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Membranous vitreous appearance

MedGen UID:
1386132
•Concept ID:
C4477006
•
Anatomical Abnormality
Synonyms: Membranous anomaly; Membranous vitreous; Membranous vitreous phenotype
 
HPO: HP:0031153

Definition

Vitreous humor of the eye displaying consisting of a vestigial gel in the retrolental space bounded by a convoluted membrane. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMembranous vitreous appearance

Conditions with this feature

Stickler syndrome type 1
MedGen UID:
810955
•Concept ID:
C2020284
•
Disease or Syndrome
Stickler syndrome is a connective tissue disorder that can include ocular findings of myopia, cataract, and retinal detachment; hearing loss that is both conductive and sensorineural; midfacial underdevelopment and cleft palate (either alone or as part of the Robin sequence); and mild spondyloepiphyseal dysplasia and/or precocious arthritis. Variable phenotypic expression of Stickler syndrome occurs both within and among families; interfamilial variability is in part explained by locus and allelic heterogeneity.
See: Condition Record
Stickler syndrome type 1

Professional guidelines

PubMed

Foveal photoreceptor disruption in ocular diseases: An optical coherence tomography-based differential diagnosis.
Singh SR, Vaidya H, Borrelli E, Chhablani J
Surv Ophthalmol 2023 Jul-Aug;68(4):655-668. Epub 2023 Mar 18 doi: 10.1016/j.survophthal.2023.03.003. PMID: 36934831
Perfluorocarbon liquid vitreous delamination and wide-angle viewing system in the management of complicated diabetic retinal detachment.
Yadarola MB, Gramajo AL, Arrambide MP, Colombres GA, Juarez CP, Luna JD
Eur J Ophthalmol 2009 May-Jun;19(3):452-9. doi: 10.1177/112067210901900321. PMID: 19396794
Management of proliferative diabetic retinopathy.
Gündüz K, Bakri SJ
Compr Ophthalmol Update 2007 Sep-Oct;8(5):245-56. PMID: 18201511

Recent clinical studies

Etiology

Subretinal drusenoid deposits AKA pseudodrusen.
Spaide RF, Ooto S, Curcio CA
Surv Ophthalmol 2018 Nov-Dec;63(6):782-815. Epub 2018 May 31 doi: 10.1016/j.survophthal.2018.05.005. PMID: 29859199
Posterior Vitreous Detachment and the Posterior Hyaloid Membrane.
Fincham GS, James S, Spickett C, Hollingshead M, Thrasivoulou C, Poulson AV, McNinch A, Richards A, Snead D, Limb GA, Snead MP
Ophthalmology 2018 Feb;125(2):227-236. Epub 2017 Sep 1 doi: 10.1016/j.ophtha.2017.08.001. PMID: 28867131
Stellate nonhereditary idiopathic foveomacular retinoschisis.
Ober MD, Freund KB, Shah M, Ahmed S, Mahmoud TH, Aaberg TM Jr, Zacks DN, Gao H, Mukkamala K, Desai U, Packo KH, Yannuzzi LA
Ophthalmology 2014 Jul;121(7):1406-13. Epub 2014 Mar 22 doi: 10.1016/j.ophtha.2014.02.002. PMID: 24661864
Stickler syndrome and the vitreous phenotype: mutations in COL2A1 and COL11A1.
Richards AJ, McNinch A, Martin H, Oakhill K, Rai H, Waller S, Treacy B, Whittaker J, Meredith S, Poulson A, Snead MP
Hum Mutat 2010 Jun;31(6):E1461-71. doi: 10.1002/humu.21257. PMID: 20513134
Management of proliferative diabetic retinopathy.
Gündüz K, Bakri SJ
Compr Ophthalmol Update 2007 Sep-Oct;8(5):245-56. PMID: 18201511

Diagnosis

Hamartomas of the Retina and Optic Disc.
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Subretinal drusenoid deposits AKA pseudodrusen.
Spaide RF, Ooto S, Curcio CA
Surv Ophthalmol 2018 Nov-Dec;63(6):782-815. Epub 2018 May 31 doi: 10.1016/j.survophthal.2018.05.005. PMID: 29859199
Posterior Vitreous Detachment and the Posterior Hyaloid Membrane.
Fincham GS, James S, Spickett C, Hollingshead M, Thrasivoulou C, Poulson AV, McNinch A, Richards A, Snead D, Limb GA, Snead MP
Ophthalmology 2018 Feb;125(2):227-236. Epub 2017 Sep 1 doi: 10.1016/j.ophtha.2017.08.001. PMID: 28867131
Stellate nonhereditary idiopathic foveomacular retinoschisis.
Ober MD, Freund KB, Shah M, Ahmed S, Mahmoud TH, Aaberg TM Jr, Zacks DN, Gao H, Mukkamala K, Desai U, Packo KH, Yannuzzi LA
Ophthalmology 2014 Jul;121(7):1406-13. Epub 2014 Mar 22 doi: 10.1016/j.ophtha.2014.02.002. PMID: 24661864
The blood-retinal barriers.
Cunha-Vaz JG
Doc Ophthalmol 1976 Oct 15;41(2):287-327. doi: 10.1007/BF00146764. PMID: 1009819

