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Hematologic neoplasm

MedGen UID:
138213
Concept ID:
C0376545
Neoplastic Process
Synonyms: Hematologic cancer; Hematological malignancies; Hematological neoplasm
SNOMED CT: Hematologic neoplasm (129154003); Hematologic malignancy (269475001)
 
Gene (location): H3C2 (6p22.2)
 
HPO: HP:0004377

Definition

Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHematologic neoplasm

Conditions with this feature

Platelet disorder, undefined
MedGen UID:
401405
Concept ID:
C1868258
Disease or Syndrome

Professional guidelines

PubMed

Valent P, Hartmann K, Schwaab J, Alvarez-Twose I, Brockow K, Bonadonna P, Hermine O, Niedoszytko M, Carter MC, Hoermann G, Sperr WR, Butterfield JH, Ustun C, Zanotti R, Radia DH, Castells M, Triggiani M, Schwartz LB, Orfao A, George TI, Sotlar K, Gotlib J, Reiter A, Horny HP, Arock M, Akin C, Metcalfe DD
J Allergy Clin Immunol Pract 2022 Aug;10(8):1999-2012.e6. Epub 2022 Mar 25 doi: 10.1016/j.jaip.2022.03.007. PMID: 35342031
Pullarkat ST, Wu W, Pullarkat V
Cancer Treat Res 2021;181:167-178. doi: 10.1007/978-3-030-78311-2_10. PMID: 34626361
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312

Curated

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

Recent clinical studies

Etiology

Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Kennedy VE, Perkins C, Reiter A, Jawhar M, Lübke J, Kluin-Nelemans HC, Shomali W, Langford C, Abuel J, Hermine O, Niedoszytko M, Gorska A, Mital A, Bonadonna P, Zanotti R, Tanasi I, Mattsson M, Hagglund H, Triggiani M, Yavuz AS, Panse J, Christen D, Heizmann M, Shoumariyeh K, Müller S, Elena C, Malcovati L, Fiorelli N, Wortmann F, Vucinic V, Brockow K, Fokoloros C, Papageorgiou SG, Breynaert C, Bullens D, Doubek M, Ilerhaus A, Angelova-Fischer I, Solomianyi O, Várkonyi J, Sabato V, Rüfer A, Schug TD, Hermans MAW, Fortina AB, Caroppo F, Bumbea H, Gulen T, Hartmann K, Elberink HO, Schwaab J, Arock M, Valent P, Sperr WR, Gotlib J
Blood Adv 2023 May 9;7(9):1713-1724. doi: 10.1182/bloodadvances.2022008292. PMID: 36094848Free PMC Article
Radia DH, Moonim MT
Best Pract Res Clin Haematol 2022 Jun;35(2):101380. Epub 2022 Sep 14 doi: 10.1016/j.beha.2022.101380. PMID: 36333068
Sullivan MJ, Palmer EL, Botero JP
Curr Hematol Malig Rep 2022 Oct;17(5):105-112. Epub 2022 Jun 25 doi: 10.1007/s11899-022-00666-4. PMID: 35751752
Wilk CM, Manz MG, Boettcher S
Curr Opin Hematol 2021 Mar 1;28(2):94-100. doi: 10.1097/MOH.0000000000000631. PMID: 33394723

Diagnosis

Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Leguit RJ, Wang SA, George TI, Tzankov A, Orazi A
Virchows Arch 2023 Jan;482(1):99-112. Epub 2022 Oct 10 doi: 10.1007/s00428-022-03423-3. PMID: 36214901
Radia DH, Moonim MT
Best Pract Res Clin Haematol 2022 Jun;35(2):101380. Epub 2022 Sep 14 doi: 10.1016/j.beha.2022.101380. PMID: 36333068
Sullivan MJ, Palmer EL, Botero JP
Curr Hematol Malig Rep 2022 Oct;17(5):105-112. Epub 2022 Jun 25 doi: 10.1007/s11899-022-00666-4. PMID: 35751752
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312

Therapy

DeAngelo DJ, Radia DH, George TI, Robinson WA, Quiery AT, Drummond MW, Bose P, Hexner EO, Winton EF, Horny HP, Tugnait M, Schmidt-Kittler O, Evans EK, Lin HM, Mar BG, Verstovsek S, Deininger MW, Gotlib J
Nat Med 2021 Dec;27(12):2183-2191. Epub 2021 Dec 6 doi: 10.1038/s41591-021-01538-9. PMID: 34873347Free PMC Article
Gotlib J, Reiter A, Radia DH, Deininger MW, George TI, Panse J, Vannucchi AM, Platzbecker U, Alvarez-Twose I, Mital A, Hermine O, Dybedal I, Hexner EO, Hicks LK, Span L, Mesa R, Bose P, Pettit KM, Heaney ML, Oh ST, Sen J, Lin HM, Mar BG, DeAngelo DJ
Nat Med 2021 Dec;27(12):2192-2199. Epub 2021 Dec 6 doi: 10.1038/s41591-021-01539-8. PMID: 34873345Free PMC Article
Bose P, Verstovsek S
Expert Rev Hematol 2021 Aug;14(8):687-696. Epub 2021 Aug 6 doi: 10.1080/17474086.2021.1959315. PMID: 34289787
Wilk CM, Manz MG, Boettcher S
Curr Opin Hematol 2021 Mar 1;28(2):94-100. doi: 10.1097/MOH.0000000000000631. PMID: 33394723
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312

