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Abnormal cardiac exercise stress test

MedGen UID:
1382540
•Concept ID:
C4477077
•
Finding
Synonyms: Abnormal cardiac exercise test; Abnormal exercise test; Abnormal treadmill test
 
HPO: HP:0500018

Definition

Abnormal results of exercise on heart function. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cardiac exercise stress test

Professional guidelines

PubMed

The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy.
Finocchiaro G, Merlo M, Sheikh N, De Angelis G, Papadakis M, Olivotto I, Rapezzi C, Carr-White G, Sharma S, Mestroni L, Sinagra G
Eur J Heart Fail 2020 Jul;22(7):1097-1107. Epub 2020 Apr 3 doi: 10.1002/ejhf.1815. PMID: 32243666
Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.
Fedorowski A
J Intern Med 2019 Apr;285(4):352-366. Epub 2018 Nov 23 doi: 10.1111/joim.12852. PMID: 30372565
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113

Recent clinical studies

Etiology

The Role of Cardiopulmonary Exercise Testing in Hypertrophic Cardiomyopathy.
Mikic L, Ristic A, Markovic Nikolic N, Tesic M, Jakovljevic DG, Arena R, Allison TG, Popovic D
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071296. PMID: 37512108Free PMC Article
Resting and Exercise Doppler Hemodynamics: How and Why?
Nanayakkara S, Kaye DM, Marwick TH
Heart Fail Clin 2019 Apr;15(2):229-239. Epub 2019 Feb 2 doi: 10.1016/j.hfc.2018.12.003. PMID: 30832814
Athlete's Heart: Diagnostic Challenges and Future Perspectives.
De Innocentiis C, Ricci F, Khanji MY, Aung N, Tana C, Verrengia E, Petersen SE, Gallina S
Sports Med 2018 Nov;48(11):2463-2477. doi: 10.1007/s40279-018-0985-2. PMID: 30251086
Stress echocardiography with semi-supine bicycle.
Skulstad H, Aakhus S
Tidsskr Nor Laegeforen 2012 Oct 16;132(19):2175-8. doi: 10.4045/tidsskr.11.1538. PMID: 23076486
Cardiac stress testing after surgery for congenital heart disease.
Helbing WA, Luijnenburg SE, Moelker A, Robbers-Visser D
Curr Opin Pediatr 2010 Oct;22(5):579-86. doi: 10.1097/MOP.0b013e32833e139e. PMID: 20736836

Diagnosis

The Role of Cardiopulmonary Exercise Testing in Hypertrophic Cardiomyopathy.
Mikic L, Ristic A, Markovic Nikolic N, Tesic M, Jakovljevic DG, Arena R, Allison TG, Popovic D
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071296. PMID: 37512108Free PMC Article
Standard and advanced echocardiography in takotsubo (stress) cardiomyopathy: clinical and prognostic implications.
Citro R, Lyon AR, Meimoun P, Omerovic E, Redfors B, Buck T, Lerakis S, Parodi G, Silverio A, Eitel I, Schneider B, Prasad A, Bossone E
J Am Soc Echocardiogr 2015 Jan;28(1):57-74. Epub 2014 Oct 1 doi: 10.1016/j.echo.2014.08.020. PMID: 25282664
Exercise testing and exercise stress echocardiography in asymptomatic aortic valve stenosis.
Ennezat PV, Maréchaux S, Iung B, Chauvel C, LeJemtel TH, Pibarot P
Heart 2009 Jun;95(11):877-84. Epub 2008 Sep 23 doi: 10.1136/hrt.2008.150011. PMID: 18812409
Dobutamine stress echocardiography.
Krahwinkel W, Ketteler T, Gödke J, Wolfertz J, Ulbricht LJ, Krakau I, Gülker H
Eur Heart J 1997 Jun;18 Suppl D:D9-15. doi: 10.1093/eurheartj/18.suppl_d.9. PMID: 9183605
Radionuclide imaging.
Robinson P
Eur Heart J 1984 Mar;5 Suppl A:65-8. doi: 10.1093/eurheartj/5.suppl_a.65. PMID: 6373285

Therapy

Long-lasting benefits of exercise for those living with a Fontan circulation.
Cordina R, d'Udekem Y
Curr Opin Cardiol 2019 Jan;34(1):79-86. doi: 10.1097/HCO.0000000000000582. PMID: 30444760
Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).
Hoffmann U, Ferencik M, Udelson JE, Picard MH, Truong QA, Patel MR, Huang M, Pencina M, Mark DB, Heitner JF, Fordyce CB, Pellikka PA, Tardif JC, Budoff M, Nahhas G, Chow B, Kosinski AS, Lee KL, Douglas PS; PROMISE Investigators
Circulation 2017 Jun 13;135(24):2320-2332. Epub 2017 Apr 7 doi: 10.1161/CIRCULATIONAHA.116.024360. PMID: 28389572Free PMC Article
Exercise testing and stress imaging in valvular heart disease.
Henri C, Piérard LA, Lancellotti P, Mongeon FP, Pibarot P, Basmadjian AJ
Can J Cardiol 2014 Sep;30(9):1012-26. Epub 2014 Mar 15 doi: 10.1016/j.cjca.2014.03.013. PMID: 25151284
Dobutamine stress echocardiography.
Krahwinkel W, Ketteler T, Gödke J, Wolfertz J, Ulbricht LJ, Krakau I, Gülker H
Eur Heart J 1997 Jun;18 Suppl D:D9-15. doi: 10.1093/eurheartj/18.suppl_d.9. PMID: 9183605
Mitral valve regurgitation.
O'Rourke RA, Crawford MH
Curr Probl Cardiol 1984 May;9(2):1-52. doi: 10.1016/0146-2806(84)90021-5. PMID: 6375982

