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Nutritional Calcium Deficient Rickets

MedGen UID:
1388842
•Concept ID:
C4330843
•
Disease or Syndrome

Definition

Nutritional rickets due to dietary deficiency of calcium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNutritional Calcium Deficient Rickets

Professional guidelines

PubMed

Evidence-Based Recommendations for an Optimal Prenatal Supplement for Women in the U.S., Part Two: Minerals.
Adams JB, Sorenson JC, Pollard EL, Kirby JK, Audhya T
Nutrients 2021 May 28;13(6) doi: 10.3390/nu13061849. PMID: 34071548Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Recent clinical studies

Etiology

Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children.
Mansur JL, Oliveri B, Giacoia E, Fusaro D, Costanzo PR
Nutrients 2022 May 1;14(9) doi: 10.3390/nu14091900. PMID: 35565867Free PMC Article
Vitamin D in Preterm and Full-Term Infants.
Abrams SA
Ann Nutr Metab 2020;76 Suppl 2:6-14. Epub 2020 Nov 24 doi: 10.1159/000508421. PMID: 33232955
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J
Endocr Rev 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126. PMID: 30321335Free PMC Article
Rickets.
Carpenter TO, Shaw NJ, Portale AA, Ward LM, Abrams SA, Pettifor JM
Nat Rev Dis Primers 2017 Dec 21;3:17101. doi: 10.1038/nrdp.2017.101. PMID: 29265106
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Diagnosis

Rickets guidance: part I-diagnostic workup.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Sep;37(9):2013-2036. Epub 2021 Dec 15 doi: 10.1007/s00467-021-05328-w. PMID: 34910242Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Screening for Metabolic Bone Disease of prematurity.
Rayannavar A, Calabria AC
Semin Fetal Neonatal Med 2020 Feb;25(1):101086. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101086. PMID: 32081592
Rickets.
Carpenter TO, Shaw NJ, Portale AA, Ward LM, Abrams SA, Pettifor JM
Nat Rev Dis Primers 2017 Dec 21;3:17101. doi: 10.1038/nrdp.2017.101. PMID: 29265106
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Therapy

Refractory Rickets.
Chinoy A, Padidela R
Indian J Pediatr 2023 Jun;90(6):574-581. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04538-4. PMID: 37074534Free PMC Article
Vitamin D and Cardiovascular Disease: An Updated Narrative Review.
Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, März W, Pilz S
Int J Mol Sci 2021 Mar 12;22(6) doi: 10.3390/ijms22062896. PMID: 33809311Free PMC Article
Vitamin D in Toddlers, Preschool Children, and Adolescents.
Taylor SN
Ann Nutr Metab 2020;76 Suppl 2:30-41. Epub 2020 Nov 24 doi: 10.1159/000505635. PMID: 33232959
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J
Endocr Rev 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126. PMID: 30321335Free PMC Article
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Prognosis

Nutritional rickets under 16 years: UK surveillance results.
Julies P, Lynn RM, Pall K, Leoni M, Calder A, Mughal Z, Shaw N, McDonnell C, McDevitt H, Blair M
Arch Dis Child 2020 Jun;105(6):587-592. Epub 2020 Jan 16 doi: 10.1136/archdischild-2019-317934. PMID: 31949032
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J
Endocr Rev 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126. PMID: 30321335Free PMC Article
Nutritional rickets: vitamin D, calcium, and the genetic make-up.
El Kholy M, Elsedfy H, Fernández-Cancio M, Hamza RT, Amr NH, Ahmed AY, Toaima NN, Audí L
Pediatr Res 2017 Feb;81(2):356-363. Epub 2016 Nov 3 doi: 10.1038/pr.2016.222. PMID: 27973470
Prevention and treatment of nutritional rickets.
Shaw NJ
J Steroid Biochem Mol Biol 2016 Nov;164:145-147. Epub 2015 Oct 19 doi: 10.1016/j.jsbmb.2015.10.014. PMID: 26493853
Rickets in Denmark.
Beck-Nielsen SS
Dan Med J 2012 Feb;59(2):B4384. PMID: 22293055

Clinical prediction guides

Influence of Vitamin D Supplementation on Growth, Body Composition, and Pubertal Development Among School-aged Children in an Area With a High Prevalence of Vitamin D Deficiency: A Randomized Clinical Trial.
Ganmaa D, Bromage S, Khudyakov P, Erdenenbaatar S, Delgererekh B, Martineau AR
JAMA Pediatr 2023 Jan 1;177(1):32-41. doi: 10.1001/jamapediatrics.2022.4581. PMID: 36441522Free PMC Article
Vitamin D and Cardiovascular Disease: An Updated Narrative Review.
Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, März W, Pilz S
Int J Mol Sci 2021 Mar 12;22(6) doi: 10.3390/ijms22062896. PMID: 33809311Free PMC Article
Vitamin D in Toddlers, Preschool Children, and Adolescents.
Taylor SN
Ann Nutr Metab 2020;76 Suppl 2:30-41. Epub 2020 Nov 24 doi: 10.1159/000505635. PMID: 33232959
Vitamin D, and Maternal and Child Health.
Moon RJ, Davies JH, Cooper C, Harvey NC
Calcif Tissue Int 2020 Jan;106(1):30-46. Epub 2019 May 14 doi: 10.1007/s00223-019-00560-x. PMID: 31089772Free PMC Article
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J
Endocr Rev 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126. PMID: 30321335Free PMC Article

Recent systematic reviews

Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials.
Wu F, Fuleihan GE, Cai G, Lamberg-Allardt C, Viljakainen HT, Rahme M, Grønborg IM, Andersen R, Khadilkar A, Zulf MM, Mølgaard C, Larnkjær A, Zhu K, Riley RD, Winzenberg T
Am J Clin Nutr 2023 Sep;118(3):498-506. Epub 2023 Aug 8 doi: 10.1016/j.ajcnut.2023.05.028. PMID: 37661104
Mineral bone disorders in chronic kidney disease.
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Nutritional rickets around the world: an update.
Creo AL, Thacher TD, Pettifor JM, Strand MA, Fischer PR
Paediatr Int Child Health 2017 May;37(2):84-98. Epub 2016 Dec 6 doi: 10.1080/20469047.2016.1248170. PMID: 27922335
Nutritional rickets around the world: causes and future directions.
Thacher TD, Fischer PR, Strand MA, Pettifor JM
Ann Trop Paediatr 2006 Mar;26(1):1-16. doi: 10.1179/146532806X90556. PMID: 16494699
A systematic review of nutritional rickets in Ethiopia: status and prospects.
Wondale Y, Shiferaw F, Lulseged S
Ethiop Med J 2005 Jul;43(3):203-10. PMID: 16370553

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