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Abnormal cardiac exercise stress test

MedGen UID:
1382540
•Concept ID:
C4477077
•
Finding
Synonyms: Abnormal cardiac exercise test; Abnormal exercise test; Abnormal treadmill test
 
HPO: HP:0500018

Definition

Abnormal results of exercise on heart function. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cardiac exercise stress test

Professional guidelines

PubMed

Exercise Testing in the Risk Assessment of Pulmonary Hypertension.
Forbes LM, Bull TM, Lahm T, Make BJ, Cornwell WK 3rd
Chest 2023 Sep;164(3):736-746. Epub 2023 Apr 14 doi: 10.1016/j.chest.2023.04.013. PMID: 37061028Free PMC Article
Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.
Fedorowski A
J Intern Med 2019 Apr;285(4):352-366. Epub 2018 Nov 23 doi: 10.1111/joim.12852. PMID: 30372565
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113

Recent clinical studies

Etiology

The Role of Cardiopulmonary Exercise Testing in Hypertrophic Cardiomyopathy.
Mikic L, Ristic A, Markovic Nikolic N, Tesic M, Jakovljevic DG, Arena R, Allison TG, Popovic D
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071296. PMID: 37512108Free PMC Article
Resting and Exercise Doppler Hemodynamics: How and Why?
Nanayakkara S, Kaye DM, Marwick TH
Heart Fail Clin 2019 Apr;15(2):229-239. Epub 2019 Feb 2 doi: 10.1016/j.hfc.2018.12.003. PMID: 30832814
Athlete's Heart: Diagnostic Challenges and Future Perspectives.
De Innocentiis C, Ricci F, Khanji MY, Aung N, Tana C, Verrengia E, Petersen SE, Gallina S
Sports Med 2018 Nov;48(11):2463-2477. doi: 10.1007/s40279-018-0985-2. PMID: 30251086
Standard and advanced echocardiography in takotsubo (stress) cardiomyopathy: clinical and prognostic implications.
Citro R, Lyon AR, Meimoun P, Omerovic E, Redfors B, Buck T, Lerakis S, Parodi G, Silverio A, Eitel I, Schneider B, Prasad A, Bossone E
J Am Soc Echocardiogr 2015 Jan;28(1):57-74. Epub 2014 Oct 1 doi: 10.1016/j.echo.2014.08.020. PMID: 25282664
Stress echocardiography with semi-supine bicycle.
Skulstad H, Aakhus S
Tidsskr Nor Laegeforen 2012 Oct 16;132(19):2175-8. doi: 10.4045/tidsskr.11.1538. PMID: 23076486

Diagnosis

The Role of Cardiopulmonary Exercise Testing in Hypertrophic Cardiomyopathy.
Mikic L, Ristic A, Markovic Nikolic N, Tesic M, Jakovljevic DG, Arena R, Allison TG, Popovic D
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071296. PMID: 37512108Free PMC Article
Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Chronotropic incompetence in end-stage liver disease.
Główczyńska R, Borodzicz-Jażdżyk S, Peller M, Raszeja-Wyszomirska J, Milkiewicz P, Zieniewicz K, Opolski G
PLoS One 2022;17(8):e0270784. Epub 2022 Aug 1 doi: 10.1371/journal.pone.0270784. PMID: 35913923Free PMC Article
Athlete's Heart: Diagnostic Challenges and Future Perspectives.
De Innocentiis C, Ricci F, Khanji MY, Aung N, Tana C, Verrengia E, Petersen SE, Gallina S
Sports Med 2018 Nov;48(11):2463-2477. doi: 10.1007/s40279-018-0985-2. PMID: 30251086
Standard and advanced echocardiography in takotsubo (stress) cardiomyopathy: clinical and prognostic implications.
Citro R, Lyon AR, Meimoun P, Omerovic E, Redfors B, Buck T, Lerakis S, Parodi G, Silverio A, Eitel I, Schneider B, Prasad A, Bossone E
J Am Soc Echocardiogr 2015 Jan;28(1):57-74. Epub 2014 Oct 1 doi: 10.1016/j.echo.2014.08.020. PMID: 25282664

Therapy

Chronotropic incompetence in end-stage liver disease.
Główczyńska R, Borodzicz-Jażdżyk S, Peller M, Raszeja-Wyszomirska J, Milkiewicz P, Zieniewicz K, Opolski G
PLoS One 2022;17(8):e0270784. Epub 2022 Aug 1 doi: 10.1371/journal.pone.0270784. PMID: 35913923Free PMC Article
Long-lasting benefits of exercise for those living with a Fontan circulation.
Cordina R, d'Udekem Y
Curr Opin Cardiol 2019 Jan;34(1):79-86. doi: 10.1097/HCO.0000000000000582. PMID: 30444760
Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).
Hoffmann U, Ferencik M, Udelson JE, Picard MH, Truong QA, Patel MR, Huang M, Pencina M, Mark DB, Heitner JF, Fordyce CB, Pellikka PA, Tardif JC, Budoff M, Nahhas G, Chow B, Kosinski AS, Lee KL, Douglas PS; PROMISE Investigators
Circulation 2017 Jun 13;135(24):2320-2332. Epub 2017 Apr 7 doi: 10.1161/CIRCULATIONAHA.116.024360. PMID: 28389572Free PMC Article
Exercise testing and stress imaging in valvular heart disease.
Henri C, Piérard LA, Lancellotti P, Mongeon FP, Pibarot P, Basmadjian AJ
Can J Cardiol 2014 Sep;30(9):1012-26. Epub 2014 Mar 15 doi: 10.1016/j.cjca.2014.03.013. PMID: 25151284
Mitral valve regurgitation.
O'Rourke RA, Crawford MH
Curr Probl Cardiol 1984 May;9(2):1-52. doi: 10.1016/0146-2806(84)90021-5. PMID: 6375982

