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Abnormal response to endocrine stimulation test

MedGen UID:
1392082
•Concept ID:
C4476952
•
Finding
HPO: HP:0031073

Definition

An anomalous response to a test that is designed to probe the function of the endocrine system. [from HPO]

Professional guidelines

PubMed

ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria.
Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L; ESHRE working group on Poor Ovarian Response Definition
Hum Reprod 2011 Jul;26(7):1616-24. Epub 2011 Apr 19 doi: 10.1093/humrep/der092. PMID: 21505041
Evaluation and management of endocrine dysfunction in fibromyalgia.
Geenen R, Jacobs JW, Bijlsma JW
Rheum Dis Clin North Am 2002 May;28(2):389-404. doi: 10.1016/s0889-857x(01)00009-6. PMID: 12122926
Diagnosis of GH deficiency: auxologic and GH response criteria.
Dash RJ, Pathmanathan G, Prakash S, Saini JS
Indian J Pediatr 1991 Sep-Oct;58 Suppl 1:59-64. doi: 10.1007/BF02750985. PMID: 1824377

Recent clinical studies

Etiology

The Cortisol and ACTH Response to Dex/CRH Testing in Women With and Without Perimenopausal Depression.
Guerrieri GM, Ben Dor R, Li X, Wei SM, Martinez PE, Neiman LK, Rubinow DR, Schmidt PJ
J Clin Endocrinol Metab 2021 Sep 27;106(10):3007-3018. doi: 10.1210/clinem/dgab407. PMID: 34097071Free PMC Article
Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.
Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M, Vaidya B, Chen L, Knight BA, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan CM, French R, Boucai L, Vafeiadi M, Grineva EN, Pop VJM, Vrijkotte TG, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Rebagliato M, Lu X, Pirzada A, Männistö T, Delles C, Feldt-Rasmussen U, Alexander EK, Nelson SM, Chaker L, Pearce EN, Guxens M, Steegers EAP, Walsh JP, Korevaar TIM
Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510. doi: 10.1016/S2213-8587(20)30061-9. PMID: 32445737Free PMC Article
ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria.
Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L; ESHRE working group on Poor Ovarian Response Definition
Hum Reprod 2011 Jul;26(7):1616-24. Epub 2011 Apr 19 doi: 10.1093/humrep/der092. PMID: 21505041
Cushing’s disease and melancholia.
Condren RM, Thakore JH
Stress 2001 Jun;4(2):91-119. doi: 10.3109/10253890109115725. PMID: 22432130
Adolescent varicocele.
Kass EJ, Reitelman C
Urol Clin North Am 1995 Feb;22(1):151-9. PMID: 7855951

Diagnosis

Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR.
Pastore LM, Christianson MS, Stelling J, Kearns WG, Segars JH
J Assist Reprod Genet 2018 Jan;35(1):17-23. Epub 2017 Oct 2 doi: 10.1007/s10815-017-1058-4. PMID: 28971280Free PMC Article
Hypothyroidism.
So M, MacIsaac RJ, Grossmann M
Aust Fam Physician 2012 Aug;41(8):556-62. PMID: 23145394
Hirsutism in women.
Bode D, Seehusen DA, Baird D
Am Fam Physician 2012 Feb 15;85(4):373-80. PMID: 22335316
ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria.
Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L; ESHRE working group on Poor Ovarian Response Definition
Hum Reprod 2011 Jul;26(7):1616-24. Epub 2011 Apr 19 doi: 10.1093/humrep/der092. PMID: 21505041
Cushing’s disease and melancholia.
Condren RM, Thakore JH
Stress 2001 Jun;4(2):91-119. doi: 10.3109/10253890109115725. PMID: 22432130

