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Carcinoid tumor of intestine

MedGen UID:
138099
•Concept ID:
C0349535
•
Neoplastic Process
Synonyms: carcinoid tumors, intestina; Carcinoid tumors, intestinal; Intestinal neuroendocrine tumor G1
SNOMED CT: Carcinoid tumor of intestine (276816003)
 
Monarch Initiative: MONDO:0021533
OMIM®: 114900

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the small or large intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Clinical features

From HPO
Intestinal carcinoid
MedGen UID:
870540
•Concept ID:
C4024988
•
Neoplastic Process
See: Feature record | Search on this feature

Professional guidelines

PubMed

Treatment of Gastroenteropancreatic Neuroendocrine Tumors.
Perez K, Chan J
Surg Pathol Clin 2019 Dec;12(4):1045-1053. doi: 10.1016/j.path.2019.08.011. PMID: 31672293
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.
Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H
Int J Mol Sci 2019 Jun 22;20(12) doi: 10.3390/ijms20123049. PMID: 31234481Free PMC Article
Principles of diagnosis and management of neuroendocrine tumours.
Raphael MJ, Chan DL, Law C, Singh S
CMAJ 2017 Mar 13;189(10):E398-E404. doi: 10.1503/cmaj.160771. PMID: 28385820Free PMC Article

Recent clinical studies

Therapy

FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
Duke ES, Bradford D, Marcovitz M, Amatya AK, Mishra-Kalyani PS, Nguyen E, Price LSL, Fourie Zirkelbach J, Li Y, Bi Y, Kraft J, Dorff SE, Scepura B, Stephenson M, Ojofeitimi I, Nair A, Han Y, Tezak Z, Lemery SJ, Pazdur R, Larkins E, Singh H
Clin Cancer Res 2023 Sep 15;29(18):3573-3578. doi: 10.1158/1078-0432.CCR-23-0459. PMID: 37265412Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Treatment of Gastroenteropancreatic Neuroendocrine Tumors.
Perez K, Chan J
Surg Pathol Clin 2019 Dec;12(4):1045-1053. doi: 10.1016/j.path.2019.08.011. PMID: 31672293
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.
Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H
Int J Mol Sci 2019 Jun 22;20(12) doi: 10.3390/ijms20123049. PMID: 31234481Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Prognosis

Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Meckel's diverticulum--a high-risk region for malignancy in the ileum. Insights from a population-based epidemiological study and implications in surgical management.
Thirunavukarasu P, Sathaiah M, Sukumar S, Bartels CJ, Zeh H 3rd, Lee KK, Bartlett DL
Ann Surg 2011 Feb;253(2):223-30. doi: 10.1097/SLA.0b013e3181ef488d. PMID: 21135700Free PMC Article
Carcinoid tumors.
Pinchot SN, Holen K, Sippel RS, Chen H
Oncologist 2008 Dec;13(12):1255-69. Epub 2008 Dec 17 doi: 10.1634/theoncologist.2008-0207. PMID: 19091780Free PMC Article
Carcinoid tumors.
Robertson RG, Geiger WJ, Davis NB
Am Fam Physician 2006 Aug 1;74(3):429-34. PMID: 16913162

Clinical prediction guides

Clinical Spectrum and Endoscopic Treatment of Gastrointestinal Carcinoid Tumour.
Xue L, Cai Y, Chen W, Chen S, Xue P
J Coll Physicians Surg Pak 2022 Oct;32(10):1330-1333. doi: 10.29271/jcpsp.2022.10.1330. PMID: 36205280
Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
The safety of lanreotide for neuroendocrine tumor.
Godara A, Siddiqui NS, Byrne MM, Saif MW
Expert Opin Drug Saf 2019 Jan;18(1):1-10. Epub 2018 Dec 24 doi: 10.1080/14740338.2019.1559294. PMID: 30582380
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Surgical management of neuroendocrine tumors.
Tamburrino D, Spoletini G, Partelli S, Muffatti F, Adamenko O, Crippa S, Falconi M
Best Pract Res Clin Endocrinol Metab 2016 Jan;30(1):93-102. Epub 2015 Oct 8 doi: 10.1016/j.beem.2015.10.003. PMID: 26971846

Recent systematic reviews

Endometriosis and its correlation with carcinoid tumor of the appendix: a systematic review.
Villaescusa M, Andres MP, Amaral AC, Barbosa RN, Abrão MS
Minerva Obstet Gynecol 2021 Oct;73(5):606-613. Epub 2021 Apr 27 doi: 10.23736/S2724-606X.21.04792-4. PMID: 33904692
Carcinoma arising in enteric diversion or rectal neobladder for bladder exstrophy.
Ragu R, Meurette G, Kim M, Le Normand L, Lehur PA
Tech Coloproctol 2016 Nov;20(11):745-752. Epub 2016 Sep 3 doi: 10.1007/s10151-016-1519-2. PMID: 27592221
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484
Systematic review of resection of primary midgut carcinoid tumour in patients with unresectable liver metastases.
Capurso G, Rinzivillo M, Bettini R, Boninsegna L, Delle Fave G, Falconi M
Br J Surg 2012 Nov;99(11):1480-6. Epub 2012 Sep 13 doi: 10.1002/bjs.8842. PMID: 22972490
Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review.
Repici A, Hassan C, De Paula Pessoa D, Pagano N, Arezzo A, Zullo A, Lorenzetti R, Marmo R
Endoscopy 2012 Feb;44(2):137-50. Epub 2012 Jan 23 doi: 10.1055/s-0031-1291448. PMID: 22271024

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