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Grade II glioma

MedGen UID:
1391502
Concept ID:
C4330050
Neoplastic Process
Synonyms: Grade 2 Glioma; Grade II Glioma; grade II glioma; WHO Grade 2 Glioma; WHO Grade II Glioma; WHO grade II glioma
 
Monarch Initiative: MONDO:0021639

Definition

A category of low grade gliomas that includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma. [from NCI]

Professional guidelines

PubMed

Delgado-López PD, Corrales-García EM, Martino J, Lastra-Aras E, Dueñas-Polo MT
Clin Transl Oncol 2017 Aug;19(8):931-944. Epub 2017 Mar 2 doi: 10.1007/s12094-017-1631-4. PMID: 28255650
Waqar M, Hanif S, Rathi N, Das K, Zakaria R, Brodbelt AR, Walker C, Jenkinson MD
J Neurooncol 2014 Nov;120(2):389-98. Epub 2014 Aug 6 doi: 10.1007/s11060-014-1563-6. PMID: 25096797
Shields LB, Choucair AK
World Neurosurg 2014 Jul-Aug;82(1-2):e299-309. Epub 2014 Feb 19 doi: 10.1016/j.wneu.2014.02.033. PMID: 24560709

Recent clinical studies

Etiology

Fleming JL, Pugh SL, Fisher BJ, Lesser GJ, Macdonald DR, Bell EH, McElroy JP, Becker AP, Timmers CD, Aldape KD, Rogers CL, Doyle TJ, Werner-Wasik M, Bahary JP, Yu HM, D'Souza DP, Laack NN, Sneed PK, Kwok Y, Won M, Mehta MP, Chakravarti A
JCO Precis Oncol 2021;5 Epub 2021 Sep 1 doi: 10.1200/PO.21.00112. PMID: 34589661Free PMC Article
van Loon EMP, Ernens W, Heijenbrok-Kal MH, Horemans HLD, Ribbers GM, van den Bent MJ
J Rehabil Med 2021 May 28;53(5):jrm00198. doi: 10.2340/16501977-2837. PMID: 33912977Free PMC Article
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Serra C, Akeret K, Staartjes VE, Ramantani G, Grunwald T, Jokeit H, Bauer J, Krayenbühl N
Neurosurg Focus 2020 Apr 1;48(4):E4. doi: 10.3171/2020.1.FOCUS19909. PMID: 32234984
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article

Diagnosis

Wang C, Liu C, Chen J, Jiang H, Zhang W, Yang L, Li X, Li Z, Peng L, Hu X, Sun P
BMC Cancer 2022 Apr 12;22(1):397. doi: 10.1186/s12885-022-09504-5. PMID: 35413858Free PMC Article
van Loon EMP, Ernens W, Heijenbrok-Kal MH, Horemans HLD, Ribbers GM, van den Bent MJ
J Rehabil Med 2021 May 28;53(5):jrm00198. doi: 10.2340/16501977-2837. PMID: 33912977Free PMC Article
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Xiong YJ, Zhao XL, Wang XY, Pan DJ, Tian DS
Medicine (Baltimore) 2017 Dec;96(52):e9456. doi: 10.1097/MD.0000000000009456. PMID: 29384930Free PMC Article
Bette S, Gempt J, Huber T, Delbridge C, Meyer B, Zimmer C, Kirschke JS, Boeckh-Behrens T
J Neurosurg 2017 Aug;127(2):417-425. Epub 2016 Oct 21 doi: 10.3171/2016.8.JNS16752. PMID: 27767397

