U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Variola minor infection

MedGen UID:
1393
Concept ID:
C0001906
Disease or Syndrome
Synonyms: Alastrim; Minor, Variola; Minors, Variola; Variola Minor; Variola Minors
SNOMED CT: Alastrim (72294005); Variola minor (72294005); Kaffir pox (72294005); Amaas (72294005)
 
Monarch Initiative: MONDO:0004720

Definition

A orthopoxvirus that causes a milder clinical syndrome than smallpox. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVariola minor infection

Professional guidelines

PubMed

Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Huang Y, Mu L, Wang W
Signal Transduct Target Ther 2022 Nov 2;7(1):373. doi: 10.1038/s41392-022-01215-4. PMID: 36319633Free PMC Article
Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y
Drugs 2022 Jun;82(9):957-963. Epub 2022 Jun 28 doi: 10.1007/s40265-022-01742-y. PMID: 35763248Free PMC Article

Recent clinical studies

Etiology

Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Kmiec D, Kirchhoff F
Int J Mol Sci 2022 Jul 17;23(14) doi: 10.3390/ijms23147866. PMID: 35887214Free PMC Article
Meyer H, Ehmann R, Smith GL
Viruses 2020 Jan 24;12(2) doi: 10.3390/v12020138. PMID: 31991671Free PMC Article
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article
Morand A, Delaigue S, Morand JJ
Med Sante Trop 2017 Feb 1;27(1):29-39. doi: 10.1684/mst.2017.0653. PMID: 28406414

Diagnosis

Soheili M, Nasseri S, Afraie M, Khateri S, Moradi Y, Mahdavi Mortazavi SM, Gilzad-Kohan H
J Pharm Pharm Sci 2022;25:297-322. doi: 10.18433/jpps33138. PMID: 36130588
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Gong Q, Wang C, Chuai X, Chiu S
Virol Sin 2022 Aug;37(4):477-482. Epub 2022 Jul 9 doi: 10.1016/j.virs.2022.07.006. PMID: 35820590Free PMC Article
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article
McCollum AM, Damon IK
Clin Infect Dis 2014 Jan;58(2):260-7. Epub 2013 Oct 24 doi: 10.1093/cid/cit703. PMID: 24158414

Therapy

Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Ahmad S, Hasan H, Ahmad Suhaimi NA, Albakri KA, Abedalbaset Alzyoud A, Kadir R, Mohamud R
Emerg Microbes Infect 2022 Dec;11(1):2600-2631. doi: 10.1080/22221751.2022.2132882. PMID: 36263798Free PMC Article
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y
Drugs 2022 Jun;82(9):957-963. Epub 2022 Jun 28 doi: 10.1007/s40265-022-01742-y. PMID: 35763248Free PMC Article
Breman JG
J Infect Dis 2021 Sep 30;224(12 Suppl 2):S379-S386. doi: 10.1093/infdis/jiaa588. PMID: 34590143Free PMC Article
Meyer H, Ehmann R, Smith GL
Viruses 2020 Jan 24;12(2) doi: 10.3390/v12020138. PMID: 31991671Free PMC Article

Prognosis

Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Martín-Delgado MC, Martín Sánchez FJ, Martínez-Sellés M, Molero García JM, Moreno Guillén S, Rodríguez-Artalejo FJ, Ruiz-Galiana J, Cantón R, De Lucas Ramos P, García-Botella A, García-Lledó A, Hernández-Sampelayo T, Gómez-Pavón J, González Del Castillo J, Muñoz P, Valerio M, Catalán P, Burillo A, Cobo A, Alcamí A, Bouza E
Rev Esp Quimioter 2022 Dec;35(6):509-518. Epub 2022 Jul 6 doi: 10.37201/req/059.2022. PMID: 35785957Free PMC Article
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network
Lancet Infect Dis 2022 Aug;22(8):1153-1162. Epub 2022 May 24 doi: 10.1016/S1473-3099(22)00228-6. PMID: 35623380Free PMC Article
Lippi D, Gotuzzo E, Caini S
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.PoH-0012-2015. PMID: 27726771
Weaver JR, Isaacs SN
Immunol Rev 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x. PMID: 18837778Free PMC Article

Clinical prediction guides

Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network
Lancet Infect Dis 2022 Aug;22(8):1153-1162. Epub 2022 May 24 doi: 10.1016/S1473-3099(22)00228-6. PMID: 35623380Free PMC Article
Petersen BW, Kabamba J, McCollum AM, Lushima RS, Wemakoy EO, Muyembe Tamfum JJ, Nguete B, Hughes CM, Monroe BP, Reynolds MG
Antiviral Res 2019 Feb;162:171-177. Epub 2018 Nov 14 doi: 10.1016/j.antiviral.2018.11.004. PMID: 30445121Free PMC Article
Grosenbach DW, Honeychurch K, Rose EA, Chinsangaram J, Frimm A, Maiti B, Lovejoy C, Meara I, Long P, Hruby DE
N Engl J Med 2018 Jul 5;379(1):44-53. doi: 10.1056/NEJMoa1705688. PMID: 29972742Free PMC Article
Weaver JR, Isaacs SN
Immunol Rev 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x. PMID: 18837778Free PMC Article

Recent systematic reviews

Fox T, Gould S, Princy N, Rowland T, Lutje V, Kuehn R
Cochrane Database Syst Rev 2023 Mar 14;3(3):CD015769. doi: 10.1002/14651858.CD015769. PMID: 36916727Free PMC Article
Sudarmaji N, Kifli N, Hermansyah A, Yeoh SF, Goh BH, Ming LC
Viruses 2022 Nov 11;14(11) doi: 10.3390/v14112496. PMID: 36423105Free PMC Article
Ling RR, Ramanathan K, Tan FL, Tai BC, Somani J, Fisher D, MacLaren G
Lancet Respir Med 2022 Jul;10(7):679-688. Epub 2022 Apr 11 doi: 10.1016/S2213-2600(22)00059-5. PMID: 35421376Free PMC Article
Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, Steffen R
PLoS Negl Trop Dis 2022 Feb;16(2):e0010141. Epub 2022 Feb 11 doi: 10.1371/journal.pntd.0010141. PMID: 35148313Free PMC Article
Beer EM, Rao VB
PLoS Negl Trop Dis 2019 Oct;13(10):e0007791. Epub 2019 Oct 16 doi: 10.1371/journal.pntd.0007791. PMID: 31618206Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...