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Growth arrest lines

MedGen UID:
1386476
Concept ID:
C1399128
Finding
Synonyms: Growth resumption lines; Harris lines
 
HPO: HP:0031164

Definition

Growth arrest lines are alternating transverse rings of sclerosis at the metaphysis of a long bone. [from HPO]

Term Hierarchy

Conditions with this feature

Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency
MedGen UID:
354935
Concept ID:
C1863236
Disease or Syndrome
Adenosine deaminase (ADA) deficiency is a systemic purine metabolic disorder that primarily affects lymphocyte development, viability, and function. The clinical phenotypic spectrum includes: Severe combined immunodeficiency disease (SCID), often diagnosed by age six months and usually by age 12 months; Less severe "delayed" onset combined immune deficiency (CID), usually diagnosed between age one and ten years; "Late/adult onset" CID, diagnosed in the second to fourth decades; Benign "partial ADA deficiency" (very low or absent ADA activity in erythrocytes but greater ADA activity in nucleated cells), which is compatible with normal immune function. Infants with typical early-onset ADA-deficient SCID have failure to thrive and opportunistic infections associated with marked depletion of T, B, and NK lymphocytes, and an absence of both humoral and cellular immune function. If immune function is not restored, children with ADA-deficient SCID rarely survive beyond age one to two years. Infections in delayed- and late-onset types (commonly, recurrent otitis, sinusitis, and upper respiratory) may initially be less severe than those in individuals with ADA-deficient SCID; however, by the time of diagnosis these individuals often have chronic pulmonary insufficiency and may have autoimmune phenomena (cytopenias, anti-thyroid antibodies), allergies, and elevated serum concentration of IgE. The longer the disorder goes unrecognized, the more immune function deteriorates and the more likely are chronic sequelae of recurrent infection.

Professional guidelines

PubMed

Liu S, Xie SM, Liu W, Gagea M, Hanker AB, Nguyen N, Singareeka Raghavendra A, Yang-Kolodji G, Chu F, Neelapu SS, Marchese A, Hanash S, Zimmermann J, Arteaga CL, Tripathy D
Breast Cancer Res 2023 Jun 6;25(1):62. doi: 10.1186/s13058-023-01665-w. PMID: 37280713Free PMC Article
Rejhová A, Opattová A, Čumová A, Slíva D, Vodička P
Eur J Med Chem 2018 Jan 20;144:582-594. Epub 2017 Dec 16 doi: 10.1016/j.ejmech.2017.12.039. PMID: 29289883
Batty M, Pugh R, Rathinam I, Simmonds J, Walker E, Forbes A, Anoopkumar-Dukie S, McDermott CM, Spencer B, Christie D, Chess-Williams R
Int J Mol Sci 2016 Aug 16;17(8) doi: 10.3390/ijms17081339. PMID: 27537875Free PMC Article

Recent clinical studies

Etiology

Zapala MA, Tsai A, Kleinman PK
Pediatr Radiol 2016 Aug;46(9):1275-81. Epub 2016 May 5 doi: 10.1007/s00247-016-3621-z. PMID: 27147078
Al Muderis M, Azzopardi T, Cundy P
J Bone Joint Surg Am 2007 Jul;89(7):1511-6. doi: 10.2106/JBJS.F.00726. PMID: 17606790
Cool WP, Carter SR, Grimer RJ, Tillman RM, Walker PS
J Bone Joint Surg Br 1997 Nov;79(6):938-42. doi: 10.1302/0301-620x.79b6.7868. PMID: 9393907
Bar-On E, Beckwith JB, Odom LF, Eilert RE
J Pediatr Orthop 1993 Mar-Apr;13(2):220-4. PMID: 8459015
Boyages SC, Halpern JP, Maberly GF, Eastman CJ, Morris J, Collins J, Jupp JJ, Jin CE, Wang ZH, You CY
J Clin Endocrinol Metab 1988 Dec;67(6):1262-71. doi: 10.1210/jcem-67-6-1262. PMID: 3056969

Diagnosis

Brian JM, Choi DH, Moore MM
Semin Musculoskelet Radiol 2018 Feb;22(1):95-103. Epub 2018 Feb 6 doi: 10.1055/s-0037-1608002. PMID: 29409076
Zapala MA, Tsai A, Kleinman PK
Pediatr Radiol 2016 Aug;46(9):1275-81. Epub 2016 May 5 doi: 10.1007/s00247-016-3621-z. PMID: 27147078
Singh D, Ferrerro A
Foot Ankle Surg 2014 Mar;20(1):e7-e10. Epub 2013 Nov 13 doi: 10.1016/j.fas.2013.10.002. PMID: 24480511
Khadilkar VV, Frazer FL, Skuse DH, Stanhope R
Arch Dis Child 1998 Sep;79(3):260-2. doi: 10.1136/adc.79.3.260. PMID: 9875024Free PMC Article
Cool WP, Carter SR, Grimer RJ, Tillman RM, Walker PS
J Bone Joint Surg Br 1997 Nov;79(6):938-42. doi: 10.1302/0301-620x.79b6.7868. PMID: 9393907

Therapy

Hong IK, Suh JS, Lee YA, Kim DY
Clin Nucl Med 2010 Sep;35(9):740-2. doi: 10.1097/RLU.0b013e3181ea3448. PMID: 20706059
Meister B, Gassner I, Streif W, Dengg K, Fink FM
Med Pediatr Oncol 1994;23(6):493-6. doi: 10.1002/mpo.2950230608. PMID: 7935176
Bar-On E, Beckwith JB, Odom LF, Eilert RE
J Pediatr Orthop 1993 Mar-Apr;13(2):220-4. PMID: 8459015
Schwartz AM, Leonidas JC
Skeletal Radiol 1984;11(1):13-6. doi: 10.1007/BF00361126. PMID: 6424236

Prognosis

Cool WP, Carter SR, Grimer RJ, Tillman RM, Walker PS
J Bone Joint Surg Br 1997 Nov;79(6):938-42. doi: 10.1302/0301-620x.79b6.7868. PMID: 9393907
Meister B, Gassner I, Streif W, Dengg K, Fink FM
Med Pediatr Oncol 1994;23(6):493-6. doi: 10.1002/mpo.2950230608. PMID: 7935176

Clinical prediction guides

Larson CM, Heikes CS, Ellingson CI, Wulf CA, Giveans MR, Stone RM, Bedi A
Arthroscopy 2016 May;32(5):860-7. Epub 2016 Mar 18 doi: 10.1016/j.arthro.2015.10.014. PMID: 26996346
Al Muderis M, Azzopardi T, Cundy P
J Bone Joint Surg Am 2007 Jul;89(7):1511-6. doi: 10.2106/JBJS.F.00726. PMID: 17606790
Boyages SC, Halpern JP, Maberly GF, Eastman CJ, Morris J, Collins J, Jupp JJ, Jin CE, Wang ZH, You CY
J Clin Endocrinol Metab 1988 Dec;67(6):1262-71. doi: 10.1210/jcem-67-6-1262. PMID: 3056969

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