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Reduced growth-hormone binding protein level

MedGen UID:
1392848
•Concept ID:
C4476923
•
Finding
Synonym: Decreased plasma GH-binding protein
 
HPO: HP:0031036

Definition

A decreased blood concentration of growth hormone binding protein. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced growth-hormone binding protein level

Professional guidelines

PubMed

Growth hormone treatment prevents the decrease in insulin-like growth factor I gene expression in patients undergoing abdominal surgery.
Bjarnason R, Wickelgren R, Hermansson M, Hammarqvist F, Carlsson B, Carlsson LM
J Clin Endocrinol Metab 1998 May;83(5):1566-72. doi: 10.1210/jcem.83.5.4793. PMID: 9589657
Body composition and physical fitness are major determinants of the growth hormone-insulin-like growth factor axis aberrations in adult Turner's syndrome, with important modulations by treatment with 17 beta-estradiol.
Gravholt CH, Naeraa RW, Fisker S, Christiansen JS
J Clin Endocrinol Metab 1997 Aug;82(8):2570-7. doi: 10.1210/jcem.82.8.4127. PMID: 9253336
Reduced concentration of serum growth hormone (GH)-binding protein in children with chronic renal failure: correlation with GH insensitivity. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. The German Study Group for Growth Hormone Treatment in Chronic Renal Failure.
Tönshoff B, Cronin MJ, Reichert M, Haffner D, Wingen AM, Blum WF, Mehls O
J Clin Endocrinol Metab 1997 Apr;82(4):1007-13. doi: 10.1210/jcem.82.4.3893. PMID: 9100565

Recent clinical studies

Etiology

GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Noonan syndrome, the Ras-MAPK signalling pathway and short stature.
Binder G
Horm Res 2009 Apr;71 Suppl 2:64-70. Epub 2009 Apr 29 doi: 10.1159/000192439. PMID: 19407499
Circulating growth hormone binding protein levels and mononuclear cell growth hormone receptor expression in uremia.
Greenstein J, Guest S, Tan JC, Tummala P, Busque S, Rabkin R
J Ren Nutr 2006 Apr;16(2):141-9. doi: 10.1053/j.jrn.2006.01.007. PMID: 16567271
Growth hormone binding protein activity in obese children.
Seminara S, Filpo A, La Cauza F, Faedda A, Miola A, Pellizzone S, Casati M, Loche S
J Endocrinol Invest 1998 Jul-Aug;21(7):441-4. doi: 10.1007/BF03347323. PMID: 9766258
Growth hormone-binding proteins, IGF-I and IGF-binding proteins in children and adolescents with type 1 diabetes mellitus.
Radetti G, Paganini C, Antoniazzi F, Pasquino B, Valentini R, Gentili L, Tato L
Horm Res 1997;47(3):110-5. doi: 10.1159/000185444. PMID: 9050949

Diagnosis

GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
A comparison of circulating and regional growth hormone-binding protein in cirrhosis.
Møller S, Fisker S, Becker U, Henriksen JH
Metabolism 2001 Nov;50(11):1340-5. doi: 10.1053/meta.2001.27207. PMID: 11699054
Growth hormone and adipocyte function in obesity.
Nam SY, Marcus C
Horm Res 2000;53 Suppl 1:87-97. doi: 10.1159/000053211. PMID: 10895049
Clinical review 112: Does serum growth hormone (GH) binding protein reflect human GH receptor function?
Amit T, Youdim MB, Hochberg Z
J Clin Endocrinol Metab 2000 Mar;85(3):927-32. doi: 10.1210/jcem.85.3.6461. PMID: 10720017
Partial growth hormone insensitivity in childhood.
Carlsson LM
Baillieres Clin Endocrinol Metab 1996 Jul;10(3):389-400. doi: 10.1016/s0950-351x(96)80515-5. PMID: 8853446

Therapy

A comparison of circulating and regional growth hormone-binding protein in cirrhosis.
Møller S, Fisker S, Becker U, Henriksen JH
Metabolism 2001 Nov;50(11):1340-5. doi: 10.1053/meta.2001.27207. PMID: 11699054
Growth hormone and adipocyte function in obesity.
Nam SY, Marcus C
Horm Res 2000;53 Suppl 1:87-97. doi: 10.1159/000053211. PMID: 10895049
Growth hormone binding protein activity in obese children.
Seminara S, Filpo A, La Cauza F, Faedda A, Miola A, Pellizzone S, Casati M, Loche S
J Endocrinol Invest 1998 Jul-Aug;21(7):441-4. doi: 10.1007/BF03347323. PMID: 9766258
Serum levels of growth hormone-binding protein and insulin-like growth factor I in children and adolescents with type 1 (insulin-dependent) diabetes mellitus.
Massa G, Dooms L, Bouillon R, Vanderschueren-Lodeweyckx M
Diabetologia 1993 Mar;36(3):239-43. doi: 10.1007/BF00399957. PMID: 8462773
Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women.
Weissberger AJ, Ho KK, Lazarus L
J Clin Endocrinol Metab 1991 Feb;72(2):374-81. doi: 10.1210/jcem-72-2-374. PMID: 1991807

Prognosis

GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia.
Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJ, Anker SD, Strasburger CJ
Eur J Endocrinol 2001 Dec;145(6):727-35. doi: 10.1530/eje.0.1450727. PMID: 11720897
A comparison of circulating and regional growth hormone-binding protein in cirrhosis.
Møller S, Fisker S, Becker U, Henriksen JH
Metabolism 2001 Nov;50(11):1340-5. doi: 10.1053/meta.2001.27207. PMID: 11699054
Serum concentrations of insulin, insulin-like growth factor(IGF)-I, IGF binding protein (IGFBP)-1 and -3 and growth hormone binding protein in obese children: fasting IGFBP-1 is suppressed in normoinsulinaemic obese children.
Saitoh H, Kamoda T, Nakahara S, Hirano T, Nakamura N
Clin Endocrinol (Oxf) 1998 Apr;48(4):487-92. doi: 10.1046/j.1365-2265.1998.00476.x. PMID: 9640416
Insulin-like growth factor binding protein-3 generation: an index of growth hormone insensitivity.
Thalange NK, Price DA, Gill MS, Whatmore AJ, Addison GM, Clayton PE
Pediatr Res 1996 May;39(5):849-55. doi: 10.1203/00006450-199605000-00018. PMID: 8726240

Clinical prediction guides

GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia.
Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJ, Anker SD, Strasburger CJ
Eur J Endocrinol 2001 Dec;145(6):727-35. doi: 10.1530/eje.0.1450727. PMID: 11720897
Growth hormone and adipocyte function in obesity.
Nam SY, Marcus C
Horm Res 2000;53 Suppl 1:87-97. doi: 10.1159/000053211. PMID: 10895049
Clinical review 112: Does serum growth hormone (GH) binding protein reflect human GH receptor function?
Amit T, Youdim MB, Hochberg Z
J Clin Endocrinol Metab 2000 Mar;85(3):927-32. doi: 10.1210/jcem.85.3.6461. PMID: 10720017
Reduced concentration of serum growth hormone-binding protein in children with idiopathic short stature. National Cooperative Growth Study.
Carlsson LM, Attie KM, Compton PG, Vitangcol RV, Merimee TJ
J Clin Endocrinol Metab 1994 Jun;78(6):1325-30. doi: 10.1210/jcem.78.6.8200933. PMID: 8200933

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