Therapy

Fleming JL, Pugh SL, Fisher BJ, Lesser GJ, Macdonald DR, Bell EH, McElroy JP, Becker AP, Timmers CD, Aldape KD, Rogers CL, Doyle TJ, Werner-Wasik M, Bahary JP, Yu HM, D'Souza DP, Laack NN, Sneed PK, Kwok Y, Won M, Mehta MP, Chakravarti A
JCO Precis Oncol 2021;5 Epub 2021 Sep 1 doi: 10.1200/PO.21.00112. PMID: 34589661Free PMC Article
Serra C, Akeret K, Staartjes VE, Ramantani G, Grunwald T, Jokeit H, Bauer J, Krayenbühl N
Neurosurg Focus 2020 Apr 1;48(4):E4. doi: 10.3171/2020.1.FOCUS19909. PMID: 32234984
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Jung TY, Yoon MS, Kim YH, Jung S, Kim IY, Jang WY, Moon KS, Lee KH, Kim SK
Clin Neurol Neurosurg 2015 Mar;130:1-5. Epub 2014 Dec 23 doi: 10.1016/j.clineuro.2014.12.006. PMID: 25569296
Ruge MI, Ilmberger J, Tonn JC, Kreth FW
J Neurooncol 2011 May;103(1):129-36. Epub 2010 Sep 5 doi: 10.1007/s11060-010-0364-9. PMID: 20820874

Prognosis

Goacher E, Mathew R, Fayaye O, Chakrabarty A, Feltbower R, Loughrey C, Roberts P, Chumas P
Br J Neurosurg 2024 Apr;38(2):314-321. Epub 2020 Dec 30 doi: 10.1080/02688697.2020.1866163. PMID: 33377401
Fleming JL, Pugh SL, Fisher BJ, Lesser GJ, Macdonald DR, Bell EH, McElroy JP, Becker AP, Timmers CD, Aldape KD, Rogers CL, Doyle TJ, Werner-Wasik M, Bahary JP, Yu HM, D'Souza DP, Laack NN, Sneed PK, Kwok Y, Won M, Mehta MP, Chakravarti A
JCO Precis Oncol 2021;5 Epub 2021 Sep 1 doi: 10.1200/PO.21.00112. PMID: 34589661Free PMC Article
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Bette S, Gempt J, Huber T, Delbridge C, Meyer B, Zimmer C, Kirschke JS, Boeckh-Behrens T
J Neurosurg 2017 Aug;127(2):417-425. Epub 2016 Oct 21 doi: 10.3171/2016.8.JNS16752. PMID: 27767397
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article

Clinical prediction guides

Ng S, Duffau H
Neurology 2022 Jul 5;99(1):e89-e97. Epub 2022 Apr 11 doi: 10.1212/WNL.0000000000200523. PMID: 35410899
Zhao K, Sun G, Wang Q, Xue Z, Liu G, Xia Y, Yao A, Zhao Y, You N, Yang C, Xu B
Acad Radiol 2021 Jul;28(7):e189-e198. Epub 2020 Apr 28 doi: 10.1016/j.acra.2020.03.008. PMID: 32359929
Delgado-López PD, Corrales-García EM, Martino J, Lastra-Aras E, Dueñas-Polo MT
Clin Transl Oncol 2017 Aug;19(8):931-944. Epub 2017 Mar 2 doi: 10.1007/s12094-017-1631-4. PMID: 28255650
Bette S, Gempt J, Huber T, Delbridge C, Meyer B, Zimmer C, Kirschke JS, Boeckh-Behrens T
J Neurosurg 2017 Aug;127(2):417-425. Epub 2016 Oct 21 doi: 10.3171/2016.8.JNS16752. PMID: 27767397
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article

Recent systematic reviews

Koutsarnakis C, Neromyliotis E, Komaitis S, Mazarakis N, O'Hara DJ, Stranjalis G, Chumas P
Radiother Oncol 2021 Jul;160:202-211. Epub 2021 May 6 doi: 10.1016/j.radonc.2021.04.023. PMID: 33964327
Fountain DM, Allen D, Joannides AJ, Nandi D, Santarius T, Chari A
Neuro Oncol 2016 Nov;18(11):1475-1486. Epub 2016 May 18 doi: 10.1093/neuonc/now107. PMID: 27194147Free PMC Article

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