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Iatrogenic Central Hypothyroidism

MedGen UID:
1385306
•Concept ID:
C4331900
•
Disease or Syndrome

Definition

Central hypothyroidism due to medical or surgical treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIatrogenic Central Hypothyroidism

Professional guidelines

PubMed

Treatment with retinoid X receptorgamma-selective ligand (bexarotene) may cause iatrogenic central hypothyroidism.
Asteria C
Eur J Endocrinol 2000 Apr;142(4):324-5. doi: 10.1530/eje.0.1420324. PMID: 10754470

Recent clinical studies

Etiology

Subclinical Hypothyroidism: A Review.
Biondi B, Cappola AR, Cooper DS
JAMA 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052. PMID: 31287527
Risks and safety of combination therapy for hypothyroidism.
Jonklaas J
Expert Rev Clin Pharmacol 2016 Aug;9(8):1057-67. Epub 2016 May 9 doi: 10.1080/17512433.2016.1182019. PMID: 27137849
Post-ablative hypothyroidism.
Yaqub A, Choudhry MI, Wheaton J, Gress T
W V Med J 2011 Mar-Apr;107(2):37-40. PMID: 21476476
Adolescent thyroid disorders.
Hanna CE, LaFranchi SH
Adolesc Med 2002 Feb;13(1):13-35, v. PMID: 11841953
Neonatal endocrinology.
Oden J, Bourgeois M
Indian J Pediatr 2000 Mar;67(3):217-23. doi: 10.1007/BF02723667. PMID: 10838725

Diagnosis

Neurologic Complications of Endocrine Disorders.
Reda H
Continuum (Minneap Minn) 2023 Jun 1;29(3):887-902. doi: 10.1212/CON.0000000000001262. PMID: 37341334
Case 306.
Mamone G, Caruso S, Milazzo M, Miraglia R
Radiology 2022 Jun;303(3):722-725. doi: 10.1148/radiol.210538. PMID: 35604842
Neuroendocrine causes of amenorrhea--an update.
Fourman LT, Fazeli PK
J Clin Endocrinol Metab 2015 Mar;100(3):812-24. Epub 2015 Jan 12 doi: 10.1210/jc.2014-3344. PMID: 25581597Free PMC Article
Hypothyroidism.
Roberts CG, Ladenson PW
Lancet 2004 Mar 6;363(9411):793-803. doi: 10.1016/S0140-6736(04)15696-1. PMID: 15016491
Adolescent thyroid disorders.
Hanna CE, LaFranchi SH
Adolesc Med 2002 Feb;13(1):13-35, v. PMID: 11841953

Therapy

Case 306.
Mamone G, Caruso S, Milazzo M, Miraglia R
Radiology 2022 Jun;303(3):722-725. doi: 10.1148/radiol.210538. PMID: 35604842
L-T4 Therapy in Enteric Malabsorptive Disorders.
Fallahi P, Ferrari SM, Elia G, Ragusa F, Paparo SR, Antonelli A
Front Endocrinol (Lausanne) 2021;12:626371. Epub 2021 Feb 23 doi: 10.3389/fendo.2021.626371. PMID: 33708175Free PMC Article
Subclinical Hypothyroidism: A Review.
Biondi B, Cappola AR, Cooper DS
JAMA 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052. PMID: 31287527
Post-ablative hypothyroidism.
Yaqub A, Choudhry MI, Wheaton J, Gress T
W V Med J 2011 Mar-Apr;107(2):37-40. PMID: 21476476
Hypothyroidism.
Roberts CG, Ladenson PW
Lancet 2004 Mar 6;363(9411):793-803. doi: 10.1016/S0140-6736(04)15696-1. PMID: 15016491

