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Skin Fibroblastic Neoplasm

MedGen UID:
138097
•Concept ID:
C0349527
•
Neoplastic Process
Synonyms: Cutaneous Fibroblastic Neoplasm; Cutaneous Fibroblastic Tumor; Cutaneous Fibrocytic Neoplasm; Cutaneous Fibrocytic Tumor; Cutaneous Fibrous Tissue Neoplasm; Cutaneous fibrous tissue tumor; Cutaneous Fibrous Tissue Tumor; Fibrous tissue neoplasm of skin; Fibrous tissue tumor of skin; Skin Fibrous Tissue Neoplasm; Skin Fibrous Tissue Tumor
SNOMED CT: Fibrous tissue neoplasm of skin (254736006); Fibrous tissue tumor of skin (254736006); Cutaneous fibrous tissue tumor (254736006)

Definition

A neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts. [from NCI]

Professional guidelines

PubMed

Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Management of dermatofibrosarcoma protuberans.
Badhey AK, Tikhtman R, Tang AL
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):278-282. doi: 10.1097/MOO.0000000000000721. PMID: 33993132
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719

Recent clinical studies

Etiology

Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Management of dermatofibrosarcoma protuberans.
Badhey AK, Tikhtman R, Tang AL
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):278-282. doi: 10.1097/MOO.0000000000000721. PMID: 33993132
Dermatofibrosarcoma Protuberans.
Allen A, Ahn C, Sangüeza OP
Dermatol Clin 2019 Oct;37(4):483-488. doi: 10.1016/j.det.2019.05.006. PMID: 31466588
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503

Diagnosis

Pseudolymphomatous Atypical Fibroxanthoma.
Garcia Castro R, Viñolas-Cuadros A, Moyano-Bueno D, Conde-Ferreiros A, Cardeñoso E, Santos-Briz A
Am J Dermatopathol 2020 Dec;42(12):972-976. doi: 10.1097/DAD.0000000000001761. PMID: 32769551
Atypical Fibroxanthoma.
Chapman LW, Yu SS, Arron ST
Semin Cutan Med Surg 2019 Mar 1;38(1):E65-E66. doi: 10.12788/j.sder.2019.008. PMID: 31051027
Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Dermatomyofibroma.
Campagnolo OA, Morais CF, Ughini MO, Aoki CM, Menegazzo M
An Bras Dermatol 2017 Jan-Feb;92(1):101-103. doi: 10.1590/abd1806-4841.20175189. PMID: 28225965Free PMC Article
Dermatofibrosarcoma protuberans.
Serra-Guillén C, Llombart B, Sanmartín O
Actas Dermosifiliogr 2012 Nov;103(9):762-77. Epub 2012 Jan 28 doi: 10.1016/j.ad.2011.10.007. PMID: 22285046

Therapy

Chronic Oral Lesions.
Bukhari AF, Farag AM, Treister NS
Dermatol Clin 2020 Oct;38(4):451-466. Epub 2020 Aug 11 doi: 10.1016/j.det.2020.05.006. PMID: 32892854
Dermatofibrosarcoma Protuberans.
Allen A, Ahn C, Sangüeza OP
Dermatol Clin 2019 Oct;37(4):483-488. doi: 10.1016/j.det.2019.05.006. PMID: 31466588
Infantile myofibromatosis.
Larralde M, Ferrari B, Martinez JP, Barbieri MAF, Méndez JH, Casas J
An Bras Dermatol 2017 Nov-Dec;92(6):854-857. doi: 10.1590/abd1806-4841.20175001. PMID: 29364448Free PMC Article
Dermatofibrosarcoma Protuberans.
Acosta AE, Vélez CS
Curr Treat Options Oncol 2017 Aug 10;18(9):56. doi: 10.1007/s11864-017-0498-5. PMID: 28795284
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Prognosis

Dermatofibrosarcoma Protuberans in Children.
Sleiwah A, Wright TC, Chapman T, Dangoor A, Maggiani F, Clancy R
Curr Treat Options Oncol 2022 Jun;23(6):843-854. Epub 2022 Apr 8 doi: 10.1007/s11864-022-00979-9. PMID: 35394606
Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Dermatofibrosarcoma Protuberans.
Acosta AE, Vélez CS
Curr Treat Options Oncol 2017 Aug 10;18(9):56. doi: 10.1007/s11864-017-0498-5. PMID: 28795284
Malignant fibrous tumors.
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Clinical prediction guides

Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Pseudolymphomatous Atypical Fibroxanthoma.
Garcia Castro R, Viñolas-Cuadros A, Moyano-Bueno D, Conde-Ferreiros A, Cardeñoso E, Santos-Briz A
Am J Dermatopathol 2020 Dec;42(12):972-976. doi: 10.1097/DAD.0000000000001761. PMID: 32769551
Soft Tissue Special Issue: Cutaneous Pleomorphic Spindle Cell Tumors.
Brenn T
Head Neck Pathol 2020 Mar;14(1):109-120. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01084-4. PMID: 31950467Free PMC Article
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Recent systematic reviews

Dermatofibrosarcoma protuberans of the scalp: Surgical management in a multicentric series of 11 cases and systematic review of the literature.
Kuhlmann C, Ehrl D, Taha S, Wachtel N, Schmid A, Bronsert P, Zeller J, Giunta RE, Eisenhardt SU, Braig D
Surgery 2023 Jun;173(6):1463-1475. Epub 2023 Apr 1 doi: 10.1016/j.surg.2023.02.026. PMID: 37012145
Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature.
Alsawas M, Dundar B, Prokop L, Murad MH, Swick B
Am J Dermatopathol 2022 Nov 1;44(11):822-827. Epub 2022 Apr 27 doi: 10.1097/DAD.0000000000002211. PMID: 35503883
Surgery for Dupuytren's contracture of the fingers.
Rodrigues JN, Becker GW, Ball C, Zhang W, Giele H, Hobby J, Pratt AL, Davis T
Cochrane Database Syst Rev 2015 Dec 9;2015(12):CD010143. doi: 10.1002/14651858.CD010143.pub2. PMID: 26648251Free PMC Article
A systematic review of outcome data for dermatofibrosarcoma protuberans with and without fibrosarcomatous change.
Liang CA, Jambusaria-Pahlajani A, Karia PS, Elenitsas R, Zhang PD, Schmults CD
J Am Acad Dermatol 2014 Oct;71(4):781-6. Epub 2014 Apr 19 doi: 10.1016/j.jaad.2014.03.018. PMID: 24755121

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