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Increased reactive oxygen species production

MedGen UID:
1390274
•Concept ID:
C4476796
•
Cell or Molecular Dysfunction
Synonyms: Increased ROS production; Oxidative stress
 
HPO: HP:0025464

Definition

An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased reactive oxygen species production

Professional guidelines

PubMed

Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype.
Arabiyat AS, Yeisley DJ, Güiza-Argüello VR, Qureshi F, Culibrk RA, Hahn J, Hahn MS
Tissue Eng Part C Methods 2022 Dec;28(12):656-671. doi: 10.1089/ten.TEC.2022.0123. PMID: 36329666Free PMC Article
Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT
Physiol Rep 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. PMID: 29611350Free PMC Article
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
Pharmacol Ther 2014 Jun;142(3):375-415. Epub 2014 Jan 22 doi: 10.1016/j.pharmthera.2014.01.003. PMID: 24462787

Recent clinical studies

Etiology

Association of Omnivorous and Vegetarian Diets With Antioxidant Defense Mechanisms in Men.
Cinegaglia N, Acosta-Navarro J, Rainho C, Antoniazzi L, Mattioli S, Pimentel C, Santos RD, Sandrim V
J Am Heart Assoc 2020 Jun 16;9(12):e015576. Epub 2020 Jun 9 doi: 10.1161/JAHA.119.015576. PMID: 32515251Free PMC Article
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article
Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.
Barrett KV, McCurley AT, Jaffe IZ
Clin Exp Pharmacol Physiol 2013 Dec;40(12):902-9. doi: 10.1111/1440-1681.12125. PMID: 23710823Free PMC Article
From fatty liver to fibrosis: a tale of "second hit".
Basaranoglu M, Basaranoglu G, Sentürk H
World J Gastroenterol 2013 Feb 28;19(8):1158-65. doi: 10.3748/wjg.v19.i8.1158. PMID: 23483818Free PMC Article
High-mobility group box 1, oxidative stress, and disease.
Tang D, Kang R, Zeh HJ 3rd, Lotze MT
Antioxid Redox Signal 2011 Apr 1;14(7):1315-35. doi: 10.1089/ars.2010.3356. PMID: 20969478Free PMC Article

Diagnosis

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells.
Yang C, Song J, Hwang S, Choi J, Song G, Lim W
Redox Biol 2021 Nov;47:102144. Epub 2021 Sep 21 doi: 10.1016/j.redox.2021.102144. PMID: 34562873Free PMC Article
Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT
Physiol Rep 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. PMID: 29611350Free PMC Article
The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction.
Dolinsky VW
Biol Chem 2017 Aug 28;398(9):955-974. doi: 10.1515/hsz-2016-0316. PMID: 28253192
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Traumatic brain injury and mitochondrial dysfunction.
Hiebert JB, Shen Q, Thimmesch AR, Pierce JD
Am J Med Sci 2015 Aug;350(2):132-8. doi: 10.1097/MAJ.0000000000000506. PMID: 26083647

Therapy

Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation.
Ying W, Meiyan S, Wen C, Kaizu X, Meifang W, Liming L
Redox Rep 2023 Dec;28(1):2218684. doi: 10.1080/13510002.2023.2218684. PMID: 37278349Free PMC Article
NRF2 as a Therapeutic Target in Neurodegenerative Diseases.
Brandes MS, Gray NE
ASN Neuro 2020 Jan-Dec;12:1759091419899782. doi: 10.1177/1759091419899782. PMID: 31964153Free PMC Article
Dichloroacetate-induced peripheral neuropathy.
Stacpoole PW, Martyniuk CJ, James MO, Calcutt NA
Int Rev Neurobiol 2019;145:211-238. Epub 2019 Jun 11 doi: 10.1016/bs.irn.2019.05.003. PMID: 31208525
The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction.
Dolinsky VW
Biol Chem 2017 Aug 28;398(9):955-974. doi: 10.1515/hsz-2016-0316. PMID: 28253192
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article

Prognosis

Phenotypic and functional characterisation of synovial fluid-derived neutrophils in knee osteoarthritis and knee infection.
Manukyan G, Gallo J, Mikulkova Z, Trajerova M, Savara J, Slobodova Z, Fidler E, Shrestha B, Kriegova E
Osteoarthritis Cartilage 2023 Jan;31(1):72-82. Epub 2022 Oct 7 doi: 10.1016/j.joca.2022.09.011. PMID: 36216277
Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1.
Rio S, Gastou M, Karboul N, Derman R, Suriyun T, Manceau H, Leblanc T, El Benna J, Schmitt C, Azouzi S, Larghéro J, Karim Z, Macias-Garcia A, Chen JJ, Hermine O, Courtois G, Puy H, Gouya L, Mohandas N, Da Costa L
Blood 2019 Mar 21;133(12):1358-1370. Epub 2019 Jan 30 doi: 10.1182/blood-2018-09-875674. PMID: 30700418Free PMC Article
Neutrophil hyperactivation correlates with Alzheimer's disease progression.
Dong Y, Lagarde J, Xicota L, Corne H, Chantran Y, Chaigneau T, Crestani B, Bottlaender M, Potier MC, Aucouturier P, Dorothée G, Sarazin M, Elbim C
Ann Neurol 2018 Feb;83(2):387-405. doi: 10.1002/ana.25159. PMID: 29369398
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article

Clinical prediction guides

Traumatic brain injury-induced inflammatory changes in the olfactory bulb disrupt neuronal networks leading to olfactory dysfunction.
Liu X, Lei Z, Gilhooly D, He J, Li Y, Ritzel RM, Li H, Wu LJ, Liu S, Wu J
Brain Behav Immun 2023 Nov;114:22-45. Epub 2023 Aug 7 doi: 10.1016/j.bbi.2023.08.004. PMID: 37557959Free PMC Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Traumatic brain injury and mitochondrial dysfunction.
Hiebert JB, Shen Q, Thimmesch AR, Pierce JD
Am J Med Sci 2015 Aug;350(2):132-8. doi: 10.1097/MAJ.0000000000000506. PMID: 26083647
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article
From fatty liver to fibrosis: a tale of "second hit".
Basaranoglu M, Basaranoglu G, Sentürk H
World J Gastroenterol 2013 Feb 28;19(8):1158-65. doi: 10.3748/wjg.v19.i8.1158. PMID: 23483818Free PMC Article

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