U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal insulin like growth factor binding protein acid labile subunit level

MedGen UID:
1390394
Concept ID:
C4476922
Finding
HPO: HP:0031034

Definition

A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal insulin like growth factor binding protein acid labile subunit level

Professional guidelines

PubMed

Limal JM, Parfait B, Cabrol S, Bonnet D, Leheup B, Lyonnet S, Vidaud M, Le Bouc Y
J Clin Endocrinol Metab 2006 Jan;91(1):300-6. Epub 2005 Nov 1 doi: 10.1210/jc.2005-0983. PMID: 16263833

Recent clinical studies

Etiology

Domené HM, Hwa V, Argente J, Wit JM, Camacho-Hübner C, Jasper HG, Pozo J, van Duyvenvoorde HA, Yakar S, Fofanova-Gambetti OV, Rosenfeld RG; International ALS Collaborative Group
Horm Res 2009;72(3):129-41. Epub 2009 Sep 1 doi: 10.1159/000232486. PMID: 19729943
Rasmussen MH, Wildschiødtz G, Juul A, Hilsted J
Obesity (Silver Spring) 2008 Jul;16(7):1516-21. Epub 2008 May 8 doi: 10.1038/oby.2008.249. PMID: 18464752
Limal JM, Parfait B, Cabrol S, Bonnet D, Leheup B, Lyonnet S, Vidaud M, Le Bouc Y
J Clin Endocrinol Metab 2006 Jan;91(1):300-6. Epub 2005 Nov 1 doi: 10.1210/jc.2005-0983. PMID: 16263833
Holt RI, Baker AJ, Jones JS, Miell JP
Pediatr Transplant 1998 Feb;2(1):76-84. PMID: 10084765
Langford K, Blum W, Nicolaides K, Jones J, McGregor A, Miell J
Eur J Clin Invest 1994 Dec;24(12):851-6. doi: 10.1111/j.1365-2362.1994.tb02030.x. PMID: 7535696

Diagnosis

Ma S, Zheng J, Xu Y, Yang Z, Zhu Y, Su X, Mo X
Ital J Pediatr 2020 May 19;46(1):63. doi: 10.1186/s13052-020-00830-7. PMID: 32430056Free PMC Article
Schreiner F, Schoenberger S, Koester B, Domené HM, Woelfle J
Horm Res Paediatr 2013;80(6):424-30. Epub 2013 Nov 27 doi: 10.1159/000355927. PMID: 24296365
Hwa V, Fang P, Derr MA, Fiegerlova E, Rosenfeld RG
Nestle Nutr Inst Workshop Ser 2013;71:43-55. Epub 2013 Jan 22 doi: 10.1159/000342548. PMID: 23502138
Rasmussen MH, Wildschiødtz G, Juul A, Hilsted J
Obesity (Silver Spring) 2008 Jul;16(7):1516-21. Epub 2008 May 8 doi: 10.1038/oby.2008.249. PMID: 18464752
Langford K, Blum W, Nicolaides K, Jones J, McGregor A, Miell J
Eur J Clin Invest 1994 Dec;24(12):851-6. doi: 10.1111/j.1365-2362.1994.tb02030.x. PMID: 7535696

Therapy

Rasmussen MH, Wildschiødtz G, Juul A, Hilsted J
Obesity (Silver Spring) 2008 Jul;16(7):1516-21. Epub 2008 May 8 doi: 10.1038/oby.2008.249. PMID: 18464752
Savage MO, Camacho-Hübner C, David A, Metherell LA, Hwa V, Rosenfeld RG, Clark AJ
Eur J Endocrinol 2007 Aug;157 Suppl 1:S33-7. doi: 10.1530/EJE-07-0292. PMID: 17785695
Limal JM, Parfait B, Cabrol S, Bonnet D, Leheup B, Lyonnet S, Vidaud M, Le Bouc Y
J Clin Endocrinol Metab 2006 Jan;91(1):300-6. Epub 2005 Nov 1 doi: 10.1210/jc.2005-0983. PMID: 16263833
Van den Berghe G
Horm Res 1999;51 Suppl 3:21-8. doi: 10.1159/000053158. PMID: 10592440
Powell DR
J Pediatr 1997 Jul;131(1 Pt 2):S13-6. doi: 10.1016/s0022-3476(97)70003-9. PMID: 9255220

Prognosis

Ma S, Zheng J, Xu Y, Yang Z, Zhu Y, Su X, Mo X
Ital J Pediatr 2020 May 19;46(1):63. doi: 10.1186/s13052-020-00830-7. PMID: 32430056Free PMC Article
Völkl TM, Rauh M, Schöfl C, Dörr HG
Growth Horm IGF Res 2011 Aug;21(4):191-8. Epub 2011 Jun 1 doi: 10.1016/j.ghir.2011.05.001. PMID: 21636299
Savage MO, Camacho-Hübner C, David A, Metherell LA, Hwa V, Rosenfeld RG, Clark AJ
Eur J Endocrinol 2007 Aug;157 Suppl 1:S33-7. doi: 10.1530/EJE-07-0292. PMID: 17785695
Van den Berghe G
Horm Res 1999;51 Suppl 3:21-8. doi: 10.1159/000053158. PMID: 10592440
Holt RI, Baker AJ, Jones JS, Miell JP
Pediatr Transplant 1998 Feb;2(1):76-84. PMID: 10084765

Clinical prediction guides

Högler W, Martin DD, Crabtree N, Nightingale P, Tomlinson J, Metherell L, Rosenfeld R, Hwa V, Rose S, Walker J, Shaw N, Barrett T, Frystyk J
J Clin Endocrinol Metab 2014 Apr;99(4):E703-12. Epub 2014 Jan 13 doi: 10.1210/jc.2013-3718. PMID: 24423360
Völkl TM, Rauh M, Schöfl C, Dörr HG
Growth Horm IGF Res 2011 Aug;21(4):191-8. Epub 2011 Jun 1 doi: 10.1016/j.ghir.2011.05.001. PMID: 21636299
Domené HM, Hwa V, Argente J, Wit JM, Camacho-Hübner C, Jasper HG, Pozo J, van Duyvenvoorde HA, Yakar S, Fofanova-Gambetti OV, Rosenfeld RG; International ALS Collaborative Group
Horm Res 2009;72(3):129-41. Epub 2009 Sep 1 doi: 10.1159/000232486. PMID: 19729943
Limal JM, Parfait B, Cabrol S, Bonnet D, Leheup B, Lyonnet S, Vidaud M, Le Bouc Y
J Clin Endocrinol Metab 2006 Jan;91(1):300-6. Epub 2005 Nov 1 doi: 10.1210/jc.2005-0983. PMID: 16263833
Powell DR
J Pediatr 1997 Jul;131(1 Pt 2):S13-6. doi: 10.1016/s0022-3476(97)70003-9. PMID: 9255220

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...