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Abnormal serum bile acid concentration

MedGen UID:
1387363
•Concept ID:
C4477099
•
Finding
HPO: HP:0030984

Definition

A deviation from the normal concentration of serum bile acid concentration. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal serum bile acid concentration

Professional guidelines

PubMed

Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action.
Ovadia C, Lövgren-Sandblom A, Edwards LA, Langedijk J, Geenes V, Chambers J, Cheng F, Clarke L, Begum S, Noori M, Pusey C, Padmagirison R, Agarwal S, Peerless J, Cheesman K, Heneghan M, Oude Elferink R, Patel VC, Marschall HU, Williamson C
J Clin Apher 2018 Dec;33(6):638-644. Epub 2018 Oct 15 doi: 10.1002/jca.21654. PMID: 30321466
Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis.
Duell PB, Salen G, Eichler FS, DeBarber AE, Connor SL, Casaday L, Jayadev S, Kisanuki Y, Lekprasert P, Malloy MJ, Ramdhani RA, Ziajka PE, Quinn JF, Su KG, Geller AS, Diffenderfer MR, Schaefer EJ
J Clin Lipidol 2018 Sep-Oct;12(5):1169-1178. Epub 2018 Jun 22 doi: 10.1016/j.jacl.2018.06.008. PMID: 30017468
Rationale and management of hyperlipidemia of the nephrotic syndrome.
Grundy SM, Vega GL
Am J Med 1989 Nov;87(5N):3N-11N. PMID: 2486542

Recent clinical studies

Etiology

Altered serum bile acid composition is associated with cardiac dysfunction in cirrhosis.
Wiese S, Danielsen KV, Busk T, Hove JD, Ytting H, Hansen SH, Andersen KK, Voiosu A, Møller S, Bendtsen F
Aliment Pharmacol Ther 2023 Aug;58(4):453-462. Epub 2023 Apr 26 doi: 10.1111/apt.17533. PMID: 37098730
Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study.
Kasai Y, Kessoku T, Tanaka K, Yamamoto A, Takahashi K, Kobayashi T, Iwaki M, Ozaki A, Nogami A, Honda Y, Ogawa Y, Kato S, Imajo K, Higurashi T, Hosono K, Yoneda M, Usuda H, Wada K, Kawanaka M, Kawaguchi T, Torimura T, Kage M, Hyogo H, Takahashi H, Eguchi Y, Aishima S, Kobayashi N, Sumida Y, Honda A, Oyamada S, Shinoda S, Saito S, Nakajima A
Clin Transl Gastroenterol 2022 Jul 1;13(7):e00503. Epub 2022 May 26 doi: 10.14309/ctg.0000000000000503. PMID: 35616321Free PMC Article
Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O'Brien R, Hak E, Baak BN, Pfeiffer R, Baloni P, Mohmoudiandehkordi S, Nho K, Kaddurah-Daouk R, Bennett DA, Gadalla SM, Thambisetty M
PLoS Med 2021 May;18(5):e1003615. Epub 2021 May 27 doi: 10.1371/journal.pmed.1003615. PMID: 34043628Free PMC Article
Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations.
Vasavan T, Deepak S, Jayawardane IA, Lucchini M, Martin C, Geenes V, Yang J, Lövgren-Sandblom A, Seed PT, Chambers J, Stone S, Kurlak L, Dixon PH, Marschall HU, Gorelik J, Chappell L, Loughna P, Thornton J, Pipkin FB, Hayes-Gill B, Fifer WP, Williamson C
J Hepatol 2021 May;74(5):1087-1096. Epub 2020 Dec 1 doi: 10.1016/j.jhep.2020.11.038. PMID: 33276032Free PMC Article
METABOLIC DYSBIOSIS OF THE GUT MICROBIOTA AND ITS BIOMARKERS.
Sitkin SI, Tkachenko EI, Vakhitov TY
Eksp Klin Gastroenterol 2016 Jul;12(12):6-29. PMID: 29889418

Diagnosis

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O'Brien R, Hak E, Baak BN, Pfeiffer R, Baloni P, Mohmoudiandehkordi S, Nho K, Kaddurah-Daouk R, Bennett DA, Gadalla SM, Thambisetty M
PLoS Med 2021 May;18(5):e1003615. Epub 2021 May 27 doi: 10.1371/journal.pmed.1003615. PMID: 34043628Free PMC Article
Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations.
Vasavan T, Deepak S, Jayawardane IA, Lucchini M, Martin C, Geenes V, Yang J, Lövgren-Sandblom A, Seed PT, Chambers J, Stone S, Kurlak L, Dixon PH, Marschall HU, Gorelik J, Chappell L, Loughna P, Thornton J, Pipkin FB, Hayes-Gill B, Fifer WP, Williamson C
J Hepatol 2021 May;74(5):1087-1096. Epub 2020 Dec 1 doi: 10.1016/j.jhep.2020.11.038. PMID: 33276032Free PMC Article
Primary biliary cirrhosis.
Talwalkar JA, Lindor KD
Lancet 2003 Jul 5;362(9377):53-61. doi: 10.1016/S0140-6736(03)13808-1. PMID: 12853201
Role of bile acid measurement in pregnancy.
Walker IA, Nelson-Piercy C, Williamson C
Ann Clin Biochem 2002 Mar;39(Pt 2):105-13. doi: 10.1258/0004563021901856. PMID: 11928758
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400