Therapy

The Cortisol and ACTH Response to Dex/CRH Testing in Women With and Without Perimenopausal Depression.
Guerrieri GM, Ben Dor R, Li X, Wei SM, Martinez PE, Neiman LK, Rubinow DR, Schmidt PJ
J Clin Endocrinol Metab 2021 Sep 27;106(10):3007-3018. doi: 10.1210/clinem/dgab407. PMID: 34097071Free PMC Article
Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome.
Fraser GL, Obermayer-Pietsch B, Laven J, Griesinger G, Pintiaux A, Timmerman D, Fauser BCJM, Lademacher C, Combalbert J, Hoveyda HR, Ramael S
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3519-e3532. doi: 10.1210/clinem/dgab320. PMID: 34000049Free PMC Article
Total and free cortisol responses and their relation to outcomes after cardiopulmonary bypass in infants.
Wald EL, Backer CL, Dearani JA, Li Z, Oliver WC, Crow SS
J Thorac Cardiovasc Surg 2017 May;153(5):1155-1163. Epub 2016 Nov 21 doi: 10.1016/j.jtcvs.2016.11.030. PMID: 28024808
Hypothyroidism.
So M, MacIsaac RJ, Grossmann M
Aust Fam Physician 2012 Aug;41(8):556-62. PMID: 23145394
Hirsutism in women.
Bode D, Seehusen DA, Baird D
Am Fam Physician 2012 Feb 15;85(4):373-80. PMID: 22335316

Prognosis

Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis.
Broer SL, Dólleman M, Opmeer BC, Fauser BC, Mol BW, Broekmans FJ
Hum Reprod Update 2011 Jan-Feb;17(1):46-54. Epub 2010 Jul 28 doi: 10.1093/humupd/dmq034. PMID: 20667894
Cushing’s disease and melancholia.
Condren RM, Thakore JH
Stress 2001 Jun;4(2):91-119. doi: 10.3109/10253890109115725. PMID: 22432130
Adolescent varicocele.
Kass EJ, Reitelman C
Urol Clin North Am 1995 Feb;22(1):151-9. PMID: 7855951
Diagnosis of GH deficiency: auxologic and GH response criteria.
Dash RJ, Pathmanathan G, Prakash S, Saini JS
Indian J Pediatr 1991 Sep-Oct;58 Suppl 1:59-64. doi: 10.1007/BF02750985. PMID: 1824377

Clinical prediction guides

The Cortisol and ACTH Response to Dex/CRH Testing in Women With and Without Perimenopausal Depression.
Guerrieri GM, Ben Dor R, Li X, Wei SM, Martinez PE, Neiman LK, Rubinow DR, Schmidt PJ
J Clin Endocrinol Metab 2021 Sep 27;106(10):3007-3018. doi: 10.1210/clinem/dgab407. PMID: 34097071Free PMC Article
Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF
J Clin Endocrinol Metab 2020 May 1;105(5):1608-16. doi: 10.1210/clinem/dgaa052. PMID: 32016383Free PMC Article
Total and free cortisol responses and their relation to outcomes after cardiopulmonary bypass in infants.
Wald EL, Backer CL, Dearani JA, Li Z, Oliver WC, Crow SS
J Thorac Cardiovasc Surg 2017 May;153(5):1155-1163. Epub 2016 Nov 21 doi: 10.1016/j.jtcvs.2016.11.030. PMID: 28024808
Cushing’s disease and melancholia.
Condren RM, Thakore JH
Stress 2001 Jun;4(2):91-119. doi: 10.3109/10253890109115725. PMID: 22432130
Adolescent varicocele.
Kass EJ, Reitelman C
Urol Clin North Am 1995 Feb;22(1):151-9. PMID: 7855951

Recent systematic reviews

Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.
Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M, Vaidya B, Chen L, Knight BA, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan CM, French R, Boucai L, Vafeiadi M, Grineva EN, Pop VJM, Vrijkotte TG, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Rebagliato M, Lu X, Pirzada A, Männistö T, Delles C, Feldt-Rasmussen U, Alexander EK, Nelson SM, Chaker L, Pearce EN, Guxens M, Steegers EAP, Walsh JP, Korevaar TIM
Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510. doi: 10.1016/S2213-8587(20)30061-9. PMID: 32445737Free PMC Article
AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis.
Broer SL, Dólleman M, Opmeer BC, Fauser BC, Mol BW, Broekmans FJ
Hum Reprod Update 2011 Jan-Feb;17(1):46-54. Epub 2010 Jul 28 doi: 10.1093/humupd/dmq034. PMID: 20667894

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