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Hyperinsulinism in the Infant of a Diabetic Mother

MedGen UID:: 1380829
•Concept ID:: C4330338
•: Disease or Syndrome

Definition

Transient hypoglycemia that occurs in the infant of a diabetic mother due to increased postnatal insulin release as a result of in utero exposure to maternal hyperglycemia. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHyperinsulinism in the Infant of a Diabetic Mother

Pathological process
- Disease
  - Disorder by Site
    - Disorder of endocrine system
      - Endocrine pancreas disorder
        Non-Neoplastic Endocrine Pancreas Disorder
        Hyperinsulinism in the Infant of a Diabetic Mother

Professional guidelines

PubMed

Impact of gestational diabetes mellitus treatment on medium/long-term outcomes after pregnancy: A systematic review and meta-analysis.

García-Patterson A, Balsells M, Solà I, Gich I, Corcoy R
Diabet Med 2023 Jan;40(1):e14998. Epub 2022 Nov 17 doi: 10.1111/dme.14998. PMID: 36326694

Evaluation of anthropometric measures for assessment of cardiometabolic risk in early childhood.

Coles N, Retnakaran R, Hanley A, Birken C, Hamilton J
Public Health Nutr 2020 Aug;23(12):2100-2108. Epub 2020 Apr 17 doi: 10.1017/S1368980019004749. PMID: 32301411 Free PMC Article

An emerging evidence base for the management of neonatal hypoglycaemia.

Harding JE, Harris DL, Hegarty JE, Alsweiler JM, McKinlay CJ
Early Hum Dev 2017 Jan;104:51-56. Epub 2016 Dec 15 doi: 10.1016/j.earlhumdev.2016.12.009. PMID: 27989586 Free PMC Article

See all (5)

Recent clinical studies

Etiology

Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond.

Tosti G, Barberio A, Tartaglione L, Rizzi A, Di Leo M, Viti L, Sirico A, De Carolis S, Pontecorvi A, Lanzone A, Pitocco D
Front Endocrinol (Lausanne) 2023;14:1176623. Epub 2023 Jun 20 doi: 10.3389/fendo.2023.1176623. PMID: 37409227 Free PMC Article

Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.

Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA
Cochrane Database Syst Rev 2023 Feb 15;2(2):CD011507. doi: 10.1002/14651858.CD011507.pub3. PMID: 36790138 Free PMC Article

The Term Newborn: Hypoglycemia.

Hubbard EM, Hay WW Jr
Clin Perinatol 2021 Aug;48(3):665-679. doi: 10.1016/j.clp.2021.05.013. PMID: 34353586

Congenital Hyperinsulinism.

Sims K
Neoreviews 2021 Apr;22(4):e230-e240. doi: 10.1542/neo.22-4-e230. PMID: 33795398

Gestational diabetes mellitus and macrosomia: a literature review.

Kc K, Shakya S, Zhang H
Ann Nutr Metab 2015;66 Suppl 2:14-20. Epub 2015 Jun 2 doi: 10.1159/000371628. PMID: 26045324

See all (196)

Diagnosis

Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond.

Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.

Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA
Cochrane Database Syst Rev 2023 Feb 15;2(2):CD011507. doi: 10.1002/14651858.CD011507.pub3. PMID: 36790138 Free PMC Article

The Term Newborn: Hypoglycemia.

Hubbard EM, Hay WW Jr
Clin Perinatol 2021 Aug;48(3):665-679. doi: 10.1016/j.clp.2021.05.013. PMID: 34353586

Congenital Hyperinsulinism.

Sims K
Neoreviews 2021 Apr;22(4):e230-e240. doi: 10.1542/neo.22-4-e230. PMID: 33795398

Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders.

Stanley CA
J Clin Endocrinol Metab 2016 Mar;101(3):815-26. Epub 2016 Feb 23 doi: 10.1210/jc.2015-3651. PMID: 26908106 Free PMC Article

See all (107)

Therapy

Lights and shadows on the use of metformin in pregnancy: from the preconception phase to breastfeeding and beyond.

Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.

Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA
Cochrane Database Syst Rev 2023 Feb 15;2(2):CD011507. doi: 10.1002/14651858.CD011507.pub3. PMID: 36790138 Free PMC Article

Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health.

Gill V, Kumar V, Singh K, Kumar A, Kim JJ
Biomolecules 2019 Dec 17;9(12) doi: 10.3390/biom9120888. PMID: 31861217 Free PMC Article

A randomized clinical trial of exercise during pregnancy to prevent gestational diabetes mellitus and improve pregnancy outcome in overweight and obese pregnant women.