Therapy

Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study.
Kasai Y, Kessoku T, Tanaka K, Yamamoto A, Takahashi K, Kobayashi T, Iwaki M, Ozaki A, Nogami A, Honda Y, Ogawa Y, Kato S, Imajo K, Higurashi T, Hosono K, Yoneda M, Usuda H, Wada K, Kawanaka M, Kawaguchi T, Torimura T, Kage M, Hyogo H, Takahashi H, Eguchi Y, Aishima S, Kobayashi N, Sumida Y, Honda A, Oyamada S, Shinoda S, Saito S, Nakajima A
Clin Transl Gastroenterol 2022 Jul 1;13(7):e00503. Epub 2022 May 26 doi: 10.14309/ctg.0000000000000503. PMID: 35616321Free PMC Article
Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations.
Vasavan T, Deepak S, Jayawardane IA, Lucchini M, Martin C, Geenes V, Yang J, Lövgren-Sandblom A, Seed PT, Chambers J, Stone S, Kurlak L, Dixon PH, Marschall HU, Gorelik J, Chappell L, Loughna P, Thornton J, Pipkin FB, Hayes-Gill B, Fifer WP, Williamson C
J Hepatol 2021 May;74(5):1087-1096. Epub 2020 Dec 1 doi: 10.1016/j.jhep.2020.11.038. PMID: 33276032Free PMC Article
Bile Acid Synthesis Disorders in Arabs: A 10-year Screening Study.
Al-Hussaini AA, Setchell KDR, AlSaleem B, Heubi JE, Lone K, Davit-Spraul A, Jacquemin E
J Pediatr Gastroenterol Nutr 2017 Dec;65(6):613-620. doi: 10.1097/MPG.0000000000001734. PMID: 28902093
Medium-chain fatty acids reduce serum cholesterol by regulating the metabolism of bile acid in C57BL/6J mice.
Liu Y, Zhang Y, Zhang X, Xu Q, Yang X, Xue C
Food Funct 2017 Jan 25;8(1):291-298. doi: 10.1039/c6fo01207h. PMID: 28009872
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Prognosis

Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia.
Nyholm I, Hukkinen M, Pihlajoki M, Davidson JR, Tyraskis A, Lohi J, Heikkilä P, Hänninen S, Andersson N, Eloranta K, Carpén O, Heikinheimo M, Davenport M, Pakarinen MP
Hepatology 2023 Apr 1;77(4):1263-1273. Epub 2023 Jan 3 doi: 10.1097/HEP.0000000000000048. PMID: 36692476Free PMC Article
NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis.
Yang F, Xu W, Wu L, Yang L, Zhu S, Wang L, Wu W, Zhang Y, Chong Y, Peng L
Front Endocrinol (Lausanne) 2022;13:898750. Epub 2022 Jul 22 doi: 10.3389/fendo.2022.898750. PMID: 35937832Free PMC Article
Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O'Brien R, Hak E, Baak BN, Pfeiffer R, Baloni P, Mohmoudiandehkordi S, Nho K, Kaddurah-Daouk R, Bennett DA, Gadalla SM, Thambisetty M
PLoS Med 2021 May;18(5):e1003615. Epub 2021 May 27 doi: 10.1371/journal.pmed.1003615. PMID: 34043628Free PMC Article
Primary biliary cirrhosis.
Talwalkar JA, Lindor KD
Lancet 2003 Jul 5;362(9377):53-61. doi: 10.1016/S0140-6736(03)13808-1. PMID: 12853201
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400

Clinical prediction guides

Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study.
Kasai Y, Kessoku T, Tanaka K, Yamamoto A, Takahashi K, Kobayashi T, Iwaki M, Ozaki A, Nogami A, Honda Y, Ogawa Y, Kato S, Imajo K, Higurashi T, Hosono K, Yoneda M, Usuda H, Wada K, Kawanaka M, Kawaguchi T, Torimura T, Kage M, Hyogo H, Takahashi H, Eguchi Y, Aishima S, Kobayashi N, Sumida Y, Honda A, Oyamada S, Shinoda S, Saito S, Nakajima A
Clin Transl Gastroenterol 2022 Jul 1;13(7):e00503. Epub 2022 May 26 doi: 10.14309/ctg.0000000000000503. PMID: 35616321Free PMC Article
Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O'Brien R, Hak E, Baak BN, Pfeiffer R, Baloni P, Mohmoudiandehkordi S, Nho K, Kaddurah-Daouk R, Bennett DA, Gadalla SM, Thambisetty M
PLoS Med 2021 May;18(5):e1003615. Epub 2021 May 27 doi: 10.1371/journal.pmed.1003615. PMID: 34043628Free PMC Article
Enzymatic methods may underestimate the total serum bile acid concentration.
Žížalová K, Vecka M, Vítek L, Leníček M
PLoS One 2020;15(7):e0236372. Epub 2020 Jul 24 doi: 10.1371/journal.pone.0236372. PMID: 32706797Free PMC Article
Primary biliary cirrhosis.
Talwalkar JA, Lindor KD
Lancet 2003 Jul 5;362(9377):53-61. doi: 10.1016/S0140-6736(03)13808-1. PMID: 12853201
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

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