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Gain of Chromosome 1q21

MedGen UID:
1386239
•Concept ID:
C4330030
•
Cell or Molecular Dysfunction
Synonym: 1q21 Amplification

Definition

A cytogenetic abnormality that refers to allelic gain within the chromosomal region 1q21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 1q21

Professional guidelines

PubMed

Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939
Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma.
Hose D, Rème T, Hielscher T, Moreaux J, Messner T, Seckinger A, Benner A, Shaughnessy JD Jr, Barlogie B, Zhou Y, Hillengass J, Bertsch U, Neben K, Möhler T, Rossi JF, Jauch A, Klein B, Goldschmidt H
Haematologica 2011 Jan;96(1):87-95. Epub 2010 Sep 30 doi: 10.3324/haematol.2010.030296. PMID: 20884712Free PMC Article

Recent clinical studies

Etiology

Lenalidomide-Based Maintenance after Autologous Hematopoietic Stem Cell Transplantation for Patients with High-Risk Multiple Myeloma.
Pasvolsky O, Milton DR, Rauf M, Tanner MR, Bashir Q, Srour S, Tang G, Saini N, Ramdial J, Masood A, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2022 Nov;28(11):752.e1-752.e6. Epub 2022 Aug 5 doi: 10.1016/j.jtct.2022.07.028. PMID: 35940528
Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Subgroup analysis of ICARIA-MM study in relapsed/refractory multiple myeloma patients with high-risk cytogenetics.
Harrison SJ, Perrot A, Alegre A, Simpson D, Wang MC, Spencer A, Delimpasi S, Hulin C, Sunami K, Facon T, Vlummens P, Yong K, Campana F, Inchauspé M, Macé S, Risse ML, van de Velde H, Richardson P
Br J Haematol 2021 Jul;194(1):120-131. Epub 2021 May 25 doi: 10.1111/bjh.17499. PMID: 34036560Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Diagnosis

Lenalidomide-Based Maintenance after Autologous Hematopoietic Stem Cell Transplantation for Patients with High-Risk Multiple Myeloma.
Pasvolsky O, Milton DR, Rauf M, Tanner MR, Bashir Q, Srour S, Tang G, Saini N, Ramdial J, Masood A, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2022 Nov;28(11):752.e1-752.e6. Epub 2022 Aug 5 doi: 10.1016/j.jtct.2022.07.028. PMID: 35940528
Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosomal 1q21 abnormalities in multiple myeloma: a review of translational, clinical research, and therapeutic strategies.
Bisht K, Walker B, Kumar SK, Spicka I, Moreau P, Martin T, Costa LJ, Richter J, Fukao T, Macé S, van de Velde H
Expert Rev Hematol 2021 Dec;14(12):1099-1114. Epub 2021 Oct 8 doi: 10.1080/17474086.2021.1983427. PMID: 34551651
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Therapy

Lenalidomide-Based Maintenance after Autologous Hematopoietic Stem Cell Transplantation for Patients with High-Risk Multiple Myeloma.
Pasvolsky O, Milton DR, Rauf M, Tanner MR, Bashir Q, Srour S, Tang G, Saini N, Ramdial J, Masood A, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2022 Nov;28(11):752.e1-752.e6. Epub 2022 Aug 5 doi: 10.1016/j.jtct.2022.07.028. PMID: 35940528
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosomal 1q21 abnormalities in multiple myeloma: a review of translational, clinical research, and therapeutic strategies.
Bisht K, Walker B, Kumar SK, Spicka I, Moreau P, Martin T, Costa LJ, Richter J, Fukao T, Macé S, van de Velde H
Expert Rev Hematol 2021 Dec;14(12):1099-1114. Epub 2021 Oct 8 doi: 10.1080/17474086.2021.1983427. PMID: 34551651
Subgroup analysis of ICARIA-MM study in relapsed/refractory multiple myeloma patients with high-risk cytogenetics.
Harrison SJ, Perrot A, Alegre A, Simpson D, Wang MC, Spencer A, Delimpasi S, Hulin C, Sunami K, Facon T, Vlummens P, Yong K, Campana F, Inchauspé M, Macé S, Risse ML, van de Velde H, Richardson P
Br J Haematol 2021 Jul;194(1):120-131. Epub 2021 May 25 doi: 10.1111/bjh.17499. PMID: 34036560Free PMC Article
1q21 gain but not t(4;14) indicates inferior outcomes in multiple myeloma treated with bortezomib.
Du C, Mao X, Xu Y, Yan Y, Yuan C, Du X, Liu J, Fan H, Wang Q, Sui W, Deng S, Fu M, Li Z, Li C, Zhao J, Yi S, Liu L, Hao M, Zou D, Zhao Y, Qiu L, An G
Leuk Lymphoma 2020 May;61(5):1201-1210. Epub 2019 Dec 16 doi: 10.1080/10428194.2019.1700503. PMID: 31842644

Prognosis

Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosomal 1q21 abnormalities in multiple myeloma: a review of translational, clinical research, and therapeutic strategies.
Bisht K, Walker B, Kumar SK, Spicka I, Moreau P, Martin T, Costa LJ, Richter J, Fukao T, Macé S, van de Velde H
Expert Rev Hematol 2021 Dec;14(12):1099-1114. Epub 2021 Oct 8 doi: 10.1080/17474086.2021.1983427. PMID: 34551651
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Li Z, Zhang J, Liu X, Li S, Wang Q, Di Chen, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X
Nat Commun 2018 Apr 20;9(1):1572. doi: 10.1038/s41467-018-04006-0. PMID: 29679004Free PMC Article
Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.
Chen L, Chan TH, Guan XY
Acta Pharmacol Sin 2010 Sep;31(9):1165-71. Epub 2010 Aug 2 doi: 10.1038/aps.2010.94. PMID: 20676120Free PMC Article

Clinical prediction guides

Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
The combination of C-Myc rearrangement and 1q21 gain is associated with poor prognosis in multiple myeloma.
Jin Y, Yu X, Du J, Li H, Tang W, Jia C, Zan Y, Chen M, Zhang Y, Yu M, Rong W, Zhou D, Zhuang J
Ann Hematol 2021 May;100(5):1251-1260. Epub 2021 Mar 8 doi: 10.1007/s00277-021-04475-2. PMID: 33686491
Clinical Characteristics and Prognosis of MAF Deletion in Chinese Patients With Multiple Myeloma.
Wang Y, Li Q, Xing S, Zhang H, Li D
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e545-e550. Epub 2019 May 29 doi: 10.1016/j.clml.2019.05.016. PMID: 31262667
Chromosome imbalances and alterations of AURKA and MYCN genes in children with neuroblastoma.
Inandiklioğlu N, Yilmaz S, Demirhan O, Erdoğan S, Tanyeli A
Asian Pac J Cancer Prev 2012;13(11):5391-7. PMID: 23317189

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