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Reduced insulin-like factor 3 level

MedGen UID:
1382475
•Concept ID:
C4476924
•
Finding
Synonym: Reduced plasma INSL3 level
 
HPO: HP:0031037

Definition

Blood concentration of insulin-like factor 3 (ILF3) is below normal limits. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced insulin-like factor 3 level

Professional guidelines

PubMed

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
IGF-I treatment of insulin resistance.
McDonald A, Williams RM, Regan FM, Semple RK, Dunger DB
Eur J Endocrinol 2007 Aug;157 Suppl 1:S51-6. doi: 10.1530/EJE-07-0271. PMID: 17785698
Insulin-like growth factor-I in diabetes mellitus: its physiology, metabolic effects, and potential clinical utility.
Thrailkill KM
Diabetes Technol Ther 2000 Spring;2(1):69-80. doi: 10.1089/152091599316775. PMID: 11467325

Recent clinical studies

Etiology

The Role of Hypoxia-Inducible Factor in the Mechanisms of Aging.
Dzhalilova DS, Makarova OV
Biochemistry (Mosc) 2022 Sep;87(9):995-1014. doi: 10.1134/S0006297922090115. PMID: 36180993
Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: a randomized controlled trial.
Moro T, Tinsley G, Longo G, Grigoletto D, Bianco A, Ferraris C, Guglielmetti M, Veneto A, Tagliabue A, Marcolin G, Paoli A
J Int Soc Sports Nutr 2020 Dec 11;17(1):65. doi: 10.1186/s12970-020-00396-z. PMID: 33308259Free PMC Article
The insulin-like growth factor axis: A biological mechanism linking physical activity to colorectal cancer survival.
Sax AT, Jenkins DG, Devin JL, Hughes GI, Bolam KA, Skinner TL
Cancer Epidemiol 2014 Aug;38(4):455-9. Epub 2014 Jun 23 doi: 10.1016/j.canep.2014.05.011. PMID: 24968815
The insulin-like growth factor system, metabolic syndrome, and cardiovascular disease risk.
Akanji AO, Smith RJ
Metab Syndr Relat Disord 2012 Feb;10(1):3-13. Epub 2011 Nov 21 doi: 10.1089/met.2011.0083. PMID: 22103319
Insulin, insulin-like growth factors and colon cancer: a review of the evidence.
Giovannucci E
J Nutr 2001 Nov;131(11 Suppl):3109S-20S. doi: 10.1093/jn/131.11.3109S. PMID: 11694656

Diagnosis

Mendelian randomization analyses of 23 known and suspected risk factors and biomarkers for breast cancer overall and by molecular subtypes.
Chen F, Wen W, Long J, Shu X, Yang Y, Shu XO, Zheng W
Int J Cancer 2022 Aug 1;151(3):372-380. Epub 2022 Apr 26 doi: 10.1002/ijc.34026. PMID: 35403707Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Dong J, Yu J, Li Z, Gao S, Wang H, Yang S, Wu L, Lan C, Zhao T, Gao C, Liu Z, Wang X, Hao J
J Cachexia Sarcopenia Muscle 2021 Jun;12(3):704-716. Epub 2021 Mar 24 doi: 10.1002/jcsm.12692. PMID: 33763996Free PMC Article
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824
Acromegaly.
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article

Therapy

Weekly Somapacitan is Effective and Well Tolerated in Children With GH Deficiency: The Randomized Phase 3 REAL4 Trial.
Miller BS, Blair JC, Rasmussen MH, Maniatis A, Kildemoes RJ, Mori J, Polak M, Bang RB, Böttcher V, Stagi S, Horikawa R
J Clin Endocrinol Metab 2022 Nov 25;107(12):3378-3388. doi: 10.1210/clinem/dgac513. PMID: 36062966Free PMC Article
Plant-Based and Ketogenic Diets As Diverging Paths to Address Cancer: A Review.
Shah UA, Iyengar NM
JAMA Oncol 2022 Aug 1;8(8):1201-1208. doi: 10.1001/jamaoncol.2022.1769. PMID: 35797039Free PMC Article
Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
Molinari L, Heskia F, Peerapornratana S, Ronco C, Guzzi L, Toback S, Birch R, Beyhaghi H, Kwan T, Kampf JP, Yealy DM, Kellum JA; Sapphire and Protocolized Care for Early Septic Shock (ProCESS) Investigators
Crit Care Med 2021 Oct 1;49(10):1706-1716. doi: 10.1097/CCM.0000000000005061. PMID: 33927121Free PMC Article
Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: a randomized controlled trial.
Moro T, Tinsley G, Longo G, Grigoletto D, Bianco A, Ferraris C, Guglielmetti M, Veneto A, Tagliabue A, Marcolin G, Paoli A
J Int Soc Sports Nutr 2020 Dec 11;17(1):65. doi: 10.1186/s12970-020-00396-z. PMID: 33308259Free PMC Article
Evidence for acne-promoting effects of milk and other insulinotropic dairy products.
Melnik BC
Nestle Nutr Workshop Ser Pediatr Program 2011;67:131-45. Epub 2011 Feb 16 doi: 10.1159/000325580. PMID: 21335995

Prognosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
HBV/Pregenomic RNA Increases the Stemness and Promotes the Development of HBV-Related HCC Through Reciprocal Regulation With Insulin-Like Growth Factor 2 mRNA-Binding Protein 3.
Ding WB, Wang MC, Yu J, Huang G, Sun DP, Liu L, Zhang JN, Yang Y, Liu H, Zhou WP, Yang F, Yuan SX
Hepatology 2021 Sep;74(3):1480-1495. Epub 2021 Jul 29 doi: 10.1002/hep.31850. PMID: 33825218
The insulin-like growth factor axis: A biological mechanism linking physical activity to colorectal cancer survival.
Sax AT, Jenkins DG, Devin JL, Hughes GI, Bolam KA, Skinner TL
Cancer Epidemiol 2014 Aug;38(4):455-9. Epub 2014 Jun 23 doi: 10.1016/j.canep.2014.05.011. PMID: 24968815
The insulin-like growth factor system, metabolic syndrome, and cardiovascular disease risk.
Akanji AO, Smith RJ
Metab Syndr Relat Disord 2012 Feb;10(1):3-13. Epub 2011 Nov 21 doi: 10.1089/met.2011.0083. PMID: 22103319
Acromegaly.
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article

Clinical prediction guides

The Role of Hypoxia-Inducible Factor in the Mechanisms of Aging.
Dzhalilova DS, Makarova OV
Biochemistry (Mosc) 2022 Sep;87(9):995-1014. doi: 10.1134/S0006297922090115. PMID: 36180993
Plant-Based and Ketogenic Diets As Diverging Paths to Address Cancer: A Review.
Shah UA, Iyengar NM
JAMA Oncol 2022 Aug 1;8(8):1201-1208. doi: 10.1001/jamaoncol.2022.1769. PMID: 35797039Free PMC Article
Myokine Expression and Tumor-Suppressive Effect of Serum after 12 wk of Exercise in Prostate Cancer Patients on ADT.
Kim JS, Wilson RL, Taaffe DR, Galvão DA, Gray E, Newton RU
Med Sci Sports Exerc 2022 Feb 1;54(2):197-205. doi: 10.1249/MSS.0000000000002783. PMID: 34559721Free PMC Article
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Dong J, Yu J, Li Z, Gao S, Wang H, Yang S, Wu L, Lan C, Zhao T, Gao C, Liu Z, Wang X, Hao J
J Cachexia Sarcopenia Muscle 2021 Jun;12(3):704-716. Epub 2021 Mar 24 doi: 10.1002/jcsm.12692. PMID: 33763996Free PMC Article
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824

Recent systematic reviews

A Systematic Review and Meta-Analysis on the Effect of Flavonoids on Insulin-like Growth Factor and Insulin-like Growth Factor Binding Protein and Incidence of Breast Cancer.
Nasr S, Nakisa A, Jandaghian S, Kouhi M, Sadeghi E, Varshosaz J
Curr Med Chem 2023;30(14):1657-1666. doi: 10.2174/0929867329666220801164740. PMID: 35927904
Effects of raloxifene administration on serum levels of insulin-like growth factor-1 and insulin-like growth factor-binding protein 3 levels: A systematic review and meta-analysis of randomized controlled trials.
Sun Y, Xiong Y, Meng YL, Santos HO, Athayde FL, de Souza IGO, Yang L
Growth Horm IGF Res 2021 Oct-Dec;60-61:101421. Epub 2021 Jul 30 doi: 10.1016/j.ghir.2021.101421. PMID: 34384975
ORAL VERSUS TRANSDERMAL ESTROGEN IN TURNER SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Zaiem F, Alahdab F, Al Nofal A, Murad MH, Javed A
Endocr Pract 2017 Apr 2;23(4):408-421. Epub 2017 Jan 17 doi: 10.4158/EP161622.OR. PMID: 28095041
Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis.
Kang DW, Lee J, Suh SH, Ligibel J, Courneya KS, Jeon JY
Cancer Epidemiol Biomarkers Prev 2017 Mar;26(3):355-365. Epub 2016 Oct 14 doi: 10.1158/1055-9965.EPI-16-0602. PMID: 27742668
Physical activity and biomarkers in breast cancer survivors: a systematic review.
Löf M, Bergström K, Weiderpass E
Maturitas 2012 Oct;73(2):134-42. Epub 2012 Jul 26 doi: 10.1016/j.maturitas.2012.07.002. PMID: 22840658

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