U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Transitional Cell Carcinoma

MedGen UID:
1382873
•Concept ID:
C3160869
•
Neoplastic Process
Synonym: Metastatic transitional cell carcinoma
SNOMED CT: Metastatic transitional cell carcinoma (40971000146100)

Definition

A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

New drugs and new approaches for the treatment of metastatic urothelial cancer.
Calabrò F, Sternberg CN
World J Urol 2002 Aug;20(3):158-66. Epub 2002 Jul 13 doi: 10.1007/s00345-002-0275-2. PMID: 12196899
Docetaxel in the management of advanced or metastatic urothelial tract cancer.
Logothetis C, Millikan R
Oncology (Williston Park) 2002 Jun;16(6 Suppl 6):107-11. PMID: 12108893
Gemcitabine in the treatment of bladder cancer.
Ryan CW, Vogelzang NJ
Expert Opin Pharmacother 2000 Mar;1(3):547-53. doi: 10.1517/14656566.1.3.547. PMID: 11249537

Recent clinical studies

Etiology

Vinflunine.
Prescrire Int 2011 Jan;20(112):11-3. PMID: 21462785
Systemic therapy for unresectable and metastatic transitional cell carcinoma of the urothelium: first-line and beyond.
Cheng T
Curr Opin Support Palliat Care 2008 Sep;2(3):153-60. doi: 10.1097/SPC.0b013e328309c72c. PMID: 18685414
High-risk metastatic urothelial cancer: chances for cure?
Calabrò F, Sternberg CN
Curr Opin Urol 2002 Sep;12(5):441-8. doi: 10.1097/00042307-200209000-00013. PMID: 12172434
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.
von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF
J Clin Oncol 2000 Sep;18(17):3068-77. doi: 10.1200/JCO.2000.18.17.3068. PMID: 11001674
Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy.
Bajorin DF, Dodd PM, Mazumdar M, Fazzari M, McCaffrey JA, Scher HI, Herr H, Higgins G, Boyle MG
J Clin Oncol 1999 Oct;17(10):3173-81. doi: 10.1200/JCO.1999.17.10.3173. PMID: 10506615

Diagnosis

Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium.
Sonpavde G, Sternberg CN, Rosenberg JE, Hahn NM, Galsky MD, Vogelzang NJ
Lancet Oncol 2010 Sep;11(9):861-70. Epub 2010 May 25 doi: 10.1016/S1470-2045(10)70086-3. PMID: 20537950
Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder.
Alphs HH, Miles-Thomas J, Attenello F, Taube JM, Fonseca G, Guzzo TJ, Schoenberg MP, Bivalacqua TJ
Nat Clin Pract Urol 2008 Dec;5(12):691-4. Epub 2008 Nov 11 doi: 10.1038/ncpuro1253. PMID: 19002126
Fine-needle aspiration cytology of metastatic transitional cell carcinoma.
Dey P, Amir T, Jogai S, Al Jussar A
Diagn Cytopathol 2005 Apr;32(4):226-8. doi: 10.1002/dc.20199. PMID: 15754372
Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy.
Bajorin DF, Dodd PM, Mazumdar M, Fazzari M, McCaffrey JA, Scher HI, Herr H, Higgins G, Boyle MG
J Clin Oncol 1999 Oct;17(10):3173-81. doi: 10.1200/JCO.1999.17.10.3173. PMID: 10506615
Transitional cell carcinoma presenting as a solitary brain lesion: a case report and review of the world literature.
Clatterbuck RE, Sampath P, Olivi A
J Neurooncol 1998 Aug;39(1):91-4. doi: 10.1023/a:1005918508317. PMID: 9760074

Therapy

Vinflunine.
Prescrire Int 2011 Jan;20(112):11-3. PMID: 21462785
Systemic chemotherapy for urothelial cancer.
Sonpavde G, Hutson TE, Berry WR
Clin Genitourin Cancer 2006 Jun;5(1):34-42. doi: 10.3816/CGC.2006.n.015. PMID: 16859577
Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.
von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M
J Clin Oncol 2005 Jul 20;23(21):4602-8. doi: 10.1200/JCO.2005.07.757. PMID: 16034041
Gemcitabine in transitional cell carcinoma of the urothelium.
von der Maase H
Expert Rev Anticancer Ther 2003 Feb;3(1):11-9. doi: 10.1586/14737140.3.1.11. PMID: 12597345
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.
von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF
J Clin Oncol 2000 Sep;18(17):3068-77. doi: 10.1200/JCO.2000.18.17.3068. PMID: 11001674

Prognosis

Vinflunine.
Prescrire Int 2011 Jan;20(112):11-3. PMID: 21462785
Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.
von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M
J Clin Oncol 2005 Jul 20;23(21):4602-8. doi: 10.1200/JCO.2005.07.757. PMID: 16034041
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.
von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM, Conte PF
J Clin Oncol 2000 Sep;18(17):3068-77. doi: 10.1200/JCO.2000.18.17.3068. PMID: 11001674
Gemcitabine in bladder cancer.
Sternberg CN
Semin Oncol 2000 Feb;27(1 Suppl 2):31-9. PMID: 10697034
Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy.
Bajorin DF, Dodd PM, Mazumdar M, Fazzari M, McCaffrey JA, Scher HI, Herr H, Higgins G, Boyle MG
J Clin Oncol 1999 Oct;17(10):3173-81. doi: 10.1200/JCO.1999.17.10.3173. PMID: 10506615

Clinical prediction guides

Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.
von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A, Arning M
J Clin Oncol 2005 Jul 20;23(21):4602-8. doi: 10.1200/JCO.2005.07.757. PMID: 16034041
New drugs and new approaches for the treatment of metastatic urothelial cancer.
Calabrò F, Sternberg CN
World J Urol 2002 Aug;20(3):158-66. Epub 2002 Jul 13 doi: 10.1007/s00345-002-0275-2. PMID: 12196899
Gemcitabine in bladder cancer.
Sternberg CN
Semin Oncol 2000 Feb;27(1 Suppl 2):31-9. PMID: 10697034
Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy.
Bajorin DF, Dodd PM, Mazumdar M, Fazzari M, McCaffrey JA, Scher HI, Herr H, Higgins G, Boyle MG
J Clin Oncol 1999 Oct;17(10):3173-81. doi: 10.1200/JCO.1999.17.10.3173. PMID: 10506615
P-glycoprotein expression in primary and metastatic transitional cell carcinoma of the bladder.
Petrylak DP, Scher HI, Reuter V, O'Brien JP, Cordon-Cardo C
Ann Oncol 1994 Nov;5(9):835-40. doi: 10.1093/oxfordjournals.annonc.a059013. PMID: 7848886

Recent systematic reviews

Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...