Therapy

STRAWBERRY RETINA: SILICONE OIL-RETINA INTERFACE ON MULTIMODAL IMAGING.
Pilli S, Murjaneh S
Retin Cases Brief Rep 2023 Jul 1;17(4):365-369. doi: 10.1097/ICB.0000000000001188. PMID: 34510049
CASE REPORT OF ABIOTROPHIA DEFECTIVA ENDOPHTHALMITIS AFTER REPEATED INJECTIONS OF DEXAMETHASONE INTRAVITREAL IMPLANT (OZURDEX).
Cruz-Iñigo YJ, Klein K, Reddy RK
Retin Cases Brief Rep 2022 Mar 1;16(2):170-173. doi: 10.1097/ICB.0000000000000925. PMID: 31479011
Angiogenesis-Inflammation Cross Talk in Diabetic Retinopathy: Novel Insights From the Chick Embryo Chorioallantoic Membrane/Human Vitreous Platform.
Rezzola S, Loda A, Corsini M, Semeraro F, Annese T, Presta M, Ribatti D
Front Immunol 2020;11:581288. Epub 2020 Sep 29 doi: 10.3389/fimmu.2020.581288. PMID: 33117388Free PMC Article
Delineation of the vitreous and posterior hyaloid using bromophenol blue.
Haritoglou C, Strauss R, Priglinger SG, Kreutzer T, Kampik A
Retina 2008 Feb;28(2):333-9. doi: 10.1097/IAE.0b013e31814fb0ff. PMID: 18301040
Complications after surgery for congenital and infantile cataracts.
Keech RV, Tongue AC, Scott WE
Am J Ophthalmol 1989 Aug 15;108(2):136-41. doi: 10.1016/0002-9394(89)90007-x. PMID: 2667370

Prognosis

Foveal photoreceptor disruption in ocular diseases: An optical coherence tomography-based differential diagnosis.
Singh SR, Vaidya H, Borrelli E, Chhablani J
Surv Ophthalmol 2023 Jul-Aug;68(4):655-668. Epub 2023 Mar 18 doi: 10.1016/j.survophthal.2023.03.003. PMID: 36934831
Clinical manifestations of ocular toxoplasmosis.
Delair E, Latkany P, Noble AG, Rabiah P, McLeod R, Brézin A
Ocul Immunol Inflamm 2011 Apr;19(2):91-102. doi: 10.3109/09273948.2011.564068. PMID: 21428746
Clinical features of the congenital vitreoretinopathies.
Edwards AO
Eye (Lond) 2008 Oct;22(10):1233-42. Epub 2008 Feb 29 doi: 10.1038/eye.2008.38. PMID: 18309337
Eales' disease: oxidant stress and weak antioxidant defence.
Ramakrishnan S, Rajesh M, Sulochana KN
Indian J Ophthalmol 2007 Mar-Apr;55(2):95-102. doi: 10.4103/0301-4738.30701. PMID: 17322597
Complications after surgery for congenital and infantile cataracts.
Keech RV, Tongue AC, Scott WE
Am J Ophthalmol 1989 Aug 15;108(2):136-41. doi: 10.1016/0002-9394(89)90007-x. PMID: 2667370

Clinical prediction guides

Hamartomas of the Retina and Optic Disc.
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Decreased Presence of Mast Cells in the Bursa Premacularis of Proliferative Diabetic Retinopathy.
Ikeda T, Nakamura K, Morishita S, Sato T, Horie T, Kida T, Oku H, Takai S, Jin D
Ophthalmic Res 2021;64(6):1002-1012. Epub 2021 Aug 12 doi: 10.1159/000518438. PMID: 34515200
Multimodal Imaging Features and Clinical Relevance of Subretinal Lipid Globules.
Fernández-Avellaneda P, Freund KB, Wang RK, He Q, Zhang Q, Fragiotta S, Xu X, Ledesma-Gil G, Sugiura Y, Breazzano MP, Yannuzzi LA, Liakopoulos S, Sarraf D, Dolz-Marco R
Am J Ophthalmol 2021 Feb;222:112-125. Epub 2020 Sep 9 doi: 10.1016/j.ajo.2020.09.003. PMID: 32918902
Cuticular Drusen: Clinical Phenotypes and Natural History Defined Using Multimodal Imaging.
Balaratnasingam C, Cherepanoff S, Dolz-Marco R, Killingsworth M, Chen FK, Mendis R, Mrejen S, Too LK, Gal-Or O, Curcio CA, Freund KB, Yannuzzi LA
Ophthalmology 2018 Jan;125(1):100-118. Epub 2017 Sep 28 doi: 10.1016/j.ophtha.2017.08.033. PMID: 28964580
Posterior Vitreous Detachment and the Posterior Hyaloid Membrane.
Fincham GS, James S, Spickett C, Hollingshead M, Thrasivoulou C, Poulson AV, McNinch A, Richards A, Snead D, Limb GA, Snead MP
Ophthalmology 2018 Feb;125(2):227-236. Epub 2017 Sep 1 doi: 10.1016/j.ophtha.2017.08.001. PMID: 28867131

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