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Abnormal factor VIII activity

MedGen UID:
1387304
Concept ID:
C4476889
Finding
HPO: HP:0030976

Definition

A deviation from the normal activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X. [from HPO]

Professional guidelines

PubMed

Seidi Zadeh O, Ahmadinejad M, Amoohossein B, Homayoun S
Blood Coagul Fibrinolysis 2020 Sep;31(6):382-386. doi: 10.1097/MBC.0000000000000932. PMID: 32815913
Lassila R
Thromb Res 2019 Sep;181 Suppl 1:S60-S61. doi: 10.1016/S0049-3848(19)30369-X. PMID: 31477231
Klamroth R
Hamostaseologie 2017 Aug 8;37(3):216-218. Epub 2016 Nov 25 doi: 10.5482/HAMO-16-07-0028. PMID: 27885373

Recent clinical studies

Etiology

Comerford C, Glavey S, Quinn J, O'Sullivan JM
J Thromb Haemost 2022 Aug;20(8):1766-1777. Epub 2022 Jun 23 doi: 10.1111/jth.15773. PMID: 35644028Free PMC Article
Calderon-Lopez MT, Garcia-Leon N, Gomez-Arevalillo S, Martin-Serrano P, Matilla-Garcia A
Blood Coagul Fibrinolysis 2021 Jan 1;32(1):44-49. doi: 10.1097/MBC.0000000000000996. PMID: 33417336
Wolberg AS, Aleman MM, Leiderman K, Machlus KR
Anesth Analg 2012 Feb;114(2):275-85. Epub 2011 Nov 21 doi: 10.1213/ANE.0b013e31823a088c. PMID: 22104070Free PMC Article
Stein PD, Goldman J
Clin Chest Med 2009 Sep;30(3):489-93, viii. doi: 10.1016/j.ccm.2009.05.006. PMID: 19700047
Kessler L, Wiesel ML, Attali P, Mossard JM, Cazenave JP, Pinget M
Diabetes Metab 1998 Sep;24(4):327-36. PMID: 9805643

Diagnosis

Ichinose A, Osaki T, Souri M, Favaloro EJ
Semin Thromb Hemost 2022 Nov;48(8):911-925. Epub 2022 Jul 8 doi: 10.1055/s-0042-1749088. PMID: 35803264
Federici AB
Int J Lab Hematol 2016 May;38 Suppl 1:41-9. doi: 10.1111/ijlh.12540. PMID: 27426859
Margetic S
Clin Chem Lab Med 2010 Dec;48 Suppl 1:S27-39. Epub 2010 Nov 5 doi: 10.1515/CCLM.2010.362. PMID: 21054193
Triplett DA
Mayo Clin Proc 1991 Aug;66(8):832-40. doi: 10.1016/s0025-6196(12)61202-6. PMID: 1907342
Rodeghiero F, Castaman G
Ric Clin Lab 1990 Apr-Jun;20(2):143-53. doi: 10.1007/BF02877561. PMID: 2196663

Therapy

Nogami K, Shima M
Br J Haematol 2023 Jan;200(1):23-34. Epub 2022 Jul 23 doi: 10.1111/bjh.18379. PMID: 35869698
Ichinose A, Osaki T, Souri M, Favaloro EJ
Semin Thromb Hemost 2022 Nov;48(8):911-925. Epub 2022 Jul 8 doi: 10.1055/s-0042-1749088. PMID: 35803264
Comerford C, Glavey S, Quinn J, O'Sullivan JM
J Thromb Haemost 2022 Aug;20(8):1766-1777. Epub 2022 Jun 23 doi: 10.1111/jth.15773. PMID: 35644028Free PMC Article
Calderon-Lopez MT, Garcia-Leon N, Gomez-Arevalillo S, Martin-Serrano P, Matilla-Garcia A
Blood Coagul Fibrinolysis 2021 Jan 1;32(1):44-49. doi: 10.1097/MBC.0000000000000996. PMID: 33417336
Mitra D, Fisher DE
Hematol Oncol Clin North Am 2009 Jun;23(3):447-65, viii. doi: 10.1016/j.hoc.2009.03.003. PMID: 19464596

Prognosis

Taves S, Sun J, Livingston EW, Chen X, Amiaud J, Brion R, Hannah WB, Bateman TA, Heymann D, Monahan PE
Sci Rep 2019 Oct 8;9(1):14428. doi: 10.1038/s41598-019-50787-9. PMID: 31594977Free PMC Article
Matsuda Y, Hagio M, Ishiwata T
World J Gastroenterol 2013 Jan 7;19(1):42-8. doi: 10.3748/wjg.v19.i1.42. PMID: 23326161Free PMC Article
Wolberg AS, Aleman MM, Leiderman K, Machlus KR
Anesth Analg 2012 Feb;114(2):275-85. Epub 2011 Nov 21 doi: 10.1213/ANE.0b013e31823a088c. PMID: 22104070Free PMC Article
Kessler L, Wiesel ML, Attali P, Mossard JM, Cazenave JP, Pinget M
Diabetes Metab 1998 Sep;24(4):327-36. PMID: 9805643
Rodeghiero F, Castaman G
Ric Clin Lab 1990 Apr-Jun;20(2):143-53. doi: 10.1007/BF02877561. PMID: 2196663

Clinical prediction guides

Nogami K, Shima M
Br J Haematol 2023 Jan;200(1):23-34. Epub 2022 Jul 23 doi: 10.1111/bjh.18379. PMID: 35869698
Ichinose A, Osaki T, Souri M, Favaloro EJ
Semin Thromb Hemost 2022 Nov;48(8):911-925. Epub 2022 Jul 8 doi: 10.1055/s-0042-1749088. PMID: 35803264
Wolberg AS, Aleman MM, Leiderman K, Machlus KR
Anesth Analg 2012 Feb;114(2):275-85. Epub 2011 Nov 21 doi: 10.1213/ANE.0b013e31823a088c. PMID: 22104070Free PMC Article
Jacquemin M, De Maeyer M, D'Oiron R, Lavend'Homme R, Peerlinck K, Saint-Remy JM
J Thromb Haemost 2003 Mar;1(3):456-63. doi: 10.1046/j.1538-7836.2003.00088.x. PMID: 12871450
Kessler L, Wiesel ML, Attali P, Mossard JM, Cazenave JP, Pinget M
Diabetes Metab 1998 Sep;24(4):327-36. PMID: 9805643

Recent systematic reviews

Lee A, Arasaratnam M, Chan DLH, Khasraw M, Howell VM, Wheeler H
Cochrane Database Syst Rev 2020 May 12;5(5):CD013238. doi: 10.1002/14651858.CD013238.pub2. PMID: 32395825Free PMC Article
Harmsen MJ, Wong CFC, Mijatovic V, Griffioen AW, Groenman F, Hehenkamp WJK, Huirne JAF
Hum Reprod Update 2019 Sep 11;25(5):647-671. doi: 10.1093/humupd/dmz024. PMID: 31504506Free PMC Article
Loures CMG, Duarte RCF, Silva MVF, Cicarini WB, de Souza LC, Caramelli P, Borges KBG, Carvalho MDG
Semin Thromb Hemost 2019 Jul;45(5):514-522. Epub 2019 May 16 doi: 10.1055/s-0039-1688444. PMID: 31096308

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