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Abnormal cardiac exercise stress test

MedGen UID:
1382540
•Concept ID:
C4477077
•
Finding
Synonyms: Abnormal cardiac exercise test; Abnormal exercise test; Abnormal treadmill test
 
HPO: HP:0500018

Definition

Abnormal results of exercise on heart function. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cardiac exercise stress test

Professional guidelines

PubMed

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.
Fedorowski A
J Intern Med 2019 Apr;285(4):352-366. Epub 2018 Nov 23 doi: 10.1111/joim.12852. PMID: 30372565
Heartbeat: Improving diagnosis and management of aortic valve disease.
Otto CM
Heart 2018 Nov;104(22):1807-1809. doi: 10.1136/heartjnl-2018-314232. PMID: 30366931
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113

Recent clinical studies

Etiology

The Role of Cardiopulmonary Exercise Testing in Hypertrophic Cardiomyopathy.
Mikic L, Ristic A, Markovic Nikolic N, Tesic M, Jakovljevic DG, Arena R, Allison TG, Popovic D
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071296. PMID: 37512108Free PMC Article
Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis.
Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR
Pediatr Cardiol 2020 Dec;41(8):1675-1688. Epub 2020 Aug 7 doi: 10.1007/s00246-020-02427-7. PMID: 32770262Free PMC Article
Resting and Exercise Doppler Hemodynamics: How and Why?
Nanayakkara S, Kaye DM, Marwick TH
Heart Fail Clin 2019 Apr;15(2):229-239. Epub 2019 Feb 2 doi: 10.1016/j.hfc.2018.12.003. PMID: 30832814
Heartbeat: Improving diagnosis and management of aortic valve disease.
Otto CM
Heart 2018 Nov;104(22):1807-1809. doi: 10.1136/heartjnl-2018-314232. PMID: 30366931
Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring.
Verrier RL, Malik M
J Electrocardiol 2013 Nov-Dec;46(6):585-90. Epub 2013 Jul 16 doi: 10.1016/j.jelectrocard.2013.06.006. PMID: 23870659

Diagnosis

Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Heartbeat: Improving diagnosis and management of aortic valve disease.
Otto CM
Heart 2018 Nov;104(22):1807-1809. doi: 10.1136/heartjnl-2018-314232. PMID: 30366931
Exercise physiology and testing in adult patients with congenital heart disease.
Buber J, Rhodes J
Heart Fail Clin 2014 Jan;10(1):23-33. Epub 2013 Oct 15 doi: 10.1016/j.hfc.2013.09.012. PMID: 24275292
Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring.
Verrier RL, Malik M
J Electrocardiol 2013 Nov-Dec;46(6):585-90. Epub 2013 Jul 16 doi: 10.1016/j.jelectrocard.2013.06.006. PMID: 23870659
Pulmonary valvular stenosis.
Lucas RV Jr, Moller JH
Cardiovasc Clin 1970;2(1):155-84. PMID: 4938797

Therapy

Exercise Catheterisation to Unmask Fontan Pathway Obstruction.
Miranda WR, Jain CC, Cabalka AK, Taggart NW, Connolly HM, Egbe AC
Can J Cardiol 2022 Jul;38(7):1125-1126. Epub 2022 May 6 doi: 10.1016/j.cjca.2022.04.027. PMID: 35526820
Super-Fontan: Is it possible?
Cordina R, du Plessis K, Tran D, d'Udekem Y
J Thorac Cardiovasc Surg 2018 Mar;155(3):1192-1194. Epub 2017 Oct 27 doi: 10.1016/j.jtcvs.2017.10.047. PMID: 29157925
Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).
Hoffmann U, Ferencik M, Udelson JE, Picard MH, Truong QA, Patel MR, Huang M, Pencina M, Mark DB, Heitner JF, Fordyce CB, Pellikka PA, Tardif JC, Budoff M, Nahhas G, Chow B, Kosinski AS, Lee KL, Douglas PS; PROMISE Investigators
Circulation 2017 Jun 13;135(24):2320-2332. Epub 2017 Apr 7 doi: 10.1161/CIRCULATIONAHA.116.024360. PMID: 28389572Free PMC Article
Silent cardiac ischemia.
Conti CR
Curr Opin Cardiol 2002 Sep;17(5):537-42. doi: 10.1097/00001573-200209000-00015. PMID: 12357132
Mitral valve regurgitation.
O'Rourke RA, Crawford MH
Curr Probl Cardiol 1984 May;9(2):1-52. doi: 10.1016/0146-2806(84)90021-5. PMID: 6375982

