U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gestational choriocarcinoma

MedGen UID:
138102
Concept ID:
C0349557
Neoplastic Process
Synonym: Choriocarcinoma, gestational
SNOMED CT: Gestational choriocarcinoma (417057000); Gestational choriocarcinoma (417570003); Gestational chorioepithelioma (417570003); Gestational chorionepithelioma (417570003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020550
Orphanet: ORPHA99926

Definition

A form of gestational trophoblastic neoplasia characterized histologically by trophoblast proliferation, absence of chorionic villi (except in cases of intraplacental choriocarcinoma) and tissue necrosis with bleeding. The tumor occurs secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole. Indicative signs are persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after removal of a hydatidiform mole; persistent unexplained metrorrhagia following spontaneous abortion or VTP; occasionally unexplained metrorrhagia in the weeks or months following normal childbirth or an ectopic pregnancy. Occasionally, metastases (lung, liver, brain, kidneys, vagina) are indicative signs in women of childbearing age. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational choriocarcinoma
Follow this link to review classifications for Gestational choriocarcinoma in Orphanet.

Professional guidelines

PubMed

Piątek S, Szczęsny N, Szymusik I, Karoń K, Piątkowski K, Bornio E, Bidziński M, Gujski M
Med Sci Monit 2023 Nov 14;29:e942078. doi: 10.12659/MSM.942078. PMID: 37957930Free PMC Article
Savage P, Winter M, Parker V, Harding V, Sita-Lumsden A, Fisher RA, Harvey R, Unsworth N, Sarwar N, Short D, Aguiar X, Tidy J, Hancock B, Coleman R, Seckl MJ
BJOG 2020 Aug;127(9):1102-1107. Epub 2020 Apr 3 doi: 10.1111/1471-0528.16202. PMID: 32146729
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Recent clinical studies

Etiology

Gu Y, Zheng H, Xue X, Wang D, Cheng H, Zong L, Xiang Y
BMC Pregnancy Childbirth 2024 Jan 2;24(1):19. doi: 10.1186/s12884-023-06144-w. PMID: 38166849Free PMC Article
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Savage P, Winter M, Parker V, Harding V, Sita-Lumsden A, Fisher RA, Harvey R, Unsworth N, Sarwar N, Short D, Aguiar X, Tidy J, Hancock B, Coleman R, Seckl MJ
BJOG 2020 Aug;127(9):1102-1107. Epub 2020 Apr 3 doi: 10.1111/1471-0528.16202. PMID: 32146729
Tarney CM, Tian C, Craig ER, Crothers BA, Chan JK, Gist GD, Bateman NW, Conrads TP, Hamilton CA, Larry Maxwell G, Darcy KM
Int J Gynecol Cancer 2018 Feb;28(2):338-345. doi: 10.1097/IGC.0000000000001156. PMID: 29232272
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066

Diagnosis

Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Buza N, Hui P
Mod Pathol 2021 Sep;34(9):1658-1672. Epub 2021 Jun 4 doi: 10.1038/s41379-021-00831-9. PMID: 34088998
Hui P
Arch Pathol Lab Med 2019 Jan;143(1):65-74. Epub 2018 Nov 8 doi: 10.5858/arpa.2018-0234-RA. PMID: 30407075

Therapy

Bolze PA, Lopez J, Allias F, Hajri T, Patrier S, Devouassoux-Shisheboran M, Massardier J, You B, Golfier F, Mallet F
Gynecol Oncol 2020 Sep;158(3):785-793. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.042. PMID: 32513563
Ino K, Shibata K, Yamamoto E, Kajiyama H, Nawa A, Mabuchi Y, Yagi S, Minami S, Tanizaki Y, Kobayashi A, Kikkawa F
Curr Cancer Drug Targets 2011 May;11(4):405-11. doi: 10.2174/156800911795538057. PMID: 21395551
Savage P, Stebbing J, Bower M, Crook T
Nat Clin Pract Oncol 2009 Jan;6(1):43-52. Epub 2008 Nov 4 doi: 10.1038/ncponc1260. PMID: 18982000
Bower M, Brock C, Fisher RA, Newlands ES, Rustin GJ
Ann Oncol 1995 May;6(5):503-8. doi: 10.1093/oxfordjournals.annonc.a059222. PMID: 7669714
Anderson NR, Lokich JJ, McDermott WV Jr, Trey C, Falchuk KR
Cancer 1979 Jul;44(1):304-6. doi: 10.1002/1097-0142(197907)44:1<304::aid-cncr2820440151>3.0.co;2-r. PMID: 455255

Prognosis

Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Baergen RN
Gen Diagn Pathol 1997 Nov;143(2-3):127-41. PMID: 9443570

Clinical prediction guides

Gu Y, Zheng H, Xue X, Wang D, Cheng H, Zong L, Xiang Y
BMC Pregnancy Childbirth 2024 Jan 2;24(1):19. doi: 10.1186/s12884-023-06144-w. PMID: 38166849Free PMC Article
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Savage P, Winter M, Parker V, Harding V, Sita-Lumsden A, Fisher RA, Harvey R, Unsworth N, Sarwar N, Short D, Aguiar X, Tidy J, Hancock B, Coleman R, Seckl MJ
BJOG 2020 Aug;127(9):1102-1107. Epub 2020 Apr 3 doi: 10.1111/1471-0528.16202. PMID: 32146729
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066

Recent systematic reviews

Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
Jia N, Chen Y, Tao X, Ou E, Lu X, Feng W
J Ovarian Res 2017 Jul 20;10(1):46. doi: 10.1186/s13048-017-0334-3. PMID: 28728581Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...