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Positive pathergy test

MedGen UID:
1391420
Concept ID:
C4476836
Finding
HPO: HP:0025532

Definition

With the pathergy test, a small, sterile needle is inserted into the skin of the forearm. The site of injectionis circuled and observed after one and two days. If a small red bump or pustule at the site of needle insertion occurs, the pathergy test is considered to have a positive (abnormal) result. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPositive pathergy test

Professional guidelines

PubMed

Davatchi F, Sadeghi Abdollahi B, Chams-Davatchi C, Shahram F, Ghodsi Z, Nadji A, Akhlaghi M, Faezi T, Shams H, Larimi R, Ashofteh F
Mod Rheumatol 2013 Jan;23(1):125-32. Epub 2012 Apr 4 doi: 10.1007/s10165-012-0626-9. PMID: 22476858
Maldini C, Lavalley MP, Cheminant M, de Menthon M, Mahr A
Rheumatology (Oxford) 2012 May;51(5):887-900. Epub 2012 Jan 11 doi: 10.1093/rheumatology/ker428. PMID: 22240504
Oliveira AC, Buosi AL, Dutra LA, de Souza AW
J Clin Rheumatol 2011 Dec;17(8):416-20. doi: 10.1097/RHU.0b013e31823a46ed. PMID: 22089985

Recent clinical studies

Etiology

Vitale A, Berlengiero V, Caggiano V, Barneschi S, Mourabi M, Sota J, Gentileschi S, Maggio MC, Gaggiano C, Tarsia M, Tosi GM, Lopalco G, Fabiani C, Frediani B, Cantarini L
Intern Emerg Med 2023 Jan;18(1):77-83. Epub 2022 Dec 21 doi: 10.1007/s11739-022-03117-3. PMID: 36542302
Uva L, Miguel D, Pinheiro C, Filipe P, Freitas JP
Acta Reumatol Port 2013 Apr-Jun;38(2):77-90. PMID: 24141344
Bhat RM, Nandakishore B, Sequeira FF, Sukumar D, Kamath GH, Martis J, Furtado S
Clin Exp Dermatol 2011 Apr;36(3):242-7. Epub 2010 Nov 10 doi: 10.1111/j.1365-2230.2010.03941.x. PMID: 21070329
Aydin F, Akpolat T, Senturk N, Bagci H, Yasar Turanli A
Clin Rheumatol 2009 Nov;28(11):1331-5. Epub 2009 Jul 29 doi: 10.1007/s10067-009-1237-5. PMID: 19639361
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Diagnosis

Uva L, Miguel D, Pinheiro C, Filipe P, Freitas JP
Acta Reumatol Port 2013 Apr-Jun;38(2):77-90. PMID: 24141344
Davatchi F, Sadeghi Abdollahi B, Chams-Davatchi C, Shahram F, Ghodsi Z, Nadji A, Akhlaghi M, Faezi T, Shams H, Larimi R, Ashofteh F
Mod Rheumatol 2013 Jan;23(1):125-32. Epub 2012 Apr 4 doi: 10.1007/s10165-012-0626-9. PMID: 22476858
Bhat RM, Nandakishore B, Sequeira FF, Sukumar D, Kamath GH, Martis J, Furtado S
Clin Exp Dermatol 2011 Apr;36(3):242-7. Epub 2010 Nov 10 doi: 10.1111/j.1365-2230.2010.03941.x. PMID: 21070329
Ebert EC
Dig Dis Sci 2009 Feb;54(2):201-7. Epub 2008 Jul 2 doi: 10.1007/s10620-008-0337-4. PMID: 18594975
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Therapy

Paim-Marques LB, Cavalcante A, Castro C, Muskardin TLW, de Oliveira JB, Niewold TB, Appenzeller S
Rheumatol Int 2021 Jan;41(1):219-225. Epub 2020 Aug 19 doi: 10.1007/s00296-020-04683-5. PMID: 32813153
Bhat RM, Nandakishore B, Sequeira FF, Sukumar D, Kamath GH, Martis J, Furtado S
Clin Exp Dermatol 2011 Apr;36(3):242-7. Epub 2010 Nov 10 doi: 10.1111/j.1365-2230.2010.03941.x. PMID: 21070329
Ziadé N, Awada H
Joint Bone Spine 2006 Oct;73(5):567-9. Epub 2006 Jul 14 doi: 10.1016/j.jbspin.2006.06.002. PMID: 16904928
Sakane T, Takeno M
Skin Therapy Lett 2000;5(6):3-5. PMID: 10889570
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Prognosis

Davatchi F, Sadeghi Abdollahi B, Chams-Davatchi C, Shahram F, Ghodsi Z, Nadji A, Akhlaghi M, Faezi T, Shams H, Larimi R, Ashofteh F
Mod Rheumatol 2013 Jan;23(1):125-32. Epub 2012 Apr 4 doi: 10.1007/s10165-012-0626-9. PMID: 22476858
Bhat RM, Nandakishore B, Sequeira FF, Sukumar D, Kamath GH, Martis J, Furtado S
Clin Exp Dermatol 2011 Apr;36(3):242-7. Epub 2010 Nov 10 doi: 10.1111/j.1365-2230.2010.03941.x. PMID: 21070329
Aydin F, Akpolat T, Senturk N, Bagci H, Yasar Turanli A
Clin Rheumatol 2009 Nov;28(11):1331-5. Epub 2009 Jul 29 doi: 10.1007/s10067-009-1237-5. PMID: 19639361
Ebert EC
Dig Dis Sci 2009 Feb;54(2):201-7. Epub 2008 Jul 2 doi: 10.1007/s10620-008-0337-4. PMID: 18594975
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Clinical prediction guides

Vitale A, Berlengiero V, Caggiano V, Barneschi S, Mourabi M, Sota J, Gentileschi S, Maggio MC, Gaggiano C, Tarsia M, Tosi GM, Lopalco G, Fabiani C, Frediani B, Cantarini L
Intern Emerg Med 2023 Jan;18(1):77-83. Epub 2022 Dec 21 doi: 10.1007/s11739-022-03117-3. PMID: 36542302
Paim-Marques LB, Cavalcante A, Castro C, Muskardin TLW, de Oliveira JB, Niewold TB, Appenzeller S
Rheumatol Int 2021 Jan;41(1):219-225. Epub 2020 Aug 19 doi: 10.1007/s00296-020-04683-5. PMID: 32813153
Davatchi F, Sadeghi Abdollahi B, Chams-Davatchi C, Shahram F, Ghodsi Z, Nadji A, Akhlaghi M, Faezi T, Shams H, Larimi R, Ashofteh F
Mod Rheumatol 2013 Jan;23(1):125-32. Epub 2012 Apr 4 doi: 10.1007/s10165-012-0626-9. PMID: 22476858
Aydin F, Akpolat T, Senturk N, Bagci H, Yasar Turanli A
Clin Rheumatol 2009 Nov;28(11):1331-5. Epub 2009 Jul 29 doi: 10.1007/s10067-009-1237-5. PMID: 19639361
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Recent systematic reviews

Maldini C, Lavalley MP, Cheminant M, de Menthon M, Mahr A
Rheumatology (Oxford) 2012 May;51(5):887-900. Epub 2012 Jan 11 doi: 10.1093/rheumatology/ker428. PMID: 22240504

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