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Small Intestinal Myeloid Sarcoma

MedGen UID:
1389378
•Concept ID:
C4331297
•
Neoplastic Process
Synonym: Myeloid Sarcoma of the Small Intestine

Definition

An extramedullary myeloid tumor that arises from the small intestine. It often presents with abdominal pain and obstruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Myeloid Sarcoma

Professional guidelines

PubMed

Gastrointestinal stromal tumors: differential diagnosis.
Dow N, Giblen G, Sobin LH, Miettinen M
Semin Diagn Pathol 2006 May;23(2):111-9. doi: 10.1053/j.semdp.2006.09.002. PMID: 17193824

Recent clinical studies

Etiology

Isolated myeloid sarcoma of the gastrointestinal tract.
Antic D, Elezovic I, Bogdanovic A, Vukovic NS, Pavlovic A, Jovanovic MP, Jakovic L, Kraguljac N
Intern Med 2010;49(9):853-6. Epub 2010 Apr 30 doi: 10.2169/internalmedicine.49.2874. PMID: 20453407
Second cancers in patients with male breast cancer: a literature review.
Grenader T, Goldberg A, Shavit L
J Cancer Surviv 2008 Jun;2(2):73-8. Epub 2008 Apr 1 doi: 10.1007/s11764-008-0042-5. PMID: 18648975
Granulocytic sarcoma of bowel: CT findings.
Choi EK, Ha HK, Park SH, Lee SJ, Jung SE, Kim KW, Lee SS
Radiology 2007 Jun;243(3):752-9. Epub 2007 Apr 19 doi: 10.1148/radiol.2433060747. PMID: 17446522
Granulocytic sarcoma of the small intestine with CBFbeta/MYH11 fusion gene: report of an aleukaemic case and review of the literature.
Xavier SG, Fagundes EM, Hassan R, Bacchi C, Conchon M, Tabak DG, Spector N, Zalcberg IR
Leuk Res 2003 Nov;27(11):1063-6. doi: 10.1016/s0145-2126(03)00070-5. PMID: 12859999
Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature.
Yamauchi K, Yasuda M
Cancer 2002 Mar 15;94(6):1739-46. doi: 10.1002/cncr.10399. PMID: 11920536

Diagnosis

Small Bowel Bleeding Caused by Myeloid Sarcoma.
Nakanishi R, Henmi S, Marusawa H
Intern Med 2022 Jan 1;61(1):123-124. Epub 2021 Jul 3 doi: 10.2169/internalmedicine.7799-21. PMID: 34219112Free PMC Article
Gastrointestinal Myeloid Sarcoma.
Pasricha TS, Abraczinskas D
N Engl J Med 2020 Aug 27;383(9):858. doi: 10.1056/NEJMicm2001235. PMID: 32846064
A myeloid sarcoma involving the small intestine, kidneys, mesentery, and mesenteric lymph nodes: A case report and literature review.
Wang P, Li Q, Zhang L, Ji H, Zhang CZ, Wang B
Medicine (Baltimore) 2017 Oct;96(42):e7934. doi: 10.1097/MD.0000000000007934. PMID: 29049187Free PMC Article
Primary Myeloid Sarcoma of the Small Intestine: Case Report and Literature Review.
McCusker S, Trangucci J, Frederick W, Richi AA, Abunnaja S
Conn Med 2016 Jun-Jul;80(6):349-52. PMID: 27509642
Granulocytic sarcoma of the small intestine.
Kohl SK, Aoun P
Arch Pathol Lab Med 2006 Oct;130(10):1570-4. doi: 10.5858/2006-130-1570-GSOTSI. PMID: 17090205

