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Microinvasive gastric cancer

MedGen UID:
138098
•Concept ID:
C0349530
•
Neoplastic Process
Synonyms: Early gastric cancer; Early Gastric Cancer; early gastric cancer; EGC; EGC - Early gastric cancer; Microinvasive Gastric Cancer; microinvasive gastric cancer; Superficial Gastric Cancer; superficial gastric cancer; Superficial Spreading Gastric Cancer; superficial spreading gastric cancer; Surface Gastric Cancer; surface gastric cancer
SNOMED CT: EGC - Early gastric cancer (276809004); Early gastric cancer (276809004)
 
Monarch Initiative: MONDO:0001060

Definition

An invasive adenocarcinoma confined to the mucosa or mucosa and submucosa of the gastric wall. The regional lymph nodes may or may not be involved. It usually occurs in the lesser curvature. The 5-year survival rate following resection is between 80 percent and 95 percent, and remains high even when lymph node metastases are present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicroinvasive gastric cancer

Recent clinical studies

Etiology

Impact of robotic and open surgery on patient wound complications in gastric cancer surgery: A meta-analysis.
Ye L, Yang Q, Xue Y, Jia R, Yang L, Zhong L, Zou L, Xie Y
Int Wound J 2023 Dec;20(10):4262-4271. Epub 2023 Jul 26 doi: 10.1111/iwj.14328. PMID: 37496310Free PMC Article
Diagnostic performance of conventional endoscopy in the identification of submucosal invasion by early gastric cancer: the "non-extension sign" as a simple diagnostic marker.
Nagahama T, Yao K, Imamura K, Kojima T, Ohtsu K, Chuman K, Tanabe H, Yamaoka R, Iwashita A
Gastric Cancer 2017 Mar;20(2):304-313. Epub 2016 May 10 doi: 10.1007/s10120-016-0612-6. PMID: 27165641
Maximum gastric cancer diameter as a prognostic indicator: univariate and multivariate analysis.
Giuliani A, Caporale A, Di Bari M, Demoro M, Gozzo P, Corona M, Miccini M, Ricciardulli T, Tocchi A
J Exp Clin Cancer Res 2003 Dec;22(4):531-8. PMID: 15053293
Signet ring cell carcinoma of the stomach: a clinicopathological comparison with the other histological types.
Yokota T, Kunii Y, Teshima S, Yamada Y, Saito T, Kikuchi S, Yamauchi H
Tohoku J Exp Med 1998 Oct;186(2):121-30. doi: 10.1620/tjem.186.121. PMID: 10223615
Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers.
Chang YC, Nagasue N, Abe S, Taniura H, Kumar DD, Nakamura T
Am J Gastroenterol 1992 Mar;87(3):321-5. PMID: 1371637

Diagnosis

Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach.
Wang N, Kong R, Han W, Lu J
Curr Mol Med 2021;21(8):655-664. doi: 10.2174/0929867327666200522215607. PMID: 32442081
NEN: Advancement in Diagnosis and Minimally Invasive Therapy.
Putzer D, Schullian P, Jaschke W, Bale R
Rofo 2020 May;192(5):422-430. Epub 2019 Nov 20 doi: 10.1055/a-1030-4631. PMID: 31747704
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
Maximum gastric cancer diameter as a prognostic indicator: univariate and multivariate analysis.
Giuliani A, Caporale A, Di Bari M, Demoro M, Gozzo P, Corona M, Miccini M, Ricciardulli T, Tocchi A
J Exp Clin Cancer Res 2003 Dec;22(4):531-8. PMID: 15053293
Staging of gastric cancer with endoscopic ultrasonography and endoscopic mucosal resection.
Kida M, Tanabe S, Watanabe M, Kokutou M, Kondou I, Yamada Y, Sakaguchi T, Saigenji K
Endoscopy 1998 Aug;30 Suppl 1:A64-8. doi: 10.1055/s-2007-1001474. PMID: 9765088

