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Brain glioblastoma

MedGen UID:
138100
•Concept ID:
C0349543
•
Neoplastic Process
Synonyms: Brain Glioblastoma; brain glioblastoma; brain glioblastoma (disease); brain glioblastoma multiforme; brain glioblastoma multiforme (disease); glioblastoma (disease) of brain; Glioblastoma multiforme of brain; glioblastoma multiforme of brain; glioblastoma multiforme of the brain; grade IV astrocytic neoplasm of brain; grade IV astrocytic neoplasm of the brain; grade IV astrocytic tumor of brain; grade IV astrocytic tumor of the brain; grade IV astrocytic tumour of brain; grade IV astrocytic tumour of the brain; grade IV brain astrocytic neoplasm; grade IV brain astrocytic tumor; grade IV brain astrocytic tumour
SNOMED CT: Glioblastoma multiforme of brain (276828006)
 
Monarch Initiative: MONDO:0002501

Definition

A glioblastoma that arises from the brain, usually the cerebral hemispheres. [from NCI]

Professional guidelines

PubMed

Live-Cell Synchrotron-Based FTIR Evaluation of Metabolic Compounds in Brain Glioblastoma Cell Lines after Riluzole Treatment.
Dučić T, Ninkovic M, Martínez-Rovira I, Sperling S, Rohde V, Dimitrijević D, Jover Mañas GV, Vaccari L, Birarda G, Yousef I
Anal Chem 2022 Feb 1;94(4):1932-1940. Epub 2021 Dec 29 doi: 10.1021/acs.analchem.1c02076. PMID: 34965097
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.
Schwartz L, Seyfried T, Alfarouk KO, Da Veiga Moreira J, Fais S
Semin Cancer Biol 2017 Apr;43:134-138. Epub 2017 Jan 22 doi: 10.1016/j.semcancer.2017.01.005. PMID: 28122260

Recent clinical studies

Etiology

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.
Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403Free PMC Article
Natural history of spinal cord metastasis from brain glioblastomas.
Amelot A, Terrier LM, Cognacq G, Jecko V, Marlier B, Seizeur R, Emery E, Bauchet L, Roualdes V, Voirin J, Joubert C, Mandonnet E, Lemnos L, Mathon B, Le Reste PJ, Coca A, Petit A, Rigau V, Mokhtari K, Rousseau A, Metellus P, Figarella-Branger D, Gauchotte G, Farah K, Pallud J, Zemmoura I
J Neurooncol 2023 Apr;162(2):373-382. Epub 2023 Mar 29 doi: 10.1007/s11060-023-04298-3. PMID: 36991306
Bisdemethoxycurcumin Induces Cell Apoptosis and Inhibits Human Brain Glioblastoma GBM 8401/Luc2 Cell Xenograft Tumor in Subcutaneous Nude Mice In Vivo.
Hsia TC, Peng SF, Chueh FS, Lu KW, Yang JL, Huang AC, Hsu FT, Wu RS
Int J Mol Sci 2022 Jan 4;23(1) doi: 10.3390/ijms23010538. PMID: 35008959Free PMC Article
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
Brain cancer stem cells.
Piccirillo SG, Binda E, Fiocco R, Vescovi AL, Shah K
J Mol Med (Berl) 2009 Nov;87(11):1087-95. Epub 2009 Sep 29 doi: 10.1007/s00109-009-0535-3. PMID: 19784875

Diagnosis

Segmenting brain glioblastoma using dense-attentive 3D DAF(2).
Domadia SG, Thakkar FN, Ardeshana MA
Phys Med 2024 Mar;119:103304. Epub 2024 Feb 10 doi: 10.1016/j.ejmp.2024.103304. PMID: 38340694
Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.
Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403Free PMC Article
Natural history of spinal cord metastasis from brain glioblastomas.
Amelot A, Terrier LM, Cognacq G, Jecko V, Marlier B, Seizeur R, Emery E, Bauchet L, Roualdes V, Voirin J, Joubert C, Mandonnet E, Lemnos L, Mathon B, Le Reste PJ, Coca A, Petit A, Rigau V, Mokhtari K, Rousseau A, Metellus P, Figarella-Branger D, Gauchotte G, Farah K, Pallud J, Zemmoura I
J Neurooncol 2023 Apr;162(2):373-382. Epub 2023 Mar 29 doi: 10.1007/s11060-023-04298-3. PMID: 36991306
Tumor Microenvironment and Microvascular Density in Human Glioblastoma.
Tamma R, Ingravallo G, Annese T, d'Amati A, Lorusso L, Ribatti D
Cells 2022 Dec 20;12(1) doi: 10.3390/cells12010011. PMID: 36611806Free PMC Article
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article

