U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tissue Factor Deficiency

MedGen UID:
1384774
•Concept ID:
C0949047
•
Disease or Syndrome
Synonym: Factor III Deficiency

Definition

A coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review.
Green PHR, Paski S, Ko CW, Rubio-Tapia A
Gastroenterology 2022 Nov;163(5):1461-1469. Epub 2022 Sep 19 doi: 10.1053/j.gastro.2022.07.086. PMID: 36137844
International recommendations on the diagnosis and treatment of acquired hemophilia A.
Tiede A, Collins P, Knoebl P, Teitel J, Kessler C, Shima M, Di Minno G, d'Oiron R, Salaj P, Jiménez-Yuste V, Huth-Kühne A, Giangrande P
Haematologica 2020 Jul;105(7):1791-1801. Epub 2020 May 7 doi: 10.3324/haematol.2019.230771. PMID: 32381574Free PMC Article
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390

Recent clinical studies

Etiology

Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans.
Groeneveld D, Pereyra D, Veldhuis Z, Adelmeijer J, Ottens P, Kopec AK, Starlinger P, Lisman T, Luyendyk JP
Blood 2019 Mar 14;133(11):1245-1256. Epub 2019 Jan 17 doi: 10.1182/blood-2018-08-869057. PMID: 30655274Free PMC Article

Therapy

Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction.
Pawlinski R, Fernandes A, Kehrle B, Pedersen B, Parry G, Erlich J, Pyo R, Gutstein D, Zhang J, Castellino F, Melis E, Carmeliet P, Baretton G, Luther T, Taubman M, Rosen E, Mackman N
Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15333-8. Epub 2002 Nov 8 doi: 10.1073/pnas.242501899. PMID: 12426405Free PMC Article

Prognosis

Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans.
Groeneveld D, Pereyra D, Veldhuis Z, Adelmeijer J, Ottens P, Kopec AK, Starlinger P, Lisman T, Luyendyk JP
Blood 2019 Mar 14;133(11):1245-1256. Epub 2019 Jan 17 doi: 10.1182/blood-2018-08-869057. PMID: 30655274Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...