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Stage IV Hypopharyngeal Carcinoma AJCC v8

MedGen UID:
1389158
Concept ID:
C4331332
Neoplastic Process

Definition

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (Any T, N3, M0); (T4b, Any N, M0); IVC: (Any T, Any N, M1). T4a: Moderately advanced local disease. Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue. Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat. T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or smaller in greatest dimension. T2: Tumor invading more than one subsite of hypopharynx or an adjacent site, or measuring more than 2 cm but not more than 4 cm in greatest dimension without fixation of hemilarynx. T3: Tumor larger than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus. T4b: Very advanced local disease. Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures. N0: No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (-). N2: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). N3: Tumor with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.) [from NCI]

Recent clinical studies

Etiology

Ilangovan B, Venkatraman M, Balasundaram S
J Cancer Res Ther 2020 Apr-Jun;16(3):575-580. doi: 10.4103/jcrt.JCRT_589_19. PMID: 32719270

Diagnosis

Ilangovan B, Venkatraman M, Balasundaram S
J Cancer Res Ther 2020 Apr-Jun;16(3):575-580. doi: 10.4103/jcrt.JCRT_589_19. PMID: 32719270

Prognosis

Ilangovan B, Venkatraman M, Balasundaram S
J Cancer Res Ther 2020 Apr-Jun;16(3):575-580. doi: 10.4103/jcrt.JCRT_589_19. PMID: 32719270

Clinical prediction guides

Ilangovan B, Venkatraman M, Balasundaram S
J Cancer Res Ther 2020 Apr-Jun;16(3):575-580. doi: 10.4103/jcrt.JCRT_589_19. PMID: 32719270

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