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Gestational choriocarcinoma

MedGen UID:
138102
Concept ID:
C0349557
Neoplastic Process
Synonym: Choriocarcinoma, gestational
SNOMED CT: Gestational choriocarcinoma (417057000); Gestational choriocarcinoma (417570003); Gestational chorioepithelioma (417570003); Gestational chorionepithelioma (417570003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020550
Orphanet: ORPHA99926

Definition

A form of gestational trophoblastic neoplasia characterized histologically by trophoblast proliferation, absence of chorionic villi (except in cases of intraplacental choriocarcinoma) and tissue necrosis with bleeding. The tumor occurs secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole. Indicative signs are persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after removal of a hydatidiform mole; persistent unexplained metrorrhagia following spontaneous abortion or VTP; occasionally unexplained metrorrhagia in the weeks or months following normal childbirth or an ectopic pregnancy. Occasionally, metastases (lung, liver, brain, kidneys, vagina) are indicative signs in women of childbearing age. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational choriocarcinoma
Follow this link to review classifications for Gestational choriocarcinoma in Orphanet.

Professional guidelines

PubMed

Piątek S, Szczęsny N, Szymusik I, Karoń K, Piątkowski K, Bornio E, Bidziński M, Gujski M
Med Sci Monit 2023 Nov 14;29:e942078. doi: 10.12659/MSM.942078. PMID: 37957930Free PMC Article
Savage P, Winter M, Parker V, Harding V, Sita-Lumsden A, Fisher RA, Harvey R, Unsworth N, Sarwar N, Short D, Aguiar X, Tidy J, Hancock B, Coleman R, Seckl MJ
BJOG 2020 Aug;127(9):1102-1107. Epub 2020 Apr 3 doi: 10.1111/1471-0528.16202. PMID: 32146729
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Recent clinical studies

Etiology

Hashimoto K, Miyagawa Y, Watanabe S, Takasaki K, Nishizawa M, Yatsuki K, Takahashi Y, Kamata H, Kihira C, Hiraike H, Sasamori Y, Kido K, Ryo E, Nagasaka K
Int J Mol Sci 2023 Sep 5;24(18) doi: 10.3390/ijms241813706. PMID: 37762005Free PMC Article
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Mangili G, Bergamini A, Giorgione V, Picchio M, Petrone M, Mapelli P, Rabaiotti E, Incerti E, Candiani M
Q J Nucl Med Mol Imaging 2016 Jun;60(2):103-16. Epub 2016 Feb 11 PMID: 26868372
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Diagnosis

Dahl J
Arch Pathol Lab Med 2024 Apr 1;148(4):398-408. doi: 10.5858/arpa.2023-0109-RA. PMID: 37977155
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Huang CY, Chen CA, Hsieh CY, Cheng WF
Int J Gynecol Cancer 2007 Sep-Oct;17(5):1166-71. Epub 2007 Apr 9 doi: 10.1111/j.1525-1438.2007.00934.x. PMID: 17425677
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Therapy

Ji L, Ma L
J Biochem Mol Toxicol 2020 Apr;34(4):e22455. Epub 2020 Feb 14 doi: 10.1002/jbt.22455. PMID: 32057180
Huang CY, Chen CA, Hsieh CY, Cheng WF
Int J Gynecol Cancer 2007 Sep-Oct;17(5):1166-71. Epub 2007 Apr 9 doi: 10.1111/j.1525-1438.2007.00934.x. PMID: 17425677
Miyazaki J, Kawai K, Hayashi H, Onozawa M, Tsukamoto S, Miyanaga N, Hinotsu S, Shimazui T, Akaza H
Jpn J Clin Oncol 2003 Aug;33(8):391-5. doi: 10.1093/jjco/hyg074. PMID: 14523058
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709
Buckner JC
Cancer Metastasis Rev 1991 Dec;10(4):335-41. doi: 10.1007/BF00554795. PMID: 1786634

Prognosis

Liu Y, Song X, Zhang H, Feng F, Zhao J, Yang J, Ren T, Wan X, Jiang F, Li Y, Xiang Y
Orphanet J Rare Dis 2024 May 22;19(1):214. doi: 10.1186/s13023-024-03199-6. PMID: 38778412Free PMC Article
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Mangili G, Bergamini A, Giorgione V, Picchio M, Petrone M, Mapelli P, Rabaiotti E, Incerti E, Candiani M
Q J Nucl Med Mol Imaging 2016 Jun;60(2):103-16. Epub 2016 Feb 11 PMID: 26868372
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Clinical prediction guides

Yuksel D, Aytekın O, Oktar O, Ayhan S, Ozkaya Ucar Y, Cakır C, Boran N, Korkmaz V, Koc S, Türkmen O, Kimyon Cömert G, Moraloğlu Tekin O, Engin Ustün Y, Turan T
Asia Pac J Clin Oncol 2024 Apr;20(2):292-298. Epub 2023 Feb 23 doi: 10.1111/ajco.13946. PMID: 36823769
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Bogani G, Ray-Coquard I, Mutch D, Vergote I, Ramirez PT, Prat J, Concin N, Ngoi NYL, Coleman RL, Enomoto T, Takehara K, Denys H, Lorusso D, Takano M, Sagae S, Wimberger P, Segev Y, Kim SI, Kim JW, Herrera F, Mariani A, Brooks RA, Tan D, Paolini B, Chiappa V, Longo M, Raspagliesi F, Benedetti Panici P, Di Donato V, Caruso G, Colombo N, Pignata S, Zannoni G, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Oct 2;33(10):1504-1514. doi: 10.1136/ijgc-2023-004704. PMID: 37758451
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Lewis JL Jr
Cancer 1993 Feb 15;71(4 Suppl):1639-47. doi: 10.1002/cncr.2820710430. PMID: 8381709

Recent systematic reviews

Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
Jia N, Chen Y, Tao X, Ou E, Lu X, Feng W
J Ovarian Res 2017 Jul 20;10(1):46. doi: 10.1186/s13048-017-0334-3. PMID: 28728581Free PMC Article

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