Prognosis

Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Chronotropic incompetence in end-stage liver disease.
Główczyńska R, Borodzicz-Jażdżyk S, Peller M, Raszeja-Wyszomirska J, Milkiewicz P, Zieniewicz K, Opolski G
PLoS One 2022;17(8):e0270784. Epub 2022 Aug 1 doi: 10.1371/journal.pone.0270784. PMID: 35913923Free PMC Article
Exercise characteristics and incidence of abnormal electrocardiogram response in long-distance runners with exercise-induced hypertension.
Kim YJ, Lee SE, Park KM
J Clin Hypertens (Greenwich) 2021 Oct;23(10):1915-1921. Epub 2021 Aug 29 doi: 10.1111/jch.14359. PMID: 34459094Free PMC Article
New York Heart Association (NYHA) classification in adults with congenital heart disease: relation to objective measures of exercise and outcome.
Bredy C, Ministeri M, Kempny A, Alonso-Gonzalez R, Swan L, Uebing A, Diller GP, Gatzoulis MA, Dimopoulos K
Eur Heart J Qual Care Clin Outcomes 2018 Jan 1;4(1):51-58. doi: 10.1093/ehjqcco/qcx031. PMID: 28950356
Pediatric stress echocardiography.
Kimball TR
Pediatr Cardiol 2002 May-Jun;23(3):347-57. doi: 10.1007/s00246-001-0198-5. PMID: 11976781

Clinical prediction guides

Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Chronotropic incompetence in end-stage liver disease.
Główczyńska R, Borodzicz-Jażdżyk S, Peller M, Raszeja-Wyszomirska J, Milkiewicz P, Zieniewicz K, Opolski G
PLoS One 2022;17(8):e0270784. Epub 2022 Aug 1 doi: 10.1371/journal.pone.0270784. PMID: 35913923Free PMC Article
Cardiopulmonary Exercise Testing: What Is its Value?
Guazzi M, Bandera F, Ozemek C, Systrom D, Arena R
J Am Coll Cardiol 2017 Sep 26;70(13):1618-1636. doi: 10.1016/j.jacc.2017.08.012. PMID: 28935040
Lung function in pulmonary hypertension.
Low AT, Medford AR, Millar AB, Tulloh RM
Respir Med 2015 Oct;109(10):1244-9. Epub 2015 May 27 doi: 10.1016/j.rmed.2015.05.022. PMID: 26033642
Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function.
Okutucu S, Karakulak UN, Aytemir K, Oto A
Expert Rev Cardiovasc Ther 2011 Nov;9(11):1417-30. doi: 10.1586/erc.11.149. PMID: 22059791

Recent systematic reviews

Cerebral oxygenation during cardiopulmonary exercise testing in cardiorespiratory diseases: A systematic review.
Galdino GAM, Rehder-Santos P, Linares SN, Beltrame T, Catai AM
Heart Lung 2023 May-Jun;59:23-32. Epub 2023 Jan 19 doi: 10.1016/j.hrtlng.2023.01.004. PMID: 36669443
Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis.
Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
JAMA Netw Open 2022 Oct 3;5(10):e2236057. doi: 10.1001/jamanetworkopen.2022.36057. PMID: 36223120Free PMC Article
Pulmonary Valve Replacement in Tetralogy of Fallot: An Updated Meta-Analysis.
Van den Eynde J, Sá MPBO, Vervoort D, Roever L, Meyns B, Budts W, Gewillig M, Ruhparwar A, Zhigalov K, Weymann A
Ann Thorac Surg 2022 Mar;113(3):1036-1046. Epub 2020 Dec 27 doi: 10.1016/j.athoracsur.2020.11.040. PMID: 33378694
Functional Capacity in Congenital Heart Disease: A Systematic Review and Meta-Analysis.
Schaan CW, Macedo ACP, Sbruzzi G, Umpierre D, Schaan BD, Pellanda LC
Arq Bras Cardiol 2017 Oct;109(4):357-367. Epub 2017 Sep 4 doi: 10.5935/abc.20170125. PMID: 28876372Free PMC Article
Utility of Exercise Electrocardiography in Pre-participation Screening in Asymptomatic Athletes: A Systematic Review.
van de Sande DA, Breuer MA, Kemps HM
Sports Med 2016 Aug;46(8):1155-64. doi: 10.1007/s40279-016-0501-5. PMID: 26893099

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