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Gestational choriocarcinoma

MedGen UID:
138102
•Concept ID:
C0349557
•
Neoplastic Process
Synonym: Choriocarcinoma, gestational
SNOMED CT: Gestational choriocarcinoma (417057000); Gestational choriocarcinoma (417570003); Gestational chorioepithelioma (417570003); Gestational chorionepithelioma (417570003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020550
Orphanet: ORPHA99926

Definition

A form of gestational trophoblastic neoplasia characterized histologically by trophoblast proliferation, absence of chorionic villi (except in cases of intraplacental choriocarcinoma) and tissue necrosis with bleeding. The tumor occurs secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole. Indicative signs are persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after removal of a hydatidiform mole; persistent unexplained metrorrhagia following spontaneous abortion or VTP; occasionally unexplained metrorrhagia in the weeks or months following normal childbirth or an ectopic pregnancy. Occasionally, metastases (lung, liver, brain, kidneys, vagina) are indicative signs in women of childbearing age. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational choriocarcinoma
Follow this link to review classifications for Gestational choriocarcinoma in Orphanet.

Professional guidelines

PubMed

Fertility-Sparing Treatment in Gestational Choriocarcinoma: Evaluating Oncological and Obstetrical Outcomes in Young Patients.
Piątek S, Szczęsny N, Szymusik I, Karoń K, Piątkowski K, Bornio E, Bidziński M, Gujski M
Med Sci Monit 2023 Nov 14;29:e942078. doi: 10.12659/MSM.942078. PMID: 37957930Free PMC Article
Demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma: a UK population study.
Savage P, Winter M, Parker V, Harding V, Sita-Lumsden A, Fisher RA, Harvey R, Unsworth N, Sarwar N, Short D, Aguiar X, Tidy J, Hancock B, Coleman R, Seckl MJ
BJOG 2020 Aug;127(9):1102-1107. Epub 2020 Apr 3 doi: 10.1111/1471-0528.16202. PMID: 32146729
Diagnosis and management of gestational trophoblastic disease.
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Recent clinical studies

Etiology

Gestational choriocarcinoma.
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma: a UK population study.
Savage P, Winter M, Parker V, Harding V, Sita-Lumsden A, Fisher RA, Harvey R, Unsworth N, Sarwar N, Short D, Aguiar X, Tidy J, Hancock B, Coleman R, Seckl MJ
BJOG 2020 Aug;127(9):1102-1107. Epub 2020 Apr 3 doi: 10.1111/1471-0528.16202. PMID: 32146729
Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma.
He W, Hou M, Zhang H, Zeng C, He S, Chen X, Xu M, Sun C, Jiang W, Wang H, Shen H, Zhang Y, Liu J, Sun S, Jiang N, Cui Y, Sun Y, Chen Y, Cao J, Wang C, Li M, Zhang Y, Wang L, Wang J, Lin M, Ke Z
Int J Cancer 2019 Mar 15;144(6):1421-1431. Epub 2018 Oct 26 doi: 10.1002/ijc.31742. PMID: 30070688Free PMC Article
Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma.
Tarney CM, Tian C, Craig ER, Crothers BA, Chan JK, Gist GD, Bateman NW, Conrads TP, Hamilton CA, Larry Maxwell G, Darcy KM
Int J Gynecol Cancer 2018 Feb;28(2):338-345. doi: 10.1097/IGC.0000000000001156. PMID: 29232272
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066

Diagnosis

Maternal and fetal outcomes of intraplacental choriocarcinoma complicated by fetomaternal hemorrhage: a systematic review.
Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Gestational choriocarcinoma.
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Gestational Trophoblastic Disease: Contemporary Diagnostic Approach.
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine.
Buza N, Hui P
Mod Pathol 2021 Sep;34(9):1658-1672. Epub 2021 Jun 4 doi: 10.1038/s41379-021-00831-9. PMID: 34088998