Prognosis

Chronotropic incompetence in end-stage liver disease.
Główczyńska R, Borodzicz-Jażdżyk S, Peller M, Raszeja-Wyszomirska J, Milkiewicz P, Zieniewicz K, Opolski G
PLoS One 2022;17(8):e0270784. Epub 2022 Aug 1 doi: 10.1371/journal.pone.0270784. PMID: 35913923Free PMC Article
Exercise characteristics and incidence of abnormal electrocardiogram response in long-distance runners with exercise-induced hypertension.
Kim YJ, Lee SE, Park KM
J Clin Hypertens (Greenwich) 2021 Oct;23(10):1915-1921. Epub 2021 Aug 29 doi: 10.1111/jch.14359. PMID: 34459094Free PMC Article
New York Heart Association (NYHA) classification in adults with congenital heart disease: relation to objective measures of exercise and outcome.
Bredy C, Ministeri M, Kempny A, Alonso-Gonzalez R, Swan L, Uebing A, Diller GP, Gatzoulis MA, Dimopoulos K
Eur Heart J Qual Care Clin Outcomes 2018 Jan 1;4(1):51-58. doi: 10.1093/ehjqcco/qcx031. PMID: 28950356
Cardiopulmonary stress testing in children and adults with congenital heart disease.
Miliaresis C, Beker S, Gewitz M
Cardiol Rev 2014 Nov-Dec;22(6):275-8. doi: 10.1097/CRD.0000000000000039. PMID: 25162333
Pediatric stress echocardiography.
Kimball TR
Pediatr Cardiol 2002 May-Jun;23(3):347-57. doi: 10.1007/s00246-001-0198-5. PMID: 11976781

Clinical prediction guides

Chronotropic incompetence in end-stage liver disease.
Główczyńska R, Borodzicz-Jażdżyk S, Peller M, Raszeja-Wyszomirska J, Milkiewicz P, Zieniewicz K, Opolski G
PLoS One 2022;17(8):e0270784. Epub 2022 Aug 1 doi: 10.1371/journal.pone.0270784. PMID: 35913923Free PMC Article
Heart failure with preserved ejection fraction: insights into diagnosis and pathophysiology.
Nagueh SF
Cardiovasc Res 2021 Mar 21;117(4):999-1014. doi: 10.1093/cvr/cvaa228. PMID: 32717061
Cardiopulmonary Exercise Testing: What Is its Value?
Guazzi M, Bandera F, Ozemek C, Systrom D, Arena R
J Am Coll Cardiol 2017 Sep 26;70(13):1618-1636. doi: 10.1016/j.jacc.2017.08.012. PMID: 28935040
Semi-supine exercise stress echocardiography in children and adolescents: feasibility and safety.
Ciliberti P, McLeod I, Cairello F, Kaski JP, Fenton M, Giardini A, Marek J
Pediatr Cardiol 2015 Mar;36(3):633-9. Epub 2014 Nov 20 doi: 10.1007/s00246-014-1058-4. PMID: 25410823Free PMC Article
Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function.
Okutucu S, Karakulak UN, Aytemir K, Oto A
Expert Rev Cardiovasc Ther 2011 Nov;9(11):1417-30. doi: 10.1586/erc.11.149. PMID: 22059791

Recent systematic reviews

Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis.
Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
JAMA Netw Open 2022 Oct 3;5(10):e2236057. doi: 10.1001/jamanetworkopen.2022.36057. PMID: 36223120Free PMC Article
Pulmonary Valve Replacement in Tetralogy of Fallot: An Updated Meta-Analysis.
Van den Eynde J, Sá MPBO, Vervoort D, Roever L, Meyns B, Budts W, Gewillig M, Ruhparwar A, Zhigalov K, Weymann A
Ann Thorac Surg 2022 Mar;113(3):1036-1046. Epub 2020 Dec 27 doi: 10.1016/j.athoracsur.2020.11.040. PMID: 33378694
Functional Capacity in Congenital Heart Disease: A Systematic Review and Meta-Analysis.
Schaan CW, Macedo ACP, Sbruzzi G, Umpierre D, Schaan BD, Pellanda LC
Arq Bras Cardiol 2017 Oct;109(4):357-367. Epub 2017 Sep 4 doi: 10.5935/abc.20170125. PMID: 28876372Free PMC Article
Utility of Exercise Electrocardiography in Pre-participation Screening in Asymptomatic Athletes: A Systematic Review.
van de Sande DA, Breuer MA, Kemps HM
Sports Med 2016 Aug;46(8):1155-64. doi: 10.1007/s40279-016-0501-5. PMID: 26893099
Low exercise blood pressure and risk of cardiovascular events and all-cause mortality: systematic review and meta-analysis.
Barlow PA, Otahal P, Schultz MG, Shing CM, Sharman JE
Atherosclerosis 2014 Nov;237(1):13-22. Epub 2014 Aug 19 doi: 10.1016/j.atherosclerosis.2014.08.029. PMID: 25190307

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