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Reduced growth-hormone binding protein level

MedGen UID:
1392848
•Concept ID:
C4476923
•
Finding
Synonym: Decreased plasma GH-binding protein
 
HPO: HP:0031036

Definition

A decreased blood concentration of growth hormone binding protein. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced growth-hormone binding protein level

Professional guidelines

PubMed

Growth hormone treatment prevents the decrease in insulin-like growth factor I gene expression in patients undergoing abdominal surgery.
Bjarnason R, Wickelgren R, Hermansson M, Hammarqvist F, Carlsson B, Carlsson LM
J Clin Endocrinol Metab 1998 May;83(5):1566-72. doi: 10.1210/jcem.83.5.4793. PMID: 9589657
Body composition and physical fitness are major determinants of the growth hormone-insulin-like growth factor axis aberrations in adult Turner's syndrome, with important modulations by treatment with 17 beta-estradiol.
Gravholt CH, Naeraa RW, Fisker S, Christiansen JS
J Clin Endocrinol Metab 1997 Aug;82(8):2570-7. doi: 10.1210/jcem.82.8.4127. PMID: 9253336
Reduced concentration of serum growth hormone (GH)-binding protein in children with chronic renal failure: correlation with GH insensitivity. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. The German Study Group for Growth Hormone Treatment in Chronic Renal Failure.
Tönshoff B, Cronin MJ, Reichert M, Haffner D, Wingen AM, Blum WF, Mehls O
J Clin Endocrinol Metab 1997 Apr;82(4):1007-13. doi: 10.1210/jcem.82.4.3893. PMID: 9100565

Recent clinical studies

Etiology

GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Growth hormone receptor gene expression in puberty.
Pagani S, Meazza C, Gertosio C, Bozzola E, Bozzola M
Horm Metab Res 2015 Jul;47(8):581-4. Epub 2015 Jan 20 doi: 10.1055/s-0034-1395591. PMID: 25602347
Circulating growth hormone binding protein levels and mononuclear cell growth hormone receptor expression in uremia.
Greenstein J, Guest S, Tan JC, Tummala P, Busque S, Rabkin R
J Ren Nutr 2006 Apr;16(2):141-9. doi: 10.1053/j.jrn.2006.01.007. PMID: 16567271
Acquired growth hormone resistance in adults.
Jenkins RC, Ross RJ
Baillieres Clin Endocrinol Metab 1998 Jul;12(2):315-29. doi: 10.1016/s0950-351x(98)80025-6. PMID: 10083899
Do androgens regulate growth hormone-binding protein in adult man?
Ip TP, Hoffman DM, O'Sullivan AJ, Leung KC, Ho KK
J Clin Endocrinol Metab 1995 Apr;80(4):1278-82. doi: 10.1210/jcem.80.4.7714101. PMID: 7714101

Diagnosis

GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia.
Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJ, Anker SD, Strasburger CJ
Eur J Endocrinol 2001 Dec;145(6):727-35. doi: 10.1530/eje.0.1450727. PMID: 11720897
A comparison of circulating and regional growth hormone-binding protein in cirrhosis.
Møller S, Fisker S, Becker U, Henriksen JH
Metabolism 2001 Nov;50(11):1340-5. doi: 10.1053/meta.2001.27207. PMID: 11699054
Growth hormone and adipocyte function in obesity.
Nam SY, Marcus C
Horm Res 2000;53 Suppl 1:87-97. doi: 10.1159/000053211. PMID: 10895049
Clinical review 112: Does serum growth hormone (GH) binding protein reflect human GH receptor function?
Amit T, Youdim MB, Hochberg Z
J Clin Endocrinol Metab 2000 Mar;85(3):927-32. doi: 10.1210/jcem.85.3.6461. PMID: 10720017

Therapy

The Placental Variant of Human Growth Hormone Reduces Maternal Insulin Sensitivity in a Dose-Dependent Manner in C57BL/6J Mice.
Liao S, Vickers MH, Stanley JL, Ponnampalam AP, Baker PN, Perry JK
Endocrinology 2016 Mar;157(3):1175-86. Epub 2015 Dec 15 doi: 10.1210/en.2015-1718. PMID: 26671184
Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice.
Dagnaes-Hansen F, Duan H, Rasmussen LM, Friend KE, Flyvbjerg A
Anticancer Res 2004 Nov-Dec;24(6):3735-42. PMID: 15736405
A comparison of circulating and regional growth hormone-binding protein in cirrhosis.
Møller S, Fisker S, Becker U, Henriksen JH
Metabolism 2001 Nov;50(11):1340-5. doi: 10.1053/meta.2001.27207. PMID: 11699054
Growth hormone and adipocyte function in obesity.
Nam SY, Marcus C
Horm Res 2000;53 Suppl 1:87-97. doi: 10.1159/000053211. PMID: 10895049
Do androgens regulate growth hormone-binding protein in adult man?
Ip TP, Hoffman DM, O'Sullivan AJ, Leung KC, Ho KK
J Clin Endocrinol Metab 1995 Apr;80(4):1278-82. doi: 10.1210/jcem.80.4.7714101. PMID: 7714101

Prognosis

A common deletion in the growth hormone receptor gene (d3-GHR) in the offspring is related to maternal placental GH levels during pregnancy.
Jensen RB, Boas M, Nielsen JE, Maroun LL, Jørgensen A, Larsen T, Main KM, Juul A
Growth Horm IGF Res 2020 Dec;55:101360. Epub 2020 Oct 16 doi: 10.1016/j.ghir.2020.101360. PMID: 33096343
GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia.
Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJ, Anker SD, Strasburger CJ
Eur J Endocrinol 2001 Dec;145(6):727-35. doi: 10.1530/eje.0.1450727. PMID: 11720897
A comparison of circulating and regional growth hormone-binding protein in cirrhosis.
Møller S, Fisker S, Becker U, Henriksen JH
Metabolism 2001 Nov;50(11):1340-5. doi: 10.1053/meta.2001.27207. PMID: 11699054
Serum growth hormone-binding protein in obesity: effect of a short-term, very low calorie diet and diet-induced weight loss.
Rasmussen MH, Ho KK, Kjems L, Hilsted J
J Clin Endocrinol Metab 1996 Apr;81(4):1519-24. doi: 10.1210/jcem.81.4.8636361. PMID: 8636361

Clinical prediction guides

Growth hormone receptor promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway.
Zhu X, Li Y, Xu G, Fu C
FEBS Open Bio 2020 Jun;10(6):1013-1020. Epub 2020 May 6 doi: 10.1002/2211-5463.12816. PMID: 32069380Free PMC Article
GH-IGF-1 Axis in Children with Cystic Fibrosis.
Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Majo F, Villani A, Bozzola M
Clin Med Res 2019 Dec;17(3-4):82-89. Epub 2019 Aug 28 doi: 10.3121/cmr.2019.1476. PMID: 31462537Free PMC Article
Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia.
Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJ, Anker SD, Strasburger CJ
Eur J Endocrinol 2001 Dec;145(6):727-35. doi: 10.1530/eje.0.1450727. PMID: 11720897
Growth hormone and adipocyte function in obesity.
Nam SY, Marcus C
Horm Res 2000;53 Suppl 1:87-97. doi: 10.1159/000053211. PMID: 10895049
Clinical review 112: Does serum growth hormone (GH) binding protein reflect human GH receptor function?
Amit T, Youdim MB, Hochberg Z
J Clin Endocrinol Metab 2000 Mar;85(3):927-32. doi: 10.1210/jcem.85.3.6461. PMID: 10720017

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