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Storage in hepatocytes

MedGen UID:
1390544
Concept ID:
C4476996
Finding
HPO: HP:0031137

Definition

Hepatocytes (liver parenchymal cells) exhibit a bloated appearance because of expansion of the cytoplasm by accumulated material. [from HPO]

Professional guidelines

PubMed

Almeida FC, Patra K, Giannisis A, Niesnerova A, Nandakumar R, Ellis E, Oliveira TG, Nielsen HM
J Lipid Res 2024 Feb;65(2):100498. Epub 2024 Jan 11 doi: 10.1016/j.jlr.2024.100498. PMID: 38216055Free PMC Article
Addison ML, Ranasinghe P, Webb DJ
Hypertension 2023 Nov;80(11):2243-2254. Epub 2023 Sep 14 doi: 10.1161/HYPERTENSIONAHA.122.19430. PMID: 37706295
Zou D, Wang H, Liu X, Xu ZP, Roberts MS, Zhao CX
Acta Biomater 2021 Aug;130:98-114. Epub 2021 Jun 12 doi: 10.1016/j.actbio.2021.06.012. PMID: 34126265

Recent clinical studies

Etiology

Ng SWK, Rouhani FJ, Brunner SF, Brzozowska N, Aitken SJ, Yang M, Abascal F, Moore L, Nikitopoulou E, Chappell L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders MA, Williams N, Coorens THH, Teague J, Raine K, Butler AP, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies SE, Stratton MR, Martincorena I, Rahbari R, Frezza C, Hoare M, Campbell PJ
Nature 2021 Oct;598(7881):473-478. Epub 2021 Oct 13 doi: 10.1038/s41586-021-03974-6. PMID: 34646017
Seebacher F, Zeigerer A, Kory N, Krahmer N
Semin Cell Dev Biol 2020 Dec;108:72-81. Epub 2020 May 20 doi: 10.1016/j.semcdb.2020.04.011. PMID: 32444289
Zanoni P, Velagapudi S, Yalcinkaya M, Rohrer L, von Eckardstein A
Atherosclerosis 2018 Aug;275:273-295. Epub 2018 Jun 23 doi: 10.1016/j.atherosclerosis.2018.06.881. PMID: 29980055
Khoury J, Zohar Y, Shehadeh N, Saadi T
Hepatobiliary Pancreat Dis Int 2018 Apr;17(2):113-118. Epub 2018 Feb 19 doi: 10.1016/j.hbpd.2018.02.006. PMID: 29709217
Demers A, Samami S, Lauzier B, Des Rosiers C, Ngo Sock ET, Ong H, Mayer G
Arterioscler Thromb Vasc Biol 2015 Dec;35(12):2517-25. Epub 2015 Oct 22 doi: 10.1161/ATVBAHA.115.306032. PMID: 26494228

Diagnosis

Szczepańska E, Gietka-Czernel M
Horm Metab Res 2022 Apr;54(4):203-211. Epub 2022 Apr 12 doi: 10.1055/a-1778-4159. PMID: 35413740
Chaudhry N, Sica M, Surabhi S, Hernandez DS, Mesquita A, Selimovic A, Riaz A, Lescat L, Bai H, MacIntosh GC, Jenny A
Autophagy 2022 Oct;18(10):2443-2458. Epub 2022 Mar 10 doi: 10.1080/15548627.2022.2038999. PMID: 35266854Free PMC Article
Heeren J, Scheja L
Mol Metab 2021 Aug;50:101238. Epub 2021 Apr 20 doi: 10.1016/j.molmet.2021.101238. PMID: 33892169Free PMC Article
Khoury J, Zohar Y, Shehadeh N, Saadi T
Hepatobiliary Pancreat Dis Int 2018 Apr;17(2):113-118. Epub 2018 Feb 19 doi: 10.1016/j.hbpd.2018.02.006. PMID: 29709217
Loudianos G, Gitlin JD
Semin Liver Dis 2000;20(3):353-64. doi: 10.1055/s-2000-9389. PMID: 11076401

