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ROS1 Gene Rearrangement

MedGen UID:
1383390
•Concept ID:
C4331214
•
Cell or Molecular Dysfunction
Synonyms: c-ros-1 Gene Rearrangement; MCF3 Gene Rearrangement; ROS Gene Rearrangement; ROS Proto-Oncogene 1, Receptor Tyrosine Kinase Gene Rearrangement; ROS1 Rearrangement

Definition

A molecular abnormality indicating rearrangement of the ROS1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVROS1 Gene Rearrangement

Professional guidelines

PubMed

Diagnostic work-up and systemic treatment for advanced non-squamous non-small-cell lung cancer in four Southeast Asian countries.
Soo R, Mery L, Bardot A, Kanesvaran R, Keong TC, Pongnikorn D, Prasongsook N, Hutajulu SH, Irawan C, Manan AA, Thiagarajan M, Sripan P, Peters S, Storm H, Bray F, Stahel R
ESMO Open 2022 Oct;7(5):100560. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100560. PMID: 35988454Free PMC Article
Immunotherapy Alone or in Combination with Chemotherapy as First-Line Treatment of Non-Small Cell Lung Cancer.
Saxena P, Singh PK, Malik PS, Singh N
Curr Treat Options Oncol 2020 Jul 27;21(8):69. doi: 10.1007/s11864-020-00768-2. PMID: 32720019
Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.
Hanna N, Johnson D, Temin S, Baker S Jr, Brahmer J, Ellis PM, Giaccone G, Hesketh PJ, Jaiyesimi I, Leighl NB, Riely GJ, Schiller JH, Schneider BJ, Smith TJ, Tashbar J, Biermann WA, Masters G
J Clin Oncol 2017 Oct 20;35(30):3484-3515. Epub 2017 Aug 14 doi: 10.1200/JCO.2017.74.6065. PMID: 28806116

Recent clinical studies

Etiology

Diagnostic work-up and systemic treatment for advanced non-squamous non-small-cell lung cancer in four Southeast Asian countries.
Soo R, Mery L, Bardot A, Kanesvaran R, Keong TC, Pongnikorn D, Prasongsook N, Hutajulu SH, Irawan C, Manan AA, Thiagarajan M, Sripan P, Peters S, Storm H, Bray F, Stahel R
ESMO Open 2022 Oct;7(5):100560. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100560. PMID: 35988454Free PMC Article
Validation of ROS1 by immunohistochemistry against fluorescent in situ hybridisation on cytology and small biopsy samples in a large teaching hospital.
Narine N, Wallace A, Dore J, O'Leary-Jackson S, Al Najjar H, Bailey S, Khan K, Teng B, Qasim M, Shelton D, Holbrook M, Abbasi S, Carter M, Irion L, Al-Habba S, Lindsay C, Blackhall F, Rana D
Cytopathology 2021 Sep;32(5):621-630. Epub 2021 Jun 15 doi: 10.1111/cyt.12994. PMID: 34033159
Clinicopathological features and immunohistochemical utility of NTRK-, ALK-, and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas.
Nozaki Y, Yamamoto H, Iwasaki T, Sato M, Jiromaru R, Hongo T, Yasumatsu R, Oda Y
Hum Pathol 2020 Dec;106:82-92. Epub 2020 Sep 25 doi: 10.1016/j.humpath.2020.09.004. PMID: 32980422
Genotyping and cytomorphological subtyping of lung adenocarcinoma based on liquid-based cytology.
Tanaka R, Sakamoto N, Suzuki H, Tachibana K, Ohtsuka K, Kishimoto K, Fujiwara M, Kamma H, Shibahara J, Kondo H
Diagn Cytopathol 2019 Jun;47(6):564-570. Epub 2019 Feb 11 doi: 10.1002/dc.24154. PMID: 30741488
ROS1 gene rearrangement and copy number gain in non-small cell lung cancer.
Jin Y, Sun PL, Kim H, Park E, Shim HS, Jheon S, Kim K, Lee CT, Chung JH
Virchows Arch 2015 Jan;466(1):45-52. Epub 2014 Nov 6 doi: 10.1007/s00428-014-1679-2. PMID: 25374304

Diagnosis

High prevalence of ROS1 gene rearrangement detected by FISH in EGFR and ALK negative lung adenocarcinoma.
Xu Y, Chang H, Wu L, Zhang X, Zhang L, Zhang J, Li Y, Shen L, Zhu X, Zhou X, Bai Q
Exp Mol Pathol 2020 Dec;117:104548. Epub 2020 Sep 24 doi: 10.1016/j.yexmp.2020.104548. PMID: 32979347
Immunotherapy Alone or in Combination with Chemotherapy as First-Line Treatment of Non-Small Cell Lung Cancer.
Saxena P, Singh PK, Malik PS, Singh N
Curr Treat Options Oncol 2020 Jul 27;21(8):69. doi: 10.1007/s11864-020-00768-2. PMID: 32720019
Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Lack of ROS1 Gene Rearrangement in Glioblastoma Multiforme.
Lim SM, Choi J, Chang JH, Sohn J, Jacobson K, Policht F, Schulz J, Cho BC, Kim SH
PLoS One 2015;10(9):e0137678. Epub 2015 Sep 14 doi: 10.1371/journal.pone.0137678. PMID: 26366867Free PMC Article
Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.
Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM
Mod Pathol 2015 May;28(5):732-9. Epub 2015 Jan 23 doi: 10.1038/modpathol.2014.165. PMID: 25612511Free PMC Article