Therapy

Chemotherapy is not needed when complete evacuation of gestational choriocarcinoma leads to hCG normalization.
Bolze P, Schoenen S, Margaillan M, Braga A, Sauthier P, Elias K, Seckl M, Winter M, Coulter J, Lok C, Joneborg U, Undurraga Malinverno M, Hajri T, Massardier J, You B, Golfier F, Goffin F
Eur J Surg Oncol 2024 Mar;50(3):108012. Epub 2024 Feb 8 doi: 10.1016/j.ejso.2024.108012. PMID: 38350264
Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma.
He W, Hou M, Zhang H, Zeng C, He S, Chen X, Xu M, Sun C, Jiang W, Wang H, Shen H, Zhang Y, Liu J, Sun S, Jiang N, Cui Y, Sun Y, Chen Y, Cao J, Wang C, Li M, Zhang Y, Wang L, Wang J, Lin M, Ke Z
Int J Cancer 2019 Mar 15;144(6):1421-1431. Epub 2018 Oct 26 doi: 10.1002/ijc.31742. PMID: 30070688Free PMC Article
Role of the renin-angiotensin system in gynecologic cancers.
Ino K, Shibata K, Yamamoto E, Kajiyama H, Nawa A, Mabuchi Y, Yagi S, Minami S, Tanizaki Y, Kobayashi A, Kikkawa F
Curr Cancer Drug Targets 2011 May;11(4):405-11. doi: 10.2174/156800911795538057. PMID: 21395551
Why does cytotoxic chemotherapy cure only some cancers?
Savage P, Stebbing J, Bower M, Crook T
Nat Clin Pract Oncol 2009 Jan;6(1):43-52. Epub 2008 Nov 4 doi: 10.1038/ncponc1260. PMID: 18982000
Gestational choriocarcinoma and thyrotoxicosis.
Anderson NR, Lokich JJ, McDermott WV Jr, Trey C, Falchuk KR
Cancer 1979 Jul;44(1):304-6. doi: 10.1002/1097-0142(197907)44:1<304::aid-cncr2820440151>3.0.co;2-r. PMID: 455255

Prognosis

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Gestational choriocarcinoma.
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Gestational Trophoblastic Disease: Contemporary Diagnostic Approach.
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Gestational choriocarcinoma.
Baergen RN
Gen Diagn Pathol 1997 Nov;143(2-3):127-41. PMID: 9443570

Clinical prediction guides

Clinical features of gestational choriocarcinoma: A retrospective bicentric study.
Yuksel D, Aytekın O, Oktar O, Ayhan S, Ozkaya Ucar Y, Cakır C, Boran N, Korkmaz V, Koc S, Türkmen O, Kimyon Cömert G, Moraloğlu Tekin O, Engin Ustün Y, Turan T
Asia Pac J Clin Oncol 2024 Apr;20(2):292-298. Epub 2023 Feb 23 doi: 10.1111/ajco.13946. PMID: 36823769
Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Gestational choriocarcinoma.
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma.
He W, Hou M, Zhang H, Zeng C, He S, Chen X, Xu M, Sun C, Jiang W, Wang H, Shen H, Zhang Y, Liu J, Sun S, Jiang N, Cui Y, Sun Y, Chen Y, Cao J, Wang C, Li M, Zhang Y, Wang L, Wang J, Lin M, Ke Z
Int J Cancer 2019 Mar 15;144(6):1421-1431. Epub 2018 Oct 26 doi: 10.1002/ijc.31742. PMID: 30070688Free PMC Article
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066

Recent systematic reviews

Maternal and fetal outcomes of intraplacental choriocarcinoma complicated by fetomaternal hemorrhage: a systematic review.
Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature.
Jia N, Chen Y, Tao X, Ou E, Lu X, Feng W
J Ovarian Res 2017 Jul 20;10(1):46. doi: 10.1186/s13048-017-0334-3. PMID: 28728581Free PMC Article

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