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Gain of Chromosome 1q21

MedGen UID:
1386239
Concept ID:
C4330030
Cell or Molecular Dysfunction
Synonym: 1q21 Amplification

Definition

A cytogenetic abnormality that refers to allelic gain within the chromosomal region 1q21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 1q21

Professional guidelines

PubMed

Zhuang J, Zhang N, Chen Y, Jiang Y, Chen X, Chen W, Chen C
Sci Rep 2024 Jan 27;14(1):2271. doi: 10.1038/s41598-024-52831-9. PMID: 38280885Free PMC Article
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939

Recent clinical studies

Etiology

Pasvolsky O, Ghanem S, Milton DR, Masood A, Tanner MR, Bashir Q, Srour S, Saini N, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2023 Dec;29(12):757-762. Epub 2023 Sep 4 doi: 10.1016/j.jtct.2023.08.031. PMID: 37673125
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Snuderl M, Kannan K, Pfaff E, Wang S, Stafford JM, Serrano J, Heguy A, Ray K, Faustin A, Aminova O, Dolgalev I, Stapleton SL, Zagzag D, Chiriboga L, Gardner SL, Wisoff JH, Golfinos JG, Capper D, Hovestadt V, Rosenblum MK, Placantonakis DG, LeBoeuf SE, Papagiannakopoulos TY, Chavez L, Ahsan S, Eberhart CG, Pfister SM, Jones DTW, Karajannis MA
Nat Commun 2018 Jul 20;9(1):2868. doi: 10.1038/s41467-018-05029-3. PMID: 30030436Free PMC Article

Diagnosis

Pasvolsky O, Ghanem S, Milton DR, Masood A, Tanner MR, Bashir Q, Srour S, Saini N, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2023 Dec;29(12):757-762. Epub 2023 Sep 4 doi: 10.1016/j.jtct.2023.08.031. PMID: 37673125
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Soekojo CY, Chung TH, Furqan MS, Chng WJ
Blood Cancer J 2022 Jan 31;12(1):24. doi: 10.1038/s41408-021-00576-3. PMID: 35102139Free PMC Article
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Therapy

Callander NS, Silbermann R, Kaufman JL, Godby KN, Laubach J, Schmidt TM, Sborov DW, Medvedova E, Reeves B, Dhakal B, Rodriguez C, Chhabra S, Chari A, Bal S, Anderson LD Jr, Dholaria BR, Nathwani N, Hari P, Shah N, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Pei H, Cortoos A, Patel S, Lin TS, Giri S, Costa LJ, Usmani SZ, Richardson PG, Voorhees PM
Blood Cancer J 2024 Apr 22;14(1):69. doi: 10.1038/s41408-024-01030-w. PMID: 38649340Free PMC Article
Pasvolsky O, Ghanem S, Milton DR, Masood A, Tanner MR, Bashir Q, Srour S, Saini N, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2023 Dec;29(12):757-762. Epub 2023 Sep 4 doi: 10.1016/j.jtct.2023.08.031. PMID: 37673125
Pasvolsky O, Milton DR, Rauf M, Tanner MR, Bashir Q, Srour S, Tang G, Saini N, Ramdial J, Masood A, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2022 Nov;28(11):752.e1-752.e6. Epub 2022 Aug 5 doi: 10.1016/j.jtct.2022.07.028. PMID: 35940528
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Gaballa MR, Ma J, Rauf M, Bassett R, Pasvolsky O, Tanner MR, Bashir Q, Srour SA, Saini N, Ramdial J, Nieto Y, Murphy R, Rezvani K, Tang G, Lin P, Lee HC, Patel KK, Ullah MR, Kaufman GP, Manasanch EE, Kebriaei P, Thomas SK, Weber DM, Shpall EJ, Champlin RE, Orlowski RZ, Qazilbash MH
Bone Marrow Transplant 2022 Jul;57(7):1142-1149. Epub 2022 May 6 doi: 10.1038/s41409-022-01697-4. PMID: 35523847

Prognosis

Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Soekojo CY, Chung TH, Furqan MS, Chng WJ
Blood Cancer J 2022 Jan 31;12(1):24. doi: 10.1038/s41408-021-00576-3. PMID: 35102139Free PMC Article
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Li Z, Zhang J, Liu X, Li S, Wang Q, Di Chen, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X
Nat Commun 2018 Apr 20;9(1):1572. doi: 10.1038/s41467-018-04006-0. PMID: 29679004Free PMC Article

Clinical prediction guides

Barbieri E, Martino EA, Rivolti E, Quaresima M, Vigna E, Neri A, Morabito F, Gentile M
Expert Opin Biol Ther 2024 May;24(5):365-381. Epub 2024 May 19 doi: 10.1080/14712598.2024.2357382. PMID: 38757726
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Varma A, Sui D, Milton DR, Tang G, Saini N, Hasan O, Mukherjee A, Joseph JJ, Bashir Q, Rondon G, Srour S, Popat UR, Hosing CM, Nieto Y, Kebriaei P, Alousi AM, Ahmed S, Mehta R, Khouri IF, Ahmed H, Iyer S, Weber DM, Thomas SK, Manasanch E, Lee HC, Patel K, Ciurea SO, Shpall EJ, Orlowski RZ, Champlin RE, Qazilbash MH
Biol Blood Marrow Transplant 2020 Apr;26(4):665-671. Epub 2019 Dec 24 doi: 10.1016/j.bbmt.2019.12.726. PMID: 31881283Free PMC Article
An G, Acharya C, Deng S, Yi S, Xu Y, Qin X, Sui W, Li Z, Shi L, Zang M, Feng X, Hao M, Zou D, Zhao Y, Qi J, Cheng T, Ru K, Wang J, Tai YT, Qiu L
Exp Hematol 2015 Mar;43(3):168-176.e2. Epub 2014 Nov 20 doi: 10.1016/j.exphem.2014.11.004. PMID: 25462022

Recent systematic reviews

Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article

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