Therapy

Diagnostic work-up and systemic treatment for advanced non-squamous non-small-cell lung cancer in four Southeast Asian countries.
Soo R, Mery L, Bardot A, Kanesvaran R, Keong TC, Pongnikorn D, Prasongsook N, Hutajulu SH, Irawan C, Manan AA, Thiagarajan M, Sripan P, Peters S, Storm H, Bray F, Stahel R
ESMO Open 2022 Oct;7(5):100560. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100560. PMID: 35988454Free PMC Article
Immunotherapy Alone or in Combination with Chemotherapy as First-Line Treatment of Non-Small Cell Lung Cancer.
Saxena P, Singh PK, Malik PS, Singh N
Curr Treat Options Oncol 2020 Jul 27;21(8):69. doi: 10.1007/s11864-020-00768-2. PMID: 32720019
A study detection of the ROS1 gene fusion by FISH and ROS1 protein expression by IHC methods in patients with ovarian malignant or borderline serous tumors.
Aydin HA, Pestereli E, Ozcan M, Bayramoglu Z, Erdogan G, Simsek T
Pathol Res Pract 2018 Nov;214(11):1868-1872. Epub 2018 Sep 18 doi: 10.1016/j.prp.2018.09.016. PMID: 30249502
Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Patients with ROS1 rearrangement-positive non-small-cell lung cancer benefit from pemetrexed-based chemotherapy.
Song Z, Su H, Zhang Y
Cancer Med 2016 Oct;5(10):2688-2693. Epub 2016 Aug 20 doi: 10.1002/cam4.809. PMID: 27544536Free PMC Article

Prognosis

Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Rare Incidence of ROS1 Rearrangement in Cholangiocarcinoma.
Lim SM, Yoo JE, Lim KH, Meng Tai DW, Cho BC, Park YN
Cancer Res Treat 2017 Jan;49(1):185-192. Epub 2016 Apr 27 doi: 10.4143/crt.2015.497. PMID: 27121721Free PMC Article
Lack of ROS1 Gene Rearrangement in Glioblastoma Multiforme.
Lim SM, Choi J, Chang JH, Sohn J, Jacobson K, Policht F, Schulz J, Cho BC, Kim SH
PLoS One 2015;10(9):e0137678. Epub 2015 Sep 14 doi: 10.1371/journal.pone.0137678. PMID: 26366867Free PMC Article
Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.
Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM
Mod Pathol 2015 May;28(5):732-9. Epub 2015 Jan 23 doi: 10.1038/modpathol.2014.165. PMID: 25612511Free PMC Article
ROS1 gene rearrangement and copy number gain in non-small cell lung cancer.
Jin Y, Sun PL, Kim H, Park E, Shim HS, Jheon S, Kim K, Lee CT, Chung JH
Virchows Arch 2015 Jan;466(1):45-52. Epub 2014 Nov 6 doi: 10.1007/s00428-014-1679-2. PMID: 25374304

Clinical prediction guides

Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Rare Incidence of ROS1 Rearrangement in Cholangiocarcinoma.
Lim SM, Yoo JE, Lim KH, Meng Tai DW, Cho BC, Park YN
Cancer Res Treat 2017 Jan;49(1):185-192. Epub 2016 Apr 27 doi: 10.4143/crt.2015.497. PMID: 27121721Free PMC Article
Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma.
Lee KH, Lee KB, Kim TY, Han SW, Oh DY, Im SA, Kim TY, Yi NJ, Lee KW, Suh KS, Jang JJ, Bang YJ
BMC Cancer 2015 Oct 16;15:721. doi: 10.1186/s12885-015-1737-4. PMID: 26475437Free PMC Article
Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.
Hornick JL, Sholl LM, Dal Cin P, Childress MA, Lovly CM
Mod Pathol 2015 May;28(5):732-9. Epub 2015 Jan 23 doi: 10.1038/modpathol.2014.165. PMID: 25612511Free PMC Article
ROS1 gene rearrangement and copy number gain in non-small cell lung cancer.
Jin Y, Sun PL, Kim H, Park E, Shim HS, Jheon S, Kim K, Lee CT, Chung JH
Virchows Arch 2015 Jan;466(1):45-52. Epub 2014 Nov 6 doi: 10.1007/s00428-014-1679-2. PMID: 25374304

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