Therapy

Addison ML, Ranasinghe P, Webb DJ
Hypertension 2023 Nov;80(11):2243-2254. Epub 2023 Sep 14 doi: 10.1161/HYPERTENSIONAHA.122.19430. PMID: 37706295
Whaley D, Damyar K, Witek RP, Mendoza A, Alexander M, Lakey JR
Cell Transplant 2021 Jan-Dec;30:963689721999617. doi: 10.1177/0963689721999617. PMID: 33757335Free PMC Article
Lan T, Yu Y, Zhang J, Li H, Weng Q, Jiang S, Tian S, Xu T, Hu S, Yang G, Zhang Y, Wang W, Wang L, Zhu Q, Rong X, Guo J
Hepatology 2021 Aug;74(2):686-703. doi: 10.1002/hep.31749. PMID: 33576035Free PMC Article
Oteng AB, Kersten S
Adv Nutr 2020 May 1;11(3):697-708. doi: 10.1093/advances/nmz125. PMID: 31782488Free PMC Article
Khoury J, Zohar Y, Shehadeh N, Saadi T
Hepatobiliary Pancreat Dis Int 2018 Apr;17(2):113-118. Epub 2018 Feb 19 doi: 10.1016/j.hbpd.2018.02.006. PMID: 29709217

Prognosis

Deng GH, Wu CF, Li YJ, Shi H, Zhong WC, Hong MK, Li JJ, Zhao JM, Liu C, Qin MC, Zeng ZY, Zhang WM, Yung KKL, Lv ZP, Gao L
Mil Med Res 2023 Nov 8;10(1):53. doi: 10.1186/s40779-023-00487-3. PMID: 37941054Free PMC Article
Lee E, Korf H, Vidal-Puig A
J Hepatol 2023 May;78(5):1048-1062. Epub 2023 Feb 3 doi: 10.1016/j.jhep.2023.01.024. PMID: 36740049
Zanoni P, Velagapudi S, Yalcinkaya M, Rohrer L, von Eckardstein A
Atherosclerosis 2018 Aug;275:273-295. Epub 2018 Jun 23 doi: 10.1016/j.atherosclerosis.2018.06.881. PMID: 29980055
Khoury J, Zohar Y, Shehadeh N, Saadi T
Hepatobiliary Pancreat Dis Int 2018 Apr;17(2):113-118. Epub 2018 Feb 19 doi: 10.1016/j.hbpd.2018.02.006. PMID: 29709217
Young B, Zaritsky J
Clin J Am Soc Nephrol 2009 Aug;4(8):1384-7. Epub 2009 Jun 25 doi: 10.2215/CJN.02190309. PMID: 19556376

Clinical prediction guides

Deng GH, Wu CF, Li YJ, Shi H, Zhong WC, Hong MK, Li JJ, Zhao JM, Liu C, Qin MC, Zeng ZY, Zhang WM, Yung KKL, Lv ZP, Gao L
Mil Med Res 2023 Nov 8;10(1):53. doi: 10.1186/s40779-023-00487-3. PMID: 37941054Free PMC Article
Ng SWK, Rouhani FJ, Brunner SF, Brzozowska N, Aitken SJ, Yang M, Abascal F, Moore L, Nikitopoulou E, Chappell L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders MA, Williams N, Coorens THH, Teague J, Raine K, Butler AP, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies SE, Stratton MR, Martincorena I, Rahbari R, Frezza C, Hoare M, Campbell PJ
Nature 2021 Oct;598(7881):473-478. Epub 2021 Oct 13 doi: 10.1038/s41586-021-03974-6. PMID: 34646017
Whaley D, Damyar K, Witek RP, Mendoza A, Alexander M, Lakey JR
Cell Transplant 2021 Jan-Dec;30:963689721999617. doi: 10.1177/0963689721999617. PMID: 33757335Free PMC Article
Khoury J, Zohar Y, Shehadeh N, Saadi T
Hepatobiliary Pancreat Dis Int 2018 Apr;17(2):113-118. Epub 2018 Feb 19 doi: 10.1016/j.hbpd.2018.02.006. PMID: 29709217
Young B, Zaritsky J
Clin J Am Soc Nephrol 2009 Aug;4(8):1384-7. Epub 2009 Jun 25 doi: 10.2215/CJN.02190309. PMID: 19556376

Recent systematic reviews

Liu J, Sun B, Yin H, Liu S
Medicine (Baltimore) 2016 Apr;95(14):e3150. doi: 10.1097/MD.0000000000003150. PMID: 27057839Free PMC Article

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