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Gain of Chromosome 1q21

MedGen UID:
1386239
•Concept ID:
C4330030
•
Cell or Molecular Dysfunction
Synonym: 1q21 Amplification

Definition

A cytogenetic abnormality that refers to allelic gain within the chromosomal region 1q21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 1q21

Professional guidelines

PubMed

Prenatal diagnosis and molecular cytogenetic characterization of fetuses with central nervous system anomalies using chromosomal microarray analysis: a seven-year single-center retrospective study.
Zhuang J, Zhang N, Chen Y, Jiang Y, Chen X, Chen W, Chen C
Sci Rep 2024 Jan 27;14(1):2271. doi: 10.1038/s41598-024-52831-9. PMID: 38280885Free PMC Article
Cytogenetics in the management of multiple Myeloma: The guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Daudignon A, Cuccuini W, Bracquemart C, Godon C, Quilichini B, Penther D
Curr Res Transl Med 2023 Oct-Dec;71(4):103427. Epub 2023 Oct 24 doi: 10.1016/j.retram.2023.103427. PMID: 38035476
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article

Recent clinical studies

Etiology

Outcomes of Autologous Stem Cell Transplantation in Patients with Ultra-High-Risk Multiple Myeloma.
Pasvolsky O, Ghanem S, Milton DR, Masood A, Tanner MR, Bashir Q, Srour S, Saini N, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2023 Dec;29(12):757-762. Epub 2023 Sep 4 doi: 10.1016/j.jtct.2023.08.031. PMID: 37673125
The prognostic role of 1q21 gain/amplification in newly diagnosed multiple myeloma: The faster, the worse.
Wang Y, Xu J, Xu B, Li P, Yang Y, Wang W, Xu T, Maihemaiti A, Lan T, Wang P, Ren L, Zhou C, Aihemaiti X, Liu P
Cancer 2023 Apr 1;129(7):1005-1016. Epub 2023 Jan 27 doi: 10.1002/cncr.34641. PMID: 36704927
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Prognostic Value of 1q21 Gain in Multiple Myeloma.
Chen D, Zhou D, Xu J, Zhou R, Ouyang J, Chen B
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e159-e164. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.002. PMID: 30685183

Diagnosis

Outcomes of Autologous Stem Cell Transplantation in Patients with Ultra-High-Risk Multiple Myeloma.
Pasvolsky O, Ghanem S, Milton DR, Masood A, Tanner MR, Bashir Q, Srour S, Saini N, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2023 Dec;29(12):757-762. Epub 2023 Sep 4 doi: 10.1016/j.jtct.2023.08.031. PMID: 37673125
Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
The prognostic role of 1q21 gain/amplification in newly diagnosed multiple myeloma: The faster, the worse.
Wang Y, Xu J, Xu B, Li P, Yang Y, Wang W, Xu T, Maihemaiti A, Lan T, Wang P, Ren L, Zhou C, Aihemaiti X, Liu P
Cancer 2023 Apr 1;129(7):1005-1016. Epub 2023 Jan 27 doi: 10.1002/cncr.34641. PMID: 36704927
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Therapy

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Outcomes of Autologous Stem Cell Transplantation in Patients with Ultra-High-Risk Multiple Myeloma.
Pasvolsky O, Ghanem S, Milton DR, Masood A, Tanner MR, Bashir Q, Srour S, Saini N, Lin P, Ramdial J, Nieto Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Weber DM, Orlowski RZ, Shpall EJ, Champlin RE, Qazilbash MH
Transplant Cell Ther 2023 Dec;29(12):757-762. Epub 2023 Sep 4 doi: 10.1016/j.jtct.2023.08.031. PMID: 37673125
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Filanesib plus bortezomib and dexamethasone in relapsed/refractory t(11;14) and 1q21 gain multiple myeloma.
Pan D, Kaufman JL, Htut M, Agrawal M, Mazumder A, Cornell RF, Zonder JA, Fay JW, Modiano MR, Moshier EL, Rush SA, Tunquist BJ, Chari A
Cancer Med 2022 Jan;11(2):358-370. Epub 2021 Dec 17 doi: 10.1002/cam4.4451. PMID: 34921527Free PMC Article
Chromosomal 1q21 abnormalities in multiple myeloma: a review of translational, clinical research, and therapeutic strategies.
Bisht K, Walker B, Kumar SK, Spicka I, Moreau P, Martin T, Costa LJ, Richter J, Fukao T, Macé S, van de Velde H
Expert Rev Hematol 2021 Dec;14(12):1099-1114. Epub 2021 Oct 8 doi: 10.1080/17474086.2021.1983427. PMID: 34551651

Prognosis

Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
The prognostic role of 1q21 gain/amplification in newly diagnosed multiple myeloma: The faster, the worse.
Wang Y, Xu J, Xu B, Li P, Yang Y, Wang W, Xu T, Maihemaiti A, Lan T, Wang P, Ren L, Zhou C, Aihemaiti X, Liu P
Cancer 2023 Apr 1;129(7):1005-1016. Epub 2023 Jan 27 doi: 10.1002/cncr.34641. PMID: 36704927
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Prognostic Value of 1q21 Gain in Multiple Myeloma.
Chen D, Zhou D, Xu J, Zhou R, Ouyang J, Chen B
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e159-e164. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.002. PMID: 30685183

Clinical prediction guides

Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma.
Mohan M, Gong Z, Ashby TC, Al Hadidi S, Thanendrarajan S, Schinke C, Alapat D, Shaughnessy JD Jr, Zhan F, van Rhee F, Sawyer JR, Tian E, Zangari M
Cancer 2023 Aug 15;129(16):2491-2498. Epub 2023 Jun 6 doi: 10.1002/cncr.34895. PMID: 37282609
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
The combination of C-Myc rearrangement and 1q21 gain is associated with poor prognosis in multiple myeloma.
Jin Y, Yu X, Du J, Li H, Tang W, Jia C, Zan Y, Chen M, Zhang Y, Yu M, Rong W, Zhou D, Zhuang J
Ann Hematol 2021 May;100(5):1251-1260. Epub 2021 Mar 8 doi: 10.1007/s00277-021-04475-2. PMID: 33686491
Clinical Characteristics and Prognosis of MAF Deletion in Chinese Patients With Multiple Myeloma.
Wang Y, Li Q, Xing S, Zhang H, Li D
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e545-e550. Epub 2019 May 29 doi: 10.1016/j.clml.2019.05.016. PMID: 31262667

Recent systematic reviews

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article

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