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Nitrosative Stress

MedGen UID:
1390881
•Concept ID:
C4505047
•
Cell or Molecular Dysfunction
Synonyms: Nitrosative Stresses; Stress, Nitrosative; Stresses, Nitrosative

Definition

A metabolic excess of REACTIVE NITROGEN SPECIES, including NITRIC OXIDE and PEROXYNITRITE, that leads to damaging effects of oxidation and nitration. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNitrosative Stress

Professional guidelines

PubMed

Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
Cai X, Cai H, Wang J, Yang Q, Guan J, Deng J, Chen Z
J Zhejiang Univ Sci B 2022 Apr 15;23(4):265-285. doi: 10.1631/jzus.B2100977. PMID: 35403383Free PMC Article
Advances in understanding and management of retinopathy of prematurity.
Hartnett ME
Surv Ophthalmol 2017 May-Jun;62(3):257-276. Epub 2016 Dec 22 doi: 10.1016/j.survophthal.2016.12.004. PMID: 28012875Free PMC Article
Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications.
Anderson G, Maes M
Curr Pharm Des 2014;20(23):3812-47. doi: 10.2174/13816128113196660738. PMID: 24180395

Recent clinical studies

Etiology

Harnessing oxidative stress for anti-glioma therapy.
Ostrowski RP, Pucko EB
Neurochem Int 2022 Mar;154:105281. Epub 2022 Jan 14 doi: 10.1016/j.neuint.2022.105281. PMID: 35038460
Oxygen and pulmonary vasodilation: The role of oxidative and nitrosative stress.
Steinhorn RH, Lakshminrusimha S
Semin Fetal Neonatal Med 2020 Apr;25(2):101083. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101083. PMID: 31983672
Experimental animal models of coronary microvascular dysfunction.
Sorop O, van de Wouw J, Chandler S, Ohanyan V, Tune JD, Chilian WM, Merkus D, Bender SB, Duncker DJ
Cardiovasc Res 2020 Mar 1;116(4):756-770. doi: 10.1093/cvr/cvaa002. PMID: 31926020Free PMC Article
Crosstalk between Oxidative and Nitrosative Stress and Arterial Stiffness.
Mozos I, Luca CT
Curr Vasc Pharmacol 2017;15(5):446-456. doi: 10.2174/1570161115666170201115428. PMID: 28155616
So depression is an inflammatory disease, but where does the inflammation come from?
Berk M, Williams LJ, Jacka FN, O'Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M
BMC Med 2013 Sep 12;11:200. doi: 10.1186/1741-7015-11-200. PMID: 24228900Free PMC Article

Diagnosis

Hepatic encephalopathy.
Häussinger D, Dhiman RK, Felipo V, Görg B, Jalan R, Kircheis G, Merli M, Montagnese S, Romero-Gomez M, Schnitzler A, Taylor-Robinson SD, Vilstrup H
Nat Rev Dis Primers 2022 Jun 23;8(1):43. doi: 10.1038/s41572-022-00366-6. PMID: 35739133
Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis.
Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA
Antioxid Redox Signal 2017 Jun 20;26(18):1078-1090. Epub 2017 Mar 22 doi: 10.1089/ars.2017.7004. PMID: 28326819
Biological hypotheses and biomarkers of bipolar disorder.
Sigitova E, Fišar Z, Hroudová J, Cikánková T, Raboch J
Psychiatry Clin Neurosci 2017 Feb;71(2):77-103. Epub 2017 Jan 6 doi: 10.1111/pcn.12476. PMID: 27800654
Hepatic encephalopathy.
Häussinger D
Acta Gastroenterol Belg 2010 Oct-Dec;73(4):457-64. PMID: 21299155
Nitrosative stress and transcription.
Kröncke KD
Biol Chem 2003 Oct-Nov;384(10-11):1365-77. doi: 10.1515/BC.2003.153. PMID: 14669980

Therapy

Passive motion of the lower extremities in sedated and ventilated patients in the ICU - a systematic review of early effects and replicability of Interventions.
Vollenweider R, Manettas AI, Häni N, de Bruin ED, Knols RH
PLoS One 2022;17(5):e0267255. Epub 2022 May 12 doi: 10.1371/journal.pone.0267255. PMID: 35552550Free PMC Article
Oxygen and pulmonary vasodilation: The role of oxidative and nitrosative stress.
Steinhorn RH, Lakshminrusimha S
Semin Fetal Neonatal Med 2020 Apr;25(2):101083. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101083. PMID: 31983672
Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn VS, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA
Nature 2019 Apr;568(7752):351-356. Epub 2019 Apr 10 doi: 10.1038/s41586-019-1100-z. PMID: 30971818Free PMC Article
Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy.
Sun MS, Jin H, Sun X, Huang S, Zhang FL, Guo ZN, Yang Y
Oxid Med Cell Longev 2018;2018:3804979. Epub 2018 Jan 31 doi: 10.1155/2018/3804979. PMID: 29770166Free PMC Article
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.
Chamorro Á, Dirnagl U, Urra X, Planas AM
Lancet Neurol 2016 Jul;15(8):869-881. Epub 2016 May 11 doi: 10.1016/S1474-4422(16)00114-9. PMID: 27180033

