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EBV positive mucocutaneous ulcer

MedGen UID:
1385652
•Concept ID:
C4324739
•
Disease or Syndrome
Synonyms: EBV-Positive Mucocutaneous Ulcer; Epstein Barr virus positive mucocutaneous ulcer; Epstein-Barr Virus-Positive Mucocutaneous Ulcer
SNOMED CT: EBV positive mucocutaneous ulcer (788572005); Epstein Barr virus positive mucocutaneous ulcer (788572005)

Definition

A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder which presents as an ulcerative mucocutaneous lesion. It is associated with immune suppression, including age-related and drug-induced immunosuppression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV positive mucocutaneous ulcer

Professional guidelines

PubMed

Hodgkin Lymphoma and Its Differential Diagnosis: New Twists on an Old Challenge.
Sohani AR
Surg Pathol Clin 2023 Jun;16(2):287-346. Epub 2023 Mar 30 doi: 10.1016/j.path.2023.02.002. PMID: 37149361

Recent clinical studies

Etiology

Impact of Epstein-Barr virus infection in patients with inflammatory bowel disease.
Zhang H, Zhao S, Cao Z
Front Immunol 2022;13:1001055. Epub 2022 Oct 28 doi: 10.3389/fimmu.2022.1001055. PMID: 36389673Free PMC Article
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer.
Ikeda T, Gion Y, Sakamoto M, Tachibana T, Nishikori A, Nishimura MF, Yoshino T, Sato Y
Mod Pathol 2020 Dec;33(12):2437-2448. Epub 2020 Jun 19 doi: 10.1038/s41379-020-0599-8. PMID: 32561847
Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.
Bhavsar T, Crane GM
Curr Hematol Malig Rep 2020 Aug;15(4):360-371. doi: 10.1007/s11899-020-00594-1. PMID: 32535851
Epstein-Barr Virus-associated Lymphoproliferative Disorders in the Skin.
Goodlad JR
Surg Pathol Clin 2017 Jun;10(2):429-453. Epub 2017 Mar 18 doi: 10.1016/j.path.2017.01.001. PMID: 28477890

Diagnosis

Impact of Epstein-Barr virus infection in patients with inflammatory bowel disease.
Zhang H, Zhao S, Cao Z
Front Immunol 2022;13:1001055. Epub 2022 Oct 28 doi: 10.3389/fimmu.2022.1001055. PMID: 36389673Free PMC Article
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Diffuse large B-cell lymphoma variants: an update.
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects.
Ikeda T, Gion Y, Yoshino T, Sato Y
J Clin Exp Hematop 2019;59(2):64-71. doi: 10.3960/jslrt.18039. PMID: 31257347Free PMC Article
Cutaneous lymphomas-An update 2019.
Kempf W, Zimmermann AK, Mitteldorf C
Hematol Oncol 2019 Jun;37 Suppl 1:43-47. doi: 10.1002/hon.2584. PMID: 31187534

Therapy

Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer.
Ikeda T, Gion Y, Sakamoto M, Tachibana T, Nishikori A, Nishimura MF, Yoshino T, Sato Y
Mod Pathol 2020 Dec;33(12):2437-2448. Epub 2020 Jun 19 doi: 10.1038/s41379-020-0599-8. PMID: 32561847
Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.
Bhavsar T, Crane GM
Curr Hematol Malig Rep 2020 Aug;15(4):360-371. doi: 10.1007/s11899-020-00594-1. PMID: 32535851
Reexamining post-transplant lymphoproliferative disorders: Newly recognized and enigmatic types.
Aguilera N, Gru AA
Semin Diagn Pathol 2018 Jul;35(4):236-246. Epub 2018 Mar 3 doi: 10.1053/j.semdp.2018.02.001. PMID: 29615296
EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder.
Hart M, Thakral B, Yohe S, Balfour HH Jr, Singh C, Spears M, McKenna RW
Am J Surg Pathol 2014 Nov;38(11):1522-9. doi: 10.1097/PAS.0000000000000282. PMID: 25007145
Azathioprine-induced EBV-positive mucocutaneous ulcer.
McGinness JL, Spicknall KE, Mutasim DF
J Cutan Pathol 2012 Mar;39(3):377-81. Epub 2012 Jan 11 doi: 10.1111/j.1600-0560.2011.01829.x. PMID: 22236092

Prognosis

Impact of Epstein-Barr virus infection in patients with inflammatory bowel disease.
Zhang H, Zhao S, Cao Z
Front Immunol 2022;13:1001055. Epub 2022 Oct 28 doi: 10.3389/fimmu.2022.1001055. PMID: 36389673Free PMC Article
Epstein-Barr Virus-Positive Mucocutaneous Ulcer: A Unique and Curious Disease Entity.
Ikeda T, Gion Y, Nishimura Y, Nishimura MF, Yoshino T, Sato Y
Int J Mol Sci 2021 Jan 21;22(3) doi: 10.3390/ijms22031053. PMID: 33494358Free PMC Article
A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects.
Ikeda T, Gion Y, Yoshino T, Sato Y
J Clin Exp Hematop 2019;59(2):64-71. doi: 10.3960/jslrt.18039. PMID: 31257347Free PMC Article
Cutaneous lymphomas-An update 2019.
Kempf W, Zimmermann AK, Mitteldorf C
Hematol Oncol 2019 Jun;37 Suppl 1:43-47. doi: 10.1002/hon.2584. PMID: 31187534
Epstein-Barr Virus-associated Lymphoproliferative Disorders in the Skin.
Goodlad JR
Surg Pathol Clin 2017 Jun;10(2):429-453. Epub 2017 Mar 18 doi: 10.1016/j.path.2017.01.001. PMID: 28477890

Clinical prediction guides

EBV-positive Mucocutaneous Ulcer With Small Lymphocytic Infiltration Mimicking Nonspecific Ulceration.
Fujimoto M, Kaku Y, Hirata M, Usui S, Yamada Y, Haga H
Am J Surg Pathol 2021 May 1;45(5):694-700. doi: 10.1097/PAS.0000000000001661. PMID: 33739792
Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer.
Ikeda T, Gion Y, Sakamoto M, Tachibana T, Nishikori A, Nishimura MF, Yoshino T, Sato Y
Mod Pathol 2020 Dec;33(12):2437-2448. Epub 2020 Jun 19 doi: 10.1038/s41379-020-0599-8. PMID: 32561847
Epstein-Barr Virus Positive Mucocutaneous Ulcer: A Case Report.
Gali V, Bleeker JS, Lynch D
S D Med 2018 Jun;71(6):252-255. PMID: 30005148
Comparison of Epstein-Barr virus-positive mucocutaneous ulcer associated with treated lymphoma or methotrexate in Japan.
Daroontum T, Kohno K, Eladl AE, Satou A, Sakakibara A, Matsukage S, Yakushiji N, Ya-In C, Nakamura S, Asano N, Kato S
Histopathology 2018 Jun;72(7):1115-1127. Epub 2018 Mar 7 doi: 10.1111/his.13464. PMID: 29314151
EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder.
Hart M, Thakral B, Yohe S, Balfour HH Jr, Singh C, Spears M, McKenna RW
Am J Surg Pathol 2014 Nov;38(11):1522-9. doi: 10.1097/PAS.0000000000000282. PMID: 25007145

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