U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDK6 Gene Amplification

MedGen UID:
1389369
•Concept ID:
C4329592
•
Cell or Molecular Dysfunction
Synonyms: CDK6 Amplification; Cyclin Dependent Kinase 6 Gene Amplification; Cyclin-Dependent Kinase 6 Gene Amplification; PLSTIRE Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the CDK6 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCDK6 Gene Amplification

Professional guidelines

PubMed

Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation.
Torres-Guzmán R, Ganado MP, Mur C, Marugan C, Baquero C, Yang Y, Zeng Y, Bian H, Du J, de Dios A, Puig O, Lallena MJ
Oncotarget 2022;13:864-875. Epub 2022 Jul 2 doi: 10.18632/oncotarget.28249. PMID: 35813283Free PMC Article
Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2'-deoxycytidine treatment induces a senescence-like state.
Timmermann S, Hinds PW, Münger K
Oncogene 1998 Dec 31;17(26):3445-53. doi: 10.1038/sj.onc.1202244. PMID: 10030668

Recent clinical studies

Etiology

Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I).
Macy ME, Mody R, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Williams PM, Patton DR, Coffey BD, Roy-Chowdhuri S, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
JCO Precis Oncol 2024 Sep;8:e2400418. doi: 10.1200/PO-24-00418. PMID: 39298716Free PMC Article
Prognostic significance of CDK6 amplification in esophageal squamous cell carcinoma.
Liu K, Lu H, Jiang D, Guan Y, Xu H, Sun Q, Jiang Q, Zheng J, Chen H, Zhang F, Luo R, Huang Y, Xu J, Hou Y
Cancer Treat Res Commun 2023;35:100698. Epub 2023 Mar 16 doi: 10.1016/j.ctarc.2023.100698. PMID: 37023643
Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation.
Torres-Guzmán R, Ganado MP, Mur C, Marugan C, Baquero C, Yang Y, Zeng Y, Bian H, Du J, de Dios A, Puig O, Lallena MJ
Oncotarget 2022;13:864-875. Epub 2022 Jul 2 doi: 10.18632/oncotarget.28249. PMID: 35813283Free PMC Article
Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions.
Sursal T, Ronecker JS, Dicpinigaitis AJ, Mohan AL, Tobias ME, Gandhi CD, Jhanwar-Uniyal M
Anticancer Res 2022 May;42(5):2225-2239. doi: 10.21873/anticanres.15703. PMID: 35489737
The Evolution of Tumors in Mice and Humans with Germline p53 Mutations.
Levine AJ, Chan CS, Dudgeon C, Puzio-Kuter A, Hainaut P
Cold Spring Harb Symp Quant Biol 2015;80:139-45. Epub 2015 Dec 7 doi: 10.1101/sqb.2015.80.027631. PMID: 26642854

Diagnosis

Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I).
Macy ME, Mody R, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Williams PM, Patton DR, Coffey BD, Roy-Chowdhuri S, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
JCO Precis Oncol 2024 Sep;8:e2400418. doi: 10.1200/PO-24-00418. PMID: 39298716Free PMC Article
MYB/MYBL1::QKI fusion-positive diffuse glioma.
Suh YY, Lee K, Shim YM, Phi JH, Park CK, Kim SK, Choi SH, Yun H, Park SH
J Neuropathol Exp Neurol 2023 Feb 21;82(3):250-260. doi: 10.1093/jnen/nlac123. PMID: 36592415Free PMC Article
Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer.
Basudan A, Priedigkeit N, Hartmaier RJ, Sokol ES, Bahreini A, Watters RJ, Boisen MM, Bhargava R, Weiss KR, Karsten MM, Denkert C, Blohmer JU, Leone JP, Hamilton RL, Brufsky AM, Elishaev E, Lucas PC, Lee AV, Oesterreich S
Mol Cancer Res 2019 Feb;17(2):457-468. Epub 2018 Oct 24 doi: 10.1158/1541-7786.MCR-18-0946. PMID: 30355675Free PMC Article
Gene amplification of CCNE1, CCND1, and CDK6 in gastric cancers detected by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.
Ooi A, Oyama T, Nakamura R, Tajiri R, Ikeda H, Fushida S, Dobashi Y
Hum Pathol 2017 Mar;61:58-67. Epub 2016 Nov 15 doi: 10.1016/j.humpath.2016.10.025. PMID: 27864121
Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence.
Yang C, Li Z, Bhatt T, Dickler M, Giri D, Scaltriti M, Baselga J, Rosen N, Chandarlapaty S
Oncogene 2017 Apr 20;36(16):2255-2264. Epub 2016 Oct 17 doi: 10.1038/onc.2016.379. PMID: 27748766Free PMC Article

