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Carcinoid tumor of intestine

MedGen UID:
138099
•Concept ID:
C0349535
•
Neoplastic Process
Synonyms: carcinoid tumors, intestina; Carcinoid tumors, intestinal; Intestinal neuroendocrine tumor G1
SNOMED CT: Carcinoid tumor of intestine (276816003)
 
Monarch Initiative: MONDO:0021533
OMIM®: 114900

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the small or large intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Clinical features

From HPO
Intestinal carcinoid
MedGen UID:
870540
•Concept ID:
C4024988
•
Neoplastic Process
See: Feature record | Search on this feature

Professional guidelines

PubMed

Treatment of Gastroenteropancreatic Neuroendocrine Tumors.
Perez K, Chan J
Surg Pathol Clin 2019 Dec;12(4):1045-1053. doi: 10.1016/j.path.2019.08.011. PMID: 31672293
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.
Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H
Int J Mol Sci 2019 Jun 22;20(12) doi: 10.3390/ijms20123049. PMID: 31234481Free PMC Article
The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors.
Strosberg JR, Halfdanarson TR, Bellizzi AM, Chan JA, Dillon JS, Heaney AP, Kunz PL, O'Dorisio TM, Salem R, Segelov E, Howe JR, Pommier RF, Brendtro K, Bashir MA, Singh S, Soulen MC, Tang L, Zacks JS, Yao JC, Bergsland EK
Pancreas 2017 Jul;46(6):707-714. doi: 10.1097/MPA.0000000000000850. PMID: 28609356Free PMC Article

Recent clinical studies

Etiology

Endometriosis and its correlation with carcinoid tumor of the appendix: a systematic review.
Villaescusa M, Andres MP, Amaral AC, Barbosa RN, Abrão MS
Minerva Obstet Gynecol 2021 Oct;73(5):606-613. Epub 2021 Apr 27 doi: 10.23736/S2724-606X.21.04792-4. PMID: 33904692
Minimally Invasive Small Bowel Cancer Surgery.
Baiu I, Visser BC
Surg Oncol Clin N Am 2019 Apr;28(2):273-283. Epub 2018 Dec 24 doi: 10.1016/j.soc.2018.11.008. PMID: 30851828
Bowel Imaging in Children: Part 2.
Kandasamy D, Sharma R, Gupta AK
Indian J Pediatr 2019 Sep;86(9):817-829. Epub 2019 Feb 21 doi: 10.1007/s12098-019-02878-8. PMID: 30790185
The Problem of Appendiceal Carcinoids.
Galanopoulos M, Toumpanakis C
Endocrinol Metab Clin North Am 2018 Sep;47(3):661-669. Epub 2018 Jul 13 doi: 10.1016/j.ecl.2018.04.004. PMID: 30098722
Small-bowel tumors.
Minardi AJ Jr, Zibari GB, Aultman DF, McMillan RW, McDonald JC
J Am Coll Surg 1998 Jun;186(6):664-8. doi: 10.1016/s1072-7515(98)00092-1. PMID: 9632155

Diagnosis

Goblet cell adenocarcinoma of the appendix: an update and practical approach to diagnosis and grading.
Bell PD, Pai RK
Hum Pathol 2023 Feb;132:183-196. Epub 2022 Jun 9 doi: 10.1016/j.humpath.2022.06.002. PMID: 35691370
Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts.
Bonds M, Rocha FG
Surg Clin North Am 2020 Jun;100(3):635-648. Epub 2020 Apr 1 doi: 10.1016/j.suc.2020.02.010. PMID: 32402306
The hairpin turn.
Bailey R, LeGout JD
Abdom Radiol (NY) 2020 Apr;45(4):1218-1219. doi: 10.1007/s00261-020-02422-9. PMID: 32008113
Carcinoid tumors.
Pinchot SN, Holen K, Sippel RS, Chen H
Oncologist 2008 Dec;13(12):1255-69. Epub 2008 Dec 17 doi: 10.1634/theoncologist.2008-0207. PMID: 19091780Free PMC Article
Carcinoid tumors.
Robertson RG, Geiger WJ, Davis NB
Am Fam Physician 2006 Aug 1;74(3):429-34. PMID: 16913162