Prognosis

Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot.
Quattrone A, Lie OH, Nestaas E, de Lange C, Try K, Lindberg HL, Skulstad H, Erikssen G, Edvardsen T, Haugaa K, Estensen ME
Open Heart 2021 Jan;8(1) doi: 10.1136/openhrt-2020-001400. PMID: 33414183Free PMC Article
New York Heart Association (NYHA) classification in adults with congenital heart disease: relation to objective measures of exercise and outcome.
Bredy C, Ministeri M, Kempny A, Alonso-Gonzalez R, Swan L, Uebing A, Diller GP, Gatzoulis MA, Dimopoulos K
Eur Heart J Qual Care Clin Outcomes 2018 Jan 1;4(1):51-58. doi: 10.1093/ehjqcco/qcx031. PMID: 28950356
Noninvasive risk stratification for sudden death in asymptomatic patients with Wolff-Parkinson-White syndrome.
Novella J, DeBiasi RM, Coplan NL, Suri R, Keller S
Rev Cardiovasc Med 2014;15(4):283-9. doi: 10.3909/ricm0717. PMID: 25662922
Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring.
Verrier RL, Malik M
J Electrocardiol 2013 Nov-Dec;46(6):585-90. Epub 2013 Jul 16 doi: 10.1016/j.jelectrocard.2013.06.006. PMID: 23870659

Clinical prediction guides

Identification of Patients with Preclinical Heart Failure with preserved Ejection Fraction Using the H(2)FPEF Score.
Koepp KE, Reddy YNV, Obokata M, Sorimachi H, Verbrugge FH, Jain CC, Egbe AC, Redfield MM, Olson TP, Borlaug BA
Nat Cardiovasc Res 2022 Jan;1(1):59-66. Epub 2022 Jan 12 doi: 10.1038/s44161-021-00005-5. PMID: 35669933Free PMC Article
Cardiopulmonary exercise testing and sports participation in adults with congenital heart disease.
Buber J, Shafer K
Heart 2019 Nov;105(21):1670-1679. Epub 2019 Jul 4 doi: 10.1136/heartjnl-2018-313928. PMID: 31273028
Cardiopulmonary Exercise Testing: What Is its Value?
Guazzi M, Bandera F, Ozemek C, Systrom D, Arena R
J Am Coll Cardiol 2017 Sep 26;70(13):1618-1636. doi: 10.1016/j.jacc.2017.08.012. PMID: 28935040
Noninvasive risk stratification for sudden death in asymptomatic patients with Wolff-Parkinson-White syndrome.
Novella J, DeBiasi RM, Coplan NL, Suri R, Keller S
Rev Cardiovasc Med 2014;15(4):283-9. doi: 10.3909/ricm0717. PMID: 25662922
How to perform and interpret provocative testing for the diagnosis of Brugada syndrome, long-QT syndrome, and catecholaminergic polymorphic ventricular tachycardia.
Obeyesekere MN, Klein GJ, Modi S, Leong-Sit P, Gula LJ, Yee R, Skanes AC, Krahn AD
Circ Arrhythm Electrophysiol 2011 Dec;4(6):958-64. doi: 10.1161/CIRCEP.111.965947. PMID: 22203660

Recent systematic reviews

Pulmonary vasodilators and exercise in Fontan circulation: a systematic review and meta-analysis.
Kosmidis D, Arvanitaki A, Farmakis IT, Liakos A, Giannopoulos A, Ziakas A, Giannakoulas G
Heart 2024 Mar 22;110(8):552-559. doi: 10.1136/heartjnl-2023-323166. PMID: 37918902
Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis.
Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
JAMA Netw Open 2022 Oct 3;5(10):e2236057. doi: 10.1001/jamanetworkopen.2022.36057. PMID: 36223120Free PMC Article
Pulmonary Valve Replacement in Tetralogy of Fallot: An Updated Meta-Analysis.
Van den Eynde J, Sá MPBO, Vervoort D, Roever L, Meyns B, Budts W, Gewillig M, Ruhparwar A, Zhigalov K, Weymann A
Ann Thorac Surg 2022 Mar;113(3):1036-1046. Epub 2020 Dec 27 doi: 10.1016/j.athoracsur.2020.11.040. PMID: 33378694
Physical exercise training in patients with a Fontan circulation: A systematic review.
Scheffers LE, Berg LEMV, Ismailova G, Dulfer K, Takkenberg JJM, Helbing WA
Eur J Prev Cardiol 2021 Sep 20;28(11):1269-1278. Epub 2020 Jul 27 doi: 10.1177/2047487320942869. PMID: 34551076
Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review.
Rodrigues T, Raposo SC, Brito D, Lopes LR
Int J Cardiol 2021 Sep 15;339:83-92. Epub 2021 Jun 30 doi: 10.1016/j.ijcard.2021.06.051. PMID: 34214502Free PMC Article

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