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Metastatic Transitional Cell Carcinoma

MedGen UID:
1382873
•Concept ID:
C3160869
•
Neoplastic Process
Synonym: Metastatic transitional cell carcinoma
SNOMED CT: Metastatic transitional cell carcinoma (40971000146100)

Definition

A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

New drugs and new approaches for the treatment of metastatic urothelial cancer.
Calabrò F, Sternberg CN
World J Urol 2002 Aug;20(3):158-66. Epub 2002 Jul 13 doi: 10.1007/s00345-002-0275-2. PMID: 12196899
Gemcitabine in the treatment of bladder cancer.
Ryan CW, Vogelzang NJ
Expert Opin Pharmacother 2000 Mar;1(3):547-53. doi: 10.1517/14656566.1.3.547. PMID: 11249537
New approaches in the treatment of metastatic transitional-cell cancer of the bladder.
Corral DA, Logothetis CJ
World J Urol 1997;15(2):139-43. doi: 10.1007/BF02201986. PMID: 9144905

Recent clinical studies

Etiology

Long-Term Results and Prognostic Factors of Pulmonary Metastasectomy in Patients with Metastatic Transitional Cell Carcinoma.
Luzzi L, Marulli G, Solli P, Cardillo G, Ghisalberti M, Mammana M, Carleo F, Spaggiari L, Rea F
Thorac Cardiovasc Surg 2017 Oct;65(7):567-571. Epub 2016 May 5 doi: 10.1055/s-0036-1583271. PMID: 27148929
Vinflunine.
Prescrire Int 2011 Jan;20(112):11-3. PMID: 21462785
Systemic therapy for unresectable and metastatic transitional cell carcinoma of the urothelium: first-line and beyond.
Cheng T
Curr Opin Support Palliat Care 2008 Sep;2(3):153-60. doi: 10.1097/SPC.0b013e328309c72c. PMID: 18685414
Trastuzumab (Herceptin) in metastatic transitional cell carcinoma of the urinary tract: report on six patients.
Peyromaure M, Scotté F, Amsellem-Ouazana D, Vieillefond A, Oudard S, Beuzeboc P
Eur Urol 2005 Nov;48(5):771-5; discussion 775-8. Epub 2005 Aug 10 doi: 10.1016/j.eururo.2005.07.015. PMID: 16126330
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.
von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF
J Clin Oncol 2000 Sep;18(17):3068-77. doi: 10.1200/JCO.2000.18.17.3068. PMID: 11001674

Diagnosis

Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium.
Sonpavde G, Sternberg CN, Rosenberg JE, Hahn NM, Galsky MD, Vogelzang NJ
Lancet Oncol 2010 Sep;11(9):861-70. Epub 2010 May 25 doi: 10.1016/S1470-2045(10)70086-3. PMID: 20537950
Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy.
Bajorin DF, Dodd PM, Mazumdar M, Fazzari M, McCaffrey JA, Scher HI, Herr H, Higgins G, Boyle MG
J Clin Oncol 1999 Oct;17(10):3173-81. doi: 10.1200/JCO.1999.17.10.3173. PMID: 10506615
Cytologic features of metastatic transitional cell carcinoma.
Johnson TL, Kini SR
Diagn Cytopathol 1993;9(3):270-8. doi: 10.1002/dc.2840090306. PMID: 8519195
Current management of invasive and metastatic transitional cell carcinoma of the bladder.
Thrasher JB, Crawford ED
J Urol 1993 May;149(5):957-72. doi: 10.1016/s0022-5347(17)36270-5. PMID: 8483247
Blood group antigens in normal and neoplastic urothelium.
Sheinfeld J, Reuter VE, Sarkis AS, Cordon-Cardo C
J Cell Biochem Suppl 1992;16I:50-5. doi: 10.1002/jcb.240501311. PMID: 1305688

Therapy

Vinflunine.
Prescrire Int 2011 Jan;20(112):11-3. PMID: 21462785
Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium.
Sonpavde G, Sternberg CN, Rosenberg JE, Hahn NM, Galsky MD, Vogelzang NJ
Lancet Oncol 2010 Sep;11(9):861-70. Epub 2010 May 25 doi: 10.1016/S1470-2045(10)70086-3. PMID: 20537950
Systemic therapy for unresectable and metastatic transitional cell carcinoma of the urothelium: first-line and beyond.
Cheng T
Curr Opin Support Palliat Care 2008 Sep;2(3):153-60. doi: 10.1097/SPC.0b013e328309c72c. PMID: 18685414
Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.
von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M
J Clin Oncol 2005 Jul 20;23(21):4602-8. doi: 10.1200/JCO.2005.07.757. PMID: 16034041
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.
von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF
J Clin Oncol 2000 Sep;18(17):3068-77. doi: 10.1200/JCO.2000.18.17.3068. PMID: 11001674

Prognosis

Vinflunine.
Prescrire Int 2011 Jan;20(112):11-3. PMID: 21462785
Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.
von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M
J Clin Oncol 2005 Jul 20;23(21):4602-8. doi: 10.1200/JCO.2005.07.757. PMID: 16034041
Locally advanced and metastatic bladder cancer.
Dreicer R
Curr Treat Options Oncol 2001 Oct;2(5):431-6. doi: 10.1007/s11864-001-0048-y. PMID: 12057106
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.
von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF
J Clin Oncol 2000 Sep;18(17):3068-77. doi: 10.1200/JCO.2000.18.17.3068. PMID: 11001674
Gemcitabine in bladder cancer.
Sternberg CN
Semin Oncol 2000 Feb;27(1 Suppl 2):31-9. PMID: 10697034

Clinical prediction guides

Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.
von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M
J Clin Oncol 2005 Jul 20;23(21):4602-8. doi: 10.1200/JCO.2005.07.757. PMID: 16034041
New drugs and new approaches for the treatment of metastatic urothelial cancer.
Calabrò F, Sternberg CN
World J Urol 2002 Aug;20(3):158-66. Epub 2002 Jul 13 doi: 10.1007/s00345-002-0275-2. PMID: 12196899
Locally advanced and metastatic bladder cancer.
Dreicer R
Curr Treat Options Oncol 2001 Oct;2(5):431-6. doi: 10.1007/s11864-001-0048-y. PMID: 12057106
Gemcitabine in bladder cancer.
Sternberg CN
Semin Oncol 2000 Feb;27(1 Suppl 2):31-9. PMID: 10697034
Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy.
Bajorin DF, Dodd PM, Mazumdar M, Fazzari M, McCaffrey JA, Scher HI, Herr H, Higgins G, Boyle MG
J Clin Oncol 1999 Oct;17(10):3173-81. doi: 10.1200/JCO.1999.17.10.3173. PMID: 10506615

Recent systematic reviews

Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

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