21103494. PMID: 32429087Free PMC Article

Recent clinical studies

Etiology

Risk and location of distant metastases in patients with locally advanced rectal cancer after total neoadjuvant treatment or chemoradiotherapy in the RAPIDO trial.
Bahadoer RR, Hospers GAP, Marijnen CAM, Peeters KCMJ, Putter H, Dijkstra EA, Kranenbarg EM, Roodvoets AGH, van Etten B, Nilsson PJ, Glimelius B, van de Velde CJH; collaborative investigators
Eur J Cancer 2023 May;185:139-149. Epub 2023 Mar 7 doi: 10.1016/j.ejca.2023.02.027. PMID: 36996624
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
The Neuropeptide System and Colorectal Cancer Liver Metastases: Mechanisms and Management.
Kasprzak A, Adamek A
Int J Mol Sci 2020 May 15;21(10) doi: 10.3390/ijms21103494. PMID: 32429087Free PMC Article
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Alcohol and cancer.
Pöschl G, Seitz HK
Alcohol Alcohol 2004 May-Jun;39(3):155-65. doi: 10.1093/alcalc/agh057. PMID: 15082451

Diagnosis

Risk and location of distant metastases in patients with locally advanced rectal cancer after total neoadjuvant treatment or chemoradiotherapy in the RAPIDO trial.
Bahadoer RR, Hospers GAP, Marijnen CAM, Peeters KCMJ, Putter H, Dijkstra EA, Kranenbarg EM, Roodvoets AGH, van Etten B, Nilsson PJ, Glimelius B, van de Velde CJH; collaborative investigators
Eur J Cancer 2023 May;185:139-149. Epub 2023 Mar 7 doi: 10.1016/j.ejca.2023.02.027. PMID: 36996624
Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Peritoneal "melanosis".
Chang ES, Bachul P, Szura M, Szpor J, Okoń K, Walocha JA
Pol J Pathol 2015 Sep;66(3):330-3. PMID: 26619112
Primary gastrointestinal lymphoma.
Ghimire P, Wu GY, Zhu L
World J Gastroenterol 2011 Feb 14;17(6):697-707. doi: 10.3748/wjg.v17.i6.697. PMID: 21390139Free PMC Article
Carcinoid tumors.
Robertson RG, Geiger WJ, Davis NB
Am Fam Physician 2006 Aug 1;74(3):429-34. PMID: 16913162

Therapy

Complications Following Transrectal and Transperineal Prostate Biopsy: Results of the ProBE-PC Randomized Clinical Trial.
Mian BM, Feustel PJ, Aziz A, Kaufman RP Jr, Bernstein A, Avulova S, Fisher HAG
J Urol 2024 Feb;211(2):205-213. Epub 2023 Nov 17 doi: 10.1097/JU.0000000000003788. PMID: 37976319
Risk and location of distant metastases in patients with locally advanced rectal cancer after total neoadjuvant treatment or chemoradiotherapy in the RAPIDO trial.
Bahadoer RR, Hospers GAP, Marijnen CAM, Peeters KCMJ, Putter H, Dijkstra EA, Kranenbarg EM, Roodvoets AGH, van Etten B, Nilsson PJ, Glimelius B, van de Velde CJH; collaborative investigators
Eur J Cancer 2023 May;185:139-149. Epub 2023 Mar 7 doi: 10.1016/j.ejca.2023.02.027. PMID: 36996624
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Primary gastrointestinal lymphoma.
Ghimire P, Wu GY, Zhu L
World J Gastroenterol 2011 Feb 14;17(6):697-707. doi: 10.3748/wjg.v17.i6.697. PMID: 21390139Free PMC Article

Prognosis

Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Determinants of metastatic competency in colorectal cancer.
Tauriello DV, Calon A, Lonardo E, Batlle E
Mol Oncol 2017 Jan;11(1):97-119. Epub 2017 Jan 3 doi: 10.1002/1878-0261.12018. PMID: 28085225Free PMC Article
Composite intestinal adenoma-microcarcinoid.
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602
Primary gastrointestinal lymphoma.
Ghimire P, Wu GY, Zhu L
World J Gastroenterol 2011 Feb 14;17(6):697-707. doi: 10.3748/wjg.v17.i6.697. PMID: 21390139Free PMC Article

Clinical prediction guides

Outcomes of open vs laparoscopic vs robotic vs transanal total mesorectal excision (TME) for rectal cancer: a network meta-analysis.
Seow W, Dudi-Venkata NN, Bedrikovetski S, Kroon HM, Sammour T
Tech Coloproctol 2023 May;27(5):345-360. Epub 2022 Dec 12 doi: 10.1007/s10151-022-02739-1. PMID: 36508067
The Frontiers of Appendiceal Controversies: Mucinous Neoplasms and Pseudomyxoma Peritonei.
Hissong E, Yantiss RK
Am J Surg Pathol 2022 Jan 1;46(1):e27-e42. doi: 10.1097/PAS.0000000000001662. PMID: 33417324
Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.
Rahma OE, Yothers G, Hong TS, Russell MM, You YN, Parker W, Jacobs SA, Colangelo LH, Lucas PC, Gollub MJ, Hall WA, Kachnic LA, Vijayvergia N, O'Rourke MA, Faller BA, Valicenti RK, Schefter TE, George S, Kainthla R, Stella PJ, Sigurdson E, Wolmark N, George TJ
JAMA Oncol 2021 Aug 1;7(8):1225-1230. doi: 10.1001/jamaoncol.2021.1683. PMID: 34196693Free PMC Article
Clinical Significance and Prognostic Relevance of Microsatellite Instability in Sporadic Colorectal Cancer Patients.
Copija A, Waniczek D, Witkoś A, Walkiewicz K, Nowakowska-Zajdel E
Int J Mol Sci 2017 Jan 6;18(1) doi: 10.3390/ijms18010107. PMID: 28067827Free PMC Article
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

[(18)F]-FDG PET in anal canal cancer: a systematic review and meta-analysis.
Mirshahvalad SA, Mesci A, Murad V, Kohan A, Ortega C, Veit-Haibach P, Metser U
Eur J Nucl Med Mol Imaging 2023 Dec;51(1):258-277. Epub 2023 Aug 18 doi: 10.1007/s00259-023-06393-z. PMID: 37592085
Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
The tip of the iceberg of colorectal perforation from enema: a systematic review and meta-analysis.
Cirocchi R, Randolph J, Panata L, Verdelli AM, Mascagni D, Mingoli A, Zago M, Chiarugi M, Lancia M, Fedeli P, Davies J, Occhionorelli S
Tech Coloproctol 2020 Nov;24(11):1109-1119. Epub 2020 Jul 14 doi: 10.1007/s10151-020-02294-7. PMID: 32666361
The use of Endo-SPONGE(®) in rectal anastomotic leaks: a systematic review.
Mahendran B, Rossi B, Coleman M, Smolarek S
Tech Coloproctol 2020 Jul;24(7):685-694. Epub 2020 May 6 doi: 10.1007/s10151-020-02200-1. PMID: 32377984

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