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Reduced insulin-like factor 3 level

MedGen UID:
1382475
Concept ID:
C4476924
Finding
Synonym: Reduced plasma INSL3 level
 
HPO: HP:0031037

Definition

Blood concentration of insulin-like factor 3 (ILF3) is below normal limits. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced insulin-like factor 3 level

Professional guidelines

PubMed

Miller BS, Blair J, Horikawa R, Linglart A, Yuen KCJ
Drug Des Devel Ther 2024;18:291-306. Epub 2024 Feb 3 doi: 10.2147/DDDT.S315172. PMID: 38333899Free PMC Article
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
McDonald A, Williams RM, Regan FM, Semple RK, Dunger DB
Eur J Endocrinol 2007 Aug;157 Suppl 1:S51-6. doi: 10.1530/EJE-07-0271. PMID: 17785698

Recent clinical studies

Etiology

Moro T, Tinsley G, Longo G, Grigoletto D, Bianco A, Ferraris C, Guglielmetti M, Veneto A, Tagliabue A, Marcolin G, Paoli A
J Int Soc Sports Nutr 2020 Dec 11;17(1):65. doi: 10.1186/s12970-020-00396-z. PMID: 33308259Free PMC Article
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Voss S, Pietzner J, Hoche F, Taylor AM, Last JI, Schubert R, Zielen S
Growth Factors 2014 Jun;32(3-4):123-9. doi: 10.3109/08977194.2014.939805. PMID: 25060036
Lightman S
Hosp Med 2002 Mar;63(3):162-5. doi: 10.12968/hosp.2002.63.3.2062. PMID: 11933820
Rosen CJ
Endocrine 2000 Apr;12(2):197-201. doi: 10.1385/ENDO:12:2:197. PMID: 10905380

Diagnosis

Chen F, Wen W, Long J, Shu X, Yang Y, Shu XO, Zheng W
Int J Cancer 2022 Aug 1;151(3):372-380. Epub 2022 Apr 26 doi: 10.1002/ijc.34026. PMID: 35403707Free PMC Article
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG; Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O'Rahilly S
Nature 2021 Nov;599(7885):436-441. Epub 2021 Nov 3 doi: 10.1038/s41586-021-04088-9. PMID: 34732894Free PMC Article
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article

Therapy

Miller BS, Blair JC, Rasmussen MH, Maniatis A, Kildemoes RJ, Mori J, Polak M, Bang RB, Böttcher V, Stagi S, Horikawa R
J Clin Endocrinol Metab 2022 Nov 25;107(12):3378-3388. doi: 10.1210/clinem/dgac513. PMID: 36062966Free PMC Article
Shah UA, Iyengar NM
JAMA Oncol 2022 Aug 1;8(8):1201-1208. doi: 10.1001/jamaoncol.2022.1769. PMID: 35797039Free PMC Article
Yang X, Kord-Varkaneh H, Talaei S, Clark CCT, Zanghelini F, Tan SC, Zarezadeh M, Mousavi SM, Rahmani J, Zhang Y
Pharmacol Res 2020 Jan;151:104588. Epub 2019 Dec 6 doi: 10.1016/j.phrs.2019.104588. PMID: 31816435
Lightman S
Hosp Med 2002 Mar;63(3):162-5. doi: 10.12968/hosp.2002.63.3.2062. PMID: 11933820
Rosen CJ
Endocrine 2000 Apr;12(2):197-201. doi: 10.1385/ENDO:12:2:197. PMID: 10905380

Prognosis

Ferreira JP, Packer M, Sattar N, Butler J, González Maldonado S, Panova-Noeva M, Sumin M, Masson S, Pocock SJ, Anker SD, Zannad F, Januzzi JL
Eur J Heart Fail 2024 Apr;26(4):806-816. Epub 2024 Apr 8 doi: 10.1002/ejhf.3227. PMID: 38587259
Januzzi JL, Mohebi R, Liu Y, Sattar N, Heerspink HJL, Tefera E, Vaduganathan M, Butler J, Yavin Y, Li J, Pollock CA, Perkovic V, Neal B, Hansen MK
Circulation 2023 Aug 22;148(8):651-660. Epub 2023 Aug 21 doi: 10.1161/CIRCULATIONAHA.123.065251. PMID: 37603600
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Akanji AO, Smith RJ
Metab Syndr Relat Disord 2012 Feb;10(1):3-13. Epub 2011 Nov 21 doi: 10.1089/met.2011.0083. PMID: 22103319
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article

Clinical prediction guides

Shah UA, Iyengar NM
JAMA Oncol 2022 Aug 1;8(8):1201-1208. doi: 10.1001/jamaoncol.2022.1769. PMID: 35797039Free PMC Article
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Gross SM, Rotwein P
J Cell Sci 2016 May 15;129(10):2052-63. Epub 2016 Apr 4 doi: 10.1242/jcs.183764. PMID: 27044757Free PMC Article
Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP
Int J Biochem Cell Biol 2013 Oct;45(10):2163-72. Epub 2013 Jun 24 doi: 10.1016/j.biocel.2013.05.036. PMID: 23806868
Di Somma C, Brunelli V, Savanelli MC, Scarano E, Savastano S, Lombardi G, Colao A
Minerva Endocrinol 2011 Sep;36(3):243-55. PMID: 22019753

Recent systematic reviews

Salido-Bueno B, Gil-Hernandez E, Rueda-Ruzafa L, Gomez-Chica P, Roman P, Cardona D
Nutr Bull 2024 Sep;49(3):264-277. Epub 2024 Jun 24 doi: 10.1111/nbu.12693. PMID: 38923748
Nasr S, Nakisa A, Jandaghian S, Kouhi M, Sadeghi E, Varshosaz J
Curr Med Chem 2023;30(14):1657-1666. doi: 10.2174/0929867329666220801164740. PMID: 35927904
Zaiem F, Alahdab F, Al Nofal A, Murad MH, Javed A
Endocr Pract 2017 Apr 2;23(4):408-421. Epub 2017 Jan 17 doi: 10.4158/EP161622.OR. PMID: 28095041
Kang DW, Lee J, Suh SH, Ligibel J, Courneya KS, Jeon JY
Cancer Epidemiol Biomarkers Prev 2017 Mar;26(3):355-365. Epub 2016 Oct 14 doi: 10.1158/1055-9965.EPI-16-0602. PMID: 27742668
Löf M, Bergström K, Weiderpass E
Maturitas 2012 Oct;73(2):134-42. Epub 2012 Jul 26 doi: 10.1016/j.maturitas.2012.07.002. PMID: 22840658

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