Wang C, Wei Y, Zhang X, Zhang Y, Xu Q, Sun Y, Su S, Zhang L, Liu C, Feng Y, Shou C, Guelfi KJ, Newnham JP, Yang H
Am J Obstet Gynecol 2017 Apr;216(4):340-351. Epub 2017 Feb 1 doi: 10.1016/j.ajog.2017.01.037. PMID: 28161306

Breastfeeding and diabetes.

Gouveri E, Papanas N, Hatzitolios AI, Maltezos E
Curr Diabetes Rev 2011 Mar;7(2):135-42. doi: 10.2174/157339911794940684. PMID: 21348815

See all (64)

Prognosis

Congenital Hyperinsulinism.

Sims K
Neoreviews 2021 Apr;22(4):e230-e240. doi: 10.1542/neo.22-4-e230. PMID: 33795398

Neonatal cardiac hypertrophy: the role of hyperinsulinism-a review of literature.

Paauw ND, Stegeman R, de Vroede MAMJ, Termote JUM, Freund MW, Breur JMPJ
Eur J Pediatr 2020 Jan;179(1):39-50. Epub 2019 Dec 16 doi: 10.1007/s00431-019-03521-6. PMID: 31840185 Free PMC Article

Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders.

Stanley CA
J Clin Endocrinol Metab 2016 Mar;101(3):815-26. Epub 2016 Feb 23 doi: 10.1210/jc.2015-3651. PMID: 26908106 Free PMC Article

Metabolic syndrome in childhood.

Crespo PS, Prieto Perera JA, Lodeiro FA, Azuara LA
Public Health Nutr 2007 Oct;10(10A):1121-5. doi: 10.1017/S1368980007000596. PMID: 17903319

Diabetes and pregnancy.

Forsbach-Sánchez G, Tamez-Peréz HE, Vazquez-Lara J
Arch Med Res 2005 May-Jun;36(3):291-9. doi: 10.1016/j.arcmed.2005.03.001. PMID: 15925019

See all (64)

Clinical prediction guides

Clinical Predictors of Transient versus Persistent Neonatal Hyperinsulinism.

Falzone N, Harrington J
Horm Res Paediatr 2020;93(5):297-303. Epub 2020 Nov 16 doi: 10.1159/000511139. PMID: 33197914

Fetuin-A and fetal growth in gestational diabetes mellitus.

Wang WJ, Zhang L, Zheng T, Zhang GH, Du K, Yang MN, He H, Wang S, Wang W, Zhang J, Ouyang F, Luo ZC; Shanghai Birth Cohort
BMJ Open Diabetes Res Care 2020 Feb;8(1) doi: 10.1136/bmjdrc-2019-000864. PMID: 32049636 Free PMC Article

Early-Life Arsenic Exposure, Nutritional Status, and Adult Diabetes Risk.

Navas-Acien A, Spratlen MJ, Abuawad A, LoIacono NJ, Bozack AK, Gamble MV
Curr Diab Rep 2019 Nov 22;19(12):147. doi: 10.1007/s11892-019-1272-9. PMID: 31758285 Free PMC Article

Metabolic syndrome in childhood.

Crespo PS, Prieto Perera JA, Lodeiro FA, Azuara LA
Public Health Nutr 2007 Oct;10(10A):1121-5. doi: 10.1017/S1368980007000596. PMID: 17903319

Effects of diabetic pregnancy on the fetus and newborn.

Schwartz R, Teramo KA
Semin Perinatol 2000 Apr;24(2):120-35. doi: 10.1053/sp.2000.6363. PMID: 10805168

See all (92)

Recent systematic reviews

Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.

Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA
Cochrane Database Syst Rev 2023 Feb 15;2(2):CD011507. doi: 10.1002/14651858.CD011507.pub3. PMID: 36790138 Free PMC Article

Impact of gestational diabetes mellitus treatment on medium/long-term outcomes after pregnancy: A systematic review and meta-analysis.

García-Patterson A, Balsells M, Solà I, Gich I, Corcoy R
Diabet Med 2023 Jan;40(1):e14998. Epub 2022 Nov 17 doi: 10.1111/dme.14998. PMID: 36326694

The role of maternal diet on offspring hyperinsulinaemia and adiposity after birth: a systematic review of randomised controlled trials.

North S, Crofts C, Thoma C, Zinn C
J Dev Orig Health Dis 2022 Oct;13(5):527-540. Epub 2021 Nov 2 doi: 10.1017/S2040174421000623. PMID: 34725018

Resistin concentration and gestational diabetes: a systematic review of the literature.

Lobo TF, Torloni MR, Gueuvoghlanian-Silva BY, Mattar R, Daher S
J Reprod Immunol 2013 Mar;97(1):120-7. doi: 10.1016/j.jri.2012.10.004. PMID: 23432878

See all (4)