Therapy

Dye-Sensitized Rare Earth Nanoparticles with Up/Down Conversion Luminescence for On-Demand Gas Therapy of Glioblastoma Guided by NIR-II Fluorescence Imaging.
Liu Z, Yun B, Han Y, Jiang Z, Zhu H, Ren F, Li Z
Adv Healthc Mater 2022 Feb;11(3):e2102042. Epub 2021 Nov 25 doi: 10.1002/adhm.202102042. PMID: 34787378
Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo.
Liao CL, Ma YS, Hsia TC, Chou YC, Lien JC, Peng SF, Kuo CL, Hsu FT
Molecules 2021 Nov 24;26(23) doi: 10.3390/molecules26237105. PMID: 34885686Free PMC Article
Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin.
Kast RE, Hill QA, Wion D, Mellstedt H, Focosi D, Karpel-Massler G, Heiland T, Halatsch ME
Tumour Biol 2017 May;39(5):1010428317699797. doi: 10.1177/1010428317699797. PMID: 28459367
Prospect of rindopepimut in the treatment of glioblastoma.
Elsamadicy AA, Chongsathidkiet P, Desai R, Woroniecka K, Farber SH, Fecci PE, Sampson JH
Expert Opin Biol Ther 2017 Apr;17(4):507-513. Epub 2017 Mar 5 doi: 10.1080/14712598.2017.1299705. PMID: 28274144Free PMC Article
Delivering siRNA and Chemotherapeutic Molecules Across BBB and BTB for Intracranial Glioblastoma Therapy.
Yang ZZ, Gao W, Liu YJ, Pang N, Qi XR
Mol Pharm 2017 Apr 3;14(4):1012-1022. Epub 2017 Mar 2 doi: 10.1021/acs.molpharmaceut.6b00819. PMID: 28252970

Prognosis

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.
Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403Free PMC Article
Natural history of spinal cord metastasis from brain glioblastomas.
Amelot A, Terrier LM, Cognacq G, Jecko V, Marlier B, Seizeur R, Emery E, Bauchet L, Roualdes V, Voirin J, Joubert C, Mandonnet E, Lemnos L, Mathon B, Le Reste PJ, Coca A, Petit A, Rigau V, Mokhtari K, Rousseau A, Metellus P, Figarella-Branger D, Gauchotte G, Farah K, Pallud J, Zemmoura I
J Neurooncol 2023 Apr;162(2):373-382. Epub 2023 Mar 29 doi: 10.1007/s11060-023-04298-3. PMID: 36991306
Deciphering the Role of Glutamate Signaling in Glioblastoma Multiforme: Current Therapeutic Modalities and Future Directions.
Mollazadeh H, Mohtashami E, Mousavi SH, Soukhtanloo M, Vahedi MM, Hosseini A, Afshari AR, Sahebkar A
Curr Pharm Des 2020;26(37):4777-4788. doi: 10.2174/1381612826666200603132456. PMID: 32493186
Characteristics of treatment and outcome in elderly patients with brain glioblastoma: a retrospective analysis of case series.
Dobran M, Nasi D, Della Costanza M, Gladi M, Iacoangeli M, Rotim K, Splavski B
Acta Clin Croat 2019 Jun;58(2):221-228. doi: 10.20471/acc.2019.58.02.04. PMID: 31819317Free PMC Article
Glioblastoma in the elderly: the impact of advanced age on treatment and survival.
Mariniello G, Peca C, De Caro Mdel B, Giamundo A, Donzelli R, Maiuri F
J Neurol Surg A Cent Eur Neurosurg 2014 Jul;75(4):276-81. Epub 2014 Jan 4 doi: 10.1055/s-0033-1349713. PMID: 24390930

Clinical prediction guides

Segmenting brain glioblastoma using dense-attentive 3D DAF(2).
Domadia SG, Thakkar FN, Ardeshana MA
Phys Med 2024 Mar;119:103304. Epub 2024 Feb 10 doi: 10.1016/j.ejmp.2024.103304. PMID: 38340694
Natural history of spinal cord metastasis from brain glioblastomas.
Amelot A, Terrier LM, Cognacq G, Jecko V, Marlier B, Seizeur R, Emery E, Bauchet L, Roualdes V, Voirin J, Joubert C, Mandonnet E, Lemnos L, Mathon B, Le Reste PJ, Coca A, Petit A, Rigau V, Mokhtari K, Rousseau A, Metellus P, Figarella-Branger D, Gauchotte G, Farah K, Pallud J, Zemmoura I
J Neurooncol 2023 Apr;162(2):373-382. Epub 2023 Mar 29 doi: 10.1007/s11060-023-04298-3. PMID: 36991306
In-Depth Matrisome and Glycoproteomic Analysis of Human Brain Glioblastoma Versus Control Tissue.
Sethi MK, Downs M, Shao C, Hackett WE, Phillips JJ, Zaia J
Mol Cell Proteomics 2022 Apr;21(4):100216. Epub 2022 Feb 23 doi: 10.1016/j.mcpro.2022.100216. PMID: 35202840Free PMC Article
Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo.
Liao CL, Ma YS, Hsia TC, Chou YC, Lien JC, Peng SF, Kuo CL, Hsu FT
Molecules 2021 Nov 24;26(23) doi: 10.3390/molecules26237105. PMID: 34885686Free PMC Article
Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: tumour progression or radionecrosis?
Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F
Clin Neurol Neurosurg 2009 May;111(4):331-4. Epub 2008 Dec 30 doi: 10.1016/j.clineuro.2008.11.003. PMID: 19117668

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