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Kir6.2-Associated Diabetes Mellitus

MedGen UID:
1390291
•Concept ID:
C4330524
•
Disease or Syndrome

Definition

Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKir6.2-Associated Diabetes Mellitus

Professional guidelines

PubMed

American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm - 2023 Update.
Samson SL, Vellanki P, Blonde L, Christofides EA, Galindo RJ, Hirsch IB, Isaacs SD, Izuora KE, Low Wang CC, Twining CL, Umpierrez GE, Valencia WM
Endocr Pract 2023 May;29(5):305-340. doi: 10.1016/j.eprac.2023.02.001. PMID: 37150579
KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease.
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764
Diagnosis and classification of diabetes mellitus: new criteria.
Mayfield J
Am Fam Physician 1998 Oct 15;58(6):1355-62, 1369-70. PMID: 9803200

Recent clinical studies

Therapy

Metformin and Cancer: Solutions to a Real-World Evidence Failure.
Yu OHY, Suissa S
Diabetes Care 2023 May 1;46(5):904-912. doi: 10.2337/dci22-0047. PMID: 37185680
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
Validation of Time in Range as an Outcome Measure for Diabetes Clinical Trials.
Beck RW, Bergenstal RM, Riddlesworth TD, Kollman C, Li Z, Brown AS, Close KL
Diabetes Care 2019 Mar;42(3):400-405. Epub 2018 Oct 23 doi: 10.2337/dc18-1444. PMID: 30352896Free PMC Article
Judgmental sampling.
Curtis JJ
Transplantation 2011 Jun 27;91(12):1320. doi: 10.1097/TP.0b013e31821d91c8. PMID: 21540782
Diabetes and biomarkers.
Caveney EJ, Cohen OJ
J Diabetes Sci Technol 2011 Jan 1;5(1):192-7. doi: 10.1177/193229681100500127. PMID: 21303644Free PMC Article

Prognosis

Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025.
Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, Song X, Ren Y, Shan PF
Sci Rep 2020 Sep 8;10(1):14790. doi: 10.1038/s41598-020-71908-9. PMID: 32901098Free PMC Article
Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Diabetes Atlas, 9th edition.
Patterson CC, Karuranga S, Salpea P, Saeedi P, Dahlquist G, Soltesz G, Ogle GD
Diabetes Res Clin Pract 2019 Nov;157:107842. Epub 2019 Sep 10 doi: 10.1016/j.diabres.2019.107842. PMID: 31518658
Gestational Diabetes Mellitus: Post-partum Risk and Follow Up.
Poola-Kella S, Steinman RA, Mesmar B, Malek R
Rev Recent Clin Trials 2018 Jan 31;13(1):5-14. doi: 10.2174/1574887112666170911124806. PMID: 28901851
Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus.
Hemmingsen B, Gimenez-Perez G, Mauricio D, Roqué I Figuls M, Metzendorf MI, Richter B
Cochrane Database Syst Rev 2017 Dec 4;12(12):CD003054. doi: 10.1002/14651858.CD003054.pub4. PMID: 29205264Free PMC Article
Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes.
Rawshani A, Rawshani A, Franzén S, Eliasson B, Svensson AM, Miftaraj M, McGuire DK, Sattar N, Rosengren A, Gudbjörnsdottir S
N Engl J Med 2017 Apr 13;376(15):1407-1418. doi: 10.1056/NEJMoa1608664. PMID: 28402770

Clinical prediction guides

LiverRisk score: An accurate, cost-effective tool to predict fibrosis, liver-related, and diabetes-related mortality in the general population.
Liu S, Chen X, Jiang X, Yin X, Fekadu G, Liu C, He Y, Chen H, Ni W, Wang R, Zeng QL, Chen Y, Yang L, Shi R, Ju SH, Shen J, Gao J, Zhao L, Ming WK, Zhong VW, Teng GJ, Qi X
Med 2024 Jun 14;5(6):570-582.e4. Epub 2024 Mar 29 doi: 10.1016/j.medj.2024.03.003. PMID: 38554711
A data-driven approach to predicting diabetes and cardiovascular disease with machine learning.
Dinh A, Miertschin S, Young A, Mohanty SD
BMC Med Inform Decis Mak 2019 Nov 6;19(1):211. doi: 10.1186/s12911-019-0918-5. PMID: 31694707Free PMC Article
The role of natriuretic peptides in diabetes and its complications.
Feng Y, Wang D, Bi H, Zhang H
Biomed Pharmacother 2016 Dec;84:1826-1832. Epub 2016 Nov 7 doi: 10.1016/j.biopha.2016.10.089. PMID: 27832993
Diagnostic Criteria and Treatment for Gestational Diabetes Mellitus.
Voormolen DN, Abell SK, James R, Hague WM, Mol BW
Semin Reprod Med 2016 Mar;34(2):102-9. Epub 2016 Feb 11 doi: 10.1055/s-0036-1572440. PMID: 26866601
The diabetes risk score: a practical tool to predict type 2 diabetes risk.
Lindström J, Tuomilehto J
Diabetes Care 2003 Mar;26(3):725-31. doi: 10.2337/diacare.26.3.725. PMID: 12610029

Recent systematic reviews

A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes.
Malaza N, Masete M, Adam S, Dias S, Nyawo T, Pheiffer C
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710846. PMID: 36078559Free PMC Article
Self-Management Nursing Intervention for Controlling Glucose among Diabetes: A Systematic Review and Meta-Analysis.
Cho MK, Kim MY
Int J Environ Res Public Health 2021 Dec 3;18(23) doi: 10.3390/ijerph182312750. PMID: 34886488Free PMC Article
Self-Care in Adults with Type 2 Diabetes Mellitus: A Systematic Review.
da Rocha RB, Silva CS, Cardoso VS
Curr Diabetes Rev 2020;16(6):598-607. doi: 10.2174/1573399815666190702161849. PMID: 31267873
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Kristensen SL, Rørth R, Jhund PS, Docherty KF, Sattar N, Preiss D, Køber L, Petrie MC, McMurray JJV
Lancet Diabetes Endocrinol 2019 Oct;7(10):776-785. Epub 2019 Aug 14 doi: 10.1016/S2213-8587(19)30249-9. PMID: 31422062
Type 1 Diabetes Mellitus and Cognitive Impairments: A Systematic Review.
Li W, Huang E, Gao S
J Alzheimers Dis 2017;57(1):29-36. doi: 10.3233/JAD-161250. PMID: 28222533

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