Therapy

Analysis of clinicopathological prognostic parameters in adenocarcinoma of the gastric cardia.
Erturk MS, Ciçek Y, Ersan Y, Saribeyoğlu K, Doğusoy G, Erginoz E
Acta Chir Belg 2003 Nov-Dec;103(6):611-5. doi: 10.1080/00015458.2003.11679503. PMID: 14743570
Probability of lymph node metastasis in small gastric cancer tumor: is it an indication for limited surgery?
Yokota T, Saito T, Teshima S, Yamada Y, Iwamoto K, Takahashi M, Kunii Y, Murata K, Ishiyama S, Yamauchi H
Int Surg 2001 Oct-Dec;86(4):206-9. PMID: 12056462
Clinicopathologic prognostic factors in patients with Borrmann type 4 gastric cancer: univariate and multivariate analyses.
Yokota T, Kunii Y, Saito T, Teshima S, Narushima Y, Yamada Y, Iwamoto K, Kagami M, Takahashi M, Kikuchi S, Yamauchi H
Ups J Med Sci 2000;105(3):227-34. PMID: 11261608
Extended surgery--left upper abdominal exenteration plus Appleby's method--for type 4 gastric carcinoma.
Furukawa H, Hiratsuka M, Iwanaga T, Imaoka S, Ishikawa O, Kabuto T, Sasaki Y, Kameyama M, Ohigashi H, Nakamori S, Yasuda T
Ann Surg Oncol 1997 Apr-May;4(3):209-14. doi: 10.1007/BF02306612. PMID: 9142381

Prognosis

Reciprocal expression of trefoil factor-1 and thyroid transcription factor-1 in lung adenocarcinomas.
Matsubara D, Yoshimoto T, Soda M, Amano Y, Kihara A, Funaki T, Ito T, Sakuma Y, Shibano T, Endo S, Hagiwara K, Ishikawa S, Fukayama M, Murakami Y, Mano H, Niki T
Cancer Sci 2020 Jun;111(6):2183-2195. Epub 2020 Apr 30 doi: 10.1111/cas.14403. PMID: 32237253Free PMC Article
NEN: Advancement in Diagnosis and Minimally Invasive Therapy.
Putzer D, Schullian P, Jaschke W, Bale R
Rofo 2020 May;192(5):422-430. Epub 2019 Nov 20 doi: 10.1055/a-1030-4631. PMID: 31747704
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
Maximum gastric cancer diameter as a prognostic indicator: univariate and multivariate analysis.
Giuliani A, Caporale A, Di Bari M, Demoro M, Gozzo P, Corona M, Miccini M, Ricciardulli T, Tocchi A
J Exp Clin Cancer Res 2003 Dec;22(4):531-8. PMID: 15053293
Signet ring cell carcinoma of the stomach: a clinicopathological comparison with the other histological types.
Yokota T, Kunii Y, Teshima S, Yamada Y, Saito T, Kikuchi S, Yamauchi H
Tohoku J Exp Med 1998 Oct;186(2):121-30. doi: 10.1620/tjem.186.121. PMID: 10223615

Clinical prediction guides

Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach.
Wang N, Kong R, Han W, Lu J
Curr Mol Med 2021;21(8):655-664. doi: 10.2174/0929867327666200522215607. PMID: 32442081
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
Diagnostic performance of conventional endoscopy in the identification of submucosal invasion by early gastric cancer: the "non-extension sign" as a simple diagnostic marker.
Nagahama T, Yao K, Imamura K, Kojima T, Ohtsu K, Chuman K, Tanabe H, Yamaoka R, Iwashita A
Gastric Cancer 2017 Mar;20(2):304-313. Epub 2016 May 10 doi: 10.1007/s10120-016-0612-6. PMID: 27165641
Maximum gastric cancer diameter as a prognostic indicator: univariate and multivariate analysis.
Giuliani A, Caporale A, Di Bari M, Demoro M, Gozzo P, Corona M, Miccini M, Ricciardulli T, Tocchi A
J Exp Clin Cancer Res 2003 Dec;22(4):531-8. PMID: 15053293
Clinicopathologic prognostic factors in patients with Borrmann type 4 gastric cancer: univariate and multivariate analyses.
Yokota T, Kunii Y, Saito T, Teshima S, Narushima Y, Yamada Y, Iwamoto K, Kagami M, Takahashi M, Kikuchi S, Yamauchi H
Ups J Med Sci 2000;105(3):227-34. PMID: 11261608

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