Therapy

Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Treatment of Gastroenteropancreatic Neuroendocrine Tumors.
Perez K, Chan J
Surg Pathol Clin 2019 Dec;12(4):1045-1053. doi: 10.1016/j.path.2019.08.011. PMID: 31672293
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.
Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H
Int J Mol Sci 2019 Jun 22;20(12) doi: 10.3390/ijms20123049. PMID: 31234481Free PMC Article
The safety of lanreotide for neuroendocrine tumor.
Godara A, Siddiqui NS, Byrne MM, Saif MW
Expert Opin Drug Saf 2019 Jan;18(1):1-10. Epub 2018 Dec 24 doi: 10.1080/14740338.2019.1559294. PMID: 30582380
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Prognosis

Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors.
Strosberg JR, Halfdanarson TR, Bellizzi AM, Chan JA, Dillon JS, Heaney AP, Kunz PL, O'Dorisio TM, Salem R, Segelov E, Howe JR, Pommier RF, Brendtro K, Bashir MA, Singh S, Soulen MC, Tang L, Zacks JS, Yao JC, Bergsland EK
Pancreas 2017 Jul;46(6):707-714. doi: 10.1097/MPA.0000000000000850. PMID: 28609356Free PMC Article
Carcinoid tumors.
Pinchot SN, Holen K, Sippel RS, Chen H
Oncologist 2008 Dec;13(12):1255-69. Epub 2008 Dec 17 doi: 10.1634/theoncologist.2008-0207. PMID: 19091780Free PMC Article
Carcinoid tumors.
Robertson RG, Geiger WJ, Davis NB
Am Fam Physician 2006 Aug 1;74(3):429-34. PMID: 16913162

Clinical prediction guides

Clinical Spectrum and Endoscopic Treatment of Gastrointestinal Carcinoid Tumour.
Xue L, Cai Y, Chen W, Chen S, Xue P
J Coll Physicians Surg Pak 2022 Oct;32(10):1330-1333. doi: 10.29271/jcpsp.2022.10.1330. PMID: 36205280
Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
The safety of lanreotide for neuroendocrine tumor.
Godara A, Siddiqui NS, Byrne MM, Saif MW
Expert Opin Drug Saf 2019 Jan;18(1):1-10. Epub 2018 Dec 24 doi: 10.1080/14740338.2019.1559294. PMID: 30582380
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors.
Strosberg JR, Halfdanarson TR, Bellizzi AM, Chan JA, Dillon JS, Heaney AP, Kunz PL, O'Dorisio TM, Salem R, Segelov E, Howe JR, Pommier RF, Brendtro K, Bashir MA, Singh S, Soulen MC, Tang L, Zacks JS, Yao JC, Bergsland EK
Pancreas 2017 Jul;46(6):707-714. doi: 10.1097/MPA.0000000000000850. PMID: 28609356Free PMC Article

Recent systematic reviews

Endometriosis and its correlation with carcinoid tumor of the appendix: a systematic review.
Villaescusa M, Andres MP, Amaral AC, Barbosa RN, Abrão MS
Minerva Obstet Gynecol 2021 Oct;73(5):606-613. Epub 2021 Apr 27 doi: 10.23736/S2724-606X.21.04792-4. PMID: 33904692
Carcinoma arising in enteric diversion or rectal neobladder for bladder exstrophy.
Ragu R, Meurette G, Kim M, Le Normand L, Lehur PA
Tech Coloproctol 2016 Nov;20(11):745-752. Epub 2016 Sep 3 doi: 10.1007/s10151-016-1519-2. PMID: 27592221
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484
Systematic review of resection of primary midgut carcinoid tumour in patients with unresectable liver metastases.
Capurso G, Rinzivillo M, Bettini R, Boninsegna L, Delle Fave G, Falconi M
Br J Surg 2012 Nov;99(11):1480-6. Epub 2012 Sep 13 doi: 10.1002/bjs.8842. PMID: 22972490
Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review.
Repici A, Hassan C, De Paula Pessoa D, Pagano N, Arezzo A, Zullo A, Lorenzetti R, Marmo R
Endoscopy 2012 Feb;44(2):137-50. Epub 2012 Jan 23 doi: 10.1055/s-0031-1291448. PMID: 22271024

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