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Ainhum(AINHUM)

MedGen UID:
1381
•Concept ID:
C0001860
•
Disease or Syndrome
Synonyms: AINHUM; Spontaneous dactylolysis
SNOMED CT: Ainhum - dactylolysis spontanea (38528001); Ainhum (38528001); Dactylolysis spontanea (38528001)
 
HPO: HP:0031009
Monarch Initiative: MONDO:0007074
OMIM®: 103400

Definition

Development of a fibrotic constriction ring involving the base of one or more toes, conditioning eversion and absorption of distal structures, possibly progressing to spontaneous amputation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAinhum

Recent clinical studies

Etiology

"African" acral keratoderma: Further evidence for a single entity. A retrospective study of 42 patients.
Dumont M, Hickman G, Hovnanian A, Bagot M, Bourrat E, Petit A
Ann Dermatol Venereol 2023 Mar;150(1):16-23. Epub 2022 Nov 21 doi: 10.1016/j.annder.2022.08.004. PMID: 36424301
Pseudoainhum in Systemic Sclerosis.
Silva M, Ribeiro R, Oliveira J
J Rheumatol 2016 Nov;43(11):2076. doi: 10.3899/jrheum.160239. PMID: 27803345
Surgical correction of pseudoainhum in chronic epidermolysis bullosa: a case report.
Kim YS, Hong HJ, Roh TS
J Plast Reconstr Aesthet Surg 2009 Jul;62(7):e191-3. Epub 2009 Apr 25 doi: 10.1016/j.bjps.2009.03.012. PMID: 19394911
Lower limb amputation in Jos, Nigeria.
Kidmas AT, Nwadiaro CH, Igun GO
East Afr Med J 2004 Aug;81(8):427-9. doi: 10.4314/eamj.v81i8.9205. PMID: 15622938
Pseudoainhum of all fingers associated with Reynolds' syndrome and breast cancer: report of a case and review of the literature.
Wollina U, Graefe T, Oelzner P, Hein G, Schreiber G
J Am Acad Dermatol 2001 Feb;44(2 Suppl):381-4. doi: 10.1067/mjd.2001.104971. PMID: 11174422

Diagnosis

Ainhum, a rare mutilating dermatological disease in a female Cameroonian: a case report.
Tchouakam DN, Tochie JN, Guifo ML, Choukem SP
BMC Dermatol 2019 Aug 12;19(1):12. doi: 10.1186/s12895-019-0092-6. PMID: 31401977Free PMC Article
A woman with a dangling digit.
Roesch A, Kinner B, Schaechinger U, Obermann EC, Landthaler M, Hohenleutner U
J Dtsch Dermatol Ges 2007 Nov;5(11):1008-9. doi: 10.1111/j.1610-0387.2007.06385.x. PMID: 17976142
Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum.
Rashid RM, Cowan E, Abbasi SA, Brieva J, Alam M
J Eur Acad Dermatol Venereol 2007 Jul;21(6):732-7. doi: 10.1111/j.1468-3083.2007.02224.x. PMID: 17567298
Congenital transverse deficiencies: bilateral presentation of the foot.
Toney PA, Mandi DM, Mandracchia VJ
Clin Podiatr Med Surg 2006 Oct;23(4):761-7, vii. doi: 10.1016/j.cpm.2006.01.003. PMID: 17067893
Ainhum (dactylolysis spontanea): a review of the literature and a report of two cases.
Baerg RH
J Am Podiatry Assoc 1971 Feb;61(2):44-54. doi: 10.7547/87507315-61-2-44. PMID: 4927166

Therapy

Novel p.Ala675Thr missense mutation in TRPV3 in Olmsted syndrome.
Chiu FP, Salas-Alanis JC, Amaya-Guerra M, Cepeda-Valdes R, McGrath JA, Hsu CK
Clin Exp Dermatol 2020 Aug;45(6):796-798. Epub 2020 May 14 doi: 10.1111/ced.14228. PMID: 32410213
Viva questions from the IJDVL.
Viswanath V, Vasani R
Indian J Dermatol Venereol Leprol 2014 Nov-Dec;80(6):583-7. doi: 10.4103/0378-6323.144226. PMID: 25543337
An unusual cause of ulceration: ainhum (dactylolysis spontanea).
Jemmott T, Foster AV, Edmonds ME
Int Wound J 2007 Sep;4(3):251-4. doi: 10.1111/j.1742-481X.2007.00297.x. PMID: 17924881Free PMC Article
Olmsted syndrome.
Ali ME, Sikdar AU, Akhtar N, Islam ZM
Mymensingh Med J 2007 Jan;16(1):100-3. doi: 10.3329/mmj.v16i1.262. PMID: 17344790
Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients.
Daccarett M, Espinosa G, Rahimi F, Eckerman CM, Wayne-Bruton S, Couture M, Rosenblum J
J Foot Ankle Surg 2002 Nov-Dec;41(6):372-8. doi: 10.1016/s1067-2516(02)80083-7. PMID: 12500788

Prognosis

Ainhum, a rare mutilating dermatological disease in a female Cameroonian: a case report.
Tchouakam DN, Tochie JN, Guifo ML, Choukem SP
BMC Dermatol 2019 Aug 12;19(1):12. doi: 10.1186/s12895-019-0092-6. PMID: 31401977Free PMC Article
Pseudoainhum in Systemic Sclerosis.
Silva M, Ribeiro R, Oliveira J
J Rheumatol 2016 Nov;43(11):2076. doi: 10.3899/jrheum.160239. PMID: 27803345
Pseudoainhum of all fingers associated with Reynolds' syndrome and breast cancer: report of a case and review of the literature.
Wollina U, Graefe T, Oelzner P, Hein G, Schreiber G
J Am Acad Dermatol 2001 Feb;44(2 Suppl):381-4. doi: 10.1067/mjd.2001.104971. PMID: 11174422
Dactylolysis spontanea (ainhum).
Dunbar WG, Hodges TO
Va Med Mon (1918) 1970 Jul;97(7):438-41. PMID: 5528014
Surgical pathology in the course of the Nile.
Burkitt D
Ann R Coll Surg Engl 1966 Oct;39(4):236-47. PMID: 5951593Free PMC Article

Clinical prediction guides

Novel mutation p.Gly59Arg in GJB6 encoding connexin 30 underlies palmoplantar keratoderma with pseudoainhum, knuckle pads and hearing loss.
Nemoto-Hasebe I, Akiyama M, Kudo S, Ishiko A, Tanaka A, Arita K, Shimizu H
Br J Dermatol 2009 Aug;161(2):452-5. Epub 2009 Mar 30 doi: 10.1111/j.1365-2133.2009.09137.x. PMID: 19416251
Keratoderma hereditaria mutilans. Etretinate treatment and electron microscope studies.
Palungwachira P, Iwahara K, Ogawa H
Australas J Dermatol 1992;33(1):19-30. doi: 10.1111/j.1440-0960.1992.tb00048.x. PMID: 1445089
The surgical pathology of ainhum (dactylolysis spontanea).
Kerhisnik W, O'Donnell E, Wenig JA, McCarthy DJ
J Foot Surg 1986 Mar-Apr;25(2):95-123. PMID: 2423578
Observations and speculations.
Seymour WG
S Afr Med J 1979 Nov 10;56(20):808-10. PMID: 505222

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