Therapy

Primary Myeloid Sarcoma of the Small Intestine: Case Report and Literature Review.
McCusker S, Trangucci J, Frederick W, Richi AA, Abunnaja S
Conn Med 2016 Jun-Jul;80(6):349-52. PMID: 27509642
High-grade KIT-negative sarcoma of the small bowel in a patient with chronic myeloid leukemia receiving long-term tyrosine kinase inhibitors.
Martz J, Jain S, Vahdat LT, Qin L, Mosquera JM, Antonescu CR, Popa EC
J Clin Oncol 2013 Apr 10;31(11):e181-5. Epub 2013 Feb 25 doi: 10.1200/JCO.2012.42.7989. PMID: 23439757Free PMC Article
Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation.
Kitagawa Y, Sameshima Y, Shiozaki H, Ogawa S, Masuda A, Mori SI, Teramura M, Masuda M, Kameoka S, Motoji T
Int J Hematol 2008 May;87(4):410-413. doi: 10.1007/s12185-008-0067-6. PMID: 18365139
Eosinophilic gastroenteritis or eosinophilic chloroma?
Julia A, Nomdedeu JF
Acta Haematol 2004;112(3):164-6. doi: 10.1159/000079729. PMID: 15345900
Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature.
Yamauchi K, Yasuda M
Cancer 2002 Mar 15;94(6):1739-46. doi: 10.1002/cncr.10399. PMID: 11920536

Prognosis

Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition.
Nemésio RA, Costa B, Abrantes C, Leite JS
BMJ Case Rep 2018 May 30;2018 doi: 10.1136/bcr-2017-222718. PMID: 29848520Free PMC Article
Primary Myeloid Sarcoma of the Small Intestine: Case Report and Literature Review.
McCusker S, Trangucci J, Frederick W, Richi AA, Abunnaja S
Conn Med 2016 Jun-Jul;80(6):349-52. PMID: 27509642
Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation.
Kitagawa Y, Sameshima Y, Shiozaki H, Ogawa S, Masuda A, Mori SI, Teramura M, Masuda M, Kameoka S, Motoji T
Int J Hematol 2008 May;87(4):410-413. doi: 10.1007/s12185-008-0067-6. PMID: 18365139
Granulocytic sarcoma of the small intestine.
Kohl SK, Aoun P
Arch Pathol Lab Med 2006 Oct;130(10):1570-4. doi: 10.5858/2006-130-1570-GSOTSI. PMID: 17090205
Granulocytic sarcoma of the small bowel causing intestinal obstruction.
Wong SW, Lai CK, Lee KF, Lai PB
Hong Kong Med J 2005 Jun;11(3):204-6. PMID: 15951586

Clinical prediction guides

Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation.
Kitagawa Y, Sameshima Y, Shiozaki H, Ogawa S, Masuda A, Mori SI, Teramura M, Masuda M, Kameoka S, Motoji T
Int J Hematol 2008 May;87(4):410-413. doi: 10.1007/s12185-008-0067-6. PMID: 18365139
Eosinophilic gastroenteritis or eosinophilic chloroma?
Julia A, Nomdedeu JF
Acta Haematol 2004;112(3):164-6. doi: 10.1159/000079729. PMID: 15345900
Granulocytic sarcoma of the small intestine with CBFbeta/MYH11 fusion gene: report of an aleukaemic case and review of the literature.
Xavier SG, Fagundes EM, Hassan R, Bacchi C, Conchon M, Tabak DG, Spector N, Zalcberg IR
Leuk Res 2003 Nov;27(11):1063-6. doi: 10.1016/s0145-2126(03)00070-5. PMID: 12859999
Bacterial infection stimulating granulocytic sarcoma of the small bowel.
Kraemer BB, Foucar K, Osborne B, Butler JJ
Am J Clin Pathol 1981 Aug;76(2):227-31. doi: 10.1093/ajcp/76.2.227. PMID: 6943927

Recent systematic reviews

Second cancers in patients with male breast cancer: a literature review.
Grenader T, Goldberg A, Shavit L
J Cancer Surviv 2008 Jun;2(2):73-8. Epub 2008 Apr 1 doi: 10.1007/s11764-008-0042-5. PMID: 18648975

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