Prognosis

Iatrogenic hyperthyroidism in primary congenital hypothyroidism: prevalence and predictive factors.
Chooprasertsuk N, Dejkhamron P, Unachak K, Wejaphikul K
J Pediatr Endocrinol Metab 2022 Oct 26;35(10):1250-1256. Epub 2022 Sep 14 doi: 10.1515/jpem-2022-0152. PMID: 36100363
Dysthyroidism and Chronic Heart Failure: Pathophysiological Mechanisms and Therapeutic Approaches.
Rizzo C, Gioia MI, Parisi G, Triggiani V, Iacoviello M
Adv Exp Med Biol 2018;1067:239-253. doi: 10.1007/5584_2017_132. PMID: 29235066
Hyponatremia and antidiuresis syndrome.
Vantyghem MC, Balavoine AS, Wémeau JL, Douillard C
Ann Endocrinol (Paris) 2011 Dec;72(6):500-12. Epub 2011 Nov 25 doi: 10.1016/j.ando.2011.10.001. PMID: 22119069
Post-ablative hypothyroidism.
Yaqub A, Choudhry MI, Wheaton J, Gress T
W V Med J 2011 Mar-Apr;107(2):37-40. PMID: 21476476
Adolescent thyroid disorders.
Hanna CE, LaFranchi SH
Adolesc Med 2002 Feb;13(1):13-35, v. PMID: 11841953

Clinical prediction guides

Iatrogenic endocrine complications of lithium therapy.
Vantyghem MC
Ann Endocrinol (Paris) 2023 May;84(3):391-397. Epub 2023 Mar 22 doi: 10.1016/j.ando.2023.03.004. PMID: 36963758
Iatrogenic hyperthyroidism in primary congenital hypothyroidism: prevalence and predictive factors.
Chooprasertsuk N, Dejkhamron P, Unachak K, Wejaphikul K
J Pediatr Endocrinol Metab 2022 Oct 26;35(10):1250-1256. Epub 2022 Sep 14 doi: 10.1515/jpem-2022-0152. PMID: 36100363
Subclinical Hypothyroidism: A Review.
Biondi B, Cappola AR, Cooper DS
JAMA 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052. PMID: 31287527
Imaging Findings of Metabolic Bone Disease.
Chang CY, Rosenthal DI, Mitchell DM, Handa A, Kattapuram SV, Huang AJ
Radiographics 2016 Oct;36(6):1871-1887. doi: 10.1148/rg.2016160004. PMID: 27726750
Post-ablative hypothyroidism.
Yaqub A, Choudhry MI, Wheaton J, Gress T
W V Med J 2011 Mar-Apr;107(2):37-40. PMID: 21476476

Recent systematic reviews

Adequacy of thyroid hormone replacement for people with hypothyroidism in real-world settings: A systematic review and meta-analysis of observational studies.
Efthymiadis A, Henry M, Spinos D, Bourlaki M, Tsikopoulos A, Bourazana A, Bastounis A, Tsikopoulos K
Clin Endocrinol (Oxf) 2024 May;100(5):488-501. Epub 2023 Nov 30 doi: 10.1111/cen.14998. PMID: 38037493
Compartment syndrome of the leg after thyroid hormone withdrawal; two cases and a systematic review of the literature.
van Veelen NM, Fischli S, Beeres FJP, Eisenhut T, Babst R, Henzen C, Link BC
BMC Endocr Disord 2020 Jun 5;20(1):80. doi: 10.1186/s12902-020-00555-y. PMID: 32503586Free PMC Article
A Systematic Review of Case-Identification Algorithms Based on Italian Healthcare Administrative Databases for Two Relevant Diseases of the Endocrine System: Diabetes Mellitus and Thyroid Disorders.
Dalla Zuanna T, Pitter G, Canova C, Simonato L, Gnavi R
Epidemiol Prev 2019 Jul-Aug;43(4 Suppl 2):17-36. doi: 10.19191/EP19.4.S2.P008.089. PMID: 31650804
The role of radioactive iodine usage in the management of thyroid disorders with emphasis on sub-Saharan Africa.
Ogbera AO, Ekpebegh C, Eregie A, Kuku SF
West Afr J Med 2008 Oct;27(4):211-7. PMID: 19469398

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