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Perinatal-Stress Induced Hyperinsulinism

MedGen UID:
1390020
•Concept ID:
C4330998
•
Disease or Syndrome

Definition

Transient hyperinsulinism that occurs in response to neonatal stress resulting in prolonged neonatal hypoglycemia, which is distinct from transitional hypoglycemia of typical infants. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerinatal-Stress Induced Hyperinsulinism

Recent clinical studies

Etiology

The Rising Incidence of Hyperinsulinemic Hypoglycemia: Connection With Maternal Health.
Sasidharan Pillai S, Fredette ME, Tanzer JR, Hoffman L, Topor LS
Endocr Pract 2023 Dec;29(12):980-985. Epub 2023 Sep 7 doi: 10.1016/j.eprac.2023.09.001. PMID: 37683825
Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism.
Thornton P, Truong L, Reynolds C, Hamby T, Nedrelow J
Horm Res Paediatr 2019;91(1):25-32. Epub 2019 Mar 19 doi: 10.1159/000497458. PMID: 30889588
Liver injury may increase the risk of diazoxide toxicity: a case report.
Tas E, Mahmood B, Garibaldi L, Sperling M
Eur J Pediatr 2015 Mar;174(3):403-6. Epub 2015 Jan 25 doi: 10.1007/s00431-015-2488-6. PMID: 25618267
Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.
Palladino AA, Bennett MJ, Stanley CA
Clin Chem 2008 Feb;54(2):256-63. Epub 2007 Dec 21 doi: 10.1373/clinchem.2007.098988. PMID: 18156285

Diagnosis

The Rising Incidence of Hyperinsulinemic Hypoglycemia: Connection With Maternal Health.
Sasidharan Pillai S, Fredette ME, Tanzer JR, Hoffman L, Topor LS
Endocr Pract 2023 Dec;29(12):980-985. Epub 2023 Sep 7 doi: 10.1016/j.eprac.2023.09.001. PMID: 37683825
Liver injury may increase the risk of diazoxide toxicity: a case report.
Tas E, Mahmood B, Garibaldi L, Sperling M
Eur J Pediatr 2015 Mar;174(3):403-6. Epub 2015 Jan 25 doi: 10.1007/s00431-015-2488-6. PMID: 25618267
Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.
Palladino AA, Bennett MJ, Stanley CA
Clin Chem 2008 Feb;54(2):256-63. Epub 2007 Dec 21 doi: 10.1373/clinchem.2007.098988. PMID: 18156285

Therapy

Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism.
Thornton P, Truong L, Reynolds C, Hamby T, Nedrelow J
Horm Res Paediatr 2019;91(1):25-32. Epub 2019 Mar 19 doi: 10.1159/000497458. PMID: 30889588
Liver injury may increase the risk of diazoxide toxicity: a case report.
Tas E, Mahmood B, Garibaldi L, Sperling M
Eur J Pediatr 2015 Mar;174(3):403-6. Epub 2015 Jan 25 doi: 10.1007/s00431-015-2488-6. PMID: 25618267
Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.
Palladino AA, Bennett MJ, Stanley CA
Clin Chem 2008 Feb;54(2):256-63. Epub 2007 Dec 21 doi: 10.1373/clinchem.2007.098988. PMID: 18156285

Prognosis

The Rising Incidence of Hyperinsulinemic Hypoglycemia: Connection With Maternal Health.
Sasidharan Pillai S, Fredette ME, Tanzer JR, Hoffman L, Topor LS
Endocr Pract 2023 Dec;29(12):980-985. Epub 2023 Sep 7 doi: 10.1016/j.eprac.2023.09.001. PMID: 37683825

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