Therapy

Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I).
Macy ME, Mody R, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Williams PM, Patton DR, Coffey BD, Roy-Chowdhuri S, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
JCO Precis Oncol 2024 Sep;8:e2400418. doi: 10.1200/PO-24-00418. PMID: 39298716Free PMC Article
The antitumor activity of osimertinib plus palbociclib in non-small cell lung cancer patient-derived xenograft (PDX)/2D/3D culture models harboring EGFR amplification and CDKN2A/2B homozygous deletions.
Fu JF, Hsu CL, Hsu PC
Neoplasia 2024 Nov;57:101039. Epub 2024 Aug 14 doi: 10.1016/j.neo.2024.101039. PMID: 39146623Free PMC Article
Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation.
Torres-Guzmán R, Ganado MP, Mur C, Marugan C, Baquero C, Yang Y, Zeng Y, Bian H, Du J, de Dios A, Puig O, Lallena MJ
Oncotarget 2022;13:864-875. Epub 2022 Jul 2 doi: 10.18632/oncotarget.28249. PMID: 35813283Free PMC Article
Co-occurrence CDK4/6 amplification serves as biomarkers of de novo EGFR TKI resistance in sensitizing EGFR mutation non-small cell lung cancer.
Sitthideatphaiboon P, Teerapakpinyo C, Korphaisarn K, Leelayuwatanakul N, Pornpatrananrak N, Poungvarin N, Chantranuwat P, Shuangshoti S, Aporntewan C, Chintanapakdee W, Sriuranpong V, Vinayanuwattikun C
Sci Rep 2022 Feb 9;12(1):2167. doi: 10.1038/s41598-022-06239-y. PMID: 35140316Free PMC Article
GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy.
Takahashi-Yanaga F, Sasaguri T
Cell Signal 2008 Apr;20(4):581-9. Epub 2007 Oct 23 doi: 10.1016/j.cellsig.2007.10.018. PMID: 18023328

Prognosis

Prognostic significance of CDK6 amplification in esophageal squamous cell carcinoma.
Liu K, Lu H, Jiang D, Guan Y, Xu H, Sun Q, Jiang Q, Zheng J, Chen H, Zhang F, Luo R, Huang Y, Xu J, Hou Y
Cancer Treat Res Commun 2023;35:100698. Epub 2023 Mar 16 doi: 10.1016/j.ctarc.2023.100698. PMID: 37023643
Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions.
Sursal T, Ronecker JS, Dicpinigaitis AJ, Mohan AL, Tobias ME, Gandhi CD, Jhanwar-Uniyal M
Anticancer Res 2022 May;42(5):2225-2239. doi: 10.21873/anticanres.15703. PMID: 35489737
Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer.
Ledet EM, Lilly MB, Sonpavde G, Lin E, Nussenzveig RH, Barata PC, Yandell M, Nagy RJ, Kiedrowski L, Agarwal N, Sartor O
Oncologist 2020 Apr;25(4):327-333. Epub 2019 Nov 11 doi: 10.1634/theoncologist.2019-0115. PMID: 32297439Free PMC Article
Gene amplification of CCNE1, CCND1, and CDK6 in gastric cancers detected by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.
Ooi A, Oyama T, Nakamura R, Tajiri R, Ikeda H, Fushida S, Dobashi Y
Hum Pathol 2017 Mar;61:58-67. Epub 2016 Nov 15 doi: 10.1016/j.humpath.2016.10.025. PMID: 27864121
LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma.
Baba Y, Watanabe M, Murata A, Shigaki H, Miyake K, Ishimoto T, Iwatsuki M, Iwagami S, Yoshida N, Oki E, Sakamaki K, Nakao M, Baba H
Clin Cancer Res 2014 Mar 1;20(5):1114-24. Epub 2014 Jan 14 doi: 10.1158/1078-0432.CCR-13-1645. PMID: 24423610

Clinical prediction guides

Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature.
Koelsche C, Benhamida JK, Kommoss FKF, Stichel D, Jones DTW, Pfister SM, Heilig CE, Fröhling S, Stenzinger A, Buslei R, Mentzel T, Baumhoer D, Ladanyi M, Antonescu CR, Flucke U, Gorp JV, Bode-Lesniewska B, Deimling AV, Mechtersheimer G
Mod Pathol 2021 Dec;34(12):2122-2129. Epub 2021 Jul 26 doi: 10.1038/s41379-021-00874-y. PMID: 34312479Free PMC Article
Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer.
Basudan A, Priedigkeit N, Hartmaier RJ, Sokol ES, Bahreini A, Watters RJ, Boisen MM, Bhargava R, Weiss KR, Karsten MM, Denkert C, Blohmer JU, Leone JP, Hamilton RL, Brufsky AM, Elishaev E, Lucas PC, Lee AV, Oesterreich S
Mol Cancer Res 2019 Feb;17(2):457-468. Epub 2018 Oct 24 doi: 10.1158/1541-7786.MCR-18-0946. PMID: 30355675Free PMC Article
HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs.
Li L, Liu M, Kang L, Li Y, Dai Z, Wang B, Liu S, Chen L, Tan Y, Wu G
Front Cell Infect Microbiol 2016;6:169. Epub 2016 Nov 30 doi: 10.3389/fcimb.2016.00169. PMID: 27965937Free PMC Article
LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma.
Baba Y, Watanabe M, Murata A, Shigaki H, Miyake K, Ishimoto T, Iwatsuki M, Iwagami S, Yoshida N, Oki E, Sakamaki K, Nakao M, Baba H
Clin Cancer Res 2014 Mar 1;20(5):1114-24. Epub 2014 Jan 14 doi: 10.1158/1078-0432.CCR-13-1645. PMID: 24423610
GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy.
Takahashi-Yanaga F, Sasaguri T
Cell Signal 2008 Apr;20(4):581-9. Epub 2007 Oct 23 doi: 10.1016/j.cellsig.2007.10.018. PMID: 18023328

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...