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Abnormal circulating thyroglobulin concentration

MedGen UID:
1384239
•Concept ID:
C4476804
•
Finding
Synonym: Abnormal circulating thyroglobulin level
 
HPO: HP:0025483

Definition

A deviation from the normal concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating thyroglobulin concentration

Recent clinical studies

Etiology

Euthyroid hyperthyrotropinemia in children born after in vitro fertilization.
Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, Kanaka-Gantenbein C
J Clin Endocrinol Metab 2009 Apr;94(4):1338-41. Epub 2009 Feb 3 doi: 10.1210/jc.2008-1624. PMID: 19190111
Measurement of thyroglobulin mRNA in peripheral blood as an adjunctive test for monitoring thyroid cancer.
Grammatopoulos D, Elliott Y, Smith SC, Brown I, Grieve RJ, Hillhouse EW, Levine MA, Ringel MD
Mol Pathol 2003 Jun;56(3):162-6. doi: 10.1136/mp.56.3.162. PMID: 12782763Free PMC Article
Asymptomatic autoimmune thyroiditis and thyroid dysfunction in Alport's syndrome. A report of three families.
De Marchi S, Cecchin E
Nephrol Dial Transplant 1991;6(2):79-85. doi: 10.1093/ndt/6.2.79. PMID: 1907000
Thyroid disease and high concentration of serum thyrotrophin in a population sample of women. A 4-year follow-up.
Nyström E, Bengtsson C, Lindquist O, Noppa H, Lindstedt G, Lundberg PA
Acta Med Scand 1981;210(1-2):39-46. doi: 10.1111/j.0954-6820.1981.tb09773.x. PMID: 7293826
Comparison of radioassay and haemagglutination methods for anti-thyroid microsomal antibodies.
Mariotti S, Pinchera A, Vitti P, Chiovato L, Marcocci C, Urbano C, Tosi M, Baschieri L
Clin Exp Immunol 1978 Oct;34(1):118-25. PMID: 582027Free PMC Article

Diagnosis

Pediatric Hashimoto's encephalopathy with peripheral nervous system involvement.
Salpietro V, Mankad K, Polizzi A, Sugawara Y, Granata F, David E, Ferraù V, Gallizzi R, Tortorella G, Ruggieri M
Pediatr Int 2014 Jun;56(3):413-6. doi: 10.1111/ped.12262. PMID: 24894926
Total pregnancy-associated plasma protein A--a first trimester maternal serum marker for Down's syndrome: clinical and technical assessment of a poly-monoclonal enzyme immunoassay.
Christiansen M, Jaliashvili I
Scand J Clin Lab Invest 2003;63(6):407-15. doi: 10.1080/00365510310002248. PMID: 14594321
Measurement of thyroglobulin mRNA in peripheral blood as an adjunctive test for monitoring thyroid cancer.
Grammatopoulos D, Elliott Y, Smith SC, Brown I, Grieve RJ, Hillhouse EW, Levine MA, Ringel MD
Mol Pathol 2003 Jun;56(3):162-6. doi: 10.1136/mp.56.3.162. PMID: 12782763Free PMC Article
Concentration of plasma thyroglobulin and urinary excretion of iodinated material in the diagnosis of thyroid disorders in congenital hypothyroidism.
Gons MH, Kok JH, Tegelaers WH, de Vijlder JJ
Acta Endocrinol (Copenh) 1983 Sep;104(1):27-34. doi: 10.1530/acta.0.1040027. PMID: 6624362

Therapy

Detection of thyroglobulin in antithyroglobulin antibody-positive sera by isoelectric focusing.
Malvoisin E, Makhloufi D, Livrozet JM
Clin Chim Acta 2015 Jul 20;447:39-42. Epub 2015 May 18 doi: 10.1016/j.cca.2015.05.009. PMID: 25998693
Changes of circulating thyroid autoantibody levels during and after the therapy with methimazole in patients with Graves' disease.
Marcocci C, Chiovato L, Mariotti S, Pinchera A
J Endocrinol Invest 1982 Jan-Feb;5(1):13-9. doi: 10.1007/BF03350476. PMID: 6896520

Prognosis

MiR-346 regulates CD4⁺CXCR5⁺ T cells in the pathogenesis of Graves' disease.
Chen J, Tian J, Tang X, Rui K, Ma J, Mao C, Liu Y, Lu L, Xu H, Wang S
Endocrine 2015 Aug;49(3):752-60. Epub 2015 Feb 11 doi: 10.1007/s12020-015-0546-5. PMID: 25666935
Measurement of thyroglobulin mRNA in peripheral blood as an adjunctive test for monitoring thyroid cancer.
Grammatopoulos D, Elliott Y, Smith SC, Brown I, Grieve RJ, Hillhouse EW, Levine MA, Ringel MD
Mol Pathol 2003 Jun;56(3):162-6. doi: 10.1136/mp.56.3.162. PMID: 12782763Free PMC Article
Changes of circulating thyroid autoantibody levels during and after the therapy with methimazole in patients with Graves' disease.
Marcocci C, Chiovato L, Mariotti S, Pinchera A
J Endocrinol Invest 1982 Jan-Feb;5(1):13-9. doi: 10.1007/BF03350476. PMID: 6896520
Thyroid disease and high concentration of serum thyrotrophin in a population sample of women. A 4-year follow-up.
Nyström E, Bengtsson C, Lindquist O, Noppa H, Lindstedt G, Lundberg PA
Acta Med Scand 1981;210(1-2):39-46. doi: 10.1111/j.0954-6820.1981.tb09773.x. PMID: 7293826

Clinical prediction guides

MiR-346 regulates CD4⁺CXCR5⁺ T cells in the pathogenesis of Graves' disease.
Chen J, Tian J, Tang X, Rui K, Ma J, Mao C, Liu Y, Lu L, Xu H, Wang S
Endocrine 2015 Aug;49(3):752-60. Epub 2015 Feb 11 doi: 10.1007/s12020-015-0546-5. PMID: 25666935
Euthyroid hyperthyrotropinemia in children born after in vitro fertilization.
Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, Kanaka-Gantenbein C
J Clin Endocrinol Metab 2009 Apr;94(4):1338-41. Epub 2009 Feb 3 doi: 10.1210/jc.2008-1624. PMID: 19190111
Changes of circulating thyroid autoantibody levels during and after the therapy with methimazole in patients with Graves' disease.
Marcocci C, Chiovato L, Mariotti S, Pinchera A
J Endocrinol Invest 1982 Jan-Feb;5(1):13-9. doi: 10.1007/BF03350476. PMID: 6896520
Comparison of radioassay and haemagglutination methods for anti-thyroid microsomal antibodies.
Mariotti S, Pinchera A, Vitti P, Chiovato L, Marcocci C, Urbano C, Tosi M, Baschieri L
Clin Exp Immunol 1978 Oct;34(1):118-25. PMID: 582027Free PMC Article

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