U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chemical and Drug Induced Liver Injury, Chronic

MedGen UID:
1389382
•Concept ID:
C4505492
•
Disease or Syndrome

Definition

Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChemical and Drug Induced Liver Injury, Chronic

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology
Am J Gastroenterol 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. PMID: 33929376
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.
Hepatol Int 2019 Jul;13(4):353-390. Epub 2019 Jun 6 doi: 10.1007/s12072-019-09946-3. PMID: 31172417Free PMC Article
The diagnosis and management of idiosyncratic drug-induced liver injury.
Hassan A, Fontana RJ
Liver Int 2019 Jan;39(1):31-41. Epub 2018 Aug 19 doi: 10.1111/liv.13931. PMID: 30003672

Recent clinical studies

Etiology

Ashwagandha-induced liver injury-A case series from India and literature review.
Philips CA, Valsan A, Theruvath AH, Ravindran R, Oommen TT, Rajesh S, Bishnu S, Augustine P; Liver Research Club India
Hepatol Commun 2023 Oct 1;7(10) Epub 2023 Sep 27 doi: 10.1097/HC9.0000000000000270. PMID: 37756041Free PMC Article
New Insights into Herb-Induced Liver Injury.
Ma ZT, Shi Z, Xiao XH, Wang JB
Antioxid Redox Signal 2023 Jun;38(16-18):1138-1149. Epub 2023 Mar 2 doi: 10.1089/ars.2022.0134. PMID: 36401515Free PMC Article
Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H
Hepatology 2022 Mar;75(3):646-660. Epub 2021 Dec 5 doi: 10.1002/hep.32152. PMID: 34510484Free PMC Article
Albendazole-Induced Liver Injury.
Piloiu C, Dumitrascu DL
Am J Ther 2021 Feb 3;28(3):e335-e340. doi: 10.1097/MJT.0000000000001341. PMID: 33590990
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J; United States Drug Induced Liver Injury Network
Gastroenterology 2015 Jun;148(7):1340-52.e7. Epub 2015 Mar 6 doi: 10.1053/j.gastro.2015.03.006. PMID: 25754159Free PMC Article

Diagnosis

Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics.
Uzun S, Zinner CP, Beenen AC, Alborelli I, Bartoszek EM, Yeung J, Calgua B, Reinscheid M, Bronsert P, Stalder AK, Haslbauer JD, Vosbeck J, Mazzucchelli L, Hoffmann T, Terracciano LM, Hutter G, Manz M, Panne I, Boettler T, Hofmann M, Bengsch B, Heim MH, Bernsmeier C, Jiang S, Tzankov A, Terziroli Beretta-Piccoli B, Matter MS
J Hepatol 2023 Sep;79(3):666-676. Epub 2023 Jun 7 doi: 10.1016/j.jhep.2023.05.020. PMID: 37290592Free PMC Article
New Insights into Herb-Induced Liver Injury.
Ma ZT, Shi Z, Xiao XH, Wang JB
Antioxid Redox Signal 2023 Jun;38(16-18):1138-1149. Epub 2023 Mar 2 doi: 10.1089/ars.2022.0134. PMID: 36401515Free PMC Article
Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism.
Xia J, Lv L, Liu B, Wang S, Zhang S, Wu Z, Yang L, Bian X, Wang Q, Wang K, Zhuge A, Li S, Yan R, Jiang H, Xu K, Li L
Microbiol Spectr 2022 Feb 23;10(1):e0159621. Epub 2022 Feb 2 doi: 10.1128/spectrum.01596-21. PMID: 35107323Free PMC Article
Acute liver failure.
Stravitz RT, Lee WM
Lancet 2019 Sep 7;394(10201):869-881. doi: 10.1016/S0140-6736(19)31894-X. PMID: 31498101Free PMC Article
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J; United States Drug Induced Liver Injury Network
Gastroenterology 2015 Jun;148(7):1340-52.e7. Epub 2015 Mar 6 doi: 10.1053/j.gastro.2015.03.006. PMID: 25754159Free PMC Article

Therapy

Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics.
Uzun S, Zinner CP, Beenen AC, Alborelli I, Bartoszek EM, Yeung J, Calgua B, Reinscheid M, Bronsert P, Stalder AK, Haslbauer JD, Vosbeck J, Mazzucchelli L, Hoffmann T, Terracciano LM, Hutter G, Manz M, Panne I, Boettler T, Hofmann M, Bengsch B, Heim MH, Bernsmeier C, Jiang S, Tzankov A, Terziroli Beretta-Piccoli B, Matter MS
J Hepatol 2023 Sep;79(3):666-676. Epub 2023 Jun 7 doi: 10.1016/j.jhep.2023.05.020. PMID: 37290592Free PMC Article
Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism.
Xia J, Lv L, Liu B, Wang S, Zhang S, Wu Z, Yang L, Bian X, Wang Q, Wang K, Zhuge A, Li S, Yan R, Jiang H, Xu K, Li L
Microbiol Spectr 2022 Feb 23;10(1):e0159621. Epub 2022 Feb 2 doi: 10.1128/spectrum.01596-21. PMID: 35107323Free PMC Article
Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H
Hepatology 2022 Mar;75(3):646-660. Epub 2021 Dec 5 doi: 10.1002/hep.32152. PMID: 34510484Free PMC Article
Albendazole-Induced Liver Injury.
Piloiu C, Dumitrascu DL
Am J Ther 2021 Feb 3;28(3):e335-e340. doi: 10.1097/MJT.0000000000001341. PMID: 33590990
Acute liver failure.
Stravitz RT, Lee WM
Lancet 2019 Sep 7;394(10201):869-881. doi: 10.1016/S0140-6736(19)31894-X. PMID: 31498101Free PMC Article