Prognosis

Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Radia DH, Moonim MT
Best Pract Res Clin Haematol 2022 Jun;35(2):101380. Epub 2022 Sep 14 doi: 10.1016/j.beha.2022.101380. PMID: 36333068
Valent P, Hartmann K, Schwaab J, Alvarez-Twose I, Brockow K, Bonadonna P, Hermine O, Niedoszytko M, Carter MC, Hoermann G, Sperr WR, Butterfield JH, Ustun C, Zanotti R, Radia DH, Castells M, Triggiani M, Schwartz LB, Orfao A, George TI, Sotlar K, Gotlib J, Reiter A, Horny HP, Arock M, Akin C, Metcalfe DD
J Allergy Clin Immunol Pract 2022 Aug;10(8):1999-2012.e6. Epub 2022 Mar 25 doi: 10.1016/j.jaip.2022.03.007. PMID: 35342031
Bose P, Verstovsek S
Expert Rev Hematol 2021 Aug;14(8):687-696. Epub 2021 Aug 6 doi: 10.1080/17474086.2021.1959315. PMID: 34289787
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312

Clinical prediction guides

Radia DH, Moonim MT
Best Pract Res Clin Haematol 2022 Jun;35(2):101380. Epub 2022 Sep 14 doi: 10.1016/j.beha.2022.101380. PMID: 36333068
Valent P, Hartmann K, Schwaab J, Alvarez-Twose I, Brockow K, Bonadonna P, Hermine O, Niedoszytko M, Carter MC, Hoermann G, Sperr WR, Butterfield JH, Ustun C, Zanotti R, Radia DH, Castells M, Triggiani M, Schwartz LB, Orfao A, George TI, Sotlar K, Gotlib J, Reiter A, Horny HP, Arock M, Akin C, Metcalfe DD
J Allergy Clin Immunol Pract 2022 Aug;10(8):1999-2012.e6. Epub 2022 Mar 25 doi: 10.1016/j.jaip.2022.03.007. PMID: 35342031
DeAngelo DJ, Radia DH, George TI, Robinson WA, Quiery AT, Drummond MW, Bose P, Hexner EO, Winton EF, Horny HP, Tugnait M, Schmidt-Kittler O, Evans EK, Lin HM, Mar BG, Verstovsek S, Deininger MW, Gotlib J
Nat Med 2021 Dec;27(12):2183-2191. Epub 2021 Dec 6 doi: 10.1038/s41591-021-01538-9. PMID: 34873347Free PMC Article
Gotlib J, Reiter A, Radia DH, Deininger MW, George TI, Panse J, Vannucchi AM, Platzbecker U, Alvarez-Twose I, Mital A, Hermine O, Dybedal I, Hexner EO, Hicks LK, Span L, Mesa R, Bose P, Pettit KM, Heaney ML, Oh ST, Sen J, Lin HM, Mar BG, DeAngelo DJ
Nat Med 2021 Dec;27(12):2192-2199. Epub 2021 Dec 6 doi: 10.1038/s41591-021-01539-8. PMID: 34873345Free PMC Article
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312

Recent systematic reviews

Sim JJL, Mitra S, Ling RR, Tan CS, Fan BE, MacLaren G, Ramanathan K
Ann Hematol 2022 Jul;101(7):1395-1406. Epub 2022 May 27 doi: 10.1007/s00277-022-04855-2. PMID: 35622097
Lopez-Santillan M, Lopez-Lopez E, Alvarez-Gonzalez P, Martinez G, Arzuaga-Mendez J, Ruiz-Diaz I, Guerra-Merino I, Gutierrez-Camino A, Martin-Guerrero I
Crit Rev Oncol Hematol 2021 Sep;165:103430. Epub 2021 Jul 30 doi: 10.1016/j.critrevonc.2021.103430. PMID: 34339834
Samuelson Bannow BT, Konkle BA
Thromb Res 2018 Mar;163:138-145. Epub 2018 Jan 31 doi: 10.1016/j.thromres.2018.01.037. PMID: 29407626Free PMC Article
Sousa DC, Rodrigues FB, Duarte G, Campos F, Pinto F, Vaz-Carneiro A
Can J Ophthalmol 2016 Dec;51(6):459-466. Epub 2016 Sep 14 doi: 10.1016/j.jcjo.2016.05.018. PMID: 27938958

Supplemental Content

Table of contents

    Clinical resources

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • Nguyen et al., 2011
      Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

    Consumer resources

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