Prognosis

Hepatic encephalopathy.
Häussinger D, Dhiman RK, Felipo V, Görg B, Jalan R, Kircheis G, Merli M, Montagnese S, Romero-Gomez M, Schnitzler A, Taylor-Robinson SD, Vilstrup H
Nat Rev Dis Primers 2022 Jun 23;8(1):43. doi: 10.1038/s41572-022-00366-6. PMID: 35739133
MicroRNAs, Multiple Sclerosis, and Depression.
Wang H
Int J Mol Sci 2021 Jul 21;22(15) doi: 10.3390/ijms22157802. PMID: 34360568Free PMC Article
High-density lipoprotein-mediated cardioprotection in heart failure.
Jackson AO, Meng J, Tang H, Yin K
Heart Fail Rev 2021 Jul;26(4):767-780. doi: 10.1007/s10741-020-09916-0. PMID: 31984450
Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy.
Sun MS, Jin H, Sun X, Huang S, Zhang FL, Guo ZN, Yang Y
Oxid Med Cell Longev 2018;2018:3804979. Epub 2018 Jan 31 doi: 10.1155/2018/3804979. PMID: 29770166Free PMC Article
Crosstalk between Oxidative and Nitrosative Stress and Arterial Stiffness.
Mozos I, Luca CT
Curr Vasc Pharmacol 2017;15(5):446-456. doi: 10.2174/1570161115666170201115428. PMID: 28155616

Clinical prediction guides

Pathomechanisms in hepatic encephalopathy.
Häussinger D, Butz M, Schnitzler A, Görg B
Biol Chem 2021 Aug 26;402(9):1087-1102. Epub 2021 May 31 doi: 10.1515/hsz-2021-0168. PMID: 34049427
Experimental animal models of coronary microvascular dysfunction.
Sorop O, van de Wouw J, Chandler S, Ohanyan V, Tune JD, Chilian WM, Merkus D, Bender SB, Duncker DJ
Cardiovasc Res 2020 Mar 1;116(4):756-770. doi: 10.1093/cvr/cvaa002. PMID: 31926020Free PMC Article
Argininosuccinic aciduria: Recent pathophysiological insights and therapeutic prospects.
Baruteau J, Diez-Fernandez C, Lerner S, Ranucci G, Gissen P, Dionisi-Vici C, Nagamani S, Erez A, Häberle J
J Inherit Metab Dis 2019 Nov;42(6):1147-1161. Epub 2019 Feb 5 doi: 10.1002/jimd.12047. PMID: 30723942
Crosstalk between Oxidative and Nitrosative Stress and Arterial Stiffness.
Mozos I, Luca CT
Curr Vasc Pharmacol 2017;15(5):446-456. doi: 10.2174/1570161115666170201115428. PMID: 28155616
Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations.
Neri M, Riezzo I, Pomara C, Schiavone S, Turillazzi E
Mediators Inflamm 2016;2016:3423450. Epub 2016 May 4 doi: 10.1155/2016/3423450. PMID: 27274621Free PMC Article

Recent systematic reviews

Passive motion of the lower extremities in sedated and ventilated patients in the ICU - a systematic review of early effects and replicability of Interventions.
Vollenweider R, Manettas AI, Häni N, de Bruin ED, Knols RH
PLoS One 2022;17(5):e0267255. Epub 2022 May 12 doi: 10.1371/journal.pone.0267255. PMID: 35552550Free PMC Article
Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis.
Nantachai G, Vasupanrajit A, Tunvirachaisakul C, Solmi M, Maes M
Ageing Res Rev 2022 Aug;79:101639. Epub 2022 May 7 doi: 10.1016/j.arr.2022.101639. PMID: 35537662
Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis.
Vasupanrajit A, Jirakran K, Tunvirachaisakul C, Maes M
J Affect Disord 2021 Dec 1;295:80-92. Epub 2021 Aug 13 doi: 10.1016/j.jad.2021.08.015. PMID: 34416621
Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis.
Maia A, Oliveira J, Lajnef M, Mallet L, Tamouza R, Leboyer M, Oliveira-Maia AJ
Acta Psychiatr Scand 2019 May;139(5):420-433. Epub 2019 Apr 9 doi: 10.1111/acps.13026. PMID: 30873609
A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis.
Castro R, Pinzón HS, Alvis-Guzman N
Colomb Med (Cali) 2015 Sep 30;46(3):135-43. PMID: 26600629Free PMC Article

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