Prognosis

COVID-19 vaccine-induced liver injury.
Shroff H
Curr Opin Gastroenterol 2024 May 1;40(3):119-125. Epub 2024 Feb 14 doi: 10.1097/MOG.0000000000001012. PMID: 38353234
In Vitro Models for Studying Chronic Drug-Induced Liver Injury.
Donato MT, Gallego-Ferrer G, Tolosa L
Int J Mol Sci 2022 Sep 28;23(19) doi: 10.3390/ijms231911428. PMID: 36232728Free PMC Article
Diagnostic and prognostic assessment of suspected drug-induced liver injury in clinical practice.
Andrade RJ, Robles-Díaz M
Liver Int 2020 Jan;40(1):6-17. Epub 2019 Oct 14 doi: 10.1111/liv.14271. PMID: 31578817
Drug-induced chronic liver injury.
Dakhoul L, Ghabril M, Chalasani N
J Hepatol 2018 Jul;69(1):248-250. Epub 2018 Mar 26 doi: 10.1016/j.jhep.2018.01.001. PMID: 29598958
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J; United States Drug Induced Liver Injury Network
Gastroenterology 2015 Jun;148(7):1340-52.e7. Epub 2015 Mar 6 doi: 10.1053/j.gastro.2015.03.006. PMID: 25754159Free PMC Article

Clinical prediction guides

Dibutyl phthalate induces liver fibrosis via p38MAPK/NF-κB/NLRP3-mediated pyroptosis.
Huo S, Li B, Du J, Zhang X, Zhang J, Wang Q, Song M, Li Y
Sci Total Environ 2023 Nov 1;897:165500. Epub 2023 Jul 11 doi: 10.1016/j.scitotenv.2023.165500. PMID: 37442457
miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury.
Wan Y, Slevin E, Koyama S, Huang CK, Shetty AK, Li X, Harrison K, Li T, Zhou B, Lorenzo SR, Zhang Y, Salinas JM, Xu W, Klaunig JE, Wu C, Tsukamoto H, Meng F
Hepatol Commun 2023 Apr 1;7(4) Epub 2023 Apr 4 doi: 10.1097/HC9.0000000000000089. PMID: 37026704Free PMC Article
Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H
Hepatology 2022 Mar;75(3):646-660. Epub 2021 Dec 5 doi: 10.1002/hep.32152. PMID: 34510484Free PMC Article
Apixaban-induced liver injury.
Machlab S, Miquel M, Vergara M, Escoda MR, Casas M
Rev Esp Enferm Dig 2019 Feb;111(2):161-163. doi: 10.17235/reed.2018.5877/2018. PMID: 30569731
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J; United States Drug Induced Liver Injury Network
Gastroenterology 2015 Jun;148(7):1340-52.e7. Epub 2015 Mar 6 doi: 10.1053/j.gastro.2015.03.006. PMID: 25754159Free PMC Article

Recent systematic reviews

Crimean-Congo haemorrhagic fever-induced liver injury: A systematic review and meta-analysis.
Rathore SS, Manju AH, Wen Q, Sondhi M, Pydi R, Haddad I, Hasan J, Ali MA, Tousif S, Singh R, Muhammed AA, Ahmed NK, Patel DM
Int J Clin Pract 2021 Nov;75(11):e14775. Epub 2021 Sep 12 doi: 10.1111/ijcp.14775. PMID: 34480502
Albendazole-Induced Liver Injury.
Piloiu C, Dumitrascu DL
Am J Ther 2021 Feb 3;28(3):e335-e340. doi: 10.1097/MJT.0000000000001341. PMID: 33590990
Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury.
Zou J, Wang SP, Wang YT, Wan JB
Pharmacol Res 2021 Feb;164:105388. Epub 2020 Dec 21 doi: 10.1016/j.phrs.2020.105388. PMID: 33359314
Systematic review: ibuprofen-induced liver injury.
Zoubek ME, Lucena MI, Andrade RJ, Stephens C
Aliment Pharmacol Ther 2020 Mar;51(6):603-611. Epub 2020 Jan 27 doi: 10.1111/apt.15645. PMID: 31984540
Drug and herb-induced liver injury: A critical review of Brazilian cases with proposals for the improvement of causality assessment using RUCAM.
Becker MW, Lunardelli MJM, Tovo CV, Blatt CR
Ann Hepatol 2019 Sep-Oct;18(5):742-750. Epub 2019 May 12 doi: 10.1016/j.aohep.2019.03